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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 844-849

Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cells

(6) Lv, Hong Shui a Kong, Xiang Qian b Ming, Qian Qian a Jin, Xing b Miao, Jun Ying a Zhao, Bao Xiang a

a SHANDONG UNIVERSITY (China)

b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY (China)

Author keywords

Apoptosis; H322 cells; Pyrazinone; Pyrazole; Synthesis; X ray

Indexed keywords

5 BENZYL 2 PHENYLPYRAZOLO[1,5 ALPHA]PYRAZIN 4,6(5H,7H) DIONE DERIVATIVE; ALKYLATING AGENT; CARBOXYLIC ACID; CHLOROACETAMIDE; ETHYL 3 PHENYL 1H PYRAZOLE 5 CARBOXYLATE DERIVATIVE; N ARYLALKYL 2 CHLOROACETAMIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZINES; PYRAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855641205 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.12.049 Document Type: Article

Times cited : (24)

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