MicroRNA and Posttranscriptional Dysregulation in Psychiatry

Biological Psychiatry

Volumn 78, Issue 4, 2015, Pages 231-239

  Geaghan, Michael ^a,c   Cairns, Murray J ^a,b,c  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

^c HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Autism; Bipolar Disorder; Depression; miRNA; Psychiatry; Schizophrenia

Indexed keywords

BIOLOGICAL MARKER; MICRORNA; MICRORNA 107; MICRORNA 132;

AUTISM; BIPOLAR DISORDER; HUMAN; MAJOR DEPRESSION; MENTAL DISEASE; NEUROBIOLOGY; NEUROPATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSYCHIATRIC TREATMENT; PSYCHIATRY; REVIEW; RNA PROCESSING; RNA TRANSCRIPTION; SCHIZOPHRENIA; ANIMAL; GENE REGULATORY NETWORK; GENETICS; METABOLISM; PROTEIN PROCESSING;

ANIMALS; AUTISM SPECTRUM DISORDER; BIOMARKERS; BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; GENE REGULATORY NETWORKS; HUMANS; MENTAL DISORDERS; MICRORNAS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SCHIZOPHRENIA;

EID: 84937637283     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.12.009     Document Type: Review

References (86)

1. T. Du, and P.D. Zamore microPrimer: The biogenesis and function of microRNA Development 132 2005 4645 4652
2. D.P. Bartel MicroRNAs: Genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
3. A. Rodriguez, S. Griffiths-Jones, J.L. Ashurst, and A. Bradley Identification of mammalian microRNA host genes and transcription units Genome Res 14 2004 1902 1910
4. Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, and et al. The nuclear RNase III Drosha initiates microRNA processing Nature 425 2003 415 419
5. R.I. Gregory, K.P. Yan, G. Amuthan, T. Chendrimada, B. Doratotaj, N. Cooch, and et al. The Microprocessor complex mediates the genesis of microRNAs Nature 432 2004 235 240
6. R.I. Gregory, T.P. Chendrimada, N. Cooch, and R. Shiekhattar Human RISC couples microRNA biogenesis and posttranscriptional gene silencing Cell 123 2005 631 640
7. A. Kozomara, and S. Griffiths-Jones miRBase: integrating microRNA annotation and deep-sequencing data Nucleic Acids Res 39 2011 D152 D157
8. B.P. Lewis, I.H. Shih, M.W. Jones-Rhoades, D.P. Bartel, and C.B. Burge Prediction of mammalian microRNA targets Cell 115 2003 787 798
9. A.P. Carroll, N. Tran, P.A. Tooney, and M.J. Cairns Alternative mRNA fates identified in microRNA-associated transcriptome analysis BMC Genomics 13 2012 561
10. L.P. Lim, N.C. Lau, P. Garrett-Engele, A. Grimson, J.M. Schelter, J. Castle, and et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs Nature 433 2005 769 773
11. A.J. Giraldez, R.M. Cinalli, M.E. Glasner, A.J. Enright, J.M. Thomson, S. Baskerville, and et al. MicroRNAs regulate brain morphogenesis in zebrafish Science 308 2005 833 838
12. T.H. Davis, T.L. Cuellar, S.M. Koch, A.J. Barker, B.D. Harfe, M.T. McManus, and et al. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus J Neurosci 28 2008 4322 4330
13. T.L. Cuellar, T.H. Davis, P.T. Nelson, G.B. Loeb, B.D. Harfe, E. Ullian, and et al. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration Proc Natl Acad Sci U S A 105 2008 5614 5619
14. D.O. Perkins, C.D. Jeffries, L.F. Jarskog, J.M. Thomson, K. Woods, M.A. Newman, and et al. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder Genome Biol 8 2007 R27
15. N.J. Beveridge, E. Gardiner, A.P. Carroll, P.A. Tooney, and M.J. Cairns Schizophrenia is associated with an increase in cortical microRNA biogenesis Mol Psychiatry 15 2010 1176 1189
16. N.J. Beveridge, P.A. Tooney, A.P. Carroll, E. Gardiner, N. Bowden, R.J. Scott, and et al. Dysregulation of miRNA 181b in the temporal cortex in schizophrenia Hum Mol Genet 17 2008 1156 1168
17. C. Liu, Z.Q. Teng, A.L. McQuate, E.M. Jobe, C.C. Christ, S.J. von Hoyningen-Huene, and et al. An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation PloS One 8 2013 e51436
18. S. Moncini, A. Salvi, P. Zuccotti, G. Viero, A. Quattrone, S. Barlati, and et al. The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration PloS One 6 2011 e20038
