메뉴 건너뛰기




Volumn 26, Issue 11, 2015, Pages 657-668

Neuronal Control of Brown Fat Activity

Author keywords

Brown adipose tissue; Hypothalamus; Sympathetic nervous system; Thermogenesis; Uncoupling protein 1

Indexed keywords

FATTY ACID; GLUCOSE; MELANOCORTIN;

EID: 84945895250     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2015.09.008     Document Type: Review
Times cited : (52)

References (102)
  • 1
    • 0000721133 scopus 로고
    • The spontaneous activity and food intake of rats with hypothalamic lesions
    • Hetherington A.W., Ranson S.W. The spontaneous activity and food intake of rats with hypothalamic lesions. Am. J. Physiol. 1942, 136:609-617.
    • (1942) Am. J. Physiol. , vol.136 , pp. 609-617
    • Hetherington, A.W.1    Ranson, S.W.2
  • 2
    • 84907535675 scopus 로고    scopus 로고
    • Inhibition of the central melanocortin system decreases brown adipose tissue activity
    • Kooijman S., et al. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J. Lipid Res. 2014, 55:2022-2032.
    • (2014) J. Lipid Res. , vol.55 , pp. 2022-2032
    • Kooijman, S.1
  • 3
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess A.M., et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 2009, 360:1509-1517.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1509-1517
    • Cypess, A.M.1
  • 4
    • 64349095231 scopus 로고    scopus 로고
    • Cold-activated brown adipose tissue in healthy men
    • van Marken Lichtenbelt W.D., et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 2009, 360:1500-1508.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1500-1508
    • van Marken Lichtenbelt, W.D.1
  • 5
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen K.A., et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 2009, 360:1518-1525.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1
  • 6
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004, 84:277-359.
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 7
    • 77950264120 scopus 로고    scopus 로고
    • Brown fat and the myth of diet-induced thermogenesis
    • Kozak L.P. Brown fat and the myth of diet-induced thermogenesis. Cell Metab. 2010, 11:263-267.
    • (2010) Cell Metab. , vol.11 , pp. 263-267
    • Kozak, L.P.1
  • 8
    • 84936771989 scopus 로고    scopus 로고
    • Genetic and functional characterization of clonally derived adult human brown adipocytes
    • Shinoda K., et al. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat. Med. 2015, 21:389-394.
    • (2015) Nat. Med. , vol.21 , pp. 389-394
    • Shinoda, K.1
  • 9
    • 84867564026 scopus 로고    scopus 로고
    • Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria
    • Fedorenko A., et al. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 2012, 151:400-413.
    • (2012) Cell , vol.151 , pp. 400-413
    • Fedorenko, A.1
  • 10
    • 84908376019 scopus 로고    scopus 로고
    • Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation
    • Contreras G.A., et al. Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation. Am. J. Physiol. Endocrinol. Metab. 2014, 307:E793-E799.
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.307 , pp. E793-E799
    • Contreras, G.A.1
  • 11
    • 3042818968 scopus 로고    scopus 로고
    • Presence and distribution of cholinergic nerves in rat mediastinal brown adipose tissue
    • Giordano A., et al. Presence and distribution of cholinergic nerves in rat mediastinal brown adipose tissue. J. Histochem. Cytochem. 2004, 52:923-930.
    • (2004) J. Histochem. Cytochem. , vol.52 , pp. 923-930
    • Giordano, A.1
  • 12
    • 0344541112 scopus 로고    scopus 로고
    • Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. II. The peripheral nervous system
    • Schafer M.K., et al. Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. II. The peripheral nervous system. Neuroscience 1998, 84:361-376.
    • (1998) Neuroscience , vol.84 , pp. 361-376
    • Schafer, M.K.1
  • 13
    • 0037008157 scopus 로고    scopus 로고
    • BetaAR signaling required for diet-induced thermogenesis and obesity resistance
    • Bachman E.S., et al. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 2002, 297:843-845.
