-
2
-
-
57649149333
-
Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009
-
Kroemer, G.; Galluzzi, L.; Vandenabeele, P.; Abrams, J.; Alnemri, E.S.; Baehrecke, E.H.; Blagosklonny, M.V.; El-Deiry, W.S.; Golstein, P.; Green, D.R.; et al. Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009. Cell. Death Differ. 2008, 16, 3-11.
-
(2008)
Cell. Death Differ.
, vol.16
, pp. 3-11
-
-
Kroemer, G.1
Galluzzi, L.2
Vandenabeele, P.3
Abrams, J.4
Alnemri, E.S.5
Baehrecke, E.H.6
Blagosklonny, M.V.7
El-Deiry, W.S.8
Golstein, P.9
Green, D.R.10
-
3
-
-
13444250347
-
-
Elsevier Health Sciences: Makati City, Philippines
-
Robbins, S.L.; Kumar, V.; Abbas, A.K.; Cotran, R.S.; Fausto, N. Robbins and Cotran's Pathologic Basis of Disease; Elsevier Health Sciences: Makati City, Philippines, 2009.
-
(2009)
Robbins and Cotran's Pathologic Basis of Disease
-
-
Robbins, S.L.1
Kumar, V.2
Abbas, A.K.3
Cotran, R.S.4
Fausto, N.5
-
5
-
-
0033214236
-
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis
-
Lin, Y.; Devin, A.; Rodriguez, Y.; Liu, Z.-G. Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis. Genes Dev. 1999, 13, 2514-2526.
-
(1999)
Genes Dev.
, vol.13
, pp. 2514-2526
-
-
Lin, Y.1
Devin, A.2
Rodriguez, Y.3
Liu, Z.-G.4
-
6
-
-
67650812332
-
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
-
Zhang, D.-W.; Shao, J.; Lin, J.; Zhang, N.; Lu, B.-J.; Lin, S.-C.; Dong, M.-Q.; Han, J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325, 332-336.
-
(2009)
Science
, vol.325
, pp. 332-336
-
-
Zhang, D.-W.1
Shao, J.2
Lin, J.3
Zhang, N.4
Lu, B.-J.5
Lin, S.-C.6
Dong, M.-Q.7
Han, J.8
-
7
-
-
84870850140
-
New frontiers in promoting tumour cell death: Targeting apoptosis, necroptosis and autophagy
-
Long, J.S.; Ryan, K.M. New frontiers in promoting tumour cell death: Targeting apoptosis, necroptosis and autophagy. Oncogene 2012, 31, 5045-5060.
-
(2012)
Oncogene
, vol.31
, pp. 5045-5060
-
-
Long, J.S.1
Ryan, K.M.2
-
8
-
-
77449153351
-
Regulation of death receptor signaling by the ubiquitin system
-
Wertz, I.E.; Dixit, V.M. Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ. 2009, 17, 14-24.
-
(2009)
Cell Death Differ.
, vol.17
, pp. 14-24
-
-
Wertz, I.E.1
Dixit, V.M.2
-
9
-
-
77954930632
-
IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer
-
Gyrd-Hansen, M.; Meier, P. IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer. Nat. Rev. Cancer 2010, 10, 561-574.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 561-574
-
-
Gyrd-Hansen, M.1
Meier, P.2
-
10
-
-
70449941949
-
Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices
-
Dewson, G.; Kratina, T.; Czabotar, P.; Day, C.L.; Adams, J.M.; Kluck, R.M. Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices. Mol. Cell. 2009, 36, 696-703.
-
(2009)
Mol. Cell.
, vol.36
, pp. 696-703
-
-
Dewson, G.1
Kratina, T.2
Czabotar, P.3
Day, C.L.4
Adams, J.M.5
Kluck, R.M.6
-
11
-
-
0033781027
-
The coordinate release of cytochrome C during apoptosis is rapid, complete and kinetically invariant
-
Goldstein, J.C.; Waterhouse, N.J.; Juin, P.; Evan, G.I.; Green, D.R. The coordinate release of cytochrome C during apoptosis is rapid, complete and kinetically invariant. Nat. Cell. Biol. 2000, 2, 156-162.
-
(2000)
Nat. Cell. Biol.
