Elucidating the function of non catalytic domains of collagenases and aggrecanases

Connective Tissue Research

Volumn 49, Issue 3-4, 2008, Pages 169-174

  Nagase, Hideaki ^a   Fushimi, Kazunari ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

ADAMTSs; Aggrecan; Collagen; Metalloproteinases; MMPs

Indexed keywords

AGGRECAN; AGGRECANASE; ASTACIN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGENASE; COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; SERINE PROTEINASE; STROMELYSIN; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ANEMIA; ANEURYSM; ARTHRITIS; ARTICLE; ATHEROSCLEROSIS; CATALYSIS; COLLAGEN DEGRADATION; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; GENE DELETION; HUMAN; MUSCULOSKELETAL PAIN; NEOPLASM; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; SIDE EFFECT; THROMBOTIC THROMBOCYTOPENIC PURPURA; TRIPLE HELIX;

ADAM PROTEINS; AGGRECANS; CATALYTIC DOMAIN; COLLAGEN; COLLAGENASES; ENDOPEPTIDASES; EXTRACELLULAR MATRIX; HEMOPEXIN; HUMANS; MATRIX METALLOPROTEINASES; PROTEIN STRUCTURE, TERTIARY;

EID: 48549102413     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.1080/03008200802151698     Document Type: Article

References (35)