    • (2002) Science , vol.297 , pp. 843-845
    • Bachman, E.S.1
  • 14
    • 0034193336 scopus 로고    scopus 로고
    • Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes
    • Bengtsson T., et al. Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes. Biochem. J. 2000, 347(Pt 3):643-651.
    • (2000) Biochem. J. , vol.347 , pp. 643-651
    • Bengtsson, T.1
  • 15
    • 0028281432 scopus 로고
    • Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice
    • Collins S., et al. Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol. Endocrinol. 1994, 8:518-527.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 518-527
    • Collins, S.1
  • 16
    • 84866276013 scopus 로고    scopus 로고
    • Beta(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice
    • Ueta C.B., et al. beta(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. J. Endocrinol. 2012, 214:359-365.
    • (2012) J. Endocrinol. , vol.214 , pp. 359-365
    • Ueta, C.B.1
  • 17
    • 79959330256 scopus 로고    scopus 로고
    • Brown adipose tissue can be activated or inhibited within an hour before 18F-FDG injection: a preliminary study with microPET
    • Wu C., et al. Brown adipose tissue can be activated or inhibited within an hour before 18F-FDG injection: a preliminary study with microPET. J. Biomed. Biotechnol. 2011, 2011:159834.
    • (2011) J. Biomed. Biotechnol. , vol.2011 , pp. 159834
    • Wu, C.1
  • 18
    • 34247485758 scopus 로고    scopus 로고
    • Low-dose oral propranolol could reduce brown adipose tissue F-18 FDG uptake in patients undergoing PET scans
    • Parysow O., et al. Low-dose oral propranolol could reduce brown adipose tissue F-18 FDG uptake in patients undergoing PET scans. Clin. Nucl. Med. 2007, 32:351-357.
    • (2007) Clin. Nucl. Med. , vol.32 , pp. 351-357
    • Parysow, O.1
  • 19
    • 0028838836 scopus 로고
    • Targeted disruption of the beta 3-adrenergic receptor gene
    • Susulic V.S., et al. Targeted disruption of the beta 3-adrenergic receptor gene. J. Biol. Chem. 1995, 270:29483-29492.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29483-29492
    • Susulic, V.S.1
  • 20
    • 0030610147 scopus 로고    scopus 로고
    • Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice
    • Grujic D., et al. Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J. Biol. Chem. 1997, 272:17686-17693.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17686-17693
    • Grujic, D.1
  • 21
    • 0032253790 scopus 로고    scopus 로고
    • Thermogenesis is beta3- but not beta1-adrenergically mediated in rat brown fat cells, even after cold acclimation
    • Zhao J., et al. Thermogenesis is beta3- but not beta1-adrenergically mediated in rat brown fat cells, even after cold acclimation. Am. J. Physiol. 1998, 275:R2002-R2011.
    • (1998) Am. J. Physiol. , vol.275 , pp. R2002-R2011
    • Zhao, J.1
  • 22
    • 84924365670 scopus 로고    scopus 로고
    • Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
    • Berbee J.F., et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat. Commun. 2015, 6:6356.
    • (2015) Nat. Commun. , vol.6 , pp. 6356
    • Berbee, J.F.1
  • 23
    • 84920627180 scopus 로고    scopus 로고
    • Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist
    • Cypess A.M., et al. Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist. Cell Metab. 2015, 21:33-38.
    • (2015) Cell Metab. , vol.21 , pp. 33-38
    • Cypess, A.M.1
  • 24
    • 84921628040 scopus 로고    scopus 로고
    • Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice
    • Cardinal P., et al. Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice. Endocrinology 2015, 156:411-418.
    • (2015) Endocrinology , vol.156 , pp. 411-418
    • Cardinal, P.1
  • 25
    • 84919779595 scopus 로고    scopus 로고
    • Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity
    • Boon M.R., et al. Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity. FASEB J. 2014, 28:5361-5375.
    • (2014) FASEB J. , vol.28 , pp. 5361-5375
    • Boon, M.R.1
  • 26
    • 84920052826 scopus 로고    scopus 로고
    • Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
    • Gnad T., et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature 2014, 516:395-399.
