Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

Biochemical Journal

Volumn 471, Issue 3, 2015, Pages 391-401

  Santamaria, Salvatore ^a,b   Yamamoto, Kazuhiro ^a   Botkjaer, Kenneth ^c   Tape, Christopher ^c,e   Dyson, Michael R ^d   McCafferty, John ^d   Murphy, Gillian ^c   Nagase, Hideaki ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d IONTAS LTD   (United Kingdom)

^e INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Adamalysin like metalloproteinases with thrombospondin motifs (ADAMTS) 5; Aggrecan; Exosite inhibition; Osteoarthritis; Phage display; Substrate selectivity

Indexed keywords

AGGRECAN; AGGRECANASE 2; COLLAGENASE 3; GELATINASE A; GELATINASE B; GLYCOSAMINOGLYCAN POLYSULFATE; ILOMASTAT; INTERSTITIAL COLLAGENASE; MATRILYSIN; STROMELYSIN; STROMELYSIN 2; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAM PROTEIN; ADAMTS5 PROTEIN, HUMAN; ANTIBODY; DIPEPTIDE; N-(2(R)-2-(HYDROXAMIDOCARBONYLMETHYL)-4-METHYLPENTANOYL)-L-TRYPTOPHAN METHYLAMIDE; PROTEIN BINDING;

ANTIBODY LIBRARY; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; HEK293 CELL LINE; HUMAN; HUMAN CELL; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOSYNTHESIS; CARTILAGE; CELL SURFACE DISPLAY; CHONDROCYTE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; IMMUNOLOGY; OSTEOARTHRITIS; PATHOLOGY; PROTEIN TERTIARY STRUCTURE;

ADAM PROTEINS; ADAMTS5 PROTEIN; AGGRECANS; ANTIBODIES; BINDING SITES; CARTILAGE; CATALYTIC DOMAIN; CELL SURFACE DISPLAY TECHNIQUES; CHONDROCYTES; DIPEPTIDES; HUMANS; OSTEOARTHRITIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 84947254846     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150758     Document Type: Article

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