메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; APOLIPOPROTEIN E; CHOLESTEROL; FATTY ACID; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; BETA 3 ADRENERGIC RECEPTOR;

EID: 84924365670     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7356     Document Type: Article
Times cited : (353)

References (45)
  • 2
    • 0036384894 scopus 로고    scopus 로고
    • Brown adipose tissue: A factor to consider in symmetrical tracer uptake in the neck and upper chest region
    • Hany, T. F. et al. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur. J. Nucl. Med. Mol. Imaging 29, 1393-1398 (2002).
    • (2002) Eur. J. Nucl. Med. Mol. Imaging , vol.29 , pp. 1393-1398
    • Hany, T.F.1
  • 3
  • 4
    • 64349095231 scopus 로고    scopus 로고
    • Cold-activated brown adipose tissue in healthy men
    • van Marken Lichtenbelt, W. D. et al. Cold-activated brown adipose tissue in healthy men. New Engl. J. Med. 360, 1500-1508 (2009).
    • (2009) New Engl. J. Med. , vol.360 , pp. 1500-1508
    • Van Marken Lichtenbelt, W.D.1
  • 5
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen, K. A. et al. Functional brown adipose tissue in healthy adults. New Engl. J. Med. 360, 1518-1525 (2009).
    • (2009) New Engl. J. Med. , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1
  • 6
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess, A. M. et al. Identification and importance of brown adipose tissue in adult humans. New Engl. J. Med. 360, 1509-1517 (2009).
    • (2009) New Engl. J. Med. , vol.360 , pp. 1509-1517
    • Cypess, A.M.1
  • 7
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti, M. C. et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113-3120 (2009).
    • (2009) FASEB J. , vol.23 , pp. 3113-3120
    • Zingaretti, M.C.1
  • 8
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: Is beige the new brown
    • Wu, J., Cohen, P. & Spiegelman, B. M. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 27, 234-250 (2013).
    • (2013) Genes Dev , vol.27 , pp. 234-250
    • Wu, J.1    Cohen, P.2    Spiegelman, B.M.3
  • 9
    • 85027909934 scopus 로고    scopus 로고
    • Adipose tissue browning and metabolic health
    • Bartelt, A. & Heeren, J. Adipose tissue browning and metabolic health. Nat. Rev. Endocrinol. 10, 24-36 (2014).
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 24-36
    • Bartelt, A.1    Heeren, J.2
  • 10
    • 84890234667 scopus 로고    scopus 로고
    • UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic
    • Shabalina, I. G. et al. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep. 5, 1196-1203 (2013).
    • (2013) Cell Rep , vol.5 , pp. 1196-1203
    • Shabalina, I.G.1
  • 11
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 12
    • 0027955155 scopus 로고
    • Anti-obesity and anti-diabetic effects of CL 316 243, a highly specific beta 3-adrenoceptor agonist, in yellow KK mice
    • Yoshida, T., Sakane, N., Wakabayashi, Y., Umekawa, T. & Kondo, M. Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist, in yellow KK mice. Life Sci. 54, 491-498 (1994).
    • (1994) Life Sci. , vol.54 , pp. 491-498
    • Yoshida, T.1    Sakane, N.2    Wakabayashi, Y.3    Umekawa, T.4    Kondo, M.5
  • 13
    • 84867564026 scopus 로고    scopus 로고
    • Mechanism of fatty-aciddependent UCP1 uncoupling in brown fat mitochondria
    • Fedorenko, A., Lishko, P. V. & Kirichok, Y. Mechanism of fatty-aciddependent UCP1 uncoupling in brown fat mitochondria. Cell 151, 400-413 (2012).
    • (2012) Cell , vol.151 , pp. 400-413
    • Fedorenko, A.1    Lishko, P.V.2    Kirichok, Y.3
  • 14
    • 84865142899 scopus 로고    scopus 로고
    • A new, powerful player in lipoprotein metabolism: Brown adipose tissue
    • Bartelt, A., Merkel, M. & Heeren, J. A new, powerful player in lipoprotein metabolism: brown adipose tissue. J. Mol. Med. (Berl) 90, 887-893 (2012).
    • (2012) J. Mol. Med. (Berl) , vol.90 , pp. 887-893
    • Bartelt, A.1    Merkel, M.2    Heeren, J.3
  • 15
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt, A. et al. Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 17, 200-205 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 200-205
    • Bartelt, A.1
  • 16
    • 84920700786 scopus 로고    scopus 로고
    • Brown adipose tissue takes up plasma triglycerides mostly after lipolysis
    • Khedoe, P. P. et al. Brown adipose tissue takes up plasma triglycerides mostly after lipolysis. J. Lipid Res. 56, 51-59 (2015).