1. Fini, M. E., Cook, J. R., Mohan, R. and Brinckerhoff, C. E. (1998) Regulation of matrix metalloproteinase gene expression. pp. 299-356.
2. Porter, S., Clark, I. M., Kevorkian, L. and Edwards, D. R. (2005) The ADAMTS metalloproteinases. 386, pp. 15-27.
3. Woessner, J. F. Jr. (1998) The matrix metalloproteinase family. In: Matrix Metalloproteinases, Parks, W.C., and Mecham, R. P. (Eds). Academic Press,. p. pp. 1.
4. Nagase, H., Visse, R. and Murphy, G. (2006) Structure and function of matrix metalloproteinases and TIMPs. 69, pp. 562-573.
5. Parks, W. C., Wilson, C. L. and Lopez-Boado, Y. S. (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. 4, pp. 617-629.
6. Overall, C. M. (2002) Molecular determinants of metalloproteinase substrate specificity: Matrix metalloproteinase substrate binding domains, modules, and exosites. 22, pp. 51-86.
7. Murphy, G., Allan, J. A., Willenbrock, F., Cockett, M. I., O'Connell, J. P. and Docherty, A. J. P. (1992) The role of the C-terminal domain in collagenase and stromelysin specificity. 267, pp. 9612-9618.
8. Chung, L., Shimokawa, K., Dinakarpandian, D., Grams, F., Fields, G. B. and Nagase, H. (2000) Identification of the (RWTNNFREY191)-R-183 region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity. 275, pp. 29610-29617.
9. Kuno, K., Kanada, N., Nakashima, E., Fujiki, F., Ichimura, F. and Matsushima, K. (1997) Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. 272, pp. 556-562.
10. Kuno, K., Terashima, Y. and Matsushima, K. (1999) ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix. 274, pp. 18821-18826.
11. Kuno, K., Okada, Y., Kawashima, H., Nakamura, H., Miyasaka, M., Ohno, H. and Matsushima, K. (2000) ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. 478, pp. 241-245.
12. Colige, A., Li, S. W., Sieron, A. L., Nusgens, B. V., Prockop, D. J. and Lapiere, C. M. (1997) cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components. 94, pp. 2374-2379.
13. Fernandes, R. J., Hirohata, S., Engle, J. M., Colige, A., Cohn, D. H., Eyre, D. R. and Apte, S. S. (2001) Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. 276, pp. 31502-31509.
14. Colige, A., Vandenberghe, I., Thiry, M., Lambert, C. A., Van Beeumen, J., Li, S. W., Prockop, D. J., Lapiere, C. M. and Nusgens, B. V. (2002) Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. 277, pp. 5756-5766.
15. Zheng, X., Nishio, K., Majerus, E. M. and Sadler, J. E. (2003) Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13. 278, pp. 30136-30141.
16. Liu, C. J., Kong, W., Ilalov, K., Yu, S., Xu, K., Prazak, L., Fajardo, M., Sehgal, B. and Di Cesare, P.E. (2006) ADAMTS-7: A metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. 20, pp. 988-990.
17. Liu, C. J., Kong, W., Xu, K., Luan, Y., Ilalov, K., Sehgal, B., Yu, S., Howell, R. D. and Di Cesare, P.E. (2006) ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. 281, pp. 15800-15808.
18. Sandy, J. D., Neame, P. J., Boynton, R. E. and Flannery, C. R. (1991) Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain. 266, pp. 8683-8685.
19. Glasson, S. S., Askew, R., Sheppard, B., Carito, B. A., Blanchet, T., Ma, H. L., Flannery, C. R., Kanki, K., Wang, E., Peluso, D., Yang, Z., Majumdar, M. K. and Morris, E. A. (2004) Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 50, pp. 2547-2558.
20. Little, C. B., Mittaz, L., Belluoccio, D., Rogerson, F. M., Campbell, I. K., Meeker, C. T., Bateman, J. F., Pritchard, M. A. and Fosang, A. J. (2005) ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. 52, pp. 1461-1472.
21. Stanton, H., Rogerson, F. M., East, C. J., Golub, S. B., Lawlor, K. E., Meeker, C. T., Little, C. B., Last, K., Farmer, P. J., Campbell, I. K., Fourie, A. M. and Fosang, A. J. (2005) ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. 434, pp. 648-652.
22. Glasson, S. S., Askew, R., Sheppard, B., Carito, B., Blanchet, T., Ma, H. L., Flannery, C. R., Peluso, D., Kanki, K., Yang, Z., Majumdar, M. K. and Morris, E. A. (2005) Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. 434, pp. 644-648.
23. Gross, J. and Lapiere, C. M. (1962) Collagenolytic activity in amphibian tissues: A tissue culture assay. 48, pp. 1014-1022.
24. Li, J., Brick, P., O'Hare, M. C., Skarzynski, T., Lloyd, L. F., Curry, V. A., Clark, I. M., Bigg, H. F., Hazleman, B. L. and Cawston, T. E. (1995) Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller. 3, pp. 541-549.
25. Chung, L., Dinakarpandian, D., Yoshida, N., Lauer-Fields, J. L., Fields, G. B., Visse, R. and Nagase, H. (2004) Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. 23, pp. 3020-3030.
26. Tortorella, M. D., Liu, R. Q., Burn, T., Newton, R. C. and Arner, E. (2002) Characterization of human aggrecanase 2 (ADAM-TS5): Substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). 21, pp. 499-511.
27. Tortorella, M., Pratta, M., Liu, R. Q., Abbaszade, I., Ross, H., Burn, T. and Arner, E. (2000) The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. 275, pp. 25791-25797.
28. Kashiwagi, M., Enghild, J. J., Gendron, C., Hughes, C., Caterson, B., Itoh, Y. and Nagase, H. (2004) Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. 279, pp. 10109-10119.
29. Gendron, C., Kashiwagi, M., Lim, N. H., Enghild, J. J., Thogersen, I. B., Hughes, C., Caterson, B. and Nagase, H. (2007) Proteolytic activities of human ADAMTS-5: Comparative Studies with ADAMTS-4. 282, pp. 18294-18306.
30. Wang, P., Tortorella, M., England, K., Malfait, A. M., Thomas, G., Arner, E. C. and Pei, D. (2004) Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. 279, pp. 15434-15440.
31. Gao, G., Plaas, A., Thompson, V. P., Jin, S., Zuo, F. and Sandy, J. D. (2004) ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. 279, pp. 10042-10051.
32. Milner, J. M. and Cawston, T. E. (2005) Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases. 4, pp. 363-375.
33. Gomis-Ruth, F. X. (2003) Structural aspects of the metzincin clan of metalloendopeptidases. 24, pp. 157-202.
34. Engel, C. K., Pirard, B., Schimanski, S., Kirsch, R., Habermann, J., Klingler, O., Schlotte, V., Weithmann, K. U. and Wendt, K. U. (2005) Structural basis for the highly selective inhibition of MMP-13. 12, pp. 181-189.
35. Johnson, A. R., Pavlovsky, A. G., Ortwine, D. F., Prior, F., Man, C. F., Bornemeier, D. A., Banotai, C. A., Mueller, W. T., McConnell, P., Yan, C., Baragi, V., Lesch, C., Roark, W. H., Wilson, M., Datta, K., Guzman, R., Han, H. K. and Dyer, R. D. (2007) Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 (MMP13) that reduces cartilage damage in vivo without joint fibroplasia side effects. 282, pp. 27781-27791.