, vol.2
, pp. 156-162
-
-
Goldstein, J.C.1
Waterhouse, N.J.2
Juin, P.3
Evan, G.I.4
Green, D.R.5
-
12
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei, M.C.; Zong, W.-X.; Cheng, E.H.-Y.; Lindsten, T.; Panoutsakopoulou, V.; Ross, A.J.; Roth, K.A.; MacGregor, G.R.; Thompson, C.B.; Korsmeyer, S.J. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 2001, 292, 727-730.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.-X.2
Cheng, E.H.-Y.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
McGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
13
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory, S.; Adams, J.M. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2002, 2, 647-656.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
14
-
-
77956908962
-
Regulation of the Apaf-1-caspase-9 apoptosome
-
Bratton, S.B.; Salvesen, G.S. Regulation of the Apaf-1-caspase-9 apoptosome. J. Cell Sci. 2010, 123, 3209-3214.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3209-3214
-
-
Bratton, S.B.1
Salvesen, G.S.2
-
16
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
Youle, R.J.; Strasser, A. The BCL-2 protein family: Opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
17
-
-
54249123632
-
IAP-targeted therapies for cancer
-
LaCasse, E.C.; Mahoney, D.J.; Cheung, H.H.; Plenchette, S.; Baird, S.; Korneluk, R.G. IAP-targeted therapies for cancer. Oncogene 2008, 27, 6252-6275.
-
(2008)
Oncogene
, vol.27
, pp. 6252-6275
-
-
LaCasse, E.C.1
Mahoney, D.J.2
Cheung, H.H.3
Plenchette, S.4
Baird, S.5
Korneluk, R.G.6
-
18
-
-
84875138006
-
Inhibitor of apoptosis (IAP) proteins-Modulators of cell death and inflammation
-
Silke, J.; Meier, P. Inhibitor of apoptosis (IAP) proteins-Modulators of cell death and inflammation. Cold Spring Harb. Perspect. Biol. 2013, 5, doi:10.1101/cshperspect.a008730.
-
(2013)
Cold Spring Harb. Perspect. Biol.
, vol.5
-
-
Silke, J.1
Meier, P.2
-
19
-
-
84928214255
-
IAPs, regulators of innate immunity and inflammation
-
Estornes, Y.; Bertrand, M.J.M. IAPs, regulators of innate immunity and inflammation. Semin. Cell Dev. Biol. 2014, doi:10.1016/j.semcdb.2014.03.035
-
(2014)
Semin. Cell Dev. Biol.
-
-
Estornes, Y.1
Bertrand, M.J.M.2
-
20
-
-
70349329714
-
Smac mimetics as new cancer therapeutics
-
Chen, D.J.; Huerta, S. Smac mimetics as new cancer therapeutics. Anticancer Drugs 2009, 20, 646-658.
-
(2009)
Anticancer Drugs
, vol.20
, pp. 646-658
-
-
Chen, D.J.1
Huerta, S.2
-
21
-
-
0036233590
-
Generation and characterization of smac/DIABLO-deficient mice
-
Okada, H.; Suh, W.-K.; Jin, J.; Woo, M.; Du, C.; Elia, A.; Duncan, G.S.; Wakeham, A.; Itie, A.; Lowe, S.W.; et al. Generation and characterization of smac/DIABLO-deficient mice. Mol. Cell. Biol. 2002, 22, 3509-3517.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3509-3517
-
-
Okada, H.1
Suh, W.-K.2
Jin, J.3
Woo, M.4
Du, C.5
Elia, A.6
Duncan, G.S.7
Wakeham, A.8
Itie, A.9
Lowe, S.W.10
-
22
-
-
0142246441
-
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of MND2 mutant mice
-
Jones, J.M.; Datta, P.; Srinivasula, S.M.; Ji, W.; Gupta, S.; Zhang, Z.; Davies, E.; Hajnoczky, G.; Saunders, T.L.; van Keuren, M.L.; et al. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of MND2 mutant mice. Nature 2003, 425, 721-727.
