-
1
-
-
0026006501
-
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
-
P. J. Coffer, J. R. Woodgett, Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur. J. Biochem. 201, 475-481 (1991).
-
(1991)
Eur. J. Biochem.
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
2
-
-
0025882091
-
Molecular cloning and identifi - Cation of a serine/threonine protein kinase of the second-messenger subfamily
-
P. F. Jones, T. Jakubowicz, F. J. Pitossi, F. Maurer, B. A. Hemmings, Molecular cloning and identifi - cation of a serine/threonine protein kinase of the second-messenger subfamily. Proc. Natl. Acad. Sci. U.S.A. 88, 4171-4175 (1991).
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
3
-
-
23944526062
-
Activation of AKT kinases in cancer: Implications for therapeutic targeting
-
A. Bellacosa, C. C. Kumar, A. Di Cristofano, J. R. Testa, Activation of AKT kinases in cancer: Implications for therapeutic targeting. Adv. Cancer Res. 94, 29-86 (2005).
-
(2005)
Adv. Cancer Res.
, vol.94
, pp. 29-86
-
-
Bellacosa, A.1
Kumar, C.C.2
Di Cristofano, A.3
Testa, J.R.4
-
4
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
D. A. Altomare, J. R. Testa, Perturbations of the AKT signaling pathway in human cancer. Oncogene 24, 7455-7464 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
5
-
-
2542528670
-
A family with severe insulin resistance and diabetes due to a mutation in AKT2
-
S. George, J. J. Rochford, C. Wolfrum, S. L. Gray, S. Schinner, J. C. Wilson, M. A. Soos, P. R. Murgatroyd, R. M. Williams, C. L. Acerini, D. B. Dunger, D. Barford, A. M. Umpleby, N. J. Wareham, H. A. Davies, A. J. Schafer, M. Stoffel, S. O'Rahilly, I. Barroso, A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 304, 1325-1328 (2004).
-
(2004)
Science
, vol.304
, pp. 1325-1328
-
-
George, S.1
Rochford, J.J.2
Wolfrum, C.3
Gray, S.L.4
Schinner, S.5
Wilson, J.C.6
Soos, M.A.7
Murgatroyd, P.R.8
Williams, R.M.9
Acerini, C.L.10
Dunger, D.B.11
Barford, D.12
Umpleby, A.M.13
Wareham, N.J.14
Davies, H.A.15
Schafer, A.J.16
Stoffel, M.17
O'Rahilly, S.18
Barroso, I.19
-
6
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serinethreonine kinase containing an SH2-like region
-
A. Bellacosa, J. R. Testa, S. P. Staal, P. N. Tsichlis, A retroviral oncogene, akt, encoding a serinethreonine kinase containing an SH2-like region. Science 254, 274-277 (1991).
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
7
-
-
0029020282
-
Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classifi cation
-
S. K. Hanks, T. Hunter, Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classifi cation. FASEB J. 9, 576-596 (1995).
-
(1995)
FASEB J
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
8
-
-
84860823513
-
An ATP-site on-off switch that restricts phosphatase accessibility of Akt
-
K. Lin, J. Lin, W.-I. Wu, J. Ballard, B. B. Lee, S. L. Gloor, G. P. A. Vigers, T. H. Morales, L. S. Friedman, N. Skelton, B. J. Brandhuber, An ATP-site on-off switch that restricts phosphatase accessibility of Akt. Sci. Signal. 5, ra37 (2012).
-
(2012)
Sci. Signal.
, vol.5
-
-
Lin, K.1
Lin, J.2
Wu, W.-I.3
Ballard, J.4
Lee, B.B.5
Gloor, S.L.6
Vigers, G.P.A.7
Morales, T.H.8
Friedman, L.S.9
Skelton, N.10
Brandhuber, B.J.11
-
9
-
-
81755163634
-
Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
-
T. O. Chan, J. Zhang, U. Rodeck, J. M. Pascal, R. S. Armen, M. Spring, C. D. Dumitru, V. Myers, X. Li, J. Y. Cheung, A. M. Feldman, Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. Proc. Natl. Acad. Sci. U.S.A. 108, E1120-E1127 (2011).
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
-
-
Chan, T.O.1
Zhang, J.2
Rodeck, U.3
Pascal, J.M.4
Armen, R.S.5
Spring, M.6
Dumitru, C.D.7
Myers, V.8
Li, X.9
Cheung, J.Y.10
Feldman, A.M.11
-
10
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
D. R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, B. A. Hemmings, Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-6551 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
12
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
T. F. Franke, S. I. Yang, T. O. Chan, K. Datta, A. Kazlauskas, D. K. Morrison, D. R. Kaplan, P. N. Tsichlis, The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736 (1995).
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
13
-
-
0030799706
-
Dual role of phosphatidylinositol- 3,4,5-trisphosphate in the activation of protein kinase B
-
D. Stokoe, L. R. Stephens, T. Copeland, P. R. Gaffney, C. B. Reese, G. F. Painter, A. B. Holmes, F. McCormick, P. T. Hawkins, Dual role of phosphatidylinositol- 3,4,5-trisphosphate in the activation of protein kinase B. Science 277, 567-570 (1997).