    • (2014) Nature , vol.516 , pp. 395-399
    • Gnad, T.1
  • 27
    • 84945935329 scopus 로고    scopus 로고
    • Purinergic signaling in the immune system
    • Di V.F., Vuerich M. Purinergic signaling in the immune system. Auton. Neurosci. 2015, 3:1-3.
    • (2015) Auton. Neurosci. , vol.3 , pp. 1-3
    • Di, V.F.1    Vuerich, M.2
  • 28
    • 0033036199 scopus 로고    scopus 로고
    • CNS origins of the sympathetic nervous system outflow to brown adipose tissue
    • Bamshad M., et al. CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am. J. Physiol. 1999, 276:R1569-R1578.
    • (1999) Am. J. Physiol. , vol.276 , pp. R1569-R1578
    • Bamshad, M.1
  • 29
    • 0037414623 scopus 로고    scopus 로고
    • Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure
    • Cano G., et al. Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure. J. Comp. Neurol. 2003, 460:303-326.
    • (2003) J. Comp. Neurol. , vol.460 , pp. 303-326
    • Cano, G.1
  • 30
    • 0037139340 scopus 로고    scopus 로고
    • The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    • Oldfield B.J., et al. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 2002, 110:515-526.
    • (2002) Neuroscience , vol.110 , pp. 515-526
    • Oldfield, B.J.1
  • 31
    • 79551512119 scopus 로고    scopus 로고
    • Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits
    • Zhang Y., et al. Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J. Neurosci. 2011, 31:1873-1884.
    • (2011) J. Neurosci. , vol.31 , pp. 1873-1884
    • Zhang, Y.1
  • 32
    • 84868012864 scopus 로고    scopus 로고
    • GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure
    • Kong D., et al. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 2012, 151:645-657.
    • (2012) Cell , vol.151 , pp. 645-657
    • Kong, D.1
  • 33
    • 84860506923 scopus 로고    scopus 로고
    • Anterograde transneuronal viral tract tracing reveals central sensory circuits from brown fat and sensory denervation alters its thermogenic responses
    • Vaughan C.H., Bartness T.J. Anterograde transneuronal viral tract tracing reveals central sensory circuits from brown fat and sensory denervation alters its thermogenic responses. Am. J. Physiol Regul. Integr. Comp. Physiol. 2012, 302:R1049-R1058.
    • (2012) Am. J. Physiol Regul. Integr. Comp. Physiol. , vol.302 , pp. R1049-R1058
    • Vaughan, C.H.1    Bartness, T.J.2
  • 34
    • 84922389914 scopus 로고    scopus 로고
    • Brown adipose tissue has sympathetic-sensory feedback circuits
    • Ryu V., et al. Brown adipose tissue has sympathetic-sensory feedback circuits. J. Neurosci. 2015, 35:2181-2190.
    • (2015) J. Neurosci. , vol.35 , pp. 2181-2190
    • Ryu, V.1
  • 35
    • 3242727776 scopus 로고    scopus 로고
    • Activation of brain areas in rat following warm and cold ambient exposure
    • Bratincsak A., Palkovits M. Activation of brain areas in rat following warm and cold ambient exposure. Neuroscience 2004, 127:385-397.
    • (2004) Neuroscience , vol.127 , pp. 385-397
    • Bratincsak, A.1    Palkovits, M.2
  • 36
    • 43749116436 scopus 로고    scopus 로고
    • Preoptic mechanism for cold-defensive responses to skin cooling
    • Nakamura K., Morrison S.F. Preoptic mechanism for cold-defensive responses to skin cooling. J. Physiol. 2008, 586:2611-2620.
    • (2008) J. Physiol. , vol.586 , pp. 2611-2620
    • Nakamura, K.1    Morrison, S.F.2
  • 37
    • 79952306625 scopus 로고    scopus 로고
    • Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling
    • Tajino K., et al. Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLoS ONE 2011, 6:e17504.
