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Volumn 1655, Issue , 2017, Pages 283-293

Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms

Author keywords

CNV; Hipsc models; Mouse models; Schizophrenia

Indexed keywords

COPY NUMBER VARIATION; DRUG DEVELOPMENT; GENETIC ENGINEERING; GENOME ANALYSIS; GENOME EDITING; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MOLECULAR GENETICS; MOLECULAR PATHOLOGY; MOUSE MODEL; NEUROPSYCHIATRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; ANIMAL; GENETICS; MENTAL DISEASE; PATHOPHYSIOLOGY; PHYSIOLOGY;

EID: 84947547489     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.11.009     Document Type: Review
Times cited : (14)

References (114)
  • 2
    • 84951908046 scopus 로고    scopus 로고
    • Common polygenic variation and risk for childhood-onset schizophrenia
    • Ahn, K., An, S.S., Shugart, Y.Y., Rapoport, J.L., Common polygenic variation and risk for childhood-onset schizophrenia. Mol. Psychiatry, 2014, 1–3, 10.1038/mp.2014.158.
    • (2014) Mol. Psychiatry , pp. 1-3
    • Ahn, K.1    An, S.S.2    Shugart, Y.Y.3    Rapoport, J.L.4
  • 5
    • 80053143413 scopus 로고    scopus 로고
    • Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model
    • Ananiev, G., Williams, E.C., Li, H., Chang, Q., Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model. PLoS One, 6, 2011, e25255, 10.1371/journal.pone.0025255.
    • (2011) PLoS One , vol.6 , pp. e25255
    • Ananiev, G.1    Williams, E.C.2    Li, H.3    Chang, Q.4
  • 6
    • 0033861549 scopus 로고    scopus 로고
    • Human and mouse gene structure: comparative analysis and application to exon prediction
    • Batzoglou, S., Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res. 10 (2000), 950–958, 10.1101/gr.10.7.950.
    • (2000) Genome Res. , vol.10 , pp. 950-958
    • Batzoglou, S.1
  • 7
    • 33845870419 scopus 로고    scopus 로고
    • Deconstructing Schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder
    • Braff, D.L., Freedman, R., Schork, N.J., Gottesman, I.I., Deconstructing Schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr. Bull. 33 (2006), 21–32, 10.1093/schbul/sbl049.
    • (2006) Schizophr. Bull. , vol.33 , pp. 21-32
    • Braff, D.L.1    Freedman, R.2    Schork, N.J.3    Gottesman, I.I.4
  • 9
    • 84901313139 scopus 로고    scopus 로고
    • Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells
    • Brennand, K.J., Landek-Salgado, M.A., Sawa, A., Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells. Biol. Psychiatry 75 (2014), 936–944, 10.1016/j.biopsych.2013.10.025.
    • (2014) Biol. Psychiatry , vol.75 , pp. 936-944
    • Brennand, K.J.1    Landek-Salgado, M.A.2    Sawa, A.3
  • 11
    • 84922359495 scopus 로고    scopus 로고
    • Genetic studies of schizophrenia: an update
    • Chen, J., Cao, F., Liu, L., Wang, L., Chen, X., Genetic studies of schizophrenia: an update. Neurosci. Bull. 31 (2015), 87–98, 10.1007/s12264-014-1494-4.
    • (2015) Neurosci. Bull. , vol.31 , pp. 87-98
    • Chen, J.1    Cao, F.2    Liu, L.3    Wang, L.4    Chen, X.5
  • 12
    • 84876374695 scopus 로고    scopus 로고
    • Molecular analysis of a deletion hotspot in the NRXN1 region reveals the involvement of short inverted repeats in deletion CNVs
    • Chen, X., Shen, Y., Zhang, F., Chiang, C., Pillalamarri, V., Blumenthal, I., Talkowski, M., Wu, B.L., Gusella, J.F., Molecular analysis of a deletion hotspot in the NRXN1 region reveals the involvement of short inverted repeats in deletion CNVs. Am. J. Hum. Genet. 92 (2013), 375–386, 10.1016/j.ajhg.2013.02.006.