-
(1997)
Science
, vol.277
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
Gaffney, P.R.4
Reese, C.B.5
Painter, G.F.6
Holmes, A.B.7
McCormick, F.8
Hawkins, P.T.9
-
14
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
T. F. Franke, D. R. Kaplan, L. C. Cantley, A. Toker, Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665-668 (1997).
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
15
-
-
0029942186
-
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
-
M. Andjelkovic, T. Jakubowicz, P. Cron, X. F. Ming, J. W. Han, B. A. Hemmings, Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 93, 5699-5704 (1996).
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 5699-5704
-
-
Andjelkovic, M.1
Jakubowicz, T.2
Cron, P.3
Ming, X.F.4
Han, J.W.5
Hemmings, B.A.6
-
16
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
T. Gao, F. Furnari, A. C. Newton, PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18, 13-24 (2005).
-
(2005)
Mol. Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
17
-
-
34547933680
-
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
-
E. K. Han, J. D. Leverson, T. McGonigal, O. J. Shah, K. W. Woods, T. Hunter, V. L. Giranda, Y. Luo, Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene 26, 5655-5661 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 5655-5661
-
-
Han, E.K.1
Leverson, J.D.2
McGonigal, T.3
Shah, O.J.4
Woods, K.W.5
Hunter, T.6
Giranda, V.L.7
Luo, Y.8
-
18
-
-
67650337799
-
Inhibitor hijacking of Akt activation
-
T. Okuzumi, D. Fiedler, C. Zhang, D. C. Gray, B. Aizenstein, R. Hoffman, K. M. Shokat, Inhibitor hijacking of Akt activation. Nat. Chem. Biol. 5, 484-493 (2009).
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 484-493
-
-
Okuzumi, T.1
Fiedler, D.2
Zhang, C.3
Gray, D.C.4
Aizenstein, B.5
Hoffman, R.6
Shokat, K.M.7
-
19
-
-
67349125149
-
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity
-
A. J. Cameron, C. Escribano, A. T. Saurin, B. Kostelecky, P. J. Parker, PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat. Struct. Mol. Biol. 16, 624-630 (2009).
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 624-630
-
-
Cameron, A.J.1
Escribano, C.2
Saurin, A.T.3
Kostelecky, B.4
Parker, P.J.5
-
20
-
-
66749155533
-
Resistance to mitogen- activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/ extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells
-
M. T. Yip-Schneider, P. J. Klein, S. C. Wentz, A. Zeni, A. Menze, C. M. Schmidt, Resistance to mitogen- activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/ extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells. J. Pharmacol. Exp. Ther. 329, 1063-1070 (2009).
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.329
, pp. 1063-1070
-
-
Yip-Schneider, M.T.1
Klein, P.J.2
Wentz, S.C.3
Zeni, A.4
Menze, A.5
Schmidt, C.M.6
-
21
-
-
0042733215
-
Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells
-
K. Sasaki, M. Sato, Y. Umezawa, Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J. Biol. Chem. 278, 30945-30951 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30945-30951
-
-
Sasaki, K.1
Sato, M.2
Umezawa, Y.3
-
22
-
-
0034730616
-
A novel method for measurement of submembrane ATP concentration
-
F. M. Gribble, G. Loussouarn, S. J. Tucker, C. Zhao, C. G. Nichols, F. M. Ashcroft, A novel method for measurement of submembrane ATP concentration. J. Biol. Chem. 275, 30046-30049 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30046-30049
-
-
Gribble, F.M.1
Loussouarn, G.2
Tucker, S.J.3
Zhao, C.4
Nichols, C.G.5
Ashcroft, F.M.6
-
23
-
-
0347089029
-
ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fl uorescence resonance energy transfer
-
T. Tsuboi, J. D. Lippiat, F. M. Ashcroft, G. A. Rutter, ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fl uorescence resonance energy transfer. Proc. Natl. Acad. Sci. U.S.A. 101, 76-81 (2004).
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 76-81
-
-
Tsuboi, T.1
Lippiat, J.D.2
Ashcroft, F.M.3
Rutter, G.A.4
-
24
-
-
70349449239
-
Visualization of ATP levels inside single living cells with fl uorescence resonance energy transfer- based genetically encoded indicators
-
H. Imamura, K. P. Huynh Nhat, H. Togawa, K. Saito, R. Iino, Y. Kato-Yamada, T. Nagai, H. Noji, Visualization of ATP levels inside single living cells with fl uorescence resonance energy transfer- based genetically encoded indicators. Proc. Natl. Acad. Sci. U.S.A. 106, 15651-15656 (2009).
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 15651-15656
-
-
Imamura, H.1
Huynh Nhat, K.P.2
Togawa, H.3
Saito, K.4
Iino, R.5
Kato-Yamada, Y.6
Nagai, T.7
Noji, H.8
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