Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish

DMM Disease Models and Mechanisms

Volumn 4, Issue 3, 2011, Pages 400-410

  Becker, Jason R ^a,b   Deo, Rahul C ^a   Werdich, Andreas A ^a,d   Panàkovà, Daniela ^a,c   Coy, Shannon ^a   MacRae, Calum A ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; TROPONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EXON; GENE; GENE MUTATION; GENETIC TRANSCRIPTION; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HYPERTROPHIC CARDIOMYOPATHY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; ZEBRA FISH;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEART VENTRICLES; HUMANS; HYPERPLASIA; MICE; MOLECULAR SEQUENCE DATA; MUTATION; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; OLIGONUCLEOTIDES, ANTISENSE; ORGANOGENESIS; SARCOMERES; TRANSCRIPTION, GENETIC; TROPONIN T; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 79956110261     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.006148     Document Type: Article

References (36)

1. Ahmad, F., Banerjee, S. K., Lage, M. L., Huang, X. N., Smith, S. H., Saba, S., Rager, J., Conner, D. A., Janczewski, A. M., Tobita, K. et al. (2008). The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS ONE 3, e2642.
2. Ahuja, P., Sdek, P. and MacLellan, W. R. (2007). Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol. Rev. 87, 521-544.
3. Alcalai, R., Seidman, J. G. and Seidman, C. E. (2007). Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics. J. Cardiovasc. Electrophysiol. 19, 104-110.
4. Arad, M., Seidman, J. G. and Seidman, C. E. (2002). Phenotypic diversity in hypertrophic cardiomyopathy. Hum. Mol. Genet. 11, 2499-2506.
5. Baudenbacher, F., Schober, T., Pinto, J. R., Sidorov, V. Y., Hilliard, F., Solaro, R. J., Potter, J. D. and Knollmann, B. C. (2008). Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J. Clin. Invest. 118, 3893-3903.
6. Berriz, G. F., Beaver, J. E., Cenik, C., Tasan, M. and Roth, F. P. (2009). Next generation software for functional trend analysis. Bioinformatics 25, 3043-3044.
7. Berriz, G. F., King, O. D., Bryant, B., Sander, C. and Roth, F. P. (2003). Characterizing gene sets with FuncAssociate. Bioinformatics 19, 2502-2504. (Pubitemid 38016661)
8. Cha, H., Jeong, H. J., Jang, S. P., Kim, J. Y., Yang, D. K., Oh, J. G. and Park, W. J. (2009). PTH accelerates decompensation following left ventricular hypertrophy. Exp. Mol. Med. 42, 61-61.
9. Chalmers, J. A., Lin, S. Y., Martino, T. A., Arab, S., Liu, P., Husain, M., Sole, M. J. and Belsham, D. D. (2008). Diurnal profiling of neuroendocrine genes in murine heart, and shift in proopiomelanocortin gene expression with pressure-overload cardiac hypertrophy. J. Mol. Endocrinol. 41, 117-124.
10. Geisterfer-Lowrance, A. A., Christe, M., Conner, D. A., Ingwall, J. S., Schoen, F. J., Seidman, C. E. and Seidman, J. G. (1996). A mouse model of familial hypertrophic cardiomyopathy. Science 272, 731-734.
11. Granata, R., Trovato, L., Gallo, M. P., Destefanis, S., Settanni, F., Scarlatti, F., Brero, A., Ramella, R., Volante, M., Isgaard, J. et al. (2009). Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart. Cardiovasc. Res. 83, 303-312.
12. Hao, L. Y., Kameyama, A., Kuroki, S., Takano, J., Takano, E., Maki, M. and Kameyama, M. (2000). Calpastatin domain L is involved in the regulation of L-type Ca2+ channels in guinea pig cardiac myocytes. Biochem. Biophys. Res. Commun. 279, 756-761.
13. Harris, K. M., Spirito, P., Maron, M. S., Zenovich, A. G., Formisano, F., Lesser, J. R., Mackey-Bojack, S., Manning, W. J., Udelson, J. E. and Maron, B. J. (2006). Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy. Circulation 114, 216-225. (Pubitemid 44297115)
14. Huang, W., Zhang, R. and Xu, X. (2009). Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2. Dev. Biol. 331, 237-249.
15. Kim, J. B., Porreca, G. J., Song, L., Greenway, S. C., Gorham, J. M., Church, G. M., Seidman, C. E. and Seidman, J. G. (2007). Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. Science 316, 1481-1484.
16. Knollmann, B. C., Kirchhof, P., Sirenko, S. G., Degen, H., Greene, A. E., Schober, T., Mackow, J. C., Fabritz, L., Potter, J. D. and Morad, M. (2003). Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling. Circ. Res. 92, 428-436.
