Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo

Developmental Biology

Volumn 322, Issue 1, 2008, Pages 65-73

  Nishii, Kiyomasa ^a   Morimoto, Sachio ^a   Minakami, Reiko ^a   Miyano, Yumi ^a   Hashizume, Kanako ^a   Ohta, Mika ^a   Zhan, Dong Yun ^a   Lu, Qun Wei ^a   Shibata, Yosaburo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

cTnT; Development; Heart; Myofibrillogenesis

Indexed keywords

ALPHA ACTININ; CARDIAC TROPONIN T; TROPOMYOSIN; TROPONIN I; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOMYOPATHY; CELL MEMBRANE DEPOLARIZATION; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE LOCUS; GENE MUTATION; HEART ARRHYTHMIA; HEART CONTRACTION; HEART DEVELOPMENT; HEART MUSCLE CELL; IN VIVO STUDY; MOUSE; MYOFILAMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PRIORITY JOURNAL; PROTEIN FUNCTION; SARCOMERE; THIN FILAMENT;

MUS;

EID: 52049099588     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2008.07.007     Document Type: Article

References (39)

1. Ahmad F., Seidman J.G., and Seidman C.E. The genetic basis for cardiac remodeling. Annu. Rev. Genomics Hum. Genet. 6 (2005) 185-216
2. Ahmad F., Banerjee S.K., Lage M.L., Huang X.N., Smith S.H., Saba S., Rager J., Conner D.A., Janczewski A.M., Tobita K., Tinney J.P., Moskowitz I.P., Perez-Atayde A.R., Keller B.B., Mathier M.A., Shroff S.G., Seidman C.E., and Seidman J.G. The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS ONE 3 (2008) e2642
3. Berdougo E., Coleman H., Lee D.H., Stainier D.Y.R., and Yelon D. Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development 130 (2003) 6121-6129
4. 2+ exchanger is essential for embryonic heart development in mice. Mol. Cells 10 (2000) 712-722
5. Du C.-K., Morimoto S., Nishii K., Minakami R., Ohta M., Tadano N., Lu Q.-W., Wang Y.-Y., Zhan D.-Y., Mochizuki M., Kita S., Miwa Y., Takahashi-Yanaga F., Iwamoto T., Ohtsuki I., and Sasaguri T. A knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. Circ. Res. 101 (2007) 185-194
6. Fritz-Six K.L., Cox P.R., Fischer R.S., Xu B., Gregorio C.C., Zoghbi H.Y., and Fowler V.M. Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality. J. Cell Biol. 163 (2003) 1033-1044
7. Fyrberg E., Fyrberg C.C., Beall C., and Saville D.L. Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities. J. Mol. Biol. 216 (1990) 657-675
8. Gomes A.V., Barnes J.A., Harada K., and Potter J.D. Role of troponin T in disease. Mol. Cell. Biochem. 263 (2004) 115-129
9. Gregorio C.C., and Antin P.B. To the heart of myofibril assembly. Trends Cell Biol. 10 (2000) 355-362
10. Hill D.K. Resting tension and the form of the twitch of rat skeletal muscle at low temperature. J. Physiol. 221 (1972) 161-171
11. Hove J.R., Köster R.W., Forouhar A.S., Acevedo-Bolton G., Fraser S.E., and Gharib M. Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 421 (2003) 172-177
12. Huang C., Sheikh F., Hollander M., Cai C., Becker D., Chu P.-H., Evans S., and Chen J. Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development 130 (2003) 6111-6119
13. Huang X., Pi Y., Lee K.J., Henkel A.S., Gregg R.G., Powers P.A., and Walker J.W. Cardiac troponin I gene knockout: a mouse model of myocardial troponin I deficiency. Circ. Res. 84 (1999) 1-8
14. Koushik S.V., Bundy J., and Conway S.J. Sodium-calcium exchanger is initially expressed in a heart-restricted pattern within the early mouse embryo. Mech. Dev. 88 (1999) 119-122
15. Koushik S.V., Wang J., Rogers R., Moskophidis D., Lambert N.A., Creazzo T.L., and Conway S.J. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 15 (2001) 1209-1211