    • (2015) J. Lipid Res. , vol.56 , pp. 51-59
    • Khedoe, P.P.1
  • 17
    • 84894412290 scopus 로고    scopus 로고
    • Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice
    • Geerling, J. J. et al. Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice. Diabetes 63, 880-891 (2014).
    • (2014) Diabetes , vol.63 , pp. 880-891
    • Geerling, J.J.1
  • 18
    • 84861037753 scopus 로고    scopus 로고
    • The holy grail of metabolic disease: Brown adipose tissue
    • Bartelt, A. & Heeren, J. The holy grail of metabolic disease: brown adipose tissue. Curr. Opin. Lipidol. 23, 190-195 (2012).
    • (2012) Curr. Opin. Lipidol. , vol.23 , pp. 190-195
    • Bartelt, A.1    Heeren, J.2
  • 19
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: Development, function and therapeutic potential
    • Harms, M. & Seale, P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19, 1252-1263 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 20
    • 84879846992 scopus 로고    scopus 로고
    • Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis
    • Dong, M. et al. Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell Metab. 18, 118-129 (2013).
    • (2013) Cell Metab , vol.18 , pp. 118-129
    • Dong, M.1
  • 21
    • 33646544088 scopus 로고    scopus 로고
    • Apolipoprotein e recycling: Implications for dyslipidemia and atherosclerosis
    • Heeren, J., Beisiegel, U. & Grewal, T. Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 26, 442-448 (2006).
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 442-448
    • Heeren, J.1    Beisiegel, U.2    Grewal, T.3
  • 22
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump, A. S. et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71, 343-353 (1992).
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1
  • 23
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein e
    • Zhang, S. H., Reddick, R. L., Piedrahita, J. A. & Maeda, N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258, 468-471 (1992).
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 24
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi, S. et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92, 883-893 (1993).
    • (1993) J. Clin. Invest. , vol.92 , pp. 883-893
    • Ishibashi, S.1
  • 25
    • 43449114204 scopus 로고    scopus 로고
    • Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin
    • De Haan, W. et al. Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin. Circulation 117, 2515-2522 (2008).
    • (2008) Circulation , vol.117 , pp. 2515-2522
    • De Haan, W.1
  • 26
    • 77955483485 scopus 로고    scopus 로고
    • Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE 3-Leiden CETP mice
    • Bijland, S. et al. Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE3-Leiden.CETP mice. J. Biol. Chem. 285, 25168-25175 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 25168-25175
    • Bijland, S.1
  • 27
    • 84879194691 scopus 로고    scopus 로고
    • Niacin reduces atherosclerosis development in APOE 3Leiden.CETP mice mainly by reducing nonHDL-cholesterol
    • Kuhnast, S. et al. Niacin reduces atherosclerosis development in APOE 3Leiden.CETP mice mainly by reducing nonHDL-cholesterol. PLoS ONE 8, e66467 (2013).
    • (2013) PLoS ONE , vol.8 , pp. 66467
    • Kuhnast, S.1
  • 28
    • 0028215636 scopus 로고
    • Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice
    • van Vlijmen, B. J. et al. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J. Clin. Invest. 93, 1403-1410 (1994).
    • (1994) J. Clin. Invest. , vol.93 , pp. 1403-1410
    • Van Vlijmen, B.J.1
  • 29
    • 84993913350 scopus 로고
    • Selective liver targeting of antivirals by recombinant chylomicrons-A new therapeutic approach to hepatitis B
    • Rensen, P. C. et al. Selective liver targeting of antivirals by recombinant chylomicrons-a new therapeutic approach to hepatitis B. Nat. Med. 1, 221-225 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 221-225
    • Rensen, P.C.1
  • 30
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
    • Saito, M. et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526-1531 (2009).
    • (2009) Diabetes , vol.58 , pp. 1526-1531
    • Saito, M.1
  • 31
    • 0021251537 scopus 로고
    • Energy balance following sympathetic denervation of brown adipose tissue
    • Dulloo, A. G. & Miller, D. S. Energy balance following sympathetic denervation of brown adipose tissue. Can. J. Physiol. Pharmacol. 62, 235-240 (1984).
