Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells

European Journal of Medicinal Chemistry

Volumn 43, Issue 11, 2008, Pages 2347-2353

  Xia, Yong ^a   Fan, Chuan Dong ^a   Zhao, Bao Xiang ^a   Zhao, Jing ^a   Shin, Dong Soo ^b   Miao, Jun Ying ^a  

^a SHANDONG UNIVERSITY   (China)

^b Changwon National University   (South Korea)

Author keywords

A549 cells; Arylpyrazole carbohydrazide; Growth inhibitory; Hydrazone; Structure activity relationship; X ray crystallography

Indexed keywords

HYDRAZIDE DERIVATIVE; HYDRAZONE DERIVATIVE; PYRAZOLE 5 CARBOHYDRAZIDE HYDRAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIPOPHILICITY; LUNG NON SMALL CELL CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54049104981     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.021     Document Type: Article

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