Nanotechnology in disease diagnostic techniques

Current Drug Metabolism

Volumn 16, Issue 8, 2015, Pages 645-661

  Savaliya, Reema ^a   Shah, Darshini ^a   Singh, Ragini ^a   Kumar, Ashutosh ^a   Shanker, Rishi ^a   Dhawan, Alok ^a   Singh, Sanjay ^a  

^a AHMEDABAD UNIVERSITY   (India)

Author keywords

Biomarkers; Biosensors; Nanomaterials; POC

Indexed keywords

BIOLOGICAL MARKER; CARBON NANOTUBE; GOLD NANOPARTICLE; METAL OXIDE; NANOMATERIAL; NANOWIRE; QUANTUM DOT;

ARTICLE; BIOSENSOR; CANCER EPIDEMIOLOGY; CARDIOVASCULAR DISEASE; CONJUGATION; DEGENERATIVE DISEASE; DIAGNOSTIC PROCEDURE; DNA HYBRIDIZATION; DNA METHYLATION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DIAGNOSIS; NANOTECHNOLOGY; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SIGNAL NOISE RATIO; SURFACE AREA; TARGET CELL; WHOLE CELL; ANIMAL; PROCEDURES;

ANIMALS; DIAGNOSTIC TECHNIQUES AND PROCEDURES; HUMANS; NANOSTRUCTURES; NANOTECHNOLOGY;

EID: 84947910789     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200216666150625121546     Document Type: Article

References (160)

1. Alivisatos, P. The use of nanocrystals in biological detection. Nat. Biotechnol., 2004, 22(1), 47-52.
2. Pelaz, B.; Jaber, S.; de Aberasturi, D. J.; Wulf, V.; Aida, T.; de la Fuente, J. M.; Feldmann, J.; Gaub, H. E.; Josephson, L.; Kagan, C. R.; Kotov, N. A.; Liz-Marzan, L. M.; Mattoussi, H.; Mulvaney, P.; Murray, C. B.; Rogach, A. L.; Weiss, P. S.; Willner, I.; Parak, W. J. The state of nanoparticle-based nanoscience and biotechnology: progress, promises, and challenges. ACS Nano, 2012, 6(10), 8468-8483.
3. Singh, S.; Sharma, A.; Robertson, G. P. Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns. Cancer Res., 2012, 72(22), 5663-5668.
4. Silva, A. K.; Di Corato, R.; Pellegrino, T.; Chat, S.; Pugliese, G.; Luciani, N.; Gazeau, F.; Wilhelm, C. Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials. Nanoscale, 2013, 5(23), 11374-11384.
5. Gautier, J.; Allard-Vannier, E.; Munnier, E.; Souce, M.; Chourpa, I. Recent advances in theranostic nanocarriers of doxorubicin based on iron oxide and gold nanoparticles. J. Control Release, 2013, 169(1-2), 48-61.
6. Li, H.; Marotta, D. E.; Kim, S.; Busch, T. M.; Wileyto, E. P.; Zheng, G. High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles. J. Biomed. Opt., 2005, 10(4), 41203 (1-7).
7. Kim, J. K.; Yuan, H.; Nie, J.; Yang, Y. T.; Leggas, M.; Potter, P. M.; Rinehart, J.; Jay, M.; Lu, X. High payload dual therapeuticimaging nanocarriers for triggered tumor delivery. Small, 2012, 8(18), 2895-2903.
8. Ambati, J.; Lopez, A. M.; Cochran, D.; Wattamwar, P.; Bean, K.; Dziubla, T. D.; Rankin, S. E. Engineered silica nanocarriers as a high-payload delivery vehicle for antioxidant enzymes. Acta. Biomater., 2012, 8(6), 2096-2103.
9. Jain, R. K. Barriers to drug delivery in solid tumors. Sci. Am., 1994, 271(1), 58-65.
10. Sudimack, J.; Lee, R. J. Targeted drug delivery via the folate receptor. Adv. Drug Deliv. Rev., 2000, 41(2), 147-162.
11. Arap, W.; Pasqualini, R.; Ruoslahti, E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science, 1998, 279(5349), 377-380.
12. Wu, Y.; Sefah, K.; Liu, H.; Wang, R.; Tan, W. DNA aptamermicelle as an efficient detection/delivery vehicle toward cancer cells. Proc. Natl. Acad. Sci. U S A, 2010, 107(1), 5-10.
13. Leamon, C. P.; Reddy, J. A. Folate-targeted chemotherapy. Adv. Drug Deliv. Rev., 2004, 56(8), 1127-1141.
14. Ward, J. F., 3rd; Rewcastle, J. C.; Ukimura, O.; Gill, I. S. Focal therapy for the treatment of localized prostate cancer: a potential therapeutic paradigm shift awaiting better imaging. Curr. Opin. Urol., 2012, 22(2), 104-108.
15. Cooperberg, M. R.; Carroll, P. R.; Klotz, L. Active surveillance for prostate cancer: progress and promise. J. Clin. Oncol., 2011, 29(27), 3669-3676.
16. Liu, T. W.; Macdonald, T. D.; Jin, C. S.; Gold, J. M.; Bristow, R. G.; Wilson, B. C.; Zheng, G. Inherently multimodal nanoparticledriven tracking and real-time delineation of orthotopic prostate tumors and micrometastases. ACS Nano, 2013, 7(5), 4221-4232.
17. Issaq, H. J.; Waybright, T. J.; Veenstra, T. D. Cancer biomarker discovery: Opportunities and pitfalls in analytical methods. Electrophoresis, 2011, 32(9), 967-975.