    • (2011) PLoS ONE , vol.6 , pp. e17504
    • Tajino, K.1
  • 38
    • 84860176201 scopus 로고    scopus 로고
    • Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity
    • Ma S., et al. Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. J. Mol. Cell Biol. 2012, 4:88-96.
    • (2012) J. Mol. Cell Biol. , vol.4 , pp. 88-96
    • Ma, S.1
  • 39
    • 84869101137 scopus 로고    scopus 로고
    • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
    • Ye L., et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 2012, 151:96-110.
    • (2012) Cell , vol.151 , pp. 96-110
    • Ye, L.1
  • 40
    • 42149163068 scopus 로고    scopus 로고
    • TRPV1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia
    • Sharif-Naeini R., et al. TRPV1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia. Neuron 2008, 58:179-185.
    • (2008) Neuron , vol.58 , pp. 179-185
    • Sharif-Naeini, R.1
  • 41
    • 79957793687 scopus 로고    scopus 로고
    • TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet
    • Iwasaki Y., et al. TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet. Biosci. Biotechnol. Biochem. 2011, 75:904-909.
    • (2011) Biosci. Biotechnol. Biochem. , vol.75 , pp. 904-909
    • Iwasaki, Y.1
  • 42
    • 84875462519 scopus 로고    scopus 로고
    • The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity
    • Coomans C.P., et al. The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity. Diabetes 2013, 62:1102-1108.
    • (2013) Diabetes , vol.62 , pp. 1102-1108
    • Coomans, C.P.1
  • 43
    • 84875695721 scopus 로고    scopus 로고
    • Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity
    • Coomans C.P., et al. Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity. FASEB J. 2013, 27:1721-1732.
    • (2013) FASEB J. , vol.27 , pp. 1721-1732
    • Coomans, C.P.1
  • 44
    • 84907370060 scopus 로고    scopus 로고
    • Characteristics of activated neurons in the suprachiasmatic nucleus when mice become hypothermic during fasting and cold exposure
    • Uchida Y., et al. Characteristics of activated neurons in the suprachiasmatic nucleus when mice become hypothermic during fasting and cold exposure. Neurosci. Lett. 2014, 579:177-182.
    • (2014) Neurosci. Lett. , vol.579 , pp. 177-182
    • Uchida, Y.1
  • 45
    • 0024418282 scopus 로고
    • Glutamate injection into the suprachiasmatic nucleus stimulates brown fat thermogenesis in the rat
    • Amir S., et al. Glutamate injection into the suprachiasmatic nucleus stimulates brown fat thermogenesis in the rat. Brain Res. 1989, 498:140-144.
    • (1989) Brain Res. , vol.498 , pp. 140-144
    • Amir, S.1
  • 46
    • 84930216250 scopus 로고    scopus 로고
    • Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity
    • Kooijman S., et al. Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 2015, 112:6748-6753.
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. 6748-6753
    • Kooijman, S.1
  • 47
    • 70350536563 scopus 로고    scopus 로고
    • Brown adipose tissue and seasonal variation in humans
    • Au-Yong I.T., et al. Brown adipose tissue and seasonal variation in humans. Diabetes 2009, 58:2583-2587.
    • (2009) Diabetes , vol.58 , pp. 2583-2587
    • Au-Yong, I.T.1
  • 48
    • 84871598846 scopus 로고    scopus 로고
    • Prevalence and pattern of brown adipose tissue distribution of 18F-FDG in patients undergoing PET-CT in a subtropical climatic zone
    • Perkins A.C., et al. Prevalence and pattern of brown adipose tissue distribution of 18F-FDG in patients undergoing PET-CT in a subtropical climatic zone. Nucl. Med. Commun. 2013, 34:168-174.
    • (2013) Nucl. Med. Commun. , vol.34 , pp. 168-174
    • Perkins, A.C.1
  • 49
    • 84883778996 scopus 로고    scopus 로고
    • FGF21 regulates metabolism and circadian behavior by acting on the nervous system
    • Bookout A.L., et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat. Med. 2013, 19:1147-1152.
