Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4766-4770

  Zheng, Liang Wen ^a   Li, Ying ^a   Ge, Di ^a   Zhao, Bao Xiang ^a   Liu, Ying Rui ^a   Lv, Hong Shui ^a   Ding, Jun ^a   Miao, Jun Ying ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b Shandong University   (China)

Author keywords

A549 cells; Apoptosis; Autophagy; Oxime; Pyrazole; Synthesis

Indexed keywords

BROMINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; OXIME DERIVATIVE; PYRAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; OXIME; PYRAZOLE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TIME; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; CONFORMATION; DRUG EFFECTS; DRUG SCREENING; LUNG NEOPLASMS; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HUMANS; LUNG NEOPLASMS; MOLECULAR CONFORMATION; OXIMES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955418372     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.121     Document Type: Article

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