    • (2013) Am. J. Hum. Genet. , vol.92 , pp. 375-386
    • Chen, X.1    Shen, Y.2    Zhang, F.3    Chiang, C.4    Pillalamarri, V.5    Blumenthal, I.6    Talkowski, M.7    Wu, B.L.8    Gusella, J.F.9
  • 13
    • 79953048441 scopus 로고    scopus 로고
    • Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation
    • Chiang, C.-H., Su, Y., Wen, Z., Yoritomo, N., Ross, C.A., Margolis, R.L., Song, H., Ming, G., Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. Mol. Psychiatry 16 (2011), 358–360, 10.1038/mp.2011.13.
    • (2011) Mol. Psychiatry , vol.16 , pp. 358-360
    • Chiang, C.-H.1    Su, Y.2    Wen, Z.3    Yoritomo, N.4    Ross, C.A.5    Margolis, R.L.6    Song, H.7    Ming, G.8
  • 18
    • 84893813097 scopus 로고    scopus 로고
    • Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function
    • Demjaha, A., Egerton, A., Murray, R.M., Kapur, S., Howes, O.D., Stone, J.M., McGuire, P.K., Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function. Biol. Psychiatry 75 (2014), e11–e13, 10.1016/j.biopsych.2013.06.011.
    • (2014) Biol. Psychiatry , vol.75 , pp. e11-e13
    • Demjaha, A.1    Egerton, A.2    Murray, R.M.3    Kapur, S.4    Howes, O.D.5    Stone, J.M.6    McGuire, P.K.7
  • 21
    • 84930370590 scopus 로고    scopus 로고
    • Phenotypic characterization of nonsocial behavioral impairment in neurexin 1α knockout rats
    • Esclassan, F., Francois, J., Phillips, K.G., Loomis, S., Gilmour, G., Phenotypic characterization of nonsocial behavioral impairment in neurexin 1α knockout rats. Behav. Neurosci. 129 (2015), 74–85, 10.1037/bne0000024.
    • (2015) Behav. Neurosci. , vol.129 , pp. 74-85
    • Esclassan, F.1    Francois, J.2    Phillips, K.G.3    Loomis, S.4    Gilmour, G.5
  • 23
    • 70449686185 scopus 로고    scopus 로고
    • Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
    • Etherton, M.R., Blaiss, C. a, Powell, C.M., Südhof, T.C., Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 17998–18003, 10.1073/pnas.0910297106.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 17998-18003
    • Etherton, M.R.1    Blaiss, C.A.2    Powell, C.M.3    Südhof, T.C.4
  • 25
    • 84890053248 scopus 로고    scopus 로고
    • MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review
    • Forstner, A.J., Degenhardt, F., Schratt, G., Nöthen, M.M., MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review. Front. Mol. Neurosci, 6, 2013, 47, 10.3389/fnmol.2013.00047.
    • (2013) Front. Mol. Neurosci , vol.6 , pp. 47
    • Forstner, A.J.1    Degenhardt, F.2    Schratt, G.3    Nöthen, M.M.4
  • 27
    • 84937637283 scopus 로고    scopus 로고
    • MicroRNA and posttranscriptional dysregulation in psychiatry
    • Geaghan, M., Cairns, M.J., MicroRNA and posttranscriptional dysregulation in psychiatry. Biol. Psychiatry, 2014, 1–9, 10.1016/j.biopsych.2014.12.009.
    • (2014) Biol. Psychiatry , pp. 1-9
    • Geaghan, M.1    Cairns, M.J.2
  • 29
    • 84879522237 scopus 로고    scopus 로고
    • Altered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders
    • Grayton, H.M., Missler, M., Collier, D.A., Fernandes, C., Altered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders. PLoS One, 8, 2013, e67114, 10.1371/journal.pone.0067114.
