Thiourea compound AW00178 sensitizes human H1299 lung carcinoma cells to TRAIL-mediated apoptosis

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 3862-3865

  Ryu, Byung Jun ^a   Hwang, Mi Kyung ^a   Park, Mikyung ^a   Lee, Kyunghee ^a   Kim, Seong Hwan ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Apoptosis; AW00178; Sensitization; TRAIL

Indexed keywords

1(5 CHLORO 2 METHYL PHENYL)3[4(5 TRIFLUOROMETHYL PYRAZOL 1 YL) PHENYL] THIOUREA; AW 00178; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SURVIVIN; THIOUREA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CARCINOMA CELL; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG POTENTIATION; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME INACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; SIGNAL TRANSDUCTION; THIOUREA; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP;

EID: 84861575622     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.013     Document Type: Article

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