Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish

Journal of Applied Toxicology

Volumn 34, Issue 2, 2014, Pages 139-148

  Zhu, Jun Jing ^a   Xu, Yi Qiao ^a   He, Jian Hui ^a   Yu, Hang Ping ^a   Huang, Chang Jiang ^c   Gao, Ji Min ^c   Dong, Qiao Xiang ^c   Xuan, Yao Xian ^b   Li, Chun Qi ^a,c  

^a Transfarland   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Animal model; Arrhythmia; Cardiotoxicity; Cardiovascular toxicity; Drug screen; Microinjection; Toxicity assessment; Zebrafish

Indexed keywords

ACETYLSALICYLIC ACID; CLOMIPRAMINE; CYCLOPHOSPHAMIDE; GENTAMICIN; NIMODIPINE; QUINIDINE; TERFENADINE; TETRACYCLINE; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; ATRIOVENTRICULAR BLOCK; BLEEDING; BRADYCARDIA; CARDIOTOXICITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HEART EDEMA; HEART RATE; HEART RHYTHM; ISCHEMIA; LC 50; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; SINUS ARREST; THROMBOSIS; TOXICITY TESTING; YOLK SAC; ZEBRA FISH;

ANIMALIA; DANIO RERIO;

ANIMAL MODEL; ARRHYTHMIA; CARDIOTOXICITY; CARDIOVASCULAR TOXICITY; DRUG SCREEN; MICROINJECTION; TOXICITY ASSESSMENT; ZEBRAFISH;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ASPIRIN; CARDIOTOXINS; CLOMIPRAMINE; CYCLOPHOSPHAMIDE; DISEASE MODELS, ANIMAL; EDEMA; GENTAMICINS; HEART DISEASES; HEART RATE; HEART VENTRICLES; LARVA; MICROINJECTIONS; NIMODIPINE; PERICARDIUM; QUINIDINE; TERFENADINE; TETRACYCLINE; TOXICITY TESTS; VERAPAMIL; YOLK SAC; ZEBRAFISH;

EID: 84890438265     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2843     Document Type: Article

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