    • (2013) Nat. Med. , vol.19 , pp. 1147-1152
    • Bookout, A.L.1
  • 50
    • 84937604339 scopus 로고    scopus 로고
    • Central Fibroblast Growth Factor 21 browns white fat via sympathetic action in male mice
    • Douris N., et al. Central Fibroblast Growth Factor 21 browns white fat via sympathetic action in male mice. Endocrinology 2015, 156:2470-2481.
    • (2015) Endocrinology , vol.156 , pp. 2470-2481
    • Douris, N.1
  • 51
    • 84908018672 scopus 로고    scopus 로고
    • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
    • Owen B.M., et al. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab. 2014, 20:670-677.
    • (2014) Cell Metab. , vol.20 , pp. 670-677
    • Owen, B.M.1
  • 52
    • 80052031271 scopus 로고    scopus 로고
    • Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis
    • Vaughan C.H., et al. Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis. Brain Res. 2011, 1411:17-27.
    • (2011) Brain Res. , vol.1411 , pp. 17-27
    • Vaughan, C.H.1
  • 53
    • 0030916289 scopus 로고    scopus 로고
    • Effect of chronic intracerebroventricular infusion of insulin on brown adipose tissue activity in fed and fasted rats
    • Muller C., et al. Effect of chronic intracerebroventricular infusion of insulin on brown adipose tissue activity in fed and fasted rats. Int. J. Obes. Relat. Metab. Disord. 1997, 21:562-566.
    • (1997) Int. J. Obes. Relat. Metab. Disord. , vol.21 , pp. 562-566
    • Muller, C.1
  • 54
    • 80052156758 scopus 로고    scopus 로고
    • Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
    • Enriori P.J., et al. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J. Neurosci. 2011, 31:12189-12197.
    • (2011) J. Neurosci. , vol.31 , pp. 12189-12197
    • Enriori, P.J.1
  • 55
    • 84930929490 scopus 로고    scopus 로고
    • Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus
    • Morgan D.A., et al. Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus. Diabetes 2015, 64:1976-1987.
    • (2015) Diabetes , vol.64 , pp. 1976-1987
    • Morgan, D.A.1
  • 56
    • 84907043858 scopus 로고    scopus 로고
    • The PVH as a site of CB1-mediated stimulation of thermogenesis by MC4R agonism in male rats
    • Monge-Roffarello B., et al. The PVH as a site of CB1-mediated stimulation of thermogenesis by MC4R agonism in male rats. Endocrinology 2014, 155:3448-3458.
    • (2014) Endocrinology , vol.155 , pp. 3448-3458
    • Monge-Roffarello, B.1
  • 57
    • 33947387967 scopus 로고    scopus 로고
    • Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue
    • Voss-Andreae A., et al. Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology 2007, 148:1550-1560.
    • (2007) Endocrinology , vol.148 , pp. 1550-1560
    • Voss-Andreae, A.1
  • 58
    • 84873362255 scopus 로고    scopus 로고
    • Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN
    • Shi Y.C., et al. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metab. 2013, 17:236-248.
    • (2013) Cell Metab. , vol.17 , pp. 236-248
    • Shi, Y.C.1
  • 59
    • 0037456768 scopus 로고    scopus 로고
    • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    • Farooqi I.S., et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 2003, 348:1085-1095.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1085-1095
    • Farooqi, I.S.1
  • 60
    • 0036065628 scopus 로고    scopus 로고
    • Central administration of oleic acid inhibits glucose production and food intake
    • Obici S., et al. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 2002, 51:271-275.
    • (2002) Diabetes , vol.51 , pp. 271-275
    • Obici, S.1
  • 61
    • 0037133185 scopus 로고    scopus 로고
    • Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice
    • Kumar M.V., et al. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:1921-1925.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 1921-1925
    • Kumar, M.V.1
  • 62
    • 77956431307 scopus 로고    scopus 로고
    • Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    • Lopez M., et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 2010, 16:1001-1008.