-
(2003)
Nature
, vol.425
, pp. 721-727
-
-
Jones, J.M.1
Datta, P.2
Srinivasula, S.M.3
Ji, W.4
Gupta, S.5
Zhang, Z.6
Davies, E.7
Hajnoczky, G.8
Saunders, T.L.9
van Keuren, M.L.10
-
23
-
-
7644230386
-
Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
-
Martins, L.M.; Morrison, A.; Klupsch, K.; Fedele, V.; Moisoi, N.; Teismann, P.; Abuin, A.; Grau, E.; Geppert, M.; Livi, G.P.; et al. Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol. Cell. Biol. 2004, 24, 9848-9862.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9848-9862
-
-
Martins, L.M.1
Morrison, A.2
Klupsch, K.3
Fedele, V.4
Moisoi, N.5
Teismann, P.6
Abuin, A.7
Grau, E.8
Geppert, M.9
Livi, G.P.10
-
24
-
-
84872811929
-
Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator
-
Zhuang, M.; Guan, S.; Wang, H.; Burlingame Alma, L.; Wells James, A. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol. Cell 2013, 49, 273-282.
-
(2013)
Mol. Cell
, vol.49
, pp. 273-282
-
-
Zhuang, M.1
Guan, S.2
Wang, H.3
Burlingame Alma, L.4
Wells James, A.5
-
25
-
-
84922068895
-
-
Maiuri, M.C.; le Toumelin, G.; Criollo, A.; Rain, J.C.; Gautier, F.; Juin, P.; Tasdemir, E.; Pierron, G.; Troulinaki, K.; Tavernarakis, N.; et al. Functional and physical interaction between Bcl-XL and a BH3-like domain in beclin-1. 2007, 26, 1527-2539.
-
(2007)
Functional and physical interaction between Bcl-XL and a BH3-like domain in beclin-1.
, vol.26
, pp. 1527-2539
-
-
Maiuri, M.C.1
le Toumelin, G.2
Criollo, A.3
Rain, J.C.4
Gautier, F.5
Juin, P.6
Tasdemir, E.7
Pierron, G.8
Troulinaki, K.9
Tavernarakis, N.10
-
26
-
-
33749162486
-
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
-
Yousefi, S.; Perozzo, R.; Schmid, I.; Ziemiecki, A.; Schaffner, T.; Scapozza, L.; Brunner, T.; Simon, H.-U. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat. Cell. Biol. 2006, 8, 1124-1132.
-
(2006)
Nat. Cell. Biol.
, vol.8
, pp. 1124-1132
-
-
Yousefi, S.1
Perozzo, R.2
Schmid, I.3
Ziemiecki, A.4
Schaffner, T.5
Scapozza, L.6
Brunner, T.7
Simon, H.-U.8
-
27
-
-
0035947776
-
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
-
Foghsgaard, L.; Wissing, D.; Mauch, D.; Lademann, U.; Bastholm, L.; Boes, M.; Elling, F.; Leist, M.; Jäättelä, M. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J. Cell Biol. 2001, 153, 999-1010.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 999-1010
-
-
Foghsgaard, L.1
Wissing, D.2
Mauch, D.3
Lademann, U.4
Bastholm, L.5
Boes, M.6
Elling, F.7
Leist, M.8
Jäättelä, M.9
-
28
-
-
84881565288
-
The lysosome: From waste bag to potential therapeutic target
-
Appelqvist, H.; Wäster, P.; Kågedal, K.; Öllinger, K. The lysosome: from waste bag to potential therapeutic target. J. Mol. Cell Biol. 2013, 5, 214-226.
-
(2013)
J. Mol. Cell Biol.
, vol.5
, pp. 214-226
-
-
Appelqvist, H.1
Wäster, P.2
Kågedal, K.3
Öllinger, K.4
-
29
-
-
77951666702
-
Regulation of apoptosis-associated lysosomal membrane permeabilization
-
Johansson, A.-C.; Appelqvist, H.; Nilsrighson, C.; Kågedal, K.; Roberg, K.; Öllinger, K. Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis 2010, 15, 527-540.
-
(2010)
Apoptosis
, vol.15
, pp. 527-540
-
-
Johansson, A.-C.1
Appelqvist, H.2
Nilsrighson, C.3
Kågedal, K.4
Roberg, K.5
Öllinger, K.6
-
30
-
-
54949137644
-
Lysosomal membrane permeabilization in cell death
-
Boya, P.; Kroemer, G. Lysosomal membrane permeabilization in cell death. Oncogene 2008, 27, 6434-6451.
