3,5-Diaryl-1H-pyrazole as a molecular scaffold for the synthesis of apoptosis-inducing agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3270-3278

  Shaw, Arthur Y ^a,d   Liau, Hao Han ^a   Lu, Pei Jung ^b   Yang, Chia Ning ^c   Lee, Chien Hsing ^b   Chen, Jun Yan ^c   Xu, Zhigang ^d   Flynn, Gary ^d  

^a TAMKANG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

3,5 Diaryl 1H pyrazole; Apoptosis inducing agent; Mitochondrial apoptotic pathway; Molecular scaffold; Structure activity relationship

Indexed keywords

3 (2 METHOXYPHENYL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (3 METHOXYPHENYL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (3,4 DIMETHOXYPHENYL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (4 BROMOPHENYL) 5 (4 METHOXYPHENYL) 1H PYRAZOLE; 3 (4 BROMOPHENYL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (4 CHLOROPHENYL) 5 (4 METHOXYPHENYL) 1H PYRAZOLE; 3 (4 CHLOROPHENYL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (4 FLUOROPHENYL) 5 (4 METHOXYPHENYL) 1H PYRAZOLE; 3 (4 FLUOROPHENYL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (4 METHOXYPHENYL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (4 METHOXYPHENYL) 5 (NAPHTHALEN 2 YL) 1H PYRAZOLE; 3 (BENZO[D][1,3]DIOXOL 5 YL) 5 (4 NITROPHENYL) 1H PYRAZOLE; 3 (BIPHENYL 2 YL) 5 (4 METHOXYPHENYL) 1H PYRAZOLE; 3,5 DIARYL 1H PYRAZOLE DERIVATIVE; 4 (3 PHENYL 1H PYRAZOL 5 YL)ANILINE; 4 [3 (2 METHOXYPHENYL) 1H PYRAZOL 5 YL]ANILINE; 4 [3 (3 METHOXYPHENYL) 1H PYRAZOL 5 YL]ANILINE; 4 [3 (3,4 DIMETHOXYPHENYL) 1H PYRAZOL 5 YL]ANILINE; 4 [3 (4 METHOXYPHENYL) 1H PYRAZOL 5 YL]ANILINE; 4 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOL 5 YL]ANILINE; 4 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOL 5 YL]PHENOL; 5 (3 NITROPHENYL) 3 PHENYL 1H PYRAZOLE; 5 (4 METHOXYPHENYL) 3 PHENYL 1H PYRAZOLE; 5 (4 NITROPHENYL) 3 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE; 5 (4 NITROPHENYL) 3 PHENYL 1H PYRAZOLE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; MOLECULAR SCAFFOLD; N,N DIMETHYL 4 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOL 5 YL]ANILINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN KINASES; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SIGNAL TRANSDUCTION;

EID: 77951206607     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.016     Document Type: Article

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