The Thermogenic Effect of Thyroid Hormone and Its Clinical Implications

Annals of Internal Medicine

Volumn 139, Issue 3, 2003, Pages 205-213

  Silva, J Enrique ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

THYROID HORMONE;

BODY WEIGHT; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; HOMEOTHERMIA; HUMAN; HYPOTHYROIDISM; LIPOGENESIS; POIKILOTHERMY; PRIORITY JOURNAL; REVIEW; THERMOGENESIS; THERMOREGULATION; THYROID DISEASE; THYROTOXICOSIS; ENERGY METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ENERGY METABOLISM; HUMANS; HYPOTHYROIDISM; THERMOGENESIS; THYROID HORMONES; THYROTOXICOSIS;

EID: 0042200747     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-139-3-200308050-00010     Document Type: Review

References (64)

1. Else PL, Hulbert AJ. Comparison of the "mammal machine" and the "reptile machine": energy production. Am J Physiol. 1981;240:R3-9. [PMID: 6257122]
2. Woledge RC. Energy transformations in living muscle. In: Wieser W, Gnaiger E, eds. Energy Transformations in Cells and Organisms. New York: Georg Thieme Verlag; 1989:36-45.
3. Dollberg S, Demarini S, Donovan EF, Hoath SB. Maturation of thermal capabilities in preterm infants. Am J Perinatol. 2000;17:47-51. [PMID: 10928604]
4. Berry MN, Gregory RB, Grivell AR, Henly DC, Phillips JW, Wallace PG, et al. The thermodynamic regulation of cellular metabolism and heat production. In: Wieser W, Gnaiger E, eds. Energy Transformations in Cells and Organisms. New York: Georg Thieme Verlag; 1989:18-27.
5. Hulbert AJ, Else PL. Comparison of the "mammal machine" and the "reptile machine": energy use and thyroid activity. Am J Physiol. 1981;241:R350-6. [PMID: 7304780]
6. Weirich RT, Schwartz HL, Oppenheimer JH. An analysis of the interrelationship of nuclear and plasma triiodothyronine in the sea lamprey, lake trout, and rat: evolutionary considerations. Endocrinology. 1987;120:664-77. [PMID: 3803297]
7. Magnus-Levy A. Ueber den respiratorischen Gaswechsel unter Einfluss de Thyroidea sowie unter verschiedenen pathologische Zustand. Berlin Klin Wochschr. 1895;32:650-2.
8. Seydoux J, Giacobino JP, Girardier L. Impaired metabolic response to nerve stimulation in brown adipose tissue of hypothyroid rats. Mol Cell Endocrinol. 1982;25:213-26. [PMID: 6276252]
9. Bianco AC, Silva JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest. 1987;79:295-300. [PMID: 3793928]
10. Weiss M, Milman B, Rosen B, Zimlichman R. Quantitation of thyroid hormone effect on skin perfusion by laser Doppler flowmetry. J Clin Endocrinol Metab. 1993;76:680-2. [PMID: 8445026]
11. Vagn Nielsen H, Hasselstrom K, Feldt-Rasmussen U, Mehlsen J, Siersbaek-Nielsen K, Friis T, et al. Increased sympathetic tone in forearm subcutaneous tissue in primary hypothyroidism. Clin Physiol. 1987;7:297-302. [PMID: 3621867]
12. Mory G, Ricquier D, Pesquies P, Hemon P. Effects of hypothyroidism on the brown adipose tissue of adult rats: comparison with the effects of adaptation to cold. J Endocrinol. 1981;91:515-24. [PMID: 7328374]
13. Bianco AC, Silva JE. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol. 1987;253: E255-63. [PMID: 3631256]
14. Carvalho SD, Kimura ET, Bianco AC, Silva JE. Central role of brown adipose tissue thyroxine 5′-deiodinase on thyroid hormone-dependent thermogenic response to cold. Endocrinology. 1991;128:2149-59. [PMID: 2004619]
15. Silva JE. Thyroid hormone control of thermogenesis and energy balance. Thyroid. 1995;5:481-92. [PMID: 8808101]
16. Rolfe DF, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev. 1997;77:731-58. [PMID: 9234964]
17. Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev. 1984;64:1-64. [PMID: 6320232]