    • (2010) Nat. Med. , vol.16 , pp. 1001-1008
    • Lopez, M.1
  • 63
    • 84907495079 scopus 로고    scopus 로고
    • GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK
    • Beiroa D., et al. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes 2014, 63:3346-3358.
    • (2014) Diabetes , vol.63 , pp. 3346-3358
    • Beiroa, D.1
  • 64
    • 84868013714 scopus 로고    scopus 로고
    • Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    • Lockie S.H., et al. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes 2012, 61:2753-2762.
    • (2012) Diabetes , vol.61 , pp. 2753-2762
    • Lockie, S.H.1
  • 65
    • 84904043360 scopus 로고    scopus 로고
    • Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK
    • Martinez de Morentin P.B., et al. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab. 2014, 20:41-53.
    • (2014) Cell Metab. , vol.20 , pp. 41-53
    • Martinez de Morentin, P.B.1
  • 66
    • 84859557325 scopus 로고    scopus 로고
    • Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
    • Martinez de Morentin P.B., et al. Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes 2012, 61:807-817.
    • (2012) Diabetes , vol.61 , pp. 807-817
    • Martinez de Morentin, P.B.1
  • 67
    • 84860850964 scopus 로고    scopus 로고
    • BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
    • Whittle A.J., et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 2012, 149:871-885.
    • (2012) Cell , vol.149 , pp. 871-885
    • Whittle, A.J.1
  • 68
    • 33847793319 scopus 로고    scopus 로고
    • Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
    • Musatov S., et al. Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:2501-2506.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 2501-2506
    • Musatov, S.1
  • 69
    • 84895792999 scopus 로고    scopus 로고
    • Increased brown adipose tissue oxidative capacity in cold-acclimated humans
    • Blondin D.P., et al. Increased brown adipose tissue oxidative capacity in cold-acclimated humans. J. Clin. Endocrinol. Metab. 2014, 99:E438-E446.
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. E438-E446
    • Blondin, D.P.1
  • 70
    • 84881221754 scopus 로고    scopus 로고
    • Recruited brown adipose tissue as an antiobesity agent in humans
    • Yoneshiro T., et al. Recruited brown adipose tissue as an antiobesity agent in humans. J. Clin. Invest. 2013, 123:3404-3408.
    • (2013) J. Clin. Invest. , vol.123 , pp. 3404-3408
    • Yoneshiro, T.1
  • 71
    • 84871611304 scopus 로고    scopus 로고
    • Ephedrine activates brown adipose tissue in lean but not obese humans
    • Carey A.L., et al. Ephedrine activates brown adipose tissue in lean but not obese humans. Diabetologia 2013, 56:147-155.
    • (2013) Diabetologia , vol.56 , pp. 147-155
    • Carey, A.L.1
  • 72
    • 84862515329 scopus 로고    scopus 로고
    • Cold but not sympathomimetics activates human brown adipose tissue in vivo
    • Cypess A.M., et al. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc. Natl. Acad. Sci. U.S.A 2012, 109:10001-10005.
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109 , pp. 10001-10005
    • Cypess, A.M.1
  • 73
    • 84868206600 scopus 로고    scopus 로고
    • Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans
    • Vosselman M.J., et al. Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans. Diabetes 2012, 61:3106-3113.
    • (2012) Diabetes , vol.61 , pp. 3106-3113
    • Vosselman, M.J.1
  • 74
    • 84929415426 scopus 로고    scopus 로고
    • Serum FGF21 levels are associated with brown adipose tissue activity in humans
    • Hanssen M.J., et al. Serum FGF21 levels are associated with brown adipose tissue activity in humans. Sci. Rep. 2015, 5:10275.
    • (2015) Sci. Rep. , vol.5 , pp. 10275
    • Hanssen, M.J.1
  • 75
    • 84930579383 scopus 로고    scopus 로고
    • Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue
    • Veniant M.M., et al. Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue. Cell Metab. 2015, 21:731-738.
    • (2015) Cell Metab. , vol.21 , pp. 731-738
    • Veniant, M.M.1
  • 76
    • 84931569401 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes
    • Berti L., et al. Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes. Mol. Metab. 2015, 4:519-527.
