-
1
-
-
33645873573
-
Thermogenic mechanisms and their hormonal regulation
-
Silva J.E. Thermogenic mechanisms and their hormonal regulation. Physiol. Rev. 2006, 86:435-464.
-
(2006)
Physiol. Rev.
, vol.86
, pp. 435-464
-
-
Silva, J.E.1
-
2
-
-
45549108071
-
The thyroid and metabolism: the action continues
-
Hollenberg A.N., Forrest D. The thyroid and metabolism: the action continues. Cell Metab. 2008, 8:10-12.
-
(2008)
Cell Metab.
, vol.8
, pp. 10-12
-
-
Hollenberg, A.N.1
Forrest, D.2
-
3
-
-
77953639982
-
Molecular aspects of thyroid hormone actions
-
Cheng S.Y., et al. Molecular aspects of thyroid hormone actions. Endocr. Rev. 2010, 31:139-170.
-
(2010)
Endocr. Rev.
, vol.31
, pp. 139-170
-
-
Cheng, S.Y.1
-
4
-
-
84865961223
-
Mechanisms of thyroid hormone action
-
Brent G.A. Mechanisms of thyroid hormone action. J. Clin. Invest. 2012, 122:3035-3043.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 3035-3043
-
-
Brent, G.A.1
-
5
-
-
43049101175
-
Classical endocrine diseases causing obesity
-
Weaver J.U. Classical endocrine diseases causing obesity. Front. Horm. Res. 2008, 36:212-228.
-
(2008)
Front. Horm. Res.
, vol.36
, pp. 212-228
-
-
Weaver, J.U.1
-
6
-
-
70349918179
-
Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review
-
Kaptein E.M., et al. Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review. J. Clin. Endocrinol. Metab. 2009, 94:3663-3675.
-
(2009)
J. Clin. Endocrinol. Metab.
, vol.94
, pp. 3663-3675
-
-
Kaptein, E.M.1
-
7
-
-
64049099095
-
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
-
Baxter J.D., Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat. Rev. Drug Discov. 2009, 8:308-320.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 308-320
-
-
Baxter, J.D.1
Webb, P.2
-
9
-
-
0002942980
-
The thyroid gland
-
W.B. Saunders Company, Philadelphia, PA, USA, J.D. Wilson, D.W. Foster (Eds.)
-
Ingbar S.H. The thyroid gland. Williams Textbook of Endocrinology 1985, 975-1170. W.B. Saunders Company, Philadelphia, PA, USA. J.D. Wilson, D.W. Foster (Eds.).
-
(1985)
Williams Textbook of Endocrinology
, pp. 975-1170
-
-
Ingbar, S.H.1
-
10
-
-
39449085830
-
Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate
-
Kim B. Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate. Thyroid 2008, 18:141-144.
-
(2008)
Thyroid
, vol.18
, pp. 141-144
-
-
Kim, B.1
-
11
-
-
84857191466
-
Role of the hypothalamus in the neuroendocrine regulation of body weight and composition during energy deficit
-
Sainsbury A., Zhang L. Role of the hypothalamus in the neuroendocrine regulation of body weight and composition during energy deficit. Obes. Rev. 2012, 13:234-257.
-
(2012)
Obes. Rev.
, vol.13
, pp. 234-257
-
-
Sainsbury, A.1
Zhang, L.2
-
12
-
-
27744449069
-
Adaptive activation of thyroid hormone and energy expenditure
-
Bianco A.C., et al. Adaptive activation of thyroid hormone and energy expenditure. Biosci. Rep. 2005, 25:191-208.
-
(2005)
Biosci. Rep.
, vol.25
, pp. 191-208
-
-
Bianco, A.C.1
-
13
-
-
73649129247
-
Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-β isoform specific and required for adaptive thermogenesis
-
Ribeiro M.O., et al. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-β isoform specific and required for adaptive thermogenesis. Endocrinology 2010, 151:432-440.
-
(2010)
Endocrinology
, vol.151
, pp. 432-440
-
-
Ribeiro, M.O.1
-
14
-
-
13844266479
-
Basal metabolic rate: history, composition, regulation, and usefulness
-
Hulbert A.J., Else P.L. Basal metabolic rate: history, composition, regulation, and usefulness. Physiol. Biochem. Zool. 2004, 77:869-876.