18. Cannon B, Nedergaard J. The biochemistry of an inefficient tissue: brown adipose tissue. Essays Biochem. 1985;20:110-64. [PMID: 3928372]
19. Brand MD. Regulation analysis of energy metabolism. J Exp Biol. 1997; 200(Pt 2):193-202. [PMID: 9050227]
20. Laloi M, Klein M, Riesmeier JW, Muller-Rober B, Fleury C, Bouillaud F, et al. A plant cold-induced uncoupling protein [Letter]. Nature. 1997;389:135-6. [PMID: 9296489]
21. Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, et al. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiol Genomics. 2001;5:137-45. [PMID: 11285367]
22. Oppenheimer JH, Schwarm HL, Lane JT, Thompson MP. Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin Invest. 1991;87:125-32. [PMID: 1985090]
23. Clausen T, Van Hardeveld C, Everts ME. Significance of cation transport in control of energy metabolism and thermogenesis. Physiol Rev. 1991;71:733-74. [PMID: 2057526]
24. Harper ME, Brand MD. The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid status. J Biol Chem. 1993;268:14850-60. [PMID: 8392060]
25. Harper ME, Ballantyne JS, Leach M, Brand MD. Effects of thyroid hormones on oxidative phosphorylation. Biochem Soc Trans. 1993;21(Pt 3):785-92. [PMID: 8224511]
26. Leijendekker WJ, van Hardeveld C, Elzinga G. Heat production during contraction in skeletal muscle of hypothyroid mice. Am J Physiol. 1987;253: E214-20. [PMID: 3618771]
27. Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ, et al. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem. 2000;275:16251-7. [PMID: 10748195]
28. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000;26:435-9. [PMID: 11101840]
29. Lehninger AL, Nelson DL, Cox MM. Principles of Biochemistry. 2nd ed. New York: Worth; 1993.
30. Barker SB, Klitgaard HM. Metabolism of tissues excised from thyroxine-injected rats. J Physiol (Lond). 1952;170:81-6.
31. Lee YP, Lardy HA. Influence of thyroid hormones on 1-α -glycerophosphate dehydrogenases and other dehydrogenases in various organs of the rat. J Biol Chem. 1965;240:1427-36.
32. Triandafillou J, Gwilliam C, Himms-Hagen J. Role of thyroid hormone in cold-induced changes in rat brown adipose tissue mitochondria. Can J Biochem. 1982;60:530-7. [PMID: 7104831]
33. Silva JE, Larsen PR. Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5′-iodothyronine deiodinase in rat brown adipose tissue. J Clin Invest. 1986;77:1214-23. [PMID: 3958187]
34. Silva JE, Rabelo R. Regulation of the uncoupling protein gene expression. Eur J Endocrinol. 1997;136:251-64. [PMID: 9100546]
35. al-Adsani H, Hoffer LJ, Silva JE. Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J Clin Endocrinol Metab. 1997;82:1118-25. [PMID: 9100583]
36. Boivin M, Camirand A, Carli F, Hoffer LJ, Silva JE. Uncoupling protein-2 and -3 messenger ribonucleic acids in adipose tissue and skeletal muscle of healthy males: variability, factors affecting expression, and relation to measures of metabolic rate. J Clin Endocrinol Metab. 2000;85:1975-83. [PMID: 10843184]
37. Mooradian AD. Age-related differences in body weight loss in response to altered thyroidal status. Exp Gerontol. 1990;25:29-35. [PMID: 2318280]
38. Sood A, Schwarm HL, Oppenheimer JH. Tissue-specific regulation of malic enzyme by thyroid hormone in the neonatal rat. Biochem Biophys Res Commun. 1996;222:287-91. [PMID: 8670197]
39. Blennemann B, Leahy P, Kim TS, Freake HC. Tissue-specific regulation of lipogenic mRNAs by thyroid hormone. Mol Cell Endocrinol. 1995;110:1-8. [PMID: 7672439]
40. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382: 250-2. [PMID: 8717038]
41. Bartalena L, Bogazzi F, Brogioni S, Grasso L, Martino E. Role of cytokines in the pathogenesis of the euthyroid sick syndrome. Eur J Endocrinol. 1998; 138: 603-14. [PMID: 9678522]