19. A.S. Bassett, E.W. Chow, J. Husted, R. Weksberg, O. Caluseriu, G.D. Webb, and et al. Clinical features of 78 adults with 22q11 deletion syndrome Am J Med Genet A 138 2005 307 313
20. A. Shiohama, T. Sasaki, S. Noda, S. Minoshima, and N. Shimizu Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region Biochem Biophys Res Commun 304 2003 184 190
21. D.M. Santarelli, N.J. Beveridge, P.A. Tooney, and M.J. Cairns Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia Biol Psychiatry 69 2011 180 187
22. A.H. Kim, M. Reimers, B. Maher, V. Williamson, O. McMichael, J.L. McClay, and et al. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders Schizophr Res 124 2010 183 191
23. J. Remenyi, M.W. van den Bosch, O. Palygin, R.B. Mistry, C. McKenzie, A. Macdonald, and et al. miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity PloS One 8 2013 e62509
24. R.Y. Wang, R.Z. Phang, P.H. Hsu, W.H. Wang, H.T. Huang, and I.Y. Liu In vivo knockdown of hippocampal miR-132 expression impairs memory acquisition of trace fear conditioning Hippocampus 23 2013 625 633
25. E. Gardiner, N.J. Beveridge, J.Q. Wu, V. Carr, R.J. Scott, P.A. Tooney, and et al. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells Mol Psychiatry 17 2012 827 840
26. H. Royo, and J. Cavaille Non-coding RNAs in imprinted gene clusters Biol Cell 100 2008 149 166
27. R. Fiore, S. Khudayberdiev, M. Christensen, G. Siegel, S.W. Flavell, T.K. Kim, and et al. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels EMBO J 28 2009 697 710
28. C.Y. Lai, S.L. Yu, M.H. Hsieh, C.H. Chen, H.Y. Chen, C.C. Wen, and et al. MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia PloS One 6 2011 e21635
29. W. Shi, J. Du, Y. Qi, G. Liang, T. Wang, S. Li, and et al. Aberrant expression of serum miRNAs in schizophrenia J Psychiatr Res 46 2012 198 204
30. S. Ripke, A. Sanders, K. Kendler, D. Levinson, P. Sklar, P. Holmans, and et al. Genome-wide association study identifies five new schizophrenia loci Nat Genet 43 2011 969 976
31. S. Ripke, B.M. Neale, A. Corvin, J.T.R. Walters, K.-H. Farh, P.A. Holmans, and et al. Biological insights from 108 schizophrenia-associated genetic loci Nature 511 2014 421 427
32. G. Sun, P. Ye, K. Murai, M.F. Lang, S. Li, H. Zhang, and et al. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells Nat Commun 2 2011 529
33. C. Wright, J.A. Turner, V.D. Calhoun, and N. Perrone-Bizzozero Potential impact of miR-137 and its targets in schizophrenia Front Genet 4 2013 58
34. I. Guella, A. Sequeira, B. Rollins, L. Morgan, F. Torri, T.G. van Erp, and et al. Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex J Psychiatr Res 47 2013 1215 1221
35. T.G. van Erp, I. Guella, M.P. Vawter, J. Turner, G.G. Brown, G. McCarthy, and et al. Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation Biol Psychiatry 75 2014 398 405
36. M. Begemann, S. Grube, S. Papiol, D. Malzahn, H. Krampe, K. Ribbe, and et al. Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms Arch Gen Psychiatry 67 2010 879 888
37. T.M. Maynard, L. Sikich, J.A. Lieberman, and A.S. LaMantia Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophrenia Schizophr Bull 27 2001 457 476
38. S.L. Hollins, K. Zavitsanou, F.R. Walker, and M.J. Cairns Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure Transl Psychiatry 4 2014 e452
39. I.S. Samuels, J.C. Karlo, A.N. Faruzzi, K. Pickering, K. Herrup, J.D. Sweatt, and et al. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function J Neurosci 28 2008 6983 6995
40. T. Miyaoka, H. Seno, and H. Ishino Increased expression of Wnt-1 in schizophrenic brains Schizophr Res 38 1999 1 6
41. M.P. Moreau, S.E. Bruse, R. David-Rus, S. Buyske, and L.M. Brzustowicz Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder Biol Psychiatry 69 2011 188 193
42. B.H. Miller, Z. Zeier, L. Xi, T.A. Lanz, S. Deng, J. Strathmann, and et al. MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function Proc Natl Acad Sci U S A 109 2012 3125 3130