-
(2004)
Physiol. Biochem. Zool.
, vol.77
, pp. 869-876
-
-
Hulbert, A.J.1
Else, P.L.2
-
15
-
-
0347989317
-
Brown adipose tissue: function and physiological significance
-
Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004, 84:277-359.
-
(2004)
Physiol. Rev.
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
16
-
-
79961028580
-
Using brown adipose tissue to treat obesity - the central issue
-
Whittle A.J., et al. Using brown adipose tissue to treat obesity - the central issue. Trends Mol. Med. 2011, 17:405-411.
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 405-411
-
-
Whittle, A.J.1
-
17
-
-
0027448937
-
Skeletal muscle as the major site of nonshivering thermogenesis in cold-acclimated ducklings
-
Duchamp C., Barre H. Skeletal muscle as the major site of nonshivering thermogenesis in cold-acclimated ducklings. Am. J. Physiol. 1993, 265:R1076-R1083.
-
(1993)
Am. J. Physiol.
, vol.265
-
-
Duchamp, C.1
Barre, H.2
-
18
-
-
34547631960
-
Unexpected evidence for active brown adipose tissue in adult humans
-
Nedergaard J., et al. Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E444-E452.
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.293
-
-
Nedergaard, J.1
-
19
-
-
0026586126
-
+-ATPase expression by thyroid hormone
-
+-ATPase expression by thyroid hormone. Semin. Nephrol. 1992, 12:44-48.
-
(1992)
Semin. Nephrol.
, vol.12
, pp. 44-48
-
-
Ismail-Beigi, F.1
-
20
-
-
0028314350
-
Thermogenesis in muscle
-
Block B.A. Thermogenesis in muscle. Annu. Rev. Physiol. 1994, 56:535-577.
-
(1994)
Annu. Rev. Physiol.
, vol.56
, pp. 535-577
-
-
Block, B.A.1
-
21
-
-
77956433431
-
Thyroid hormones: igniting brown fat via the brain
-
Cannon B., Nedergaard J. Thyroid hormones: igniting brown fat via the brain. Nat. Med. 2010, 16:965-967.
-
(2010)
Nat. Med.
, vol.16
, pp. 965-967
-
-
Cannon, B.1
Nedergaard, J.2
-
22
-
-
0035163169
-
Mechanism of thyroid-hormone regulated expression of the SERCA genes in skeletal muscle: implications for thermogenesis
-
Simonides W.S., et al. Mechanism of thyroid-hormone regulated expression of the SERCA genes in skeletal muscle: implications for thermogenesis. Biosci. Rep. 2001, 21:139-154.
-
(2001)
Biosci. Rep.
, vol.21
, pp. 139-154
-
-
Simonides, W.S.1
-
23
-
-
79955024094
-
Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure
-
van den Berg S.A., et al. Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure. Curr. Opin. Clin. Nutr. Metab. Care 2011, 14:243-249.
-
(2011)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.14
, pp. 243-249
-
-
van den Berg, S.A.1
-
24
-
-
0024202118
-
Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis
-
Bianco A.C., et al. Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J. Biol. Chem. 1988, 263:18168-18175.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 18168-18175
-
-
Bianco, A.C.1
-
25
-
-
77957279363
-
The T3 receptor β1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes
-
Martinez de M.R., et al. The T3 receptor β1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology 2010, 151:5074-5083.
-
(2010)
Endocrinology
, vol.151
, pp. 5074-5083
-
-
Martinez de, M.R.1
-
26
-
-
0032518922
-
Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor α1
-
Wikstrom L., et al. Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor α1. EMBO J. 1998, 17:455-461.
-
(1998)
EMBO J.
, vol.17
, pp. 455-461
-
-
Wikstrom, L.1
-
27
-
-
0842334467
-
Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors
-
Golozoubova V., et al. Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors. Mol. Endocrinol. 2004, 18:384-401.
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 384-401
-
-
Golozoubova, V.1
-
28
-
-
22144494186
-
Temperature homeostasis in transgenic mice lacking thyroid hormone receptor-α gene products
-
Marrif H., et al. Temperature homeostasis in transgenic mice lacking thyroid hormone receptor-α gene products. Endocrinology 2005, 146:2872-2884.