42. Clarke SD, Hembree J. Inhibition of triiodothyronine's induction of rat liver lipogenic enzymes by dietary fat. J Nutr. 1990;120:625-30. [PMID: 2352037]
43. Pijl H, de Meijer PH, Langius J, Coenegracht CI, van den Berk AH, Chandie Shaw PK, et al. Food choice in hyperthyroidism: potential influence of the autonomic nervous system and brain serotonin precursor availability. J Clin Endocrinol Metab. 2001;86:5848-53. [PMID: 11739450]
44. Syed MA, Thompson MP, Pachucki J, Burmeister LA. The effect of thyroid hormone on size of fat depots accounts for most of the changes in leptin mRNA and serum levels in the rat. Thyroid. 1999;9:503-12. [PMID: 10365683]
45. Wilding JP. Neuropeptides and appetite control. Diabet Med. 2002;19:619-27. [PMID: 12147141]
46. Lopez M, Seoane L, Senaris RM, Dieguez C. Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status. Neurosci Lett. 2001; 300:171-5. [PMID: 11226638]
47. Calza L, Forrest D, Vennstrom B, Hokfelt T. Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors. Neuroscience. 2000;101:1001-12. [PMID: 11113349]
48. Read NW. Role of gastrointestinal factors in hunger and satiety in man. Proc Nutr Soc. 1992;51:7-11. [PMID: 1508932]
49. Meguid MM, Fetissov SO, Varma M, Sato T, Zhang L, Laviano A, et al. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition. 2000;16:843-57. [PMID: 11054589]
50. Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001;81:1097-142. [PMID: 11427693]
51. Hodin RA, Lazar MA, Chin WW. Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone. J Clin Invest. 1990;85:101-5. [PMID: 2153150]
52. Freake HC, Santos A, Goldberg Y, Ghysdael J, Oppenheimer JH. Differences in antibody recognition of the triiodothyronine nuclear receptor and c-erbA products. Mol Endocrinol. 1988;2:986-91. [PMID: 2903441]
53. Forrest D, Vennstrom B. Functions of thyroid hormone receptors in mice. Thyroid. 2000;10:41-52. [PMID: 10691312]
54. Gloss B, Trost S, Bluhm W, Swanson E, Clark R, Winkfein R, et al. Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta. Endocrinology. 2001;142:544-50. [PMID: 11159823]
55. Johansson C, Gothe S, Forrest D, Vennstrom B, Thoren P. Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-beta or both alpha1 and beta. Am J Physiol. 1999;276:H2006-12. [PMID: 10362681]
56. Weiss RE, Murata Y, Cua K, Hayashi Y, Seo H, Refetoff S. Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice. Endocrinology. 1998;139:4945-52. [PMID: 9832432]
57. Wikstrom L, Johansson C, Salto C, Barlow C, Campos Barros A, Baas F, et al. Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1. EMBO J. 1998; 17:455-61. [PMID: 9430637]
58. Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, et al. Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. J Clin Invest. 2001;108:97-105. [PMID: 11435461]
59. Sundin U. GDP binding to rat brown fat mitochondria: effects of thyroxine at different ambient temperatures. Am J Physiol. 1981;241:C134-9. [PMID: 7282915]
60. Silva JE. Catecholamines and the sympathoadrenal system in thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid. 8th ed. Baltimore: Lippincott Williams & Wilkins; 2000:642-51.
61. Silva JE, Larsen PR. Hormonal regulation of iodothyronine 5′-deiodinase in rat brown adipose tissue. Am J Physiol. 1986;251:E639-43. [PMID: 3538896]
62. Rubio A, Raasmaja A, Silva JE. Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. Endocrinology. 1995; 136:3277-84. [PMID: 7628361]
63. Larsen PR. Mammalian type 2 deiodinase sequences: finally, the end of the beginning [Editorial]. J Clin Invest. 1996;98:242-3. [PMID: 8755629]
64. Silva JE. Catecholamines and the sympathoadrenal system in hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid. 8th ed. Baltimore: Lippincott Williams & Wilkins; 2000:820-3.