18. Lyons, T. J.; Basu, A. Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers. Transl. Res., 2012, 159(4), 303-312.
19. Rhee, E. P.; Gerszten, R. E. Metabolomics and cardiovascular biomarker discovery. Clin. Chem., 2012, 58(1), 139-147.
20. Dasilva, N.; Diez, P.; Matarraz, S.; Gonzalez-Gonzalez, M.; Paradinas, S.; Orfao, A.; Fuentes, M. Biomarker discovery by novel sensors based on nanoproteomics approaches. Sensors (Basel), 2012, 12(2), 2284-2308.
21. Chan, C. P.; Mak, W. C.; Cheung, K. Y.; Sin, K. K.; Yu, C. M.; Rainer, T. H.; Renneberg, R. Evidence-based point-of-care diagnostics: current status and emerging technologies. Annu. Rev. Anal. Chem. (Palo Alto Calif), 2013, 6, 191-211.
22. Crommelin, D. J.; Florence, A. T. Towards more effective advanced drug delivery systems. Int. J. Pharm., 2013, 454(1), 496-511.
23. Dharap, S. S.; Wang, Y.; Chandna, P.; Khandare, J. J.; Qiu, B.; Gunaseelan, S.; Sinko, P. J.; Stein, S.; Farmanfarmaian, A.; Minko, T. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc. Natl. Acad. Sci. USA., 2005, 102(36), 12962-12967.
24. Frank, D.; Tyagi, C.; Tomar, L.; Choonara, Y. E.; du Toit, L. C.; Kumar, P.; Penny, C.; Pillay, V. Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors. Int. J. Nanomedicine, 2014, 9, 589-613.
25. Patra, H. K.; Turner, A. P. The potential legacy of cancer nanotechnology: cellular selection. Trends Biotechnol., 2014, 32(1), 21-31.
26. Babu, A.; Templeton, A. K.; Munshi, A.; Ramesh, R. Nanodrug Delivery Systems: A Promising Technology for Detection, Diagnosis, and Treatment of Cancer. AAPS Pharm. Sci. Tech., 2014, 15(3), 709-721.
27. Sanna, V.; Pala, N.; Sechi, M. Targeted therapy using nanotechnology: focus on cancer. Int. J. Nanomedicine, 2014, 9, 467-483.
28. Ambrosi, A.; Airo, F.; Merkoci, A. Enhanced gold nanoparticle based ELISA for a breast cancer biomarker. Anal. Chem., 2008, 82(3), 1151-1156.
29. Gao, L.; Zhuang, J.; Nie, L.; Zhang, J.; Zhang, Y.; Gu, N.; Wang, T.; Feng, J.; Yang, D.; Perrett, S.; Yan, X. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat. Nanotechnol., 2007, 2(9), 577-583.
30. Cui, R.; Han, Z.; Zhu, J. J. Helical carbon nanotubes: intrinsic peroxidase catalytic activity and its application for biocatalysis and biosensing. Chemistry, 2011, 17(34), 9377-9384.
31. Singh, S.; Dosani, T.; Karakoti, A. S.; Kumar, A.; Seal, S.; Self, W. T. A phosphate-dependent shift in redox state of cerium oxide nanoparticles and its effects on catalytic properties. Biomaterials, 2011, 32(28), 6745-6753.
32. Karakoti, A.; Singh, S.; Dowding, J. M.; Seal, S.; Self, W. T. Redoxactive radical scavenging nanomaterials. Chem. Soc. Rev., 2010, 39(11), 4422-4432.
33. Pirmohamed, T.; Dowding, J. M.; Singh, S.; Wasserman, B.; Heckert, E.; Karakoti, A. S.; King, J. E.; Seal, S.; Self, W. T. Nanoceria exhibit redox state-dependent catalase mimetic activity. Chem. Commun. (Camb), 2010, 46(16), 2736-2738.
34. Karakoti, A. S.; Singh, S.; Kumar, A.; Malinska, M.; Kuchibhatla, S. V.; Wozniak, K.; Self, W. T.; Seal, S. PEGylated nanoceria as radical scavenger with tunable redox chemistry. J. Am. Chem. Soc., 2009, 131(40), 14144-14145.
35. Asati, A.; Kaittanis, C.; Santra, S.; Perez, J. M. pH-tunable oxidaselike activity of cerium oxide nanoparticles achieving sensitive fluorigenic detection of cancer biomarkers at neutral pH. Anal. Chem., 2011, 83(7), 2547-2553.
36. Hogg, T.; Kuekes, P. J. Mobile microscopic sensors for high resolution in vivo diagnostics. Nanomedicine, 2006, 2(4), 239-247.
37. Parker, C. E.; Borchers, C. H. Mass spectrometry based biomarker discovery, verification, and validation - Quality assurance and control of protein biomarker assays. Mol. Oncol., 2014, 8(4), 840-858.
38. Hanahan, D.; Weinberg, R. A. The hallmarks of cancer. Cell, 2000, 100(1), 57-70.
39. Srinivas, P. R.; Kramer, B. S.; Srivastava, S. Trends in biomarker research for cancer detection. Lancet Oncol., 2001, 2(11), 698-704.
40. Sidransky, D. Emerging molecular markers of cancer. Nat. Rev. Cancer, 2002, 2(3), 210-219.
41. Alizadeh, A. A.; Eisen, M. B.; Davis, R. E.; Ma, C.; Lossos, I. S.; Rosenwald, A.; Boldrick, J. C.; Sabet, H.; Tran, T.; Yu, X.; Powell, J. I.; Yang, L.; Marti, G. E.; Moore, T.; Hudson, J., Jr.; Lu, L.; Lewis, D. B.; Tibshirani, R.; Sherlock, G.; Chan, W. C.; Greiner, T. C.; Weisenburger, D. D.; Armitage, J. O.; Warnke, R.; Levy, R.; Wilson, W.; Grever, M. R.; Byrd, J. C.; Botstein, D.; Brown, P. O.; Staudt, L. M. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature, 2000, 403(6769), 503-511.