-
(2008)
Oncogene
, vol.27
, pp. 6434-6451
-
-
Boya, P.1
Kroemer, G.2
-
31
-
-
28844490007
-
The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway
-
Chen, W.; Li, N.; Chen, T.; Han, Y.; Li, C.; Wang, Y.; He, W.; Zhang, L.; Wan, T.; Cao, X. The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway. J. Biol. Chem. 2005, 280, 40985-40995.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40985-40995
-
-
Chen, W.1
Li, N.2
Chen, T.3
Han, Y.4
Li, C.5
Wang, Y.6
He, W.7
Zhang, L.8
Wan, T.9
Cao, X.10
-
32
-
-
0036547417
-
Death and anti-death: Tumour resistance to apoptosis
-
Igney, F.H.; Krammer, P.H. Death and anti-death: Tumour resistance to apoptosis. Nat. Rev. Cancer 2002, 2, 277-288.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
33
-
-
68049143304
-
Apoptosis and cancer: Mutations within caspase genes
-
Ghavami, S.; Hashemi, M.; Ande, S.; Yeganeh, B.; Xiao, W.; Eshraghi, M.; Bus, C.; Kadkhoda, K.; Wiechec, E.; Halayko, A.; et al. Apoptosis and cancer: Mutations within caspase genes. J. Med. Genet. 2009, 46, 497-510.
-
(2009)
J. Med. Genet.
, vol.46
, pp. 497-510
-
-
Ghavami, S.1
Hashemi, M.2
Ande, S.3
Yeganeh, B.4
Xiao, W.5
Eshraghi, M.6
Bus, C.7
Kadkhoda, K.8
Wiechec, E.9
Halayko, A.10
-
34
-
-
0343953047
-
Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: Novel insights into the mechanism of t(14;18) translocation
-
Jager, U.; Bocskor, S.; Le, T.; Mitterbauer, G.; Bolz, I.; Chott, A.; Kneba, M.; Mannhalter, C.; Nadel, B. Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: Novel insights into the mechanism of t(14;18) translocation. Blood 2000, 95, 3520-3529.
-
(2000)
Blood
, vol.95
, pp. 3520-3529
-
-
Jager, U.1
Bocskor, S.2
Le, T.3
Mitterbauer, G.4
Bolz, I.5
Chott, A.6
Kneba, M.7
Mannhalter, C.8
Nadel, B.9
-
35
-
-
0025165221
-
Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia
-
Adachi, M.; Tefferi, A.; Greipp, P.R.; Kipps, T.J.; Tsujimoto, Y. Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia. J. Exp. Med. 1990, 171, 559-564.
-
(1990)
J. Exp. Med.
, vol.171
, pp. 559-564
-
-
Adachi, M.1
Tefferi, A.2
Greipp, P.R.3
Kipps, T.J.4
Tsujimoto, Y.5
-
36
-
-
3042594986
-
BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma
-
Iqbal, J.; Sanger, W.G.; Horsman, D.E.; Rosenwald, A.; Pickering, D.L.; Dave, B.; Dave, S.; Xiao, L.; Cao, K.; Zhu, Q.; et al. BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. Am. J. Pathol. 2004, 165, 159-166.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 159-166
-
-
Iqbal, J.1
Sanger, W.G.2
Horsman, D.E.3
Rosenwald, A.4
Pickering, D.L.5
Dave, B.6
Dave, S.7
Xiao, L.8
Cao, K.9
Zhu, Q.10
-
37
-
-
33750531056
-
Follicular lymphoma-like B cells in healthy individuals: A novel intermediate step in early lymphomagenesis
-
Roulland, S.; Navarro, J.-M.; Grenot, P.; Milili, M.; Agopian, J.; Montpellier, B.; Gauduchon, P.; Lebailly, P.; Schiff, C.; Nadel, B. Follicular lymphoma-like B cells in healthy individuals: A novel intermediate step in early lymphomagenesis. J. Exp. Med. 2006, 203, 2425-2431.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2425-2431
-
-
Roulland, S.1
Navarro, J.-M.2
Grenot, P.3
Milili, M.4
Agopian, J.5
Montpellier, B.6
Gauduchon, P.7
Lebailly, P.8
Schiff, C.9
Nadel, B.10
-
38
-
-
0031018674
-
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
-
Rampino, N.; Yamamoto, H.; Ionov, Y.; Li, Y.; Sawai, H.; Reed, J.C.; Perucho, M. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997, 275, 967-969.