16. Kumai M., Nishii K., Nakamura K., Takeda N., Suzuki M., and Shibata Y. Loss of connexin45 causes a cushion defect in early cardiogenesis. Development 127 (2000) 3501-3512
17. Mogensen J., Murphy R.T., Shaw T., Bahl A., Redwood C., Watkins H., Burke M., Elliott P.M., and McKenna W.J. Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 44 (2004) 2033-2040
18. 2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy. Am. J. Physiol. 275 (1998) C200-C207
19. 2+ regulation in developing rabbit cardiac muscle. Biochem. Biophys. Res. Commun. 267 (2000) 912-917
20. 2+-desensitizing effect of a deletion mutation ΔK210 in cardiac troponin T that causes familial dilated cardiomyopathy. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 913-918
21. Morimoto S. Sarcomeric proteins and inherited cardiomyopathies. Cardiovasc. Res. 77 (2008) 659-666
22. Navaratnam V., Kaufman M.H., Skepper J.N., Barton S., and Guttridge K.M. Differentiation of the myocardial rudiment of mouse embryos: an ultrastructural study including freeze-fracture replication. J. Anat. 146 (1986) 65-85
23. Nishii K., Kumai M., and Shibata Y. Regulation of the epithelial-mesenchymal transformation through gap junction channels in heart development. Trends Cardiovasc. Med. 11 (2001) 213-218
24. Nishii K., Kumai M., Egashira K., Miwa T., Hashizume K., Miyano Y., and Shibata Y. Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect. Cell Commun. Adhes. 10 (2003) 365-369
25. Nishii K., and Shibata Y. Mode and determination of the initial contraction stage in the mouse embryo heart. Anat. Embryol. 211 (2006) 95-100
26. Ohtsuki I., Maruyama K., and Ebashi S. Regulatory and cytoskeletal proteins of vertebrate skeletal muscle. Adv. Protein Chem. 38 (1986) 1-67
27. Parmacek M.S., and Solaro R.J. Biology of the troponin complex in cardiac myocytes. Prog. Cardiovasc. Dis. 47 (2004) 159-176
28. 2+ exchanger is essential for the action of cardiac glycosides. Circ. Res. 90 (2002) 305-308
29. Sapega A.A., Heppenstall R.B., Sokolow D.P., Graham T.J., Maris J.M., Ghosh A.K., Chance B., and Osterman A.L. The bioenergetics of preservation of limbs before replantation: the rationale for intermediate hypothermia. J. Bone Jt. Surg. 70 (1988) 1500-1513
30. Sehnert A.J., Huq A., Weinstein B.M., Walker C., Fishman M., and Stainier D.Y.R. Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nat. Genet. 31 (2002) 106-110
31. Siedner S., Krüger M., Schroeter M., Metzler D., Roell W., Fleischmann B.K., Hescheler J., Pfitzer G., and Stehle R. Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J. Physiol. 548 (2003) 493-505
32. Steenbergen C., Murphy E., Watts J.A., and London R.E. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ. Res. 66 (1990) 135-146
33. 2+-saturated form. Nature 424 (2003) 35-41
34. Van Driest S.L., Ellsworth E.G., Ommen S.R., Tajik A.J., Gersh B.J., and Ackerman M.J. Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy. Circulation 108 (2003) 445-451
35. 2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J. Biol. Chem. 275 (2000) 36991-36998
36. 2+ exchanger (NCX1) gene in the developmental mouse embryo and adult mouse brain. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 130 (2001) 191-198
37. 2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 135 (2003) 9-15
38. Wang Q., Reiter R.S., Huang Q.-Q., Jin J.-P., and Lin J.J.-C. Comparative studies on the expression patterns of three troponin T genes during mouse development. Anat. Rec. 263 (2001) 72-84
39. Yagi T., Ikawa Y., Yoshida K., Shigetani Y., Takeda N., Mabuchi I., Yamamoto T., and Aizawa S. Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 9918-9922