    • (2015) Mol. Metab. , vol.4 , pp. 519-527
    • Berti, L.1
  • 77
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • Gaich G., et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab. 2013, 18:333-340.
    • (2013) Cell Metab. , vol.18 , pp. 333-340
    • Gaich, G.1
  • 78
    • 3342984674 scopus 로고    scopus 로고
    • The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes
    • Harder H., et al. The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes. Diabetes Care 2004, 27:1915-1921.
    • (2004) Diabetes Care , vol.27 , pp. 1915-1921
    • Harder, H.1
  • 79
    • 84865070709 scopus 로고    scopus 로고
    • Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes
    • Horowitz M., et al. Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes. Diabetes Res. Clin. Pract. 2012, 97:258-266.
    • (2012) Diabetes Res. Clin. Pract. , vol.97 , pp. 258-266
    • Horowitz, M.1
  • 80
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    • Astrup A., et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int. J. Obes. (Lond.) 2012, 36:843-854.
    • (2012) Int. J. Obes. (Lond.) , vol.36 , pp. 843-854
    • Astrup, A.1
  • 81
    • 84877839950 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity
    • Shimasaki T., et al. The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity. PLoS ONE 2013, 8:e63626.
    • (2013) PLoS ONE , vol.8 , pp. e63626
    • Shimasaki, T.1
  • 82
  • 83
    • 84930824303 scopus 로고    scopus 로고
    • Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes
    • Kato H., et al. Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes. Diabetes Res. Clin. Pract. 2015, 109:199-205.
    • (2015) Diabetes Res. Clin. Pract. , vol.109 , pp. 199-205
    • Kato, H.1
  • 84
    • 84929837322 scopus 로고    scopus 로고
    • Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice
    • Clemmensen C., et al. Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice. EMBO Mol. Med. 2015, 7:288-298.
    • (2015) EMBO Mol. Med. , vol.7 , pp. 288-298
    • Clemmensen, C.1
  • 85
    • 84927618698 scopus 로고    scopus 로고
    • RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals
    • Chen K.Y., et al. RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals. J. Clin. Endocrinol. Metab. 2015, 100:1639-1645.
    • (2015) J. Clin. Endocrinol. Metab. , vol.100 , pp. 1639-1645
    • Chen, K.Y.1
  • 86
    • 84859046511 scopus 로고    scopus 로고
    • Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans
    • Yoneshiro T., et al. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am. J. Clin. Nutr. 2012, 95:845-850.
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 845-850
    • Yoneshiro, T.1
  • 87
    • 84886404045 scopus 로고    scopus 로고
    • Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management
    • Yoneshiro T., Saito M. Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management. Curr. Opin. Clin. Nutr. Metab. Care 2013, 16:625-631.
    • (2013) Curr. Opin. Clin. Nutr. Metab. Care , vol.16 , pp. 625-631
    • Yoneshiro, T.1    Saito, M.2
  • 88
    • 84870902173 scopus 로고    scopus 로고
    • Targeted estrogen delivery reverses the metabolic syndrome
    • Finan B., et al. Targeted estrogen delivery reverses the metabolic syndrome. Nat. Med. 2012, 18:1847-1856.
    • (2012) Nat. Med. , vol.18 , pp. 1847-1856
    • Finan, B.1
  • 89
    • 84925282923 scopus 로고    scopus 로고
    • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
    • Finan B., et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat. Med. 2015, 21:27-36.
    • (2015) Nat. Med. , vol.21 , pp. 27-36
    • Finan, B.1
  • 90
    • 84924508257 scopus 로고    scopus 로고
    • BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS
    • Peluffo H., et al. BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS. Biotechnol. Adv. 2015, 33:277-287.
    • (2015) Biotechnol. Adv. , vol.33 , pp. 277-287
    • Peluffo, H.1
  • 91
    • 84883410614 scopus 로고    scopus 로고
    • Activation of brown adipose tissue thermogenesis by electrical stimulation to the dorsal surface of the tissue in rats
    • Iwami M., et al. Activation of brown adipose tissue thermogenesis by electrical stimulation to the dorsal surface of the tissue in rats. Biomed. Res. 2013, 34:173-178.
