Crystal structure of the TAO2 kinase domain: Activation and specificity of a Ste20p MAP3K

Structure

Volumn 12, Issue 10, 2004, Pages 1891-1900

  Zhou, Tianjun ^a   Raman, Malavika ^a   Gao, Yan ^a   Earnest, Svetlana ^a   Chen, Zhu ^a   Machius, Mischa ^a   Cobb, Melanie H ^a   Goldsmith, Elizabeth J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN KINASE; PROTEIN P21; PROTEIN TAO 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; CRYSTALLOGRAPHY; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; MAP KINASE KINASE 6; MAP KINASE KINASE KINASES; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RATS; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

EID: 4644232397     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2004.07.021     Document Type: Article

References (44)

1. Akamine P., Madhusudan, Wu J., Xuong N.H., Ten Eyck L.F., Taylor S.S. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J. Mol. Biol. 327:2003;159-171
2. Alessi D.R., Saito Y., Campbell D.G., Cohen P., Sithanandam G., Rapp U., Ashworth A., Marshall C.J., Cowley S. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J. 13:1994;1610-1619
3. Bellizzi J.J., Widom J., Kemp C.W., Clardy J. Producing selenomethionine-labeled proteins with a baculovirus expression vector system. Struct. Fold. Des. 7:1999;R263-R267
4. Bellon S., Fitzgibbon M.J., Fox T., Hsiao H.M., Wilson K.P. The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation. Struct. Fold. Des. 7:1999;1057-1065
5. Biondi R.M., Cheung P.C., Casamayor A., Deak M., Currie R.A., Alessi D.R. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J. 19:2000;979-988
6. Bossemeyer D., Engh R.A., Kinzel V., Ponstingl H., Huber R. Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24). EMBO J. 12:1993;849-859
7. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S., et al. Crystallography & NMR system. A new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54:1998;905-921
8. Burack W.R., Sturgill T.W. The activating dual phosphorylation of MAPK by MEK is nonprocessive. Biochemistry. 36:1997;5929-5933
9. Canagarajah B.J., Khokhlatchev A., Cobb M.H., Goldsmith E.J. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell. 90:1997;859-869
10. Chang C.I., Xu B.E., Akella R., Cobb M.H., Goldsmith E.J. Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol. Cell. 9:2002;1241-1249
11. Chen Z., Cobb M.H. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J. Biol. Chem. 276:2001;16070-16075
12. Chen Z., Hutchison M., Cobb M.H. Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. J. Biol. Chem. 274:1999;28803-28807
13. Chen Z., Gibson T.B., Robinson F., Silvestro L., Pearson G., Xu B., Wright A., Vanderbilt C., Cobb M.H. MAP kinases. Chem. Rev. 101:2001;2449-2476
14. Chen Z., Raman M., Chen L., Lee S.F., Gilman A.G., Cobb M.H. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J. Biol. Chem. 278:2003;22278-22283
15. Dajani R., Fraser E., Roe S.M., Young N., Good V., Dale T.C., Pearl L.H. Crystal structure of glycogen synthase kinase 3 beta. structural basis for phosphate-primed substrate specificity and autoinhibition Cell. 105:2001;721-732
16. Dan I., Watanabe N.M., Kusumi A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 11:2001;220-230
17. De Bondt H.L., Rosenblatt J., Jancarik J., Jones H.D., Morgan D.O., Kim S.H. Crystal structure of cyclin-dependent kinase 2. Nature. 363:1993;595-602
18. Drogen F., O'Rourke S.M., Stucke V.M., Jaquenoud M., Neiman A.M., Peter M. Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo. Curr. Biol. 10:2000;630-639
19. Hubbard S.R. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J. 16:1997;5572-5581
20. Hutchison M., Berman K.S., Cobb M.H. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 273:1998;28625-28632
21. Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A. 47:1991;110-119
22. Knighton D.R., Zheng J.H., Ten Eyck L.F., Ashford V.A., Xuong N.H., Taylor S.S., Sowadski J.M. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 253:1991;407-414. a
23. Knighton D.R., Zheng J.H., Ten Eyck L.F., Xuong N.H., Taylor S.S., Sowadski J.M. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 253:1991;414-420. b
24. Kraulis P.J. Molscript. a program to produce both detailed and schematic plots of protein structures J. Appl. Crystallogr. 24:1991;946-950
25. Kyriakis J.M., Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81:2001;807-869
26. Lei M., Lu W., Meng W., Parrini M.C., Eck M.J., Mayer B.J., Harrison S.C. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell. 102:2000;387-397
27. Lowe E.D., Noble M.E., Skamnaki V.T., Oikonomakos N.G., Owen D.J., Johnson L.N. The crystal structure of a phosphorylase kinase peptide substrate complex. kinase substrate recognition EMBO J. 16:1997;6646-6658
28. Manning G., Plowman G.D., Hunter T., Sudarsanam S. Evolution of protein kinase signaling from yeast to man. Trends Biochem. Sci. 27:2002;514-520
29. Manser E., Leung T., Salihuddin H., Zhao Z.S., Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 367:1994;40-46
30. Moore T.M., Garg R., Johnson C., Coptcoat M.J., Ridley A.J., Morris J.D. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. J. Biol. Chem. 275:2000;4311-4322
31. Nicholls A., Sharp K.A., Honig B. Protein folding and association. insights from the interfacial and thermodynamic properties of hydrocarbons Proteins. 11:1991;281-296
32. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., Cobb M.H. Mitogen-activated protein (MAP) kinase pathways. regulation and physiological functions Endocr. Rev. 22:2001;153-183
33. Peter M., Neiman A.M., Park H.O., van Lohuizen M., Herskowitz I. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15:1996;7046-7059
34. Russo A.A., Jeffrey P.D., Pavletich N.P. Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat. Struct. Biol. 3:1996;696-700
35. Songyang Z., Blechner S., Hoagland N., Hoekstra M.F., Piwnica-Worms H., Cantley L.C. Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr. Biol. 4:1994;973-982
36. Tassi E., Biesova Z., Di Fiore P.P., Gutkind J.S., Wong W.T. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. J. Biol. Chem. 274:1999;33287-33295
37. Wan P.T., Garnett M.J., Roe S.M., Lee S., Niculescu-Duvaz D., Good V.M., Jones C.M., Marshall C.J., Springer C.J., Barford D., Marais R. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 116:2004;855-867
38. Wang Z., Harkins P.C., Ulevitch R.J., Han J., Cobb M.H., Goldsmith E.J. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc. Natl. Acad. Sci. USA. 94:1997;2327-2332
39. Xu W., Harrison S.C., Eck M.J. Three-dimensional structure of the tyrosine kinase c-Src. Nature. 385:1997;595-602
40. Yamaguchi H., Hendrickson W.A. Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation. Nature. 384:1996;484-489
41. Yang J., Cron P., Thompson V., Good V.M., Hess D., Hemmings B.A., Barford D. Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol. Cell. 9:2002;1227-1240
42. Yustein J.T., Li D., Robinson D., Kung H.J. KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway. Oncogene. 19:2000;710-718
43. Zhang F., Strand A., Robbins D., Cobb M.H., Goldsmith E.J. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature. 367:1994;704-711
44. Zhang J., Zhang F., Ebert D., Cobb M.H., Goldsmith E.J. Activity of the MAP kinase ERK2 is controlled by a flexible surface loop. Structure. 3:1995;299-307