43. N.R. Smalheiser, G. Lugli, H. Zhang, H. Rizavi, E.H. Cook, and Y. Dwivedi Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects PloS One 9 2014 e86469
44. M.G. Banigan, P.F. Kao, J.A. Kozubek, A.R. Winslow, J. Medina, J. Costa, and et al. Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients PloS One 8 2013 e48814
45. H.C. Whalley, M. Papmeyer, L. Romaniuk, E. Sprooten, E.C. Johnstone, J. Hall, and et al. Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder Neuropsychopharmacology 37 2012 2720 2729
46. Z. Zhang, P. Convertini, M. Shen, X. Xu, F. Lemoine, P. de la Grange, and et al. Valproic acid causes proteasomal degradation of DICER and influences miRNA expression PloS One 8 2013 e82895
47. B. Etain, S. Jamain, V. Milhiet, M. Lajnef, C. Boudebesse, A. Dumaine, and et al. Association between circadian genes, bipolar disorders and chronotypes Chronobiol Int 31 2014 807 814
48. O.A. Rahman, M. Sasvari-Szekely, A. Szekely, G. Faludi, A. Guttman, and Z. Nemoda Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene Electrophoresis 31 2010 1790 1795
49. B. Sperlagh, E.S. Vizi, K. Wirkner, and P. Illes P2X7 receptors in the nervous system Prog Neurobiol 78 2006 327 346
50. Y. Xu, H. Liu, F. Li, N. Sun, Y. Ren, Z. Liu, and et al. A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform J Affect Disord 127 2010 332 336
51. Y. He, Y. Zhou, Q. Xi, H. Cui, T. Luo, H. Song, and et al. Genetic variations in microRNA processing genes are associated with susceptibility in depression DNA Cell Biol 31 2012 1499 1506
52. N.R. Smalheiser, G. Lugli, H.S. Rizavi, V.I. Torvik, G. Turecki, and Y. Dwivedi MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects PloS One 7 2012 e33201
53. N.R. Smalheiser, G. Lugli, H.S. Rizavi, H. Zhang, V.I. Torvik, G.N. Pandey, and et al. MicroRNA expression in rat brain exposed to repeated inescapable shock: Differential alterations in learned helplessness vs. non-learned helplessness Int J Neuropsychopharmacol 14 2011 1315 1325
54. S. Xu, P.D. Witmer, S. Lumayag, B. Kovacs, and D. Valle MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster J Biol Chem 282 2007 25053 25066
55. J. Mendlewicz Disruption of the circadian timing systems: Molecular mechanisms in mood disorders CNS Drugs 23 suppl 2 2009 15 26
56. Y.J. Li, M. Xu, Z.H. Gao, Y.Q. Wang, Z. Yue, Y.X. Zhang, and et al. Alterations of serum levels of BDNF-related miRNAs in patients with depression PloS One 8 2013 e63648
57. Z. Zheng, Y. Zeng, H. Huang, and F. Xu MicroRNA-132 may play a role in coexistence of depression and cardiovascular disease: A hypothesis Med Sci Monit 19 2013 438 443
58. H.Y. Cheng, J.W. Papp, O. Varlamova, H. Dziema, B. Russell, J.P. Curfman, and et al. microRNA modulation of circadian-clock period and entrainment Neuron 54 2007 813 829
59. K. Abu-Elneel, T. Liu, F.S. Gazzaniga, Y. Nishimura, D.P. Wall, D.H. Geschwind, and et al. Heterogeneous dysregulation of microRNAs across the autism spectrum Neurogenetics 9 2008 153 161
60. S. Buyske Comment on the article "Heterogeneous dysregulation of microRNAs across the autism spectrum" by Abu-Elneel et al Neurogenetics 10 2009 167 author reply 169-170
61. Z. Talebizadeh, M.G. Butler, and M.F. Theodoro Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism Autism Res 1 2008 240 250
62. T. Sarachana, R. Zhou, G. Chen, H.K. Manji, and V.W. Hu Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines Genome Med 2 2010 23
63. M.M. Ghahramani Seno, P. Hu, F.G. Gwadry, D. Pinto, C.R. Marshall, G. Casallo, and et al. Gene and miRNA expression profiles in autism spectrum disorders Brain Res 1380 2011 85 97
64. M. Hemmat, M.J. Rumple, L.W. Mahon, C.M. Strom, A. Anguiano, M. Talai, and et al. Short stature, digit anomalies and dysmorphic facial features are associated with the duplication of miR-17 ~ 92 cluster Mol Cytogenet 7 2014 27