    • (2013) PLoS One , vol.8 , pp. e67114
    • Grayton, H.M.1    Missler, M.2    Collier, D.A.3    Fernandes, C.4
  • 30
    • 82455199147 scopus 로고    scopus 로고
    • Induced pluripotent stem cells — opportunities for disease modelling and drug discovery
    • Grskovic, M., Javaherian, A., Strulovici, B., Daley, G.Q., Induced pluripotent stem cells — opportunities for disease modelling and drug discovery. Nat. Rev. Drug Discov., 2011, 10, 10.1038/nrd3577.
    • (2011) Nat. Rev. Drug Discov. , pp. 10
    • Grskovic, M.1    Javaherian, A.2    Strulovici, B.3    Daley, G.Q.4
  • 31
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han, J., The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18 (2004), 3016–3027, 10.1101/gad.1262504.
    • (2004) Genes Dev. , vol.18 , pp. 3016-3027
    • Han, J.1
  • 33
    • 84888293604 scopus 로고    scopus 로고
    • Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders
    • Hiroi, N., Takahashi, T., Hishimoto, A., Izumi, T., Boku, S., Hiramoto, T., Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders. Mol. Psychiatry 18 (2013), 1153–1165, 10.1038/mp.2013.92.
    • (2013) Mol. Psychiatry , vol.18 , pp. 1153-1165
    • Hiroi, N.1    Takahashi, T.2    Hishimoto, A.3    Izumi, T.4    Boku, S.5    Hiramoto, T.6
  • 34
    • 84981734325 scopus 로고    scopus 로고
    • From “directed differentiatio” to “neuronal induction”: modeling neuropsychiatric disease
    • Ho, S., Topol, A., Brennand, K.J., From “directed differentiatio” to “neuronal induction”: modeling neuropsychiatric disease. Biomark. Insights, 10, 2015, 31, 10.4137/BMI.S20066.
    • (2015) Biomark. Insights , vol.10 , pp. 31
    • Ho, S.1    Topol, A.2    Brennand, K.J.3
  • 35
    • 84908030684 scopus 로고    scopus 로고
    • Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons
    • Hook, V., Brennand, K.J., Kim, Y., Toneff, T., Funkelstein, L., Lee, K.C., Ziegler, M., Gage, F.H., Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports 3 (2014), 531–538, 10.1016/j.stemcr.2014.08.001.
    • (2014) Stem Cell Reports , vol.3 , pp. 531-538
    • Hook, V.1    Brennand, K.J.2    Kim, Y.3    Toneff, T.4    Funkelstein, L.5    Lee, K.C.6    Ziegler, M.7    Gage, F.H.8
  • 37
    • 84902096048 scopus 로고    scopus 로고
    • Development and applications of CRISPR-Cas9 for genome engineering
    • Hsu, P.D., Lander, E.S., Zhang, F., Development and applications of CRISPR-Cas9 for genome engineering. Cell 157 (2014), 1262–1278, 10.1016/j.cell.2014.05.010.
    • (2014) Cell , vol.157 , pp. 1262-1278
    • Hsu, P.D.1    Lander, E.S.2    Zhang, F.3
  • 38
    • 51649107017 scopus 로고    scopus 로고
    • Rare chromosomal deletions and duplications increase risk of schizophrenia
    • International, T., Consortium, S., Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455 (2008), 237–241, 10.1038/nature07239.
    • (2008) Nature , vol.455 , pp. 237-241
    • International, T.1    Consortium, S.2
  • 39
    • 84874608929 scopus 로고    scopus 로고
    • RNA-guided editing of bacterial genomes using CRISPR-Cas systems
    • Jiang, W., Bikard, D., Cox, D., Zhang, F., Marraffini, L., RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat. Biotechnol. 31 (2013), 233–239, 10.1038/nbt.2508.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 233-239
    • Jiang, W.1    Bikard, D.2    Cox, D.3    Zhang, F.4    Marraffini, L.5
  • 41
    • 84929945448 scopus 로고    scopus 로고
    • Prader–Willi, Angelman, and 15q11–q13 duplication syndromes
    • Kalsner, L., Chamberlain, S.J., Prader–Willi, Angelman, and 15q11–q13 duplication syndromes. Pediatr. Clin. North Am. 62 (2015), 587–606.
