β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos

Journal of Biomedical Science

Volumn 18, Issue 1, 2011, Pages

  Wu, Yi Ting ^a   Lin, Che Yi ^a   Tsai, Ming Yuan ^b   Chen, Yi Hua ^c   Lu, Yu Fen ^c   Huang, Chang Jen ^d   Cheng, Chao Min ^e   Hwang, Sheng Ping L ^a,c  

^a NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^b NATIONAL DEFENSE UNIVERSITY   (Taiwan)

^c INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

^d INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^e NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Lapachone; apoptosis; endocardium; erythrocyte deficiency; heart morphogenesis; zebrafish

Indexed keywords

BETA LAPACHONE; BONE MORPHOGENETIC PROTEIN 4; DEXTRAN; DIANISIDINE; DICHLORODIHYDROFLUORESCEIN DIACETATE; DICOUMAROL; DIMETHYL SULFOXIDE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; REACTIVE OXYGEN METABOLITE; RHODAMINE; TRANSCRIPTION FACTOR NFAT; VERSICAN; BETA-LAPACHONE; NAPHTHOQUINONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

APOPTOSIS; ARTICLE; BRADYCARDIA; CIRCULATION; DNA FRAGMENTATION; EMBRYO; ENDOCARDIUM; ERYTHROCYTE; FLUORESCENCE MICROSCOPY; HEART ASSIST DEVICE; HEART CONTRACTION; HEART DEVELOPMENT; HEART EDEMA; IN SITU HYBRIDIZATION; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETICULUM CELL; SHEAR STRESS; ZEBRA FISH; ANIMAL; CHEMICALLY INDUCED DISORDER; CONGENITAL HEART MALFORMATION; CONGENITAL MALFORMATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EMBRYO DEVELOPMENT; ERYTHROCYTE COUNT; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART; METABOLISM; MORPHOGENESIS; PATHOPHYSIOLOGY; PRENATAL DEVELOPMENT; TIME LAPSE IMAGING;

DANIO RERIO;

ANIMALS; APOPTOSIS; DICUMAROL; DIMETHYL SULFOXIDE; EMBRYONIC DEVELOPMENT; ENDOCARDIUM; ERYTHROCYTE COUNT; ERYTHROCYTES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEART DEFECTS, CONGENITAL; MICROSCOPY, FLUORESCENCE; MORPHOGENESIS; NAD(P)H DEHYDROGENASE (QUINONE); NAPHTHOQUINONES; REACTIVE OXYGEN SPECIES; TIME-LAPSE IMAGING; ZEBRAFISH;

EID: 80053173285     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-18-70     Document Type: Article

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