The Structural Basis of ATP as an Allosteric Modulator

PLoS Computational Biology

Volumn 10, Issue 9, 2014, Pages

  Lu, Shaoyong ^a   Huang, Wenkang ^a   Wang, Qi ^a   Shen, Qiancheng ^a   Li, Shuai ^a   Nussinov, Ruth ^b,c   Zhang, Jian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; BIOLOGICAL SYSTEMS; MOLECULES; PROTEINS; SIGNAL TRANSDUCTION;

ADENOSINE-5-TRIPHOSPHATE; ALLOSTERIC MODULATORS; BINDING-SITES; BIOLOGICAL FUNCTIONS; CELLULAR SIGNAL TRANSDUCTION; CRITICAL BEHAVIOUR; ENERGY CURRENCIES; PROTEIN MODIFICATIONS; STRUCTURAL BASIS; SUBSTRATE-BINDING SITES;

CONFORMATIONS;

1 PHOSPHOFRUCTOKINASE; 5' NUCLEOTIDASE; ADENOSINE TRIPHOSPHATE; ASPARTATE CARBAMOYLTRANSFERASE; CHAPERONIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ENDOPEPTIDASE CLPX; GLYCOGEN PHOSPHORYLASE; PROTEIN MUTS; PURINERGIC P2X4 RECEPTOR; REPLICATION INITIATOR PROTEIN DNAA; RIBONUCLEOTIDE REDUCTASE; SULFATE ADENYLYLTRANSFERASE; URIDINE PHOSPHATE; ENZYME; PROTEIN;

ALGORITHM; ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CELL FUNCTION; CLUSTER ANALYSIS; COMPUTER SIMULATION; ENZYME REGULATION; HUMAN; MATHEMATICAL COMPUTING; MOLECULAR DOCKING; MOLECULAR MECHANICS; NONHUMAN; PHYLOGENY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; BACTERIUM; CHEMISTRY; FUNGUS; METABOLISM; MOLECULAR DYNAMICS; THERMODYNAMICS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; BACTERIA; ENZYMES; FUNGI; HUMANS; MOLECULAR DYNAMICS SIMULATION; PROTEINS; SIGNAL TRANSDUCTION; THERMODYNAMICS;

EID: 84907572342     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003831     Document Type: Article

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