    • (2015) Pediatr. Clin. North Am. , vol.62 , pp. 587-606
    • Kalsner, L.1    Chamberlain, S.J.2
  • 42
    • 77952738956 scopus 로고    scopus 로고
    • 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia
    • Karayiorgou, M., Simon, T.J., Gogos, J. a, 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat. Rev. Neurosci. 11 (2010), 402–416, 10.1038/nrn2841.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 402-416
    • Karayiorgou, M.1    Simon, T.J.2    Gogos, J.A.3
  • 43
    • 66249116695 scopus 로고    scopus 로고
    • Modeling cognitive endophenotypes of schizophrenia in mice
    • Kellendonk, C., Simpson, E.H., Kandel, E.R., Modeling cognitive endophenotypes of schizophrenia in mice. Trends Neurosci. 32 (2009), 347–358, 10.1016/j.tins.2009.02.003.
    • (2009) Trends Neurosci. , vol.32 , pp. 347-358
    • Kellendonk, C.1    Simpson, E.H.2    Kandel, E.R.3
  • 47
    • 84897502442 scopus 로고    scopus 로고
    • Concise review: drug discovery in the age of the induced pluripotent stem cell
    • Ko, H.C., Gelb, B.D., Concise review: drug discovery in the age of the induced pluripotent stem cell. Stem Cells Trans. Med. 3 (2014), 500–509, 10.5966/sctm.2013-0162.
    • (2014) Stem Cells Trans. Med. , vol.3 , pp. 500-509
    • Ko, H.C.1    Gelb, B.D.2
  • 50
    • 84856878562 scopus 로고    scopus 로고
    • Sex-dependent novelty response in neurexin-1?? mutant mice
    • Laarakker, M.C., Reinders, N.R., Bruining, H., Ophoff, R. a, Kas, M.J.H., Sex-dependent novelty response in neurexin-1?? mutant mice. PLoS One 7 (2012), 3–8, 10.1371/journal.pone.0031503.
    • (2012) PLoS One , vol.7 , pp. 3-8
    • Laarakker, M.C.1    Reinders, N.R.2    Bruining, H.3    Ophoff, R.A.4    Kas, M.J.H.5
  • 52
    • 84886993480 scopus 로고    scopus 로고
    • CRISPR interference (CRISPRi) for sequence-specific control of gene expression
    • Larson, M.H., Gilbert, L. a, Wang, X., Lim, W. a, Weissman, J.S., Qi, L.S., CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat. Protoc. 8 (2013), 2180–2196, 10.1038/nprot.2013.132.
    • (2013) Nat. Protoc. , vol.8 , pp. 2180-2196
    • Larson, M.H.1    Gilbert, L.A.2    Wang, X.3    Lim, W.A.4    Weissman, J.S.5    Qi, L.S.6
  • 56
  • 57
    • 84858434210 scopus 로고    scopus 로고
    • CNVs: Harbingers of a rare variant revolution in psychiatric genetics
    • Malhotra, D., Sebat, J., CNVs: Harbingers of a rare variant revolution in psychiatric genetics. Cell 148 (2012), 1223–1241, 10.1016/j.cell.2012.02.039.
    • (2012) Cell , vol.148 , pp. 1223-1241
    • Malhotra, D.1    Sebat, J.2
  • 61
    • 84868592827 scopus 로고    scopus 로고
    • Cxcr4 regulation of interneuron migration is disrupted in 22q11.2 deletion syndrome
    • Meechan, D.W., Tucker, E.S., Maynard, T.M., LaMantia, A.-S., Cxcr4 regulation of interneuron migration is disrupted in 22q11.2 deletion syndrome. Proc. Natl. Acad. Sci. 109 (2012), 18601–18606, 10.1073/pnas.1211507109.