-
(1997)
Science
, vol.275
, pp. 967-969
-
-
Rampino, N.1
Yamamoto, H.2
Ionov, Y.3
Li, Y.4
Sawai, H.5
Reed, J.C.6
Perucho, M.7
-
39
-
-
4344657971
-
Inactivating mutations of proapoptotic Bad gene in human colon cancers
-
Lee, J.W.; Soung, Y.H.; Kim, S.Y.; Nam, S.W.; Kim, C.J.; Cho, Y.G.; Lee, J.H.; Kim, H.S.; Park, W.S.; Kim, S.H.; et al. Inactivating mutations of proapoptotic Bad gene in human colon cancers. Carcinogenesis 2004, 25, 1371-1376.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1371-1376
-
-
Lee, J.W.1
Soung, Y.H.2
Kim, S.Y.3
Nam, S.W.4
Kim, C.J.5
Cho, Y.G.6
Lee, J.H.7
Kim, H.S.8
Park, W.S.9
Kim, S.H.10
-
40
-
-
0030746636
-
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
-
Ambrosini, G.; Adida, C.; Altieri, D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 1997, 3, 917-921.
-
(1997)
Nat. Med.
, vol.3
, pp. 917-921
-
-
Ambrosini, G.1
Adida, C.2
Altieri, D.C.3
-
41
-
-
0034789355
-
Cancer gene therapy using a survivin mutant adenovirus
-
Mesri, M.; Wall, N.R.; Li, J.; Kim, R.W.; Altieri, D.C. Cancer gene therapy using a survivin mutant adenovirus. J. Clin. Investig. 2001, 108, 981-990.
-
(2001)
J. Clin. Investig.
, vol.108
, pp. 981-990
-
-
Mesri, M.1
Wall, N.R.2
Li, J.3
Kim, R.W.4
Altieri, D.C.5
-
42
-
-
0242442595
-
Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas
-
Byun, D.-S.; Cho, K.; Ryu, B.-K.; Lee, M.-G.; Kang, M.-J.; Kim, H.-R.; Chi, S.-G. Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Cancer Res. 2003, 63, 7068-7075.
-
(2003)
Cancer Res.
, vol.63
, pp. 7068-7075
-
-
Byun, D.-S.1
Cho, K.2
Ryu, B.-K.3
Lee, M.-G.4
Kang, M.-J.5
Kim, H.-R.6
Chi, S.-G.7
-
43
-
-
6344221309
-
Cell division and cell survival in the absence of survivin
-
Yang, D.; Welm, A.; Bishop, J.M. Cell division and cell survival in the absence of survivin. Proc. Natl. Acad. Sci. USA 2004, 101, 15100-15105.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15100-15105
-
-
Yang, D.1
Welm, A.2
Bishop, J.M.3
-
44
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata, C.M.; Davis, R.E.; Demchenko, Y.; Bellamy, W.; Gabrea, A.; Zhan, F.; Lenz, G.; Hanamura, I.; Wright, G.; Xiao, W.; et al. Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007, 12, 115-130.
-
(2007)
Cancer Cell.
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
Zhan, F.6
Lenz, G.7
Hanamura, I.8
Wright, G.9
Xiao, W.10
-
45
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF-κB pathway in multiple myeloma
-
Keats, J.J.; Fonseca, R.; Chesi, M.; Schop, R.; Baker, A.; Chng, W.-J.; van Wier, S.; Tiedemann, R.; Shi, C.-X.; Sebag, M.; et al. Promiscuous mutations activate the noncanonical NF-κB pathway in multiple myeloma. Cancer Cell 2007, 12, 131-144.