42. Bild, A. H.; Yao, G.; Chang, J. T.; Wang, Q.; Potti, A.; Chasse, D.; Joshi, M. B.; Harpole, D.; Lancaster, J. M.; Berchuck, A.; Olson, J. A., Jr.; Marks, J. R.; Dressman, H. K.; West, M.; Nevins, J. R. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature, 2006, 439(7074), 353-357.
43. Stelzl, U.; Worm, U.; Lalowski, M.; Haenig, C.; Brembeck, F. H.; Goehler, H.; Stroedicke, M.; Zenkner, M.; Schoenherr, A.; Koeppen, S.; Timm, J.; Mintzlaff, S.; Abraham, C.; Bock, N.; Kietzmann, S.; Goedde, A.; Toksoz, E.; Droege, A.; Krobitsch, S.; Korn, B.; Birchmeier, W.; Lehrach, H.; Wanker, E. E. A human proteinprotein interaction network: a resource for annotating the proteome. Cell, 2005, 122(6), 957-968.
44. Rual, J. F.; Venkatesan, K.; Hao, T.; Hirozane-Kishikawa, T.; Dricot, A.; Li, N.; Berriz, G. F.; Gibbons, F. D.; Dreze, M.; Ayivi-Guedehoussou, N.; Klitgord, N.; Simon, C.; Boxem, M.; Milstein, S.; Rosenberg, J.; Goldberg, D. S.; Zhang, L. V.; Wong, S. L.; Franklin, G.; Li, S.; Albala, J. S.; Lim, J.; Fraughton, C.; Llamosas, E.; Cevik, S.; Bex, C.; Lamesch, P.; Sikorski, R. S.; Vandenhaute, J.; Zoghbi, H. Y.; Smolyar, A.; Bosak, S.; Sequerra, R.; Doucette-Stamm, L.; Cusick, M. E.; Hill, D. E.; Roth, F. P.; Vidal, M. Towards a proteome-scale map of the human protein-protein interaction network. Nature, 2005, 437(7062), 1173-1178.
45. Ho, J. A.; Chang, H. C.; Shih, N. Y.; Wu, L. C.; Chang, Y. F.; Chen, C. C.; Chou, C. Diagnostic detection of human lung cancerassociated antigen using a gold nanoparticle-based electrochemical immunosensor. Anal. Chem., 2010, 82(14), 5944-5950.
46. Nguyen, C. T.; Nguyen, J. T.; Rutledge, S.; Zhang, J.; Wang, C.; Walker, G. C. Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles. Cancer Lett., 2010, 292(1), 91-97.
47. Morales-Narvaez, E.; Monton, H.; Fomicheva, A.; Merkoci, A. Signal enhancement in antibody microarrays using quantum dots nanocrystals: application to potential Alzheimer's disease biomarker screening. Anal. Chem., 2012, 84(15), 6821-6827.
48. Li, T.; Yang, M. Electrochemical sensor utilizing ferrocene loaded porous polyelectrolyte nanoparticles as label for the detection of protein biomarker IL-6. Sensors and Actuators B: Chemical, 2011, 158(1), 361-365.
49. Yuen, C.; Liu, Q. Optimization of Fe3O4@Ag nanoshells in magnetic field-enriched surface-enhanced resonance Raman scattering for malaria diagnosis. Analyst, 2013, 138(21), 6494-6500.
50. Liu, X.; Dai, Q.; Austin, L.; Coutts, J.; Knowles, G.; Zou, J.; Chen, H.; Huo, Q. A one-step homogeneous immunoassay for cancer biomarker detection using gold nanoparticle probes coupled with dynamic light scattering. J. Am. Chem. Soc., 2008, 130(9), 2780-2782.
51. Li, L.; Xu, J.; Zheng, X.; Ma, C.; Song, X.; Ge, S.; Yu, J.; Yan, M. Growth of gold-manganese oxide nanostructures on a 3D origami device for glucose-oxidase label based electrochemical immunosensor. Biosens. Bioelectron., 2014, 61, 76-82.
52. Xiong, Y.; Deng, C.; Zhang, X. Development of aptamerconjugated magnetic graphene/gold nanoparticle hybrid nanocomposites for specific enrichment and rapid analysis of thrombin by MALDI-TOF MS. Talanta, 2014, 129, 282-289.
53. Zapp, E.; Westphal, E.; Gallardo, H.; de Souza, B.; Cruz Vieira, I. Liquid crystal and gold nanoparticles applied to electrochemical immunosensor for cardiac biomarker. Biosens. Bioelectron., 2014, 59, 127-133.
54. Al-Ogaidi, I.; Gou, H.; Aguilar, Z. P.; Guo, S.; Melconian, A. K.; Al-Kazaz, A. K.; Meng, F.; Wu, N. Detection of the ovarian cancer biomarker CA-125 using chemiluminescence resonance energy transfer to graphene quantum dots. Chem. Commun. (Camb), 2014, 50(11), 1344-1346.
55. Zhao, Q.; Duan, R.; Yuan, J.; Quan, Y.; Yang, H.; Xi, M. A reusable localized surface plasmon resonance biosensor for quantitative detection of serum squamous cell carcinoma antigen in cervical cancer patients based on silver nanoparticles array. Int. J. Nanomedicine, 2014, 9, 1097-1104.
56. Li, H.; Wei, Q.; Wang, G.; Yang, M.; Qu, F.; Qian, Z. Sensitive electrochemical immunosensor for cancer biomarker with signal enhancement based on nitrodopamine-functionalized iron oxide nanoparticles. Biosens. Bioelectron., 2011, 26(6), 3044-3049.