-
(2005)
Endocrinology
, vol.146
, pp. 2872-2884
-
-
Marrif, H.1
-
29
-
-
79960726792
-
Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor α-deficient mice
-
Ramadan W., et al. Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor α-deficient mice. Endocrinology 2011, 152:3093-3102.
-
(2011)
Endocrinology
, vol.152
, pp. 3093-3102
-
-
Ramadan, W.1
-
30
-
-
0035185505
-
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
-
De Jesus L.A., et al. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J. Clin. Invest. 2001, 108:1379-1385.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1379-1385
-
-
De Jesus, L.A.1
-
31
-
-
10744221610
-
Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
-
Christoffolete M.A., et al. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes 2004, 53:577-584.
-
(2004)
Diabetes
, vol.53
, pp. 577-584
-
-
Christoffolete, M.A.1
-
32
-
-
79953225879
-
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality
-
Castillo M., et al. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes 2011, 60:1082-1089.
-
(2011)
Diabetes
, vol.60
, pp. 1082-1089
-
-
Castillo, M.1
-
33
-
-
35648985719
-
Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor α1
-
Sjogren M., et al. Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor α1. EMBO J. 2007, 26:4535-4545.
-
(2007)
EMBO J.
, vol.26
, pp. 4535-4545
-
-
Sjogren, M.1
-
34
-
-
57349178401
-
Mice lacking the thyroid hormone receptor-α gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity
-
Pelletier P., et al. Mice lacking the thyroid hormone receptor-α gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity. Endocrinology 2008, 149:6471-6486.
-
(2008)
Endocrinology
, vol.149
, pp. 6471-6486
-
-
Pelletier, P.1
-
35
-
-
79959237471
-
Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity
-
Marsili A., et al. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS ONE 2011, 6:e20832.
-
(2011)
PLoS ONE
, vol.6
-
-
Marsili, A.1
-
36
-
-
0030891139
-
The interaction between thyroid and brown-fat thermogenesis. Central or peripheral effects?
-
Nedergaard J., et al. The interaction between thyroid and brown-fat thermogenesis. Central or peripheral effects?. Ann. N. Y. Acad. Sci. 1997, 813:712-717.
-
(1997)
Ann. N. Y. Acad. Sci.
, vol.813
, pp. 712-717
-
-
Nedergaard, J.1
-
37
-
-
0027263239
-
Immunocytochemical delineation of thyroid hormone receptor β 2-like immunoreactivity in the rat central nervous system
-
Lechan R.M., et al. Immunocytochemical delineation of thyroid hormone receptor β 2-like immunoreactivity in the rat central nervous system. Endocrinology 1993, 132:2461-2469.
-
(1993)
Endocrinology
, vol.132
, pp. 2461-2469
-
-
Lechan, R.M.1
-
38
-
-
23044479645
-
Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus
-
Alkemade A., et al. Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J. Clin. Endocrinol. Metab. 2005, 90:4322-4334.
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 4322-4334
-
-
Alkemade, A.1
-
39
-
-
77956431307
-
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
-
Lopez M., et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 2010, 16:1001-1008.
-
(2010)
Nat. Med.
, vol.16
, pp. 1001-1008
-
-
Lopez, M.1
-
40
-
-
84865785750
-
Thyroid hormone transporters and deiodinases in the developing human hypothalamus
-
Friesema E.C., et al. Thyroid hormone transporters and deiodinases in the developing human hypothalamus. Eur. J. Endocrinol. 2012, 167:379-386.
-
(2012)
Eur. J. Endocrinol.
, vol.167
, pp. 379-386
-
-
Friesema, E.C.1
-
41
-
-
77953193611
-
Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells
-
Freitas B.C., et al. Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J. Clin. Invest. 2010, 120:2206-2217.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2206-2217
-
-
Freitas, B.C.1
-
42
-
-
78650916392
-
Thyroid hormone transporters: the knowns and the unknowns
-
Visser W.E., et al. Thyroid hormone transporters: the knowns and the unknowns. Mol. Endocrinol. 2011, 25:1-14.
-
(2011)
Mol. Endocrinol.
, vol.25
, pp. 1-14
-
-
Visser, W.E.1
-
43
-
-
79956320514
-
Expression of thyroid hormone transporters in the human hypothalamus
-
Alkemade A., et al. Expression of thyroid hormone transporters in the human hypothalamus. J. Clin. Endocrinol. Metab. 2011, 96:E967-E971.