    • (2012) Proc. Natl. Acad. Sci. , vol.109 , pp. 18601-18606
    • Meechan, D.W.1    Tucker, E.S.2    Maynard, T.M.3    LaMantia, A.-S.4
  • 62
    • 70349492911 scopus 로고    scopus 로고
    • Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome
    • Meechan, D.W., Tucker, E.S., Maynard, T.M., LaMantia, A.-S., Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 16434–16445, 10.1073/pnas.0905696106.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 16434-16445
    • Meechan, D.W.1    Tucker, E.S.2    Maynard, T.M.3    LaMantia, A.-S.4
  • 66
    • 0031983653 scopus 로고    scopus 로고
    • Neurexins: Three genes and 1001 products
    • Missler, M., Südhof, T.C., Neurexins: Three genes and 1001 products. Trends Genet. 14 (1998), 20–26, 10.1016/S0168-9525(97)01324-3.
    • (1998) Trends Genet. , vol.14 , pp. 20-26
    • Missler, M.1    Südhof, T.C.2
  • 70
    • 84937120796 scopus 로고    scopus 로고
    • Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation
    • Neale, B.M., Sklar, P., Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation. Curr. Opin. Neurobiol. 30 (2015), 131–138, 10.1016/j.conb.2014.12.001.
    • (2015) Curr. Opin. Neurobiol. , vol.30 , pp. 131-138
    • Neale, B.M.1    Sklar, P.2
  • 71
    • 84945952127 scopus 로고    scopus 로고
    • Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies
    • n/a–n/a. doi:10.1002/aur.1570
    • Nestor, M.W., Phillips, A.W., Artimovich, E., Nestor, J.E., Hussman, J.P., Blatt, G.J., 2015. Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies. Autism Res. n/a–n/a. doi:10.1002/aur.1570.
    • (2015) Autism Res.
    • Nestor, M.W.1    Phillips, A.W.2    Artimovich, E.3    Nestor, J.E.4    Hussman, J.P.5    Blatt, G.J.6
  • 73
    • 84944037049 scopus 로고    scopus 로고
    • Reversion of FMR1 methylation and silencing by editing the triplet repeats in fragile X iPSC-derived neurons
    • Park, C., Halevy, T., Lee, D.R., Sung, J.J., Lee, J.S., Yanuka, O., Benvenisty, N., Kim, D., Reversion of FMR1 methylation and silencing by editing the triplet repeats in fragile X iPSC-derived neurons. Cell Rep, 2015, 1–8, 10.1016/j.celrep.2015.08.084.
    • (2015) Cell Rep , pp. 1-8
    • Park, C.1    Halevy, T.2    Lee, D.R.3    Sung, J.J.4    Lee, J.S.5    Yanuka, O.6    Benvenisty, N.7    Kim, D.8
  • 76
    • 0035510566 scopus 로고    scopus 로고
    • Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments
    • Paylor, R., Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments. Hum. Mol. Genet. 10 (2001), 2645–2650, 10.1093/hmg/10.23.2645.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2645-2650
    • Paylor, R.1
  • 77
    • 33745196411 scopus 로고    scopus 로고
    • Mouse models of 22q11 deletion syndrome
    • Paylor, R., Lindsay, E., Mouse models of 22q11 deletion syndrome. Biol. Psychiatry 59 (2006), 1172–1179, 10.1016/j.biopsych.2006.01.018.
    • (2006) Biol. Psychiatry , vol.59 , pp. 1172-1179
    • Paylor, R.1    Lindsay, E.2
  • 80
    • 84904731433 scopus 로고    scopus 로고
    • Neurexin dysfunction in adult neurons results in autistic-like behavior in mice
    • Rabaneda, L.G., Robles-Lanuza, E., Nieto-González, J., Scholl, F.G., Neurexin dysfunction in adult neurons results in autistic-like behavior in mice. Cell Rep 8 (2014), 338–346, 10.1016/j.celrep.2014.06.022.
