7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages

Nature Genetics

Volumn 47, Issue 2, 2015, Pages 132-141

  Adamo, Antonio ^a   Atashpaz, Sina ^a   Germain, Pierre Luc ^a   Zanella, Matteo ^a   D'Agostino, Giuseppe ^a   Albertin, Veronica ^a   Chenoweth, Josh ^b   Micale, Lucia ^c   Fusco, Carmela ^c   Unger, Christian ^d   Augello, Bartolomeo ^c   Palumbo, Orazio ^c   Hamilton, Brad ^e   Carella, Massimo ^c   Donti, Emilio ^f   Pruneri, Giancarlo ^a   Selicorni, Angelo ^g   Biamino, Elisa ^h   Prontera, Paolo ^f   McKay, Ronald ^b   Merla, Giuseppe ^c   Testa, Giuseppe ^a,i   more..

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b LIEBER INSTITUTE FOR BRAIN DEVELOPMENT   (United States)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e Stemgent   (United States)

^f UNIVERSITY OF PERUGIA   (Italy)

^g SAN GERARDO HOSPITAL   (Italy)

^h UNIVERSITY OF TURIN   (Italy)

ⁱ UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

7Q MICRODUPLICATION SYNDROME; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CELL MOTILITY; CELL NUCLEUS TRANSPLANTATION; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 7Q; CHROMOSOME DUPLICATION; COMPARATIVE STUDY; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA DAMAGE; EMBRYONIC STEM CELL; FERTILIZATION IN VITRO; GENE DOSAGE; GENE EXPRESSION; GENE ONTOLOGY; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENOTYPE; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOLECULAR DIAGNOSIS; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RNA INTERFERENCE; SOMATIC CELL; SYNAPTIC TRANSMISSION; TRANSCRIPTION INITIATION SITE; TRANSGENE; UPREGULATION; WILLIAMS BEUREN SYNDROME;

EID: 84965113064     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3169     Document Type: Article

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