Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines

European Journal of Medicinal Chemistry

Volumn 87, Issue , 2014, Pages 140-149

  Pirol, Şeyma Cankara ^a   Çalişkan, Burcu ^a   Durmaz, Irem ^b   Atalay, Rengül ^b   Banoglu, Erden ^a  

^a GAZI UNIVERSITY   (Turkey)

^b BILKENT UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Autophagy; Cytotoxicity; Diarylpyrazole; Quinoline

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYLIC ACID; PYRAZOLE; PYRAZOLE DERIVATIVE; QUINOLONE DERIVATIVE;

APOPTOSIS; CELL CYCLE CHECKPOINT; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; EVALUATION STUDY; FLOW CYTOMETRY; HUMAN; NEOPLASMS; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARBOXYLIC ACIDS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; G1 PHASE; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; PYRAZOLES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84937193820     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.056     Document Type: Article

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