The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation

Structure

Volumn 23, Issue 9, 2015, Pages 1725-1734

  Lu, Shaoyong ^a   Deng, Rong ^a   Jiang, Haiming ^a   Song, Huili ^a   Li, Shuai ^a   Shen, Qiancheng ^a   Huang, Wenkang ^a   Nussinov, Ruth ^b,c   Yu, Jianxiu ^a   Zhang, Jian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AKT1 PROTEIN; MUTANT PROTEIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HELA CELL LINE; METABOLISM; PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; BINDING SITES; HELA CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84947045490     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.06.027     Document Type: Article

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