57. Yang, C. C.; Yang, S. Y.; Chieh, J. J.; Horng, H. E.; Hong, C. Y.; Yang, H. C.; Chen, K. H.; Shih, B. Y.; Chen, T. F.; Chiu, M. J. Biofunctionalized magnetic nanoparticles for specifically detecting biomarkers of Alzheimer's disease in vitro. ACS Chem. Neurosci., 2011, 2(9), 500-505.
58. Wang, Z.; Liu, N.; Ma, Z. Platinum porous nanoparticles hybrid with metal ions as probes for simultaneous detection of multiplex cancer biomarkers. Biosens. Bioelectron., 2014, 53, 324-329.
59. Shen, W.; Tian, D.; Cui, H.; Yang, D.; Bian, Z. Nanoparticle-based electrochemiluminescence immunosensor with enhanced sensitivity for cardiac troponin I using N-(aminobutyl)-N-(ethylisoluminol) - functionalized gold nanoparticles as labels. Biosens. Bioelectron., 2011, 27(1), 18-24.
60. Lin, K. Y.; Kwong, G. A.; Warren, A. D.; Wood, D. K.; Bhatia, S. N. Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis. ACS Nano., 2013, 7(10), 9001-9009.
61. Parolo, C.; Merkoci, A. Paper-based nanobiosensors for diagnostics. Chem. Soc. Rev., 2013, 42(2), 450-457.
62. Perfezou, M.; Turner, A.; Merkoci, A. Cancer detection using nanoparticle-based sensors. Chem. Soc. Rev., 2012, 41(7), 2606-2622.
63. Yao, J.; Yang, M.; Duan, Y. Chemistry, Biology, and Medicine of Fluorescent Nanomaterials and Related Systems: New Insights into Biosensing, Bioimaging, Genomics, Diagnostics, and Therapy. Chem. Rev., 2014, 114(12), 6130-6178.
64. Liang, H.; Zhang, X. B.; Lv, Y.; Gong, L.; Wang, R.; Zhu, X.; Yang, R.; Tan, W. Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted Therapy. Acc. Chem. Res., 2014, 47(6), 1891-1901.
65. Yan, M.; Sun, G.; Liu, F.; Lu, J.; Yu, J.; Song, X. An aptasensor for sensitive detection of human breast cancer cells by using porous GO/Au composites and porous PtFe alloy as effective sensing platform and signal amplification labels. Anal. Chim. Acta, 2013, 798, 33-39.
66. Ding, L.; Bond, A. M.; Zhai, J.; Zhang, J. Utilization of nanoparticle labels for signal amplification in ultrasensitive electrochemical affinity biosensors: a review. Anal. Chim. Acta, 2013, 797, 1-12.
67. de la Escosura-Muniz, A.; Merkoci, A. Electrochemical detection of proteins using nanoparticles: applications to diagnostics. Expert Opin. Med. Diagn., 2010, 4(1), 21-37.
68. Li, H.; Rothberg, L. Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles. Proc. Natl. Acad. Sci. USA., 2004, 101(39), 14036-14039.
69. Ge, Z.; Lin, M.; Wang, P.; Pei, H.; Yan, J.; Shi, J.; Huang, Q.; He, D.; Fan, C.; Zuo, X. Hybridization chain reaction amplification of microRNA detection with a tetrahedral DNA nanostructure-based electrochemical biosensor. Anal. Chem., 2014, 86(4), 2124-2130.
70. Ge, Y.; Wu, J.; Ju, H.; Wu, S. Ultrasensitive enzyme-free electrochemical immunosensor based on hybridization chain reaction triggered double strand DNA@Au nanoparticle tag. Talanta, 2014, 120, 218-223.
71. Dai, Q.; Liu, X.; Coutts, J.; Austin, L.; Huo, Q. A one-step highly sensitive method for DNA detection using dynamic light scattering. J. Am. Chem. Soc., 2008, 130(26), 8138-8139.
72. Pumera, M.; Castaneda, M. T.; Pividori, M. I.; Eritja, R.; Merkoci, A.; Alegret, S. Magnetically trigged direct electrochemical detection of DNA hybridization using Au67 quantum dot as electrical tracer. Langmuir, 2005, 21(21), 9625-9629.
73. Zhao, W.; Wang, L.; Tan, W. Fluorescent nanoparticle for bacteria and DNA detection. Adv. Exp. Med. Biol., 2007, 620, 129-135.
74. Chen, X. J.; Sanchez-Gaytan, B. L.; Qian, Z.; Park, S. J. Noble metal nanoparticles in DNA detection and delivery. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2012, 4(3), 273-290.
75. Kalidasan, K.; Neo, J. L.; Uttamchandani, M. Direct visual detection of Salmonella genomic DNA using gold nanoparticles. Mol. Biosyst., 2013, 9(4), 618-621.
76. Huang, Y.; Zhao, S.; Liu, Y. M.; Chen, J.; Chen, Z. F.; Shi, M.; Liang, H. An amplified single-walled carbon nanotube-mediated chemiluminescence turn-on sensing platform for ultrasensitive DNA detection. Chem. Commun. (Camb), 2012, 48(75), 9400-9402.
77. Lee, K.; Cui, Y.; Lee, L. P.; Irudayaraj, J. Quantitative imaging of single mRNA splice variants in living cells. Nat. Nanotechnol., 2014, 9(6), 474-480.
78. Zhu, H.; Wang, G.; Xie, D.; Cai, B.; Liu, Y.; Zhao, X. Au nanoparticles enhanced fluorescence detection of DNA hybridization in picoliter microfluidic droplets. Biomed. Microdevices, 2014, 16(3), 479-485.
