An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

Blood

Volumn 115, Issue 8, 2010, Pages 1640-1649

  Pos, Wouter ^a   Crawley, James T B ^b   Fijnheer, Rob ^c   Voorberg, Jan ^a   Lane, David A ^b   Luken, Brenda M ^b  

^a CENTRAL LABORATORY   (Netherlands)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE; MONOCLONAL ANTIBODY; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAM PROTEIN; ADAMTS13 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL ASSESSMENT; HUMAN; MUTANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN VARIANT; SURFACE PLASMON RESONANCE; THROMBOTIC THROMBOCYTOPENIC PURPURA; AMINO ACID SUBSTITUTION; EPITOPE MAPPING; FEMALE; GENETICS; MALE; METABOLISM; METHODOLOGY; MISSENSE MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

ADAM PROTEINS; AMINO ACID SUBSTITUTION; AUTOANTIBODIES; BINDING SITES; EPITOPE MAPPING; EPITOPES; FEMALE; HUMANS; MALE; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PURPURA, THROMBOTIC THROMBOCYTOPENIC; SURFACE PLASMON RESONANCE; VON WILLEBRAND FACTOR;

EID: 77949882442     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-06-229203     Document Type: Article

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