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
-
-
Alkemade, A.1
-
44
-
-
5644276275
-
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
-
Friesema E.C., et al. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 2004, 364:1435-1437.
-
(2004)
Lancet
, vol.364
, pp. 1435-1437
-
-
Friesema, E.C.1
-
45
-
-
0347634343
-
A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene
-
Dumitrescu A.M., et al. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am. J. Hum. Genet. 2004, 74:168-175.
-
(2004)
Am. J. Hum. Genet.
, vol.74
, pp. 168-175
-
-
Dumitrescu, A.M.1
-
46
-
-
56449117024
-
AMPK: a metabolic gauge regulating whole-body energy homeostasis
-
Lage R., et al. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol. Med. 2008, 14:539-549.
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 539-549
-
-
Lage, R.1
-
47
-
-
42949146633
-
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
-
Lopez M., et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab. 2008, 7:389-399.
-
(2008)
Cell Metab.
, vol.7
, pp. 389-399
-
-
Lopez, M.1
-
48
-
-
71949089603
-
Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo
-
Klieverik L.P., et al. Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo. Endocrinology 2009, 150:5639-5648.
-
(2009)
Endocrinology
, vol.150
, pp. 5639-5648
-
-
Klieverik, L.P.1
-
49
-
-
84856800207
-
Update in lipid alterations in subclinical hypothyroidism
-
Pearce E.N. Update in lipid alterations in subclinical hypothyroidism. J. Clin. Endocrinol. Metab. 2012, 97:326-333.
-
(2012)
J. Clin. Endocrinol. Metab.
, vol.97
, pp. 326-333
-
-
Pearce, E.N.1
-
50
-
-
84858778749
-
The effect of thyroid disorders on lipid levels and metabolism
-
Duntas L.H., Brenta G. The effect of thyroid disorders on lipid levels and metabolism. Med. Clin. North Am. 2012, 96:269-281.
-
(2012)
Med. Clin. North Am.
, vol.96
, pp. 269-281
-
-
Duntas, L.H.1
Brenta, G.2
-
51
-
-
84860850964
-
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
-
Whittle A.J., et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 2012, 149:871-885.
-
(2012)
Cell
, vol.149
, pp. 871-885
-
-
Whittle, A.J.1
-
52
-
-
84859557325
-
Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
-
Martinez de Morentin P.B., et al. Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes 2012, 61:807-817.
-
(2012)
Diabetes
, vol.61
, pp. 807-817
-
-
Martinez de Morentin, P.B.1
-
53
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess A.M., et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 2009, 360:1509-1517.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
-
54
-
-
75149193049
-
Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance
-
Skarulis M.C., et al. Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. J. Clin. Endocrinol. Metab. 2010, 95:256-262.
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 256-262
-
-
Skarulis, M.C.1
-
55
-
-
0035896470
-
Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status
-
Lopez M., et al. Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status. Neurosci. Lett. 2001, 300:171-175.
-
(2001)
Neurosci. Lett.
, vol.300
, pp. 171-175
-
-
Lopez, M.1
-
56
-
-
0037038126
-
Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus
-
Lopez M., et al. Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus. Neuroreport 2002, 13:1775-1779.
-
(2002)
Neuroreport
, vol.13
, pp. 1775-1779
-
-
Lopez, M.1
-
57
-
-
84860671774
-
Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
-
Varela L., et al. Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism. J. Pathol. 2012, 227:209-222.
-
(2012)
J. Pathol.
, vol.227
, pp. 209-222
-
-
Varela, L.1
-
58
-
-
24044496599
-
Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting
-
Coppola A., et al. Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting. FEBS Lett. 2005, 579:4654-4658.
-
(2005)
FEBS Lett.
, vol.579
, pp. 4654-4658
-
-
Coppola, A.1
-
59
-
-
33845582594
-
A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2
-
Coppola A., et al. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab. 2007, 5:21-33.
-
(2007)
Cell Metab.
, vol.5
, pp. 21-33
-
-
Coppola, A.1
-
60
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S., et al. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
-
61
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
Cota D., et al. Hypothalamic mTOR signaling regulates food intake. Science 2006, 312:927-930.
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
-
62
-
-
73649142794
-
Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation
-
Mayer C.M., Belsham D.D. Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation. Endocrinology 2010, 151:75-84.