79. de la Escosura-Muniz, A.; Mekoci, A. Nanoparticle based enhancement of electrochemical DNA hybridization signal using nanoporous electrodes. Chem. Commun. (Camb), 2010, 46(47), 9007-9009.
80. Carrascosa, L. G.; Sina, A. A.; Palanisamy, R.; Sepulveda, B.; Otte, M. A.; Rauf, S.; Shiddiky, M. J.; Trau, M. Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation. Chem. Commun. (Camb), 2014, 50(27), 3585-3588.
81. Jing, X.; Cao, X.; Wang, L.; Lan, T.; Li, Y.; Xie, G. DNA-AuNPs based signal amplification for highly sensitive detection of DNA methylation, methyltransferase activity and inhibitor screening. Biosens. Bioelectron., 2014, 58, 40-47.
82. Fujiwara, K.; Watarai, H.; Itoh, H.; Nakahama, E.; Ogawa, N. Measurement of antibody binding to protein immobilized on gold nanoparticles by localized surface plasmon spectroscopy. Anal. Bioanal. Chem., 2006, 386(3), 639-644.
83. Wang, C. I.; Chen, W. T.; Chang, H. T. Enzyme mimics of Au/Ag nanoparticles for fluorescent detection of acetylcholine. Anal. Chem., 2012, 84(22), 9706-9712.
84. Jia, H.; Gao, P.; Ma, H.; Wu, D.; Du, B.; Wei, Q. Preparation of Au-Pt nanostructures by combining top-down with bottom-up strategies and application in label-free electrochemical immunosensor for detection of NMP22. Bioelectrochemistry, 2014, 101 C, 22-27.
85. Jiang, Z.; Qin, Y.; Peng, Z.; Chen, S.; Chen, S.; Deng, C.; Xiang, J. The simultaneous detection of free and total prostate antigen in serum samples with high sensitivity and specificity by using the dualchannel surface plasmon resonance. Biosens. Bioelectron., 2014, 62, 268-273.
86. Wang, C. W.; Chang, H. T. Sensitive Detection of Platelet-Derived Growth Factor through Surface-Enhanced Raman Scattering. Anal. Chem., 2014, 86(15), 7606-7611.
87. Zhang, Q.; Jing, L.; Zhang, J.; Ren, Y.; Wang, Y.; Wang, Y.; Wei, T.; Liedberg, B. Surface plasmon resonance sensor for femtomolar detection of testosterone with water-compatible macroporous molecularly imprinted film. Anal. Biochem., 2014, 463, 7-14.
88. Li, Y. S.; Zhou, Y.; Meng, X. Y.; Zhang, Y. Y.; Song, F.; Lu, S. Y.; Ren, H. L.; Hu, P.; Liu, Z. S.; Zhang, J. H. Gold nanoparticle aggregation-based colorimetric assay for beta-casein detection in bovine milk samples. Food Chem., 2014, 162, 22-26.
89. Mishra, S. K.; Sharma, V.; Kumar, D.; Rajesh. Biofunctionalized Gold Nanoparticle-Conducting Polymer Nanocomposite Based Bioelectrode for CRP Detection. Appl. Biochem. Biotechnol., 2014, 174(3), 984-997.
90. Zhao, Q.; Lu, X.; Yuan, C. G.; Li, X. F.; Le, X. C. Aptamer-linked assay for thrombin using gold nanoparticle amplification and inductively coupled plasma-mass spectrometry detection. Anal. Chem., 2009, 81(17), 7484-7489.
91. Medintz, I. L.; Mattoussi, H. Quantum dot-based resonance energy transfer and its growing application in biology. Phys. Chem. Chem. Phys., 2009, 11(1), 17-45.
92. Liu, J.; Lee, J. H.; Lu, Y. Quantum dot encoding of aptamer-linked nanostructures for one-pot simultaneous detection of multiple analytes. Anal. Chem., 2007, 79(11), 4120-4125.
93. Tang, B.; Cao, L.; Xu, K.; Zhuo, L.; Ge, J.; Li, Q.; Yu, L. A new nanobiosensor for glucose with high sensitivity and selectivity in serum based on fluorescence resonance Energy transfer (FRET) between CdTe quantum dots and Au nanoparticles. Chemistry, 2008, 14(12), 3637-3644.
94. Qian, J.; Wang, C.; Pan, X.; Liu, S. A high-throughput homogeneous immunoassay based on Forster resonance energy transfer between quantum dots and gold nanoparticles. Anal. Chim. Acta, 2013, 763, 43-49.
95. Wang, M.; Gu, X.; Zhang, G.; Zhang, D.; Zhu, D. Continuous colorimetric assay for acetylcholinesterase and inhibitor screening with gold nanoparticles. Langmuir, 2009, 25(4), 2504-2507.
96. Rusling, J. F.; Kumar, C. V.; Gutkind, J. S.; Patel, V. Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst, 2010, 135(10), 2496-2511.
97. Leuschner, C.; Kumar, C. S.; Hansel, W.; Soboyejo, W.; Zhou, J.; Hormes, J. LHRH-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases. Breast Cancer Res. Treat., 2006, 99(2), 163-176.
98. Viator, J. A.; Gupta, S.; Goldschmidt, B. S.; Bhattacharyyal, K.; Kannan, R.; Shukla, R.; Dale, P. S.; Boote, E.; Katti, K. Gold nanoparticle mediated detection of prostate cancer cells using photoacoustic flowmetry with optical reflectance. J. Biomed. Nanotechnol., 2010, 6(2), 187-191.
99. Estevez, M. C.; Huang, Y. F.; Kang, H.; O'Donoghue, M. B.; Bamrungsap, S.; Yan, J.; Chen, X.; Tan, W. Nanoparticle-aptamer conjugates for cancer cell targeting and detection. Methods Mol. Biol., 2010, 624, 235-248.