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
Schop, R.4
Baker, A.5
Chng, W.-J.6
van Wier, S.7
Tiedemann, R.8
Shi, C.-X.9
Sebag, M.10
-
46
-
-
33745167654
-
The role of NF-κB-1 and NF-κB-2-mediated resistance to apoptosis in lymphomas
-
Bernal-Mizrachi, L.; Lovly, C.M.; Ratner, L. The role of NF-κB-1 and NF-κB-2-mediated resistance to apoptosis in lymphomas. Proc. Natl. Acad. Sci. USA 2006, 103, 9220-9225.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 9220-9225
-
-
Bernal-Mizrachi, L.1
Lovly, C.M.2
Ratner, L.3
-
47
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence, M.S.; Stojanov, P.; Mermel, C.H.; Robinson, J.T.; Garraway, L.A.; Golub, T.R.; Meyerson, M.; Gabriel, S.B.; Lander, E.S.; Getz, G. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 2014, 505, 495-501.
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
Robinson, J.T.4
Garraway, L.A.5
Golub, T.R.6
Meyerson, M.7
Gabriel, S.B.8
Lander, E.S.9
Getz, G.10
-
48
-
-
2342453921
-
Death receptors in chemotherapy and cancer
-
Debatin, K.-M.; Krammer, P.H. Death receptors in chemotherapy and cancer. Oncogene 2004, 23, 2950-2966.
-
(2004)
Oncogene
, vol.23
, pp. 2950-2966
-
-
Debatin, K.-M.1
Krammer, P.H.2
-
49
-
-
0037376788
-
Cell surface death receptor signaling in normal and cancer cells
-
Özören, N.; El-Deiry, W.S. Cell surface death receptor signaling in normal and cancer cells. Semin. Cancer Biol. 2003, 13, 135-147.
-
(2003)
Semin. Cancer Biol.
, vol.13
, pp. 135-147
-
-
Özören, N.1
El-Deiry, W.S.2
-
50
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf, T.; Elmore, S.W.; Shoemaker, A.R.; Armstrong, R.C.; Augeri, D.J.; Belli, B.A.; Bruncko, M.; Deckwerth, T.L.; Dinges, J.; Hajduk, P.J.; et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005, 435, 677-681.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
-
51
-
-
44849112219
-
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
-
Tse, C.; Shoemaker, A.R.; Adickes, J.; Anderson, M.G.; Chen, J.; Jin, S.; Johnson, E.F.; Marsh, K.C.; Mitten, M.J.; Nimmer, P.; et al. ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor. Cancer Res. 2008, 68, 3421-3428.
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
Johnson, E.F.7
Marsh, K.C.8
Mitten, M.J.9
Nimmer, P.10
-
52
-
-
84862489317
-
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
-
Mérino, D.; Khaw, S.L.; Glaser, S.P.; Anderson, D.J.; Belmont, L.D.; Wong, C.; Yue, P.; Robati, M.; Phipson, B.; Fairlie, W.D.; et al. Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood 2012, 119, 5807-5816.
-
(2012)
Blood
, vol.119
, pp. 5807-5816
-
-
Mérino, D.1
Khaw, S.L.2
Glaser, S.P.3
Anderson, D.J.4
Belmont, L.D.5
Wong, C.6
Yue, P.7
Robati, M.8
Phipson, B.9
Fairlie, W.D.10
-
53
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease
-
Roberts, A.W.; Seymour, J.F.; Brown, J.R.; Wierda, W.G.; Kipps, T.J.; Khaw, S.L.; Carney, D.A.; He, S.Z.; Huang, D.C.S.; Xiong, H.; et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease. J. Clin. Oncol. 2012, 30, 488-496.
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
Wierda, W.G.4
Kipps, T.J.5
Khaw, S.L.6
Carney, D.A.7
He, S.Z.8
Huang, D.C.S.9
Xiong, H.10
-
54
-
-
79952721599
-
Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models
-
Tan, N.; Malek, M.; Zha, J.; Yue, P.; Kassees, R.; Berry, L.; Fairbrother, W.J.; Sampath, D.; Belmont, L.D. Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models. Clin. Cancer Res. 2011, 17, 1394-1404.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1394-1404
-
-
Tan, N.1
Malek, M.2
Zha, J.3
Yue, P.4
Kassees, R.5
Berry, L.6
Fairbrother, W.J.7
Sampath, D.8
Belmont, L.D.9
-
55
-
-
65849378710
-
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
-
Cragg, M.S.; Harris, C.; Strasser, A.; Scott, C.L. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat. Rev. Cancer 2009, 9, 321-326.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 321-326
-
-
Cragg, M.S.1
Harris, C.2
Strasser, A.3
Scott, C.L.4
-
56
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
Souers, A.J.; Leverson, J.D.; Boghaert, E.R.; Ackler, S.L.; Catron, N.D.; Chen, J.; Dayton, B.D.; Ding, H.; Enschede, S.H.; Fairbrother, W.J.; et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 2013, 19, 202-208.