    • (2014) Cell Rep , vol.8 , pp. 338-346
    • Rabaneda, L.G.1    Robles-Lanuza, E.2    Nieto-González, J.3    Scholl, F.G.4
  • 85
    • 84884669370 scopus 로고    scopus 로고
    • Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients
    • Robicsek, O., Karry, R., Petit, I., Salman-Kesner, N., Müller, F.-J., Klein, E., Aberdam, D., Ben-Shachar, D., Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients. Mol. Psychiatry 18 (2013), 1067–1076, 10.1038/mp.2013.67.
    • (2013) Mol. Psychiatry , vol.18 , pp. 1067-1076
    • Robicsek, O.1    Karry, R.2    Petit, I.3    Salman-Kesner, N.4    Müller, F.-J.5    Klein, E.6    Aberdam, D.7    Ben-Shachar, D.8
  • 86
    • 1542313966 scopus 로고    scopus 로고
    • Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder
    • Robinson, D.G., Woerner, M.G., McMeniman, M., Mendelowitz, A., Bilder, R.M., Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am. J. Psychiatry 161 (2004), 473–479, 10.1176/appi.ajp.161.3.473.
    • (2004) Am. J. Psychiatry , vol.161 , pp. 473-479
    • Robinson, D.G.1    Woerner, M.G.2    McMeniman, M.3    Mendelowitz, A.4    Bilder, R.M.5
  • 87
    • 34548668183 scopus 로고    scopus 로고
    • Structural variation in the human genome: the impact of copy number variants on clinical diagnosis
    • Rodriguez-Revenga, L., Mila, M., Rosenberg, C., Lamb, A., Lee, C., Structural variation in the human genome: the impact of copy number variants on clinical diagnosis. Genet. Med. 9 (2007), 600–606, 10.1097/GIM.0b013e318149e1e3.
    • (2007) Genet. Med. , vol.9 , pp. 600-606
    • Rodriguez-Revenga, L.1    Mila, M.2    Rosenberg, C.3    Lamb, A.4    Lee, C.5
  • 88
    • 84868203369 scopus 로고    scopus 로고
    • Genomic stability in reprogramming
    • Ronen, D., Benvenisty, N., Genomic stability in reprogramming. Curr. Opin. Genet. Dev. 22 (2012), 444–449, 10.1016/j.gde.2012.09.003.
    • (2012) Curr. Opin. Genet. Dev. , vol.22 , pp. 444-449
    • Ronen, D.1    Benvenisty, N.2
  • 89
    • 84921718446 scopus 로고    scopus 로고
    • Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders
    • Schadt, E.E., Buchanan, S., Brennand, K.J., Merchant, K.M., Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Front. Pharmacol. 5 (2014), 1–15, 10.3389/fphar.2014.00252.
    • (2014) Front. Pharmacol. , vol.5 , pp. 1-15
    • Schadt, E.E.1    Buchanan, S.2    Brennand, K.J.3    Merchant, K.M.4
  • 93
    • 84862778046 scopus 로고    scopus 로고
    • Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
    • Shi, Y., Kirwan, P., Smith, J., Robinson, H.P.C., Livesey, F.J., Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat. Neurosci. 15 (2012), 477–486, 10.1038/nn.3041.
    • (2012) Nat. Neurosci. , vol.15 , pp. 477-486
    • Shi, Y.1    Kirwan, P.2    Smith, J.3    Robinson, H.P.C.4    Livesey, F.J.5
  • 94
    • 77950431449 scopus 로고    scopus 로고
    • Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
    • Sigurdsson, T., Stark, K.L., Karayiorgou, M., Gogos, J. a, Gordon, J. a, Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia. Nature 464 (2010), 763–767, 10.1038/nature08855.
    • (2010) Nature , vol.464 , pp. 763-767
    • Sigurdsson, T.1    Stark, K.L.2    Karayiorgou, M.3    Gogos, J.A.4    Gordon, J.A.5
  • 95
    • 84891711854 scopus 로고    scopus 로고
    • Efficacy of antipsychotic drugs for schizophrenia
    • Siu, C.O., Agid, O., Remington, G., Efficacy of antipsychotic drugs for schizophrenia. Lancet, 382, 2013, 1874, 10.1016/S0140-6736(13)62616-1.