100. McCormack, D. R.; Bhattacharyya, K.; Kannan, R.; Katti, K.; Viator, J. A. Enhanced photoacoustic detection of melanoma cells using gold nanoparticles. Lasers Surg. Med., 2011, 43(4), 333-338.
101. Chang, Y. C.; Yang, C. Y.; Sun, R. L.; Cheng, Y. F.; Kao, W. C.; Yang, P. C. Rapid single cell detection of Staphylococcus aureus by aptamer-conjugated gold nanoparticles. Sci. Rep., 2013, 3, 1863.
102. Hathaway, H. J.; Butler, K. S.; Adolphi, N. L.; Lovato, D. M.; Belfon, R.; Fegan, D.; Monson, T. C.; Trujillo, J. E.; Tessier, T. E.; Bryant, H. C.; Huber, D. L.; Larson, R. S.; Flynn, E. R. Detection of breast cancer cells using targeted magnetic nanoparticles and ultrasensitive magnetic field sensors. Breast Cancer Res., 2011, 13(5), R108.
103. Nima, Z. A.; Mahmood, M.; Xu, Y.; Mustafa, T.; Watanabe, F.; Nedosekin, D. A.; Juratli, M. A.; Fahmi, T.; Galanzha, E. I.; Nolan, J. P.; Basnakian, A. G.; Zharov, V. P.; Biris, A. S. Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonances. Sci. Rep., 2014, 4, 4752.
104. Tabatabaei-Panah, A. S.; Jeddi-Tehrani, M.; Ghods, R.; Akhondi, M. M.; Mojtabavi, N.; Mahmoudi, A. R.; Mirzadegan, E.; Shojaeian, S.; Zarnani, A. H. Accurate sensitivity of quantum dots for detection of HER2 expression in breast cancer cells and tissues. J. Fluoresc., 2013, 23(2), 293-302.
105. Zdobnova, T. A.; Dorofeev, S. G.; Tananaev, P. N.; Vasiliev, R. B.; Balandin, T. G.; Edelweiss, E. F.; Stremovskiy, O. A.; Balalaeva, I. V.; Turchin, I. V.; Lebedenko, E. N.; Zlomanov, V. P.; Deyev, S. M. Fluorescent immunolabeling of cancer cells by quantum dots and antibody scFv fragment. J. Biomed. Opt., 2009, 14(2), 021001-021004.
106. Ditto, A. J.; Shah, K. N.; Robishaw, N. K.; Panzner, M. J.; Youngs, W. J.; Yun, Y. H. The Interactions between L-tyrosine based nanoparticles decorated with folic acid and cervical cancer cells under physiological flow. Mol. Pharm., 2012, 9(11), 3089-3098.
107. Wong, T. S.; Brough, B.; Ho, C. M. Creation of functional micro/nano systems through top-down and bottom-up approaches. Mol. Cell Biomech., 2009, 6(1), 1-55.
108. Gaspari, M.; Ming-Cheng Cheng, M.; Terracciano, R.; Liu, X.; Nijdam, A. J.; Vaccari, L.; di Fabrizio, E.; Petricoin, E. F.; Liotta, L. A.; Cuda, G.; Venuta, S.; Ferrari, M. Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma. J. Proteome Res., 2006, 5(5), 1261-1266.
109. Fan, J.; Deng, X.; Gallagher, J. W.; Huang, H.; Huang, Y.; Wen, J.; Ferrari, M.; Shen, H.; Hu, Y. Monitoring the progression of metastatic breast cancer on nanoporous silica chips. Philos Trans A Math. Phys. Eng. Sci., 2012, 370(1967), 2433-2447.
110. Hu, Y.; Gopal, A.; Lin, K.; Peng, Y.; Tasciotti, E.; Zhang, X. J.; Ferrari, M. Microfluidic enrichment of small proteins from com plex biological mixture on nanoporous silica chip. Biomicrofluidics, 2011, 5(1), 13410 (1-7).
111. Fan, J.; Niu, S.; Dong, A.; Shi, J.; Wu, H. J.; Fine, D. H.; Tian, Y.; Zhou, C.; Liu, X.; Sun, T.; Anderson, G. J.; Ferrari, M.; Nie, G.; Hu, Y.; Zhao, Y. Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids. Nanomedicine, 2014, 10(5), 879-888.
112. Terracciano, R.; Pasqua, L.; Casadonte, F.; Frasca, S.; Preiano, M.; Falcone, D.; Savino, R. Derivatized mesoporous silica beads for MALDI-TOF MS profiling of human plasma and urine. Bioconjug. Chem., 2009, 20(5), 913-923.
113. Terracciano, R.; Preiano, M.; Palladino, G. P.; Carpagnano, G. E.; Barbaro, M. P.; Pelaia, G.; Savino, R.; Maselli, R. Peptidome profiling of induced sputum by mesoporous silica beads and MALDITOF MS for non-invasive biomarker discovery of chronic inflammatory lung diseases. Proteomics, 2011, 11(16), 3402-3414.
114. Lai, C. Y.; Trewyn, B. G.; Jeftinija, D. M.; Jeftinija, K.; Xu, S.; Jeftinija, S.; Lin, V. S. A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J. Am. Chem. Soc., 2003, 125(15), 4451-4459.
115. Zhao, Y.; Trewyn, B. G.; Slowing, I. I; Lin, V. S. Mesoporous silica nanoparticle-based double drug delivery system for glucoseresponsive controlled release of insulin and cyclic AMP. J. Am. Chem. Soc., 2009, 131(24), 8398-8400.
116. Lin, T. Y.; Li, B. R.; Tsai, S. T.; Chen, C. W.; Chen, C. H.; Chen, Y. T.; Pan, C. Y. Improved silicon nanowire field-effect transistors for fast protein-protein interaction screening. Lab Chip, 2013, 13(4), 676-684.