-
(2013)
Nat. Med.
, vol.19
, pp. 202-208
-
-
Souers, A.J.1
Leverson, J.D.2
Boghaert, E.R.3
Ackler, S.L.4
Catron, N.D.5
Chen, J.6
Dayton, B.D.7
Ding, H.8
Enschede, S.H.9
Fairbrother, W.J.10
-
57
-
-
84877929526
-
ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
-
Vandenberg, C.J.; Cory, S. ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia. Blood 2013, 121, 2285-2288.
-
(2013)
Blood
, vol.121
, pp. 2285-2288
-
-
Vandenberg, C.J.1
Cory, S.2
-
58
-
-
84880028368
-
Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer
-
Vaillant, F.; Merino, D.; Lee, L.; Breslin, K.; Pal, B.; Ritchie Matthew, E.; Smyth Gordon, K.; Christie, M.; Phillipson Louisa, J.; Burns Christopher, J.; et al. Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer. Cancer Cell 2013, 24, 120-129.
-
(2013)
Cancer Cell
, vol.24
, pp. 120-129
-
-
Vaillant, F.1
Merino, D.2
Lee, L.3
Breslin, K.4
Pal, B.5
Ritchie Matthew, E.6
Smyth Gordon, K.7
Christie, M.8
Phillipson Louisa, J.9
Burns Christopher, J.10
-
59
-
-
84891872385
-
The Bcl-2 specific BH3 mimetic ABT-199: A promising targeted therapy for t(11;14) multiple myeloma
-
Touzeau, C.; Dousset, C.; le Gouill, S.; Sampath, D.; Leverson, J.D.; Souers, A.J.; Maiga, S.; Bene, M.C.; Moreau, P.; Pellat-Deceunynck, C.; et al. The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma. Leukemia 2014, 28, 210-212.
-
(2014)
Leukemia
, vol.28
, pp. 210-212
-
-
Touzeau, C.1
Dousset, C.2
le Gouill, S.3
Sampath, D.4
Leverson, J.D.5
Souers, A.J.6
Maiga, S.7
Bene, M.C.8
Moreau, P.9
Pellat-Deceunynck, C.10
-
60
-
-
84922061054
-
Selective Bcl-2 inhibition with ABT-199 is highly active against chronic lymphocytic leukemia (CLL) irrespective of TP53 mutation or dysfunction
-
Tam, C.C.S.; Seymour, J.F.; Bell, A.; Westerman, D.A.; Juneja, S.; Huang, D.C.S.; Roberts, A.W. Selective Bcl-2 inhibition with ABT-199 is highly active against chronic lymphocytic leukemia (CLL) irrespective of TP53 mutation or dysfunction. Blood 2013, 122, 1304-1304.
-
(2013)
Blood
, vol.122
, pp. 1304
-
-
Tam, C.C.S.1
Seymour, J.F.2
Bell, A.3
Westerman, D.A.4
Juneja, S.5
Huang, D.C.S.6
Roberts, A.W.7
-
61
-
-
84890909335
-
Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy
-
Czabotar, P.E.; Lessene, G.; Strasser, A.; Adams, J.M. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 2014, 15, 49-63.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 49-63
-
-
Czabotar, P.E.1
Lessene, G.2
Strasser, A.3
Adams, J.M.4
-
62
-
-
77649239222
-
IAP antagonists: Promising candidates for cancer therapy
-
Mannhold, R.; Fulda, S.; Carosati, E. IAP antagonists: Promising candidates for cancer therapy. Drug Discov. Today 2010, 15, 210-219.
-
(2010)
Drug Discov. Today
, vol.15
, pp. 210-219
-
-
Mannhold, R.1
Fulda, S.2
Carosati, E.3
-
63
-
-
33846878524
-
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)
-
Chauhan, D.; Neri, P.; Velankar, M.; Podar, K.; Hideshima, T.; Fulciniti, M.; Tassone, P.; Raje, N.; Mitsiades, C.; Mitsiades, N.; et al. Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM). Blood 2007, 109, 1220-1227.