65. P. Kannu, A.B. Campos-Xavier, D. Hull, D. Martinet, D. Ballhausen, and L. Bonafe Post-axial polydactyly type A2, overgrowth and autistic traits associated with a chromosome 13q31.3 microduplication encompassing miR-17-92 and GPC5 Eur J Med Genet 56 2013 452 457
66. D.T. Miller, Y. Shen, L.A. Weiss, J. Korn, I. Anselm, C. Bridgemohan, and et al. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders J Med Genet 46 2009 242 248
67. V. Vaishnavi, M. Manikandan, B.K. Tiwary, and A.K. Munirajan Insights on the functional impact of microRNAs present in autism-associated copy number variants PloS One 8 2013 e56781
68. M. Marrale, N.N. Albanese, F. Cali, and V. Romano Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation PloS One 9 2014 e90947
69. M.E. Davis, J.E. Zuckerman, C.H. Choi, D. Seligson, A. Tolcher, C.A. Alabi, and et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles Nature 464 2010 1067 1070
70. T.G. Hullinger, R.L. Montgomery, A.G. Seto, B.A. Dickinson, H.M. Semus, J.M. Lynch, and et al. Inhibition of miR-15 protects against cardiac ischemic injury Circ Res 110 2012 71 81
71. J. Krutzfeldt, S. Kuwajima, R. Braich, K.G. Rajeev, J. Pena, T. Tuschl, and et al. Specificity, duplex degradation and subcellular localization of antagomirs Nucleic Acids Res 35 2007 2885 2892
72. Y.B. Ouyang, Y. Lu, S. Yue, L.J. Xu, X.X. Xiong, R.E. White, and et al. miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo Neurobiol Dis 45 2012 555 563
73. K.J. Yin, Z. Deng, H. Huang, M. Hamblin, C. Xie, J. Zhang, and et al. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia Neurobiol Dis 38 2010 17 26
74. M.N. Ziats, and O.M. Rennert Identification of differentially expressed microRNAs across the developing human brain Mol Psychiatry 19 2014 848 852
75. N.J. Beveridge, D.M. Santarelli, X. Wang, P.A. Tooney, M.J. Webster, C.S. Weickert, and et al. Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression Schizophr Bull 40 2014 399 409
76. S.L. Hollins, B.J. Goldie, A.P. Carroll, E.A. Mason, F.R. Walker, D.W. Eyles, and et al. Ontogeny of small RNA in the regulation of mammalian brain development BMC Genom 15 2014 777
77. Y. Sasaki, C. Gross, L. Xing, Y. Goshima, and G.J. Bassell Identification of axon-enriched microRNAs localized to growth cones of cortical neurons Dev Neurobiol 74 2014 397 406
78. C. Barbato, M.T. Ciotti, A. Serafino, P. Calissano, and C. Cogoni Dicer expression and localization in post-mitotic neurons Brain Res 1175 2007 17 27
79. M.J. Green, M.J. Cairns, J. Wu, M. Dragovic, A. Jablensky, P.A. Tooney, and et al. Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia Mol Psychiatry 18 2013 774 780
80. J. Wong, C.E. Duncan, N.J. Beveridge, M.J. Webster, M.J. Cairns, and C.S. Weickert Expression of NPAS3 in the human cortex and evidence of its posttranscriptional regulation by miR-17 during development, with implications for schizophrenia Schizophr Bull 39 2013 396 406
81. Y. Xu, F. Li, B. Zhang, K. Zhang, F. Zhang, X. Huang, and et al. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia Schizophr Res 119 2010 219 227
82. N. Mellios, M. Galdzicka, E. Ginns, S.P. Baker, E. Rogaev, J. Xu, and et al. Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia Schizophr Bull 38 2012 433 443
83. R. Tabares-Seisdedos, and J.L. Rubenstein Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: Implications for schizophrenia, autism and cancer Mol Psychiatry 14 2009 563 589
84. W.L. Shih, C.F. Kao, L.C. Chuang, and P.H. Kuo Incorporating information of microRNAs into pathway analysis in a genome-wide association study of bipolar disorder Front Genet 3 2012 293
85. R. Belzeaux, A. Bergon, V. Jeanjean, B. Loriod, C. Formisano-Treziny, L. Verrier, and et al. Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode Transl Psychiatry 2 2012 e185
86. M.Q. Cao, D.H. Chen, C.H. Zhang, and Z.Z. Wu Screening of specific microRNA in hippocampus of depression model rats and intervention effect of Chaihu Shugan San [in Chinese] Zhongguo Zhong Yao Za Zhi 38 2013 1585 1589