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European Journal of Medicinal Chemistry

Volumn 90, Issue , 2015, Pages 889-896

Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives: Synthesis and anticancer activity

(5) Shi, Jing Bo a Tang, Wen Jian a Qi, Xing Bao a Li, Rong a Liu, Xin Hua a,b

a ANHUI MEDICAL UNIVERSITY (China)

b NANJING UNIVERSITY (China)

Author keywords

Anticancer activity; Pyrazole 5 carboxamide; Synthesis; Telomerase

Indexed keywords

1 METHYL 3 PROPYL 4 (2,4,5 TRIMETHOXYBENZAMIDO) 1H PYRAZOLE 5 CARBOXAMIDE; 1 METHYL 3 PROPYL 4 (3,4,5 TRIMETHOXYBENZAMIDO) 1H PYRAZOLE 5 CARBOXAMIDE; 1 METHYL 3 PROPYL 4 [3 (3,4,5 TRIMETHOXYPHENYL) ACRYLAMIDO] 1H PYRAZOLE 5 CARBOXAMIDE; 1 METHYL 3 PROPYL 5 (2,4,5 TRIMETHOXYPHENYL) 1H PYRAZOLO[4,3 D]PYRIMIDIN 7(6H) ONE; 1 METHYL 3 PROPYL 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOLO[4,3 D]PYRIMIDIN 7(6H) ONE; 1 METHYL 3 PROPYL 5 (3,4,5 TRIMETHOXYSTYRYL) 1H PYRAZOLO[4,3 D]PYRIMIDIN 7(6H) ONE; 1 METHYL 3 PROPYL 5 STYRYL 1H PYRAZOLO[4,3 D] PYRIMIDIN 7(6H) ONE; 4 CINNAMAMIDO 1 METHYL 3 PROPYL 1H PYRAZOLE 5 CARBOXAMIDE; 4 [3 (FURAN 2 YL)ACRYLAMIDO] 1 METHYL 3 PROPYL 1H PYRAZOLE 5 CARBOXAMIDE; 5 [2 (FURAN 2 YL)VINYL] 1 METHYL 3 PROPYL 1H PYRAZOLO[4,3 D]PYRIMIDIN 7(6H) ONE; AMIDE; ANTINEOPLASTIC AGENT; ETHIDIUM BROMIDE; FLUOROURACIL; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG; PYRIMIDINE;

ACYLATION; AMIDATION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL PROLIFERATION; CLAISEN CONDENSATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROLYSIS; IC50; IN VITRO STUDY; MASS SPECTROMETRY; METHYLATION; MOLECULAR DOCKING; NITRATION; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84920191522 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2014.12.013 Document Type: Article

Times cited : (104)

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