    • (1984) Can. J. Physiol. Pharmacol. , vol.62 , pp. 235-240
    • Dulloo, A.G.1    Miller, D.S.2
  • 32
    • 79959305513 scopus 로고    scopus 로고
    • Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity
    • Wang, Q. et al. Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity. PLoS ONE 6, e21006 (2011).
    • (2011) PLoS ONE , vol.6 , pp. 21006
    • Wang, Q.1
  • 33
    • 84881221754 scopus 로고    scopus 로고
    • Recruited brown adipose tissue as an antiobesity agent in humans
    • Yoneshiro, T. et al. Recruited brown adipose tissue as an antiobesity agent in humans. J. Clin. Invest. 123, 3404-3408 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 3404-3408
    • Yoneshiro, T.1
  • 34
    • 0031010389 scopus 로고    scopus 로고
    • Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo
    • Rensen, P. C. et al. Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo. J. Lipid Res. 38, 1070-1084 (1997).
    • (1997) J. Lipid Res. , vol.38 , pp. 1070-1084
    • Rensen, P.C.1
  • 35
    • 0026593804 scopus 로고
    • Characterization of the chylomicron-remnant-recognition sites on parenchymal and Kupffer cells of rat liver. Selective inhibition of parenchymal cell recognition by lactoferrin
    • van Dijk, M. C., Ziere, G. J. & van Berkel, T. J. Characterization of the chylomicron-remnant-recognition sites on parenchymal and Kupffer cells of rat liver. Selective inhibition of parenchymal cell recognition by lactoferrin. Eur. J. Biochem. 205, 775-784 (1992).
    • (1992) Eur. J. Biochem. , vol.205 , pp. 775-784
    • Van Dijk, M.C.1    Ziere, G.J.2    Van Berkel, T.J.3
  • 36
    • 84920627180 scopus 로고    scopus 로고
    • Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist
    • Cypess, A. M. et al. Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist. Cell Metab. 21, 33-38 (2015).
    • (2015) Cell Metab , vol.21 , pp. 33-38
    • Cypess, A.M.1
  • 37
    • 0017364207 scopus 로고
    • Thermogenic defect in pre-obese ob/ob mice
    • Trayhurn, P., Thurlby, P. L. & James, W. P. Thermogenic defect in pre-obese ob/ob mice. Nature 266, 60-62 (1977).
    • (1977) Nature , vol.266 , pp. 60-62
    • Trayhurn, P.1    Thurlby, P.L.2    James, W.P.3
  • 38
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell, N. J. & Stock, M. J. A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35 (1979).
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 39
    • 79952089254 scopus 로고    scopus 로고
    • Brown adipose tissue in morbidly obese subjects
    • Vijgen, G. H. et al. Brown adipose tissue in morbidly obese subjects. PLoS ONE 6, e17247 (2011).
    • (2011) PLoS ONE , vol.6 , pp. 17247
    • Vijgen, G.H.1
  • 40
    • 84881260642 scopus 로고    scopus 로고
    • Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
    • van der Lans, A. A. et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J. Clin. Invest. 123, 3395-3403 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 3395-3403
    • Van Der Lans, A.A.1
  • 41
    • 84895421825 scopus 로고    scopus 로고
    • Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: A prospective, case-controlled observational study
    • Bakker, L. E. et al. Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study. Lancet Diabetes Endocrinol. 2, 210-217 (2014).
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 210-217
    • Bakker, L.E.1
  • 43
    • 0026128307 scopus 로고
    • Table of nonprotein respiratory quotient: An update
    • Peronnet, F. & Massicotte, D. Table of nonprotein respiratory quotient: an update. Can. J. Sport Sci. 16, 23-29 (1991).
    • (1991) Can. J. Sport Sci. , vol.16 , pp. 23-29
    • Peronnet, F.1    Massicotte, D.2
  • 44
    • 0034749662 scopus 로고    scopus 로고
    • Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice
    • Jong, M. C. et al. Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice. J. Lipid Res. 42, 1578-1585 (2001).
    • (2001) J. Lipid Res. , vol.42 , pp. 1578-1585
    • Jong, M.C.1
  • 45
    • 84855927124 scopus 로고    scopus 로고
    • Hepatocyte-specific IKKbeta expression aggravates atherosclerosis development in APOE 3-Leiden mice
    • Wong, M. C. et al. Hepatocyte-specific IKKbeta expression aggravates atherosclerosis development in APOE 3-Leiden mice. Atherosclerosis 220, 362-368 (2012).
    • (2012) Atherosclerosis , vol.220 , pp. 362-368
    • Wong, M.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.