Mobile microscopic sensors for high resolution in vivo diagnostics

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 2, Issue 4, 2006, Pages 239-247

  Hogg, Tad ^a   Kuekes, Philip J ^a  

^a HEWLETT PACKARD LABORATORIES   (United States)

Author keywords

Medical diagnostics; Microfluidics; Molecular electronics; Nanorobotics; Nanoscale chemical sensors

Indexed keywords

BLOOD; CELLS; DIAGNOSIS; MICROSCOPIC EXAMINATION; MOLECULAR BIOLOGY; OPTICAL RESOLVING POWER; TISSUE;

MEDICAL DIAGNOSTICS; MICROFLUIDICS; MOLECULAR ELECTRONICS; NANOROBOTICS; NANOSCALE CHEMICAL SENSORS;

BIOSENSORS;

NANOPARTICLE;

ARTICLE; BLOOD VOLUME; CELL SIZE; CHEMICAL ANALYSIS; DEPTH PERCEPTION; DEVICE; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DILUTION; ELECTRONIC SENSOR; EVALUATION; MICROFLUIDICS; MICROSCOPY; NANOTECHNOLOGY; PERFORMANCE; TIME PERCEPTION; TISSUE INJURY;

BIOSENSING TECHNIQUES; CHEMISTRY; CHEMISTRY, CLINICAL; ELECTRONICS; EQUIPMENT DESIGN; HEMATOLOGIC TESTS; HUMANS; MATERIALS TESTING; MICROELECTRODES; MOLECULAR PROBE TECHNIQUES; NANOMEDICINE; NANOSTRUCTURES; NANOTECHNOLOGY; ROBOTICS;

EID: 33845325344     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2006.10.004     Document Type: Article

References (36)

1. Freitas Jr. R.A. Nanomedicine, Vol I: basic capabilities (1999), Landes Bioscience, Georgetown (TX). Available at www.nanomedicine.com/NMI.htm
2. Morris K. Macrodoctor, come meet the nanodoctors. Lancet 357 (2001) 778
3. Keszler BL, Majoros IJ, Baker Jr JR. Molecular engineering in nanotechnology: structure and composition of multifunctional devices for medical application Proceedings of the Ninth Foresight Conference on Molecular Nanotechnology; November 9-11, 2001, Santa Clara, CA.
4. Berna J., et al. Macroscopic transport by synthetic molecular machines. Nature Materials 4 (2005) 704-710
5. Collier C.P., Wong E.W., Belohradský M., Raymo F.M., Stoddart J.F., Kuekes P.J., Williams R.S., and Heath J.R. Electronically configurable molecular-based logic gates. Science 285 (1999) 391-394
6. Craighead H.G. Nanoelectromechanical systems. Science 290 (2001) 1532-1535
7. Fritz J., et al. Translating biomolecular recognition into nanomechanics. Science 288 (2000) 316-318
8. Patolsky F., and Lieber C.M. Nanowire nanosensors. Materials Today 8 (2005) 20-28
9. Sheehan P.E., and Whitman L.J. Detection limits for nanoscale biosensors. Nano Lett 5 4 (2005) 803-807
10. In: Wang S.-Y., and Williams R.S. (Eds). Nanoelectronics, Appl A. Physics (2005) [80 Special Issue]
11. Vo-Dinh T., Kasili K., and Wabuyele M. Nanoprobes and nanobiosensors for monitoring and imaging individual living cells. Nanomed: Nanotechnol, Biol Med 2 (2006) 22-30
12. Natterer F. The mathematics of computerized tomography (2001), Society for Industrial and Applied Math (SIAM), Philadelphia
13. Arbuckle D., and Requicha A.A.G. Active self-assembly. Proceedings of the IEEE International Conference on Robotics and Automation (2004) 896-901
14. Bonabeau E., Dorigo M., and Theraulaz G. Swarm intelligence: from natural to artificial systems (1999), Oxford University Press, Oxford
15. Holland O., and Melhuish C. Stigmergy, self-organization and sorting in collective robotics. Artificial Life 5 (1999) 173-202
16. Dhariwal A, Sukhatme GS, Requicha AAG. Bacterium-inspired robots for environmental monitoring Proceedings of the IEEE International Conference. on Robotics and Automation; April 26-May 1, 2004, New Orleans, LA, pp. 1436-1443.
17. Cavalcanti A., and Freitas Jr. R.A. Autonomous multi-robot sensor-based cooperation for nanomedicine. Int J Nonlinear Sci Num Simulation 3 (2002) 743-746
18. Hogg T., and Huberman B.A. Dynamics of large autonomous computational systems. In: Tumer K., and Wolpert D. (Eds). Collectives and the design of complex systems (2004), Springer, New York 295-315
19. Lerman K., et al. A macroscopic analytical model of collaboration in distributed robotic systems. Artificial Life 7 (2001) 375-393
20. Galstyan A, Hogg T, Lerman K. Modeling and mathematical analysis of swarms of microscopic robots P. Arabshahi A. Martinoli Proceedings of the IEEE Swarm Intelligence Symposium (SIS2005); June8-10, 2005, Pasadena, CA, p. 201-208
21. Purcell E.M. Life at low Reynolds number. Am J Phys 45 (1977) 3-11
22. Vogel S. Life in moving fluids. 2nd ed. (1994), Princeton Univ. Press, Princeton, New Jersey
23. Fung Y.C. Biomechanics: circulation. 2nd ed. (1997), Springer, New York
24. Karniadakis G.E.M., and Beskok A. Micro flows: fundamentals and simulation (2002), Springer, Berlin
25. Berg H.C., and Purcell E.M. Physics of chemoreception. Biophys J 20 (1997) 193-219
26. Berg H.C. Random walks in biology. 2nd ed. (1993), Princeton Univ. Press, Princeton, New Jersey
27. Wang Z.L., and Song J. Piezoelectric nanogenerators based on zinc oxide nanowire arrays. Science 312 (2006) 242-246
28. Janeway C.A., Travers P., Walport M., and Shlomchik M. Immunobiology: the immune system in health and disease. 5th ed. (2001) Garland
29. Ghosh S., et al. Carbon nanotube flow sensors. Science 299 (2003) 1042-1044
30. Sretavan D., Chang W., Keller C., and Kliot M. Microscale surgery on axons for nerve injury treatment. Neurosurgery 57 4 (2005) 635-646
31. Hogg T., and Sretavan D.W. Controlling tiny multi-scale robots for nerve repair. Proceedings of the 20th National Conference on Artificial Intelligence (AAAI2005), July 9-13 (2005), AAAI Press, Pittsburgh, PA 1286-1291
32. Freitas Jr. R.A. Pharmacytes: an ideal vehicle for targeted drug delivery. Journal of Nanosci Nanotechnol 6 (2006) 2769-2775
33. Benenson Y., Gil B., Ben-Dor U., Adar R., and Shapiro E. An autonomous molecular computer for logical control of gene expression. Nature 429 (2004) 423-429
34. Gourley P.L., Gourley P., Hendricks J., McDonald A., Copeland R., et al. Ultrafast nanolaser flow device for detecting cancer in single cells. Biomed Microdevices 7 (2005) 331-339
35. Freitas Jr. R.A. Nanomedicine, Vol IIA: biocompatibility (2003), Landes Bioscience, Georgetown (TX). http://www.nanomedicine.com/NMIIA.htm Available from
36. Nel A., Xia T., Mädler L., Li N., et al. Toxic potential of materials at the nanolevel. Science 311 (2006) 622-627