    • (2013) Lancet , vol.382 , pp. 1874
    • Siu, C.O.1    Agid, O.2    Remington, G.3
  • 102
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007), 861–872, 10.1016/j.cell.2007.11.019.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 103
    • 33846424247 scopus 로고    scopus 로고
    • The failure of torcetrapib: was it the molecule or the mechanism?
    • Tall, A.R., Yvan-Charvet, L., Wang, N., The failure of torcetrapib: was it the molecule or the mechanism?. Arterioscler. Thromb. Vasc. Biol. 27 (2007), 257–260, 10.1161/01.ATV.0000256728.60226.77.
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 257-260
    • Tall, A.R.1    Yvan-Charvet, L.2    Wang, N.3
  • 104
    • 78650730519 scopus 로고    scopus 로고
    • Decreased exploratory activity in a mouse model of 15q duplication syndrome: implications for disturbance of serotonin signaling
    • Tamada, K., Tomonaga, S., Hatanaka, F., Nakai, N., Takao, K., Miyakawa, T., Nakatani, J., Takumi, T., Decreased exploratory activity in a mouse model of 15q duplication syndrome: implications for disturbance of serotonin signaling. PLoS One, 5, 2010, e15126, 10.1371/journal.pone.0015126.
    • (2010) PLoS One , vol.5 , pp. e15126
    • Tamada, K.1    Tomonaga, S.2    Hatanaka, F.3    Nakai, N.4    Takao, K.5    Miyakawa, T.6    Nakatani, J.7    Takumi, T.8
  • 106
    • 0037965627 scopus 로고    scopus 로고
    • Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance
    • Walz, K., Caratini-Rivera, S., Bi, W., Fonseca, P., Mansouri, D.L., Lynch, J., Vogel, H., Noebels, J.L., Bradley, A., Lupski, J.R., Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol. Cell. Biol. 23 (2003), 3646–3655, 10.1128/MCB.23.10.3646-3655.2003.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3646-3655
    • Walz, K.1    Caratini-Rivera, S.2    Bi, W.3    Fonseca, P.4    Mansouri, D.L.5    Lynch, J.6    Vogel, H.7    Noebels, J.L.8    Bradley, A.9    Lupski, J.R.10
  • 107
    • 33847323881 scopus 로고    scopus 로고
    • DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
    • Wang, Y., Medvid, R., Melton, C., Jaenisch, R., Blelloch, R., DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 39 (2007), 380–385, 10.1038/ng1969.
    • (2007) Nat. Genet. , vol.39 , pp. 380-385
    • Wang, Y.1    Medvid, R.2    Melton, C.3    Jaenisch, R.4    Blelloch, R.5
  • 109
    • 0023215296 scopus 로고
    • Implications of normal brain development for the pathogenesis of schizophrenia
    • Weinberger, D.R., Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry 44 (1987), 660–669, 10.1001/archpsyc.1988.01800350089019.
    • (1987) Arch. Gen. Psychiatry , vol.44 , pp. 660-669
    • Weinberger, D.R.1
  • 114
    • 84940780822 scopus 로고    scopus 로고
    • MicroRNA profiling of neurons generated using induced pluripotent stem cells derived from patients with schizophrenia and schizoaffective disorder, and 22q11.2 Del
    • Zhao, D., Lin, M., Chen, J., Pedrosa, E., Hrabovsky, A., Fourcade, H.M., Zheng, D., Lachman, H.M., MicroRNA profiling of neurons generated using induced pluripotent stem cells derived from patients with schizophrenia and schizoaffective disorder, and 22q11.2 Del. PLoS One, 10, 2015, e0132387, 10.1371/journal.pone.0132387.
    • (2015) PLoS One , vol.10 , pp. e0132387
    • Zhao, D.1    Lin, M.2    Chen, J.3    Pedrosa, E.4    Hrabovsky, A.5    Fourcade, H.M.6    Zheng, D.7    Lachman, H.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.