-
(2007)
Blood
, vol.109
, pp. 1220-1227
-
-
Chauhan, D.1
Neri, P.2
Velankar, M.3
Podar, K.4
Hideshima, T.5
Fulciniti, M.6
Tassone, P.7
Raje, N.8
Mitsiades, C.9
Mitsiades, N.10
-
64
-
-
34447308516
-
Potentiation of antileukemic therapies by Smac mimetic, LBW242: Effects on mutant FLT3-expressing cells
-
Weisberg, E.; Kung, A.L.; Wright, R.D.; Moreno, D.; Catley, L.; Ray, A.; Zawel, L.; Tran, M.; Cools, J.; Gilliland, G.; et al. Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells. Mol. Cancer Ther. 2007, 6, 1951-1961.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 1951-1961
-
-
Weisberg, E.1
Kung, A.L.2
Wright, R.D.3
Moreno, D.4
Catley, L.5
Ray, A.6
Zawel, L.7
Tran, M.8
Cools, J.9
Gilliland, G.10
-
65
-
-
84885015530
-
Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
-
Steinhart, L.; Belz, K.; Fulda, S. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis. Cell Death Dis. 2013, 4, doi:10.1038/cddis.2013.320.
-
(2013)
Cell Death Dis.
, vol.4
-
-
Steinhart, L.1
Belz, K.2
Fulda, S.3
-
66
-
-
84904104369
-
Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly
-
Belz, K.; Schoeneberger, H.; Wehner, S.; Weigert, A.; Bonig, H.; Klingebiel, T.; Fichtner, I.; Fulda, S. Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly. Blood 2014, 124, 240-250.
-
(2014)
Blood
, vol.124
, pp. 240-250
-
-
Belz, K.1
Schoeneberger, H.2
Wehner, S.3
Weigert, A.4
Bonig, H.5
Klingebiel, T.6
Fichtner, I.7
Fulda, S.8
-
67
-
-
79955775758
-
Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases
-
Yang, J.; McEachern, D.; Li, W.; Davis, M.A.; Li, H.; Morgan, M.A.; Bai, L.; Sebolt, J.T.; Sun, H.; Lawrence, T.S.; et al. Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases. Mol. Cancer Ther. 2011, 10, 658-669.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 658-669
-
-
Yang, J.1
McEachern, D.2
Li, W.3
Davis, M.A.4
Li, H.5
Morgan, M.A.6
Bai, L.7
Sebolt, J.T.8
Sun, H.9
Lawrence, T.S.10
-
68
-
-
84871120623
-
Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells
-
Zhang, S.; Li, G.; Zhao, Y.; Liu, G.; Wang, Y.; Ma, X.; Li, D.; Wu, Y.; Lu, J. Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells. PLoS One 2012, 7, e51461.
-
(2012)
PLoS One
, vol.7
-
-
Zhang, S.1
Li, G.2
Zhao, Y.3
Liu, G.4
Wang, Y.5
Ma, X.6
Li, D.7
Wu, Y.8
Lu, J.9
-
69
-
-
84862776560
-
The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac
-
Ramachandiran, S.; Cain, J.; Liao, A.; He, Y.; Guo, X.; Boise, L.H.; Fu, H.; Ratner, L.; Khoury, H.J.; Bernal-Mizrachi, L. The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac. Leuk. Res. 2012, 36, 784-790.
-
(2012)
Leuk. Res.
, vol.36
, pp. 784-790
-
-
Ramachandiran, S.1
Cain, J.2
Liao, A.3
He, Y.4
Guo, X.5
Boise, L.H.6
Fu, H.7
Ratner, L.8
Khoury, H.J.9
Bernal-Mizrachi, L.10
-
70
-
-
84878024573
-
A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice
-
Sheng, R.; Sun, H.; Liu, L.; Lu, J.; McEachern, D.; Wang, G.; Wen, J.; Min, P.; Du, Z.; Lu, H.; et al. A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. J. Med. Chem. 2013, 56, 3969-3979.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 3969-3979
-
-
Sheng, R.1
Sun, H.2
Liu, L.3
Lu, J.4
McEachern, D.5
Wang, G.6
Wen, J.7
Min, P.8
Du, Z.9
Lu, H.10
|