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Volumn 23, Issue 17, 2015, Pages 5799-5808

Synthesis and apoptotic activity of new pyrazole derivatives in cancer cell lines

(7) Nitulescu, George Mihai a Draghici, Constantin b Olaru, Octavian Tudorel a Matei, Lilia c Ioana, Aldea c Dragu, Laura Denisa c Bleotu, Coralia c

a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY (Romania)

b INSTITUTE OF ORGANIC CHEMISTRY (Romania)

c STEFAN S NICOLAU INSTITUTE OF VIROLOGY (Romania)

Author keywords

Akt; Apoptosis; Cell cycle; IAP; Pyrazole; TRAIL R2

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; DEATH RECEPTOR 4; DEATH RECEPTOR 5; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; N [(1 METHYL 1H PYRAZOL 4 YL)CARBONYL] N' (2 BROMOPHENYL)THIOUREA; N [(1 METHYL 1H PYRAZOL 4 YL)CARBONYL] N' (2 IODOPHENYL)THIOUREA; N [(1 METHYL 1H PYRAZOL 4 YL)CARBONYL] N' (3 BROMOPHENYL)THIOUREA; N [(1 METHYL 1H PYRAZOL 4 YL)CARBONYL] N' (4 BROMOPHENYL)THIOUREA; N [(1 METHYL 1H PYRAZOL 4 YL)CARBONYL] N' (4 IODOPHENYL)THIOUREA; N [3 (4 BROMOPHENYL) 4 METHYLTHIAZOL 2(3H) YLIDENE] 1 METHYL 1H PYRAZOLE 4 CARBOXAMIDE; N [3 (4 IODOPHENYL) 4 METHYLTHIAZOL 2(3H) YLIDENE] 1 METHYL 1H PYRAZOLE 4 CARBOXAMIDE; N [4 HYDROXY 4 METHYL 3 (4 BROMOPHENYL) 1,3 THIAZOLIDIN 2 YLIDENE] 1 METHYL 1H PYRAZOLE 4 CARBOXAMIDE; N [4 HYDROXY 4 METHYL 3 (4 IODOPHENYL) 1,3 THIAZOLIDIN 2 YLIDENE] 1 METHYL 1H PYRAZOLE 4 CARBOXAMIDE; PROTEIN KINASE B; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; PYRAZOLE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE; PROTEIN CLEAVAGE; APOPTOSIS; CHEMISTRY; SYNTHESIS; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; HUMANS; PYRAZOLES;

EID: 84946490114 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.07.010 Document Type: Article

Times cited : (45)

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