    • (2013) Biomed. Res. , vol.34 , pp. 173-178
    • Iwami, M.1
  • 93
    • 84922708236 scopus 로고    scopus 로고
    • TSH effects on thermogenesis in rat brown adipocytes
    • Martinez-deMena R., et al. TSH effects on thermogenesis in rat brown adipocytes. Mol. Cell. Endocrinol. 2015, 404:151-158.
    • (2015) Mol. Cell. Endocrinol. , vol.404 , pp. 151-158
    • Martinez-deMena, R.1
  • 94
    • 84879788603 scopus 로고    scopus 로고
    • Energy balance regulation by thyroid hormones at central level
    • Lopez M., et al. Energy balance regulation by thyroid hormones at central level. Trends Mol. Med. 2013, 19:418-427.
    • (2013) Trends Mol. Med. , vol.19 , pp. 418-427
    • Lopez, M.1
  • 95
    • 0042200747 scopus 로고    scopus 로고
    • The thermogenic effect of thyroid hormone and its clinical implications
    • Silva J.E. The thermogenic effect of thyroid hormone and its clinical implications. Ann. Intern. Med. 2003, 139:205-213.
    • (2003) Ann. Intern. Med. , vol.139 , pp. 205-213
    • Silva, J.E.1
  • 96
    • 0021014269 scopus 로고
    • Involvement of adrenergic receptor mechanisms within hypothalamus in the fever induced by amphetamine and thyrotropin-releasing hormone in the rat
    • Chi M.L., Lin M.T. Involvement of adrenergic receptor mechanisms within hypothalamus in the fever induced by amphetamine and thyrotropin-releasing hormone in the rat. J. Neural Transm. 1983, 58:213-222.
    • (1983) J. Neural Transm. , vol.58 , pp. 213-222
    • Chi, M.L.1    Lin, M.T.2
  • 97
    • 15244361460 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone induced thermogenesis in Syrian hamsters: site of action and receptor subtype
    • Shintani M., et al. Thyrotropin-releasing hormone induced thermogenesis in Syrian hamsters: site of action and receptor subtype. Brain Res. 2005, 1039:22-29.
    • (2005) Brain Res. , vol.1039 , pp. 22-29
    • Shintani, M.1
  • 98
    • 84912074564 scopus 로고    scopus 로고
    • Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone
    • van den Beukel J.C., et al. Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone. FASEB J. 2014, 28:4857-4867.
    • (2014) FASEB J. , vol.28 , pp. 4857-4867
    • van den Beukel, J.C.1
  • 99
    • 0025213293 scopus 로고
    • Effect of corticotropin releasing hormone and neuropeptide Y on electrophysiological activity of sympathetic nerves to interscapular brown adipose tissue
    • Egawa M., et al. Effect of corticotropin releasing hormone and neuropeptide Y on electrophysiological activity of sympathetic nerves to interscapular brown adipose tissue. Neuroscience 1990, 34:771-775.
    • (1990) Neuroscience , vol.34 , pp. 771-775
    • Egawa, M.1
  • 100
    • 0021724901 scopus 로고
    • Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
    • Munck A., et al. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 1984, 5:25-44.
    • (1984) Endocr. Rev. , vol.5 , pp. 25-44
    • Munck, A.1
  • 101
    • 35548930677 scopus 로고    scopus 로고
    • High-fat diet disrupts behavioral and molecular circadian rhythms in mice
    • Kohsaka A., et al. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab. 2007, 6:414-421.
    • (2007) Cell Metab. , vol.6 , pp. 414-421
    • Kohsaka, A.1
  • 102
    • 0034997787 scopus 로고    scopus 로고
    • Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes
    • Viengchareun S., et al. Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes. Am. J. Physiol. Endocrinol. Metab. 2001, 280:E640-E649.
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.280 , pp. E640-E649
    • Viengchareun, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.