Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Duan, Junchao ^a   Yu, Yongbo ^a   Li, Yang ^b   Yu, Yang ^a   Li, Yanbo ^a   Zhou, Xianqing ^a   Huang, Peili ^a   Sun, Zhiwei ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CYCLIN B1; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NANOPARTICLE; PROTEIN CDC25C; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; SILICA NANOPARTICLE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CELL TRANSPORT; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME RELEASE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PARTICLE SIZE; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; ZETA POTENTIAL;

APOPTOSIS; COMET ASSAY; DNA DAMAGE; ENDOCYTOSIS; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINTS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDRODYNAMICS; INTRACELLULAR SPACE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NANOPARTICLES; NECROSIS; OXIDATIVE STRESS; PARTICLE SIZE; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SILICON DIOXIDE; STATIC ELECTRICITY; SUBCELLULAR FRACTIONS;

EID: 84876425519     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062087     Document Type: Article

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