17. Kubalova, Z., Gyorke, I., Terentyeva, R., Viatchenko-Karpinski, S., Terentyev, D., Williams, S. C. and Gyorke, S. (2004). Modulation of cytosolic and intrasarcoplasmic reticulum calcium waves by calsequestrin in rat cardiac myocytes. J. Physiol. 561, 515-524. (Pubitemid 39646539)
18. Lombardi, R., Rodriguez, G., Chen, S. N., Ripplinger, C. M., Li, W., Chen, J., Willerson, J. T., Betocchi, S., Wickline, S. A., Efimov, I. R. et al. (2009). Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation 119, 1398-1407.
19. Mably, J. D., Mohideen, M. A., Burns, C. G., Chen, J. N. and Fishman, M. C. (2003). heart of glass regulates the concentric growth of the heart in zebrafish. Curr. Biol. 13, 2138-2147.
20. Ostlund, G., Schmitt, T., Forslund, K., Kostler, T., Messina, D. N., Roopra, S., Frings, O. and Sonnhammer, E. L. (2010). InParanoid 7, new algorithms and tools for eukaryotic orthology analysis. Nucleic Acids Res. 38, D196-D203.
21. Rivello, H. G., Meckert, P. C., Vigliano, C., Favaloro, R. and Laguens, R. P. (2001). Cardiac myocyte nuclear size and ploidy status decrease after mechanical support. Cardiovasc. Pathol. 10, 53-57.
22. Saiki, Y., Konig, A., Waddell, J. and Rebeyka, I. M. (1997). Hemodynamic alteration by fetal surgery accelerates myocyte proliferation in fetal guinea pig hearts. Surgery 122, 412-419.
23. Sedmera, D., Thompson, R. P. and Kolar, F. (2003). Effect of increased pressure loading on heart growth in neonatal rats. J. Mol. Cell. Cardiol. 35, 301-309.
24. Sehnert, A. J., Huq, A., Weinstein, B. M., Walker, C., Fishman, M. and Stainier, D. Y. (2002). Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nat. Genet. 31, 106-110.
25. Seidman, J. G. and Seidman, C. (2001). The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms. Cell 104, 557-567. (Pubitemid 32201950)
26. Song, L., Alcalai, R., Arad, M., Wolf, C. M., Toka, O., Conner, D. A., Berul, C. I., Eldar, M., Seidman, C. E. and Seidman, J. G. (2007). Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J. Clin. Invest. 117, 1814-1823.
27. Sprague, J., Bayraktaroglu, L., Bradford, Y., Conlin, T., Dunn, N., Fashena, D., Frazer, K., Haendel, M., Howe, D. G., Knight, J. et al. (2008). The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes. Nucleic Acids Res. 36, D768-D772. (Pubitemid 351149821)
28. Strimmer, K. (2008). fdrtool: a versatile R package for estimating local and tail area-based false discovery rates. Bioinformatics 24, 1461-1462.
29. Szczesna, D., Zhang, R., Zhao, J., Jones, M., Guzman, G. and Potter, J. D. (2000). Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy. J. Biol. Chem. 275, 624-630.
30. Tardiff, J. C., Factor, S. M., Tompkins, B. D., Hewett, T. E., Palmer, B. M., Moore, R. L., Schwartz, S., Robbins, J. and Leinwand, L. A. (1998). A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J. Clin. Invest. 101, 2800-2811.
31. Tardiff, J. C., Hewett, T. E., Palmer, B. M., Olsson, C., Factor, S. M., Moore, R. L., Robbins, J. and Leinwand, L. A. (1999). Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J. Clin. Invest. 104, 469-481.
32. Thierfelder, L., Watkins, H., MacRae, C., Lamas, R., McKenna, W., Vosberg, H. P., Seidman, J. G. and Seidman, C. E. (1994). Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell 77, 701-712.
33. Tzanidis, A., Hannan, R. D., Thomas, W. G., Onan, D., Autelitano, D. J., See, F., Kelly, D. J., Gilbert, R. E. and Krum, H. (2003). Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy. Circ. Res. 93, 246-253.
34. Wagner, K. D., Wagner, N., Ghanbarian, H., Grandjean, V., Gounon, P., Cuzin, F. and Rassoulzadegan, M. (2008). RNA induction and inheritance of epigenetic cardiac hypertrophy in the mouse. Dev. Cell 14, 962-969. (Pubitemid 351757196)
35. Wolf, C. M., Moskowitz, I. P., Arno, S., Branco, D. M., Semsarian, C., Bernstein, S. A., Peterson, M., Maida, M., Morley, G. E., Fishman, G. et al. (2005). Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proc. Natl. Acad. Sci. USA 102, 18123-18128.
36. Yoshida, M., Minamisawa, S., Shimura, M., Komazaki, S., Kume, H., Zhang, M., Matsumura, K., Nishi, M., Saito, M., Saeki, Y. et al. (2005). Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice. J. Biol. Chem. 280, 3500-3506.