117. Zheng, G.; Lieber, C. M. Nanowire biosensors for label-free, realtime, ultrasensitive protein detection. Methods Mol. Biol., 2011, 790, 223-237.
118. Chua, J. H.; Chee, R. E.; Agarwal, A.; Wong, S. M.; Zhang, G. J. Label-free electrical detection of cardiac biomarker with complementary metal-oxide semiconductor-compatible silicon nanowire sensor arrays. Anal. Chem., 2009, 81(15), 6266-6271.
119. Kwon, S. M.; Kang, G. B.; Kim, Y. T.; Kim, Y. H.; Ju, B. K. Insitu detection of C-reactive protein using silicon nanowire field effect transistor. J. Nanosci. Nanotechnol., 2011, 11(2), 1511-1514.
120. Calin, G. A.; Croce, C. M. MicroRNA signatures in human cancers. Nat. Rev. Cancer, 2006, 6(11), 857-866.
121. Winter, J.; Jung, S.; Keller, S.; Gregory, R. I.; Diederichs, S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol., 2009, 11(3), 228-234.
122. Thomson, J. M.; Newman, M.; Parker, J. S.; Morin-Kensicki, E. M.; Wright, T.; Hammond, S. M. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev., 2006, 20(16), 2202-2207.
123. Zhang, G. J.; Chua, J. H.; Chee, R. E.; Agarwal, A.; Wong, S. M. Label-free direct detection of MiRNAs with silicon nanowire biosensors. Biosens. Bioelectron., 2009, 24(8), 2504-2508.
124. Singh, S. Nanomaterials as Non-viral siRNA Delivery Agents for Cancer Therapy. Bioimpacts, 2013, 3(2), 53-65.
125. Lee, H. S.; Kim, K. S.; Kim, C. J.; Hahn, S. K.; Jo, M. H. Electrical detection of VEGFs for cancer diagnoses using anti-vascular endotherial growth factor aptamer-modified Si nanowire FETs. Biosens. Bioelectron., 2009, 24(6), 1801-1805.
126. Huang, M. J.; Xie, H.; Wan, Q.; Zhang, L.; Ning, Y.; Zhang, G. J. Serotype-specific identification of Dengue virus by silicon nanowire array biosensor. J. Nanosci. Nanotechnol., 2013, 13(6), 3810-3817.
127. Cao, X.; Liu, S.; Feng, Q.; Wang, N. Silver nanowire-based electrochemical immunoassay for sensing immunoglobulin G with signal amplification using strawberry-like ZnO nanostructures as labels. Biosens. Bioelectron., 2013, 49, 256-262.
128. Choi, J. H.; Kim, H.; Kim, H. S.; Um, S. H.; Choi, J. W.; Oh, B. K. MMP-2 detective silicon nanowire biosensor using enzymatic cleavage reaction. J. Biomed. Nanotechnol., 2013, 9(4), 732-735.
129. Lee, M. H.; Lee, K.; Jung, S. W. Multiplexed detection of protein markers with silicon nanowire FET and sol-gel matrix. Conf. Proc. IEEE Eng. Med. Biol. Soc., 2012, 2012, 570-573.
130. Wang, Y.; Zhu, Y.; Chen, J.; Zeng, Y. Amperometric biosensor based on 3D ordered freestanding porous Pt nanowire array electrode. Nanoscale, 2012, 4(19), 6025-6031.
131. Hansen, K. M.; Thundat, T. Microcantilever biosensors. Methods, 2005, 37(1), 57-64.
132. Fritz, J.; Baller, M. K.; Lang, H. P.; Rothuizen, H.; Vettiger, P.; Meyer, E.; Guntherodt, H.; Gerber, C.; Gimzewski, J. K. Translating biomolecular recognition into nanomechanics. Science, 2000, 288(5464), 316-318.
133. Braun, T.; Barwich, V.; Ghatkesar, M. K.; Bredekamp, A. H.; Gerber, C.; Hegner, M.; Lang, H. P. Micromechanical mass sensors for biomolecular detection in a physiological environment. Phys. Rev. E Stat. Nonlin Soft Matter Phys., 2005, 72(3 Pt 1), 031907.
134. Kwon, T. Y.; Eom, K.; Park, J. H.; Yoon, D. S.; Kim, T. S.; Lee, H. L. In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid. Appl. Phy. Lett., 2007, 90(22), 223903-223903-3.
135. Yin, T. I.; Zhao, Y.; Horak, J.; Bakirci, H.; Liao, H. H.; Tsai, H. H.; Juang, Y. Z.; Urban, G. A micro-cantilever sensor chip based on contact angle analysis for a label-free troponin I immunoassay. Lab Chip, 2013, 13(5), 834-842.
136. Wu, G.; Datar, R. H.; Hansen, K. M.; Thundat, T.; Cote, R. J.; Majumdar, A. Bioassay of prostate-specific antigen (PSA) using microcantilevers. Nat. Biotechnol., 2001, 19(9), 856-860.
137. Alvarez, M.; Lechuga, L. M. Microcantilever-based platforms as biosensing tools. Analyst, 2010, 135(5), 827-836.
138. Shu, W.; Laurenson, S.; Knowles, T. P.; Ko Ferrigno, P.; Seshia, A. A. Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors. Biosens. Bioelectron., 2008, 24(2), 233-237.
139. Ndieyira, J. W.; Watari, M.; Barrera, A. D.; Zhou, D.; Vogtli, M.; Batchelor, M.; Cooper, M. A.; Strunz, T.; Horton, M. A.; Abell, C.; Rayment, T.; Aeppli, G.; McKendry, R. A. Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance. Nat. Nanotechnol., 2008, 3(11), 691-696.