-
(2010)
Endocrinology
, vol.151
, pp. 75-84
-
-
Mayer, C.M.1
Belsham, D.D.2
-
63
-
-
84860897594
-
Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
-
Townsend K.L., et al. Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J. 2012, 26:2187-2196.
-
(2012)
FASEB J.
, vol.26
, pp. 2187-2196
-
-
Townsend, K.L.1
-
64
-
-
49649122302
-
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
-
Andrews Z.B., et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008, 454:846-851.
-
(2008)
Nature
, vol.454
, pp. 846-851
-
-
Andrews, Z.B.1
-
65
-
-
77950608113
-
Novel neural pathways for metabolic effects of thyroid hormone
-
Fliers E., et al. Novel neural pathways for metabolic effects of thyroid hormone. Trends Endocrinol. Metab. 2010, 21:230-236.
-
(2010)
Trends Endocrinol. Metab.
, vol.21
, pp. 230-236
-
-
Fliers, E.1
-
66
-
-
79953701322
-
Effect of hyperthyroidism on clearance and secretion of glucagon in man
-
Dimitriadis G., et al. Effect of hyperthyroidism on clearance and secretion of glucagon in man. Exp. Clin. Endocrinol. Diabetes 2011, 119:214-217.
-
(2011)
Exp. Clin. Endocrinol. Diabetes
, vol.119
, pp. 214-217
-
-
Dimitriadis, G.1
-
67
-
-
40449135787
-
Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats
-
Klieverik L.P., et al. Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E513-E520.
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.294
-
-
Klieverik, L.P.1
-
68
-
-
65249162834
-
Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver
-
Klieverik L.P., et al. Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:5966-5971.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 5966-5971
-
-
Klieverik, L.P.1
-
69
-
-
33745834734
-
Ghrelin action in the brain controls adipocyte metabolism
-
Theander-Carrillo C., et al. Ghrelin action in the brain controls adipocyte metabolism. J. Clin. Invest. 2006, 116:1983-1993.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1983-1993
-
-
Theander-Carrillo, C.1
-
70
-
-
48749105887
-
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
-
Ono H., et al. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J. Clin. Invest. 2008, 118:2959-2968.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2959-2968
-
-
Ono, H.1
-
71
-
-
44949163013
-
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
-
Buettner C., et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat. Med. 2008, 14:667-675.
-
(2008)
Nat. Med.
, vol.14
, pp. 667-675
-
-
Buettner, C.1
-
72
-
-
70349326314
-
Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
-
Sangiao-Alvarellos S., et al. Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology 2009, 150:4562-4574.
-
(2009)
Endocrinology
, vol.150
, pp. 4562-4574
-
-
Sangiao-Alvarellos, S.1
-
73
-
-
76749093995
-
Sensory and sympathetic nervous system control of white adipose tissue lipolysis
-
Bartness T.J., et al. Sensory and sympathetic nervous system control of white adipose tissue lipolysis. Mol. Cell. Endocrinol. 2010, 318:34-43.
-
(2010)
Mol. Cell. Endocrinol.
, vol.318
, pp. 34-43
-
-
Bartness, T.J.1
-
74
-
-
34249984656
-
Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination
-
Refetoff S., Dumitrescu A.M. Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination. Best Pract. Res. Clin. Endocrinol. Metab. 2007, 21:277-305.
-
(2007)
Best Pract. Res. Clin. Endocrinol. Metab.
, vol.21
, pp. 277-305
-
-
Refetoff, S.1
Dumitrescu, A.M.2
-
75
-
-
84856190300
-
A mutation in the thyroid hormone receptor α gene
-
Bochukova E., et al. A mutation in the thyroid hormone receptor α gene. N. Engl. J. Med. 2012, 366:243-249.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 243-249
-
-
Bochukova, E.1
-
76
-
-
84859527602
-
Clinical phenotype and mutant TRα1
-
van Mullem A., et al. Clinical phenotype and mutant TRα1. N. Engl. J. Med. 2012, 366:1451-1453.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1451-1453
-
-
van Mullem, A.1
-
77
-
-
57349119069
-
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling
-
Gereben B., et al. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr. Rev. 2008, 29:898-938.
-
(2008)
Endocr. Rev.
, vol.29
, pp. 898-938
-
-
Gereben, B.1
-
78
-
-
84870167700
-
Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor
-
Lin J.Z., et al. Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology 2012, 153:6136-6144.
