Morphological score assignment guidelines for the dechorionated zebrafish teratogenicity assay

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 89, Issue 5, 2010, Pages 382-395

  Panzica Kelly, Julieta M ^a   Zhang, Cindy X ^a   Danberry, Tracy L ^a,c   Flood, Annette ^b   DeLan, Judiann W ^b   Brannen, Kimberly C ^a,d   Augustine Rauch, Karen A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Lampire Biological Laboratories Inc   (United States)

^c Training and Compliance   (United States)

^d CHARLES RIVER LABORATORIES   (United States)

Author keywords

Alternative; Embryo; Morphological assessment; Teratogenicity; Zebrafish

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; ASSAY; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; EMBRYO CULTURE; FEMALE; MALE; MORPHOLOGY; NONHUMAN; ORGAN; PRIORITY JOURNAL; SCORING SYSTEM; TERATOGENICITY; ZEBRA FISH;

ANIMALS; CELLS, CULTURED; EMBRYO CULTURE TECHNIQUES; EMBRYO, NONMAMMALIAN; FEMALE; GUIDELINES AS TOPIC; MALE; MODELS, ANIMAL; NO-OBSERVED-ADVERSE-EFFECT LEVEL; TERATOGENS; ZEBRAFISH;

DANIO RERIO;

EID: 78650463895     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20260     Document Type: Article

References (6)

1. Augustine KA. 2009. HESI DART. Alternative Assays Workshop II: Generation and Preliminary Assessment of a Zebrafish Teratogenicity Assay. Arles, France: European Teratology Society
2. Augustine-rauch KA, Zhang CX, Panzica Kelly JM. 2010. In vitro developmental toxicology assays: a review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays. Birth Defects Research Part C 90:87-98.
3. Brannen KC, Panzica-Kelly JM, Danberry TL, Augustine-Rauch KA. 2010. Development of a zebrafish embryo teratogenicity assay and quantitative prediction model. Birth Defects Res 89:66-77.
4. Westerfield M. 2007. The zebrafish book, 5th ed. Eugene: University of Oregon Press.
5. Zhang CX, Panzica-Kelly J, Augustine-Rauch KA. Way forward essay on developmental toxicological assays: current and future state of the science. ALTOX website. Way Forward Essays. 2009. Available at
6. Zon LI, Peterson RT. 2005. In vivo drug discovery in the zebrafish. Nature Rev 4:35-44.