Design, synthesis, and preliminary biological evaluation of novel ethyl 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carboxyla te

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6342-6347

  Wei, Fang ^a   Zhao, Bao Xiang ^a   Huang, Bin ^a   Zhang, Lu ^a   Sun, Chun Hui ^a   Dong, Wen Liang ^a   Shin, Dong Soo ^b   Miao, Jun Ying ^a  

^a SHANDONG UNIVERSITY   (China)

^b Changwon National University   (South Korea)

Author keywords

A549 cells; Growth inhibition; Pyrazole derivatives

Indexed keywords

ACETONITRILE; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; ETHYL 1 (2' HYDROXY 3' PHENOXYPROPYL) 3 (4' METHOXYPHENYL) 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 1 (2' HYDROXY 3' PHENOXYPROPYL) 3 PHENYL 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 1 [2' HYDROXY 3' (2' METHOXYPHENOXY)PROPYL] 3 (4' METHOXYPHENYL) 1H PYRAZOLE 5 CARBOXYLATE.; ETHYL 1 [2' HYDROXY 3' (2' METHOXYPHENOXY)PROPYL] 3 PHENYL 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 1 [2' HYDROXY 3' (2' NITROPHENOXY)PROPYL] 3 (4' METHOXYPHENYL) 1H PYRAZOLE 5 CARBOXYLATE.; ETHYL 1 [2' HYDROXY 3' (2' NITROPHENOXY)PROPYL] 3 PHENYL 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 1 [2' HYDROXY 3' (4' NITROPHENOXY)PROPYL] 3 (4' METHOXYPHENYL) 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 1 [2' HYDROXY 3' (4' NITROPHENOXY)PROPYL] 3 PHENYL 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 1 [3' (4' CHLOROPHENOXY) 2' HYDROXYPROPYL] 3 (4' CHLOROPHENYL) 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 1 [3' (4' CHLOROPHENOXY) 2' HYDROXYPROPYL] 3 (4' METHOXYPHENYL) 1H PYRAZOLE 5 CARBOXYLATE.; ETHYL 1 [3' (4' CHLOROPHENOXY) 2' HYDROXYPROPYL] 3 PHENYL 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 3 (4' CHLOROPHENYL) 1 (2' HYDROXY 3' PHENOXYPROPYL) 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 3 (4' CHLOROPHENYL) 1 [2' HYDROXY 3' (2' METHOXYPHENOXY)PROPYL] 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 3 (4' CHLOROPHENYL) 1 [2' HYDROXY 3' (2' NITROPHENOXY)PROPYL] 1H PYRAZOLE 5 CARBOXYLATE; ETHYL 3 (4' CHLOROPHENYL) 1 [2' HYDROXY 3' (4' NITROPHENOXY)PROPYL] 1H PYRAZOLE 5 CARBOXYLATE; POTASSIUM CARBONATE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL DIFFERENTIATION; CELL GROWTH; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; ESTERS; HUMANS; LUNG NEOPLASMS; MODELS, MOLECULAR; PYRAZOLES;

EID: 33750806826     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.008     Document Type: Article

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