140. Hwang, K. S.; Eom, K.; Lee, J. H.; Chun, D. W.; Cha, B. H.; Yoon, D. S.; Kim, T. S.; Park, J. H. Dominant surface stress driven by biomolecular interactions in the dynamical response of nanomechanical microcantilevers. Appl. Phy. Lett., 2006, 89(17), 173905-173905-3.
141. Savran, C. A.; Knudsen, S. M.; Ellington, A. D.; Manalis, S. R. Micromechanical detection of proteins using aptamer-based receptor molecules. Anal. Chem., 2004, 76(11), 3194-3198.
142. Hwang, K. S.; Lee, S. M.; Eom, K.; Lee, J. H.; Lee, Y. S.; Park, J. H.; Yoon, D. S.; Kim, T. S. Nanomechanical microcantilever operated in vibration modes with use of RNA aptamer as receptor molecules for label-free detection of HCV helicase. Biosens. Bioelectron., 2007, 23(4), 459-465.
143. Zhai, L.; Wang, T.; Kang, K.; Zhao, Y.; Shrotriya, P.; Nilsen-Hamilton, M. An RNA aptamer-based microcantilever sensor to detect the inflammatory marker, mouse lipocalin-2. Anal. Chem., 2012, 84(20), 8763-8770.
144. Brousseau, L. C., 3rd, Label-free "digital detection" of singlemolecule DNA hybridization with a single electron transistor. J. Am. Chem. Soc., 2006, 128(35), 11346-11347.
145. He, H.; Pham-Huy, L. A.; Dramou, P.; Xiao, D.; Zuo, P.; Pham-Huy, C. Carbon nanotubes: applications in pharmacy and medicine. Biomed. Res. Int., 2013, 2013, 1-12.
146. De Volder, M. F.; Tawfick, S. H.; Baughman, R. H.; Hart, A. J. Carbon nanotubes: present and future commercial applications. Science, 2013, 339(6119), 535-539.
147. Yang, R.; Tang, Z.; Yan, J.; Kang, H.; Kim, Y.; Zhu, Z.; Tan, W. Noncovalent assembly of carbon nanotubes and single-stranded DNA: an effective sensing platform for probing biomolecular interactions. Anal. Chem., 2008, 80(19), 7408-7413.
148. Wang, J.; Kawde, A. N.; Musameh, M. Carbon-nanotube-modified glassy carbon electrodes for amplified label-free electrochemical detection of DNA hybridization. Analyst, 2003, 128(7), 912-916.
149. Fu, D.; Li, L. J. Label-free electrical detection of DNA hybridization using carbon nanotubes and graphene. Nano. Rev., 2010, 1, 5354.
150. Baghayeri, M.; Nazarzadeh Zare, E.; Hasanzadeh, R. Facile synthesis of PSMA-g-3ABA/MWCNTs nanocomposite as a substrate for hemoglobin immobilization: application to catalysis of H (2) O (2). Mater. Sci. Eng. C Mater. Biol. Appl., 2014, 39, 213-220.
151. Tang, W.; Li, L.; Wu, L.; Gong, J.; Zeng, X. Glucose biosensor based on a glassy carbon electrode modified with polythionine and multiwalled carbon nanotubes. PLoS One, 2014, 9(5), e95030 (1-8).
152. Siqueira, J. R., Jr.; Molinnus, D.; Beging, S.; Schoning, M. J. Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection. Anal. Chem., 2014, 86(11), 5370-5375.
153. Li, F.; Peng, J.; Wang, J.; Tang, H.; Tan, L.; Xie, Q.; Yao, S. Carbon nanotube-based label-free electrochemical biosensor for sensitive detection of miRNA-24. Biosens. Bioelectron., 2014, 54, 158-164.
154. Huang, Y.; Hu, K.; Zhao, S.; Li, M.; Chen, Z. F.; Lv, Q.; Liang, H. Carbon nanotube-enhanced polarization of fluorescent peptides: a novel amplification strategy for homogeneous detection of proteases. Chem. Asian J., 2014, 9(1), 87-92.
155. Hu, C.; Zheng, J.; Su, X.; Wang, J.; Wu, W.; Hu, S. Ultrasensitive all-carbon photoelectrochemical bioprobes for zeptomole immunosensing of tumor markers by an inexpensive visible laser light. Anal. Chem., 2013, 85(21), 10612-10619.
156. Fang, Y. S.; Wang, H. Y.; Wang, L. S.; Wang, J. F. Electrochemical immunoassay for procalcitonin antigen detection based on signal amplification strategy of multiple nanocomposites. Biosens. Bioelectron., 2014, 51, 310-316.
157. Oh, J.; Yoo, G.; Chang, Y. W.; Kim, H. J.; Jose, J.; Kim, E.; Pyun, J. C.; Yoo, K. H. A carbon nanotube metal semiconductor field effect transistor-based biosensor for detection of amyloid-beta in human serum. Biosens. Bioelectron., 2013, 50, 345-350.
158. Karimi-Maleh, H.; Biparva, P.; Hatami, M. A novel modified carbon paste electrode based on NiO/CNTs nanocomposite and (9, 10-dihydro-9, 10-ethanoanthracene-11, 12-dicarboximido)-4-ethylbenzene-1, 2-diol as a mediator for simultaneous determination of cysteamine, nicotinamide adenine dinucleotide and folic acid. Biosens. Bioelectron., 2013, 48, 270-275.
159. Tyner, K.; Sadrieh, N., Considerations when submitting nanotherapeutics to FDA/CDER for regulatory review. Methods Mol. Biol., 2011, 697, 17-31.
160. Pene, F.; Courtine, E.; Cariou, A.; Mira, J. P. Toward theragnostics. Crit. Care Med., 2009, 37(1 Suppl), S50-S58.