-
(2012)
Endocrinology
, vol.153
, pp. 6136-6144
-
-
Lin, J.Z.1
-
79
-
-
38649135692
-
The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans
-
Berkenstam A., et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:663-667.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 663-667
-
-
Berkenstam, A.1
-
80
-
-
84873834310
-
Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions
-
Mittag J., et al. Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J. Clin. Invest. 2013, 123:509-516.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 509-516
-
-
Mittag, J.1
-
81
-
-
34147119799
-
The hormonal control of food intake
-
Coll A.P., et al. The hormonal control of food intake. Cell 2007, 129:251-262.
-
(2007)
Cell
, vol.129
, pp. 251-262
-
-
Coll, A.P.1
-
82
-
-
34248200002
-
Peripheral tissue-brain interactions in the regulation of food intake
-
Lopez M., et al. Peripheral tissue-brain interactions in the regulation of food intake. Proc. Nutr. Soc. 2007, 66:131-155.
-
(2007)
Proc. Nutr. Soc.
, vol.66
, pp. 131-155
-
-
Lopez, M.1
-
83
-
-
84866705627
-
From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
-
Williams K.W., Elmquist J.K. From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nat. Neurosci. 2012, 15:1350-1355.
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 1350-1355
-
-
Williams, K.W.1
Elmquist, J.K.2
-
84
-
-
84866666334
-
Unraveling the brain regulation of appetite: lessons from genetics
-
Yeo G.S., Heisler L.K. Unraveling the brain regulation of appetite: lessons from genetics. Nat. Neurosci. 2012, 15:1343-1349.
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 1343-1349
-
-
Yeo, G.S.1
Heisler, L.K.2
-
85
-
-
0037329602
-
Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle
-
Minokoshi Y., Kahn B.B. Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem. Soc. Trans. 2003, 31:196-201.
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 196-201
-
-
Minokoshi, Y.1
Kahn, B.B.2
-
86
-
-
79951605794
-
Thyronamines - past, present, and future
-
Piehl S., et al. Thyronamines - past, present, and future. Endocr. Rev. 2011, 32:64-80.
-
(2011)
Endocr. Rev.
, vol.32
, pp. 64-80
-
-
Piehl, S.1
-
87
-
-
24644520286
-
3,5-Diiodo-l-thyronine powerfully reduces adiposity in rats by increasing the burning of fats
-
Lanni A., et al. 3,5-Diiodo-l-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB J. 2005, 19:1552-1554.
-
(2005)
FASEB J.
, vol.19
, pp. 1552-1554
-
-
Lanni, A.1
-
88
-
-
80755184749
-
Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-l-thyronine in rats
-
de Lange P., et al. Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-l-thyronine in rats. Diabetes 2011, 60:2730-2739.
-
(2011)
Diabetes
, vol.60
, pp. 2730-2739
-
-
de Lange, P.1
-
89
-
-
80053913540
-
3,5-Diiodo-l-thyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations
-
Moreno M., et al. 3,5-Diiodo-l-thyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations. FASEB J. 2011, 25:3312-3324.
-
(2011)
FASEB J.
, vol.25
, pp. 3312-3324
-
-
Moreno, M.1
-
90
-
-
84864062918
-
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
-
Nogueiras R., et al. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol. Rev. 2012, 92:1479-1514.
-
(2012)
Physiol. Rev.
, vol.92
, pp. 1479-1514
-
-
Nogueiras, R.1
-
91
-
-
84856020533
-
3,5-Diiodo-l-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects
-
Antonelli A., et al. 3,5-Diiodo-l-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects. J. Biol. Regul. Homeost. Agents 2011, 25:655-660.
-
(2011)
J. Biol. Regul. Homeost. Agents
, vol.25
, pp. 655-660
-
-
Antonelli, A.1
-
92
-
-
2942731384
-
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone
-
Scanlan T.S., et al. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10:638-642.
-
(2004)
Nat. Med.
, vol.10
, pp. 638-642
-
-
Scanlan, T.S.1
-
93
-
-
38649090089
-
3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation
-
Braulke L.J., et al. 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation. J. Comp. Physiol. B 2008, 178:167-177.
-
(2008)
J. Comp. Physiol. B
, vol.178
, pp. 167-177
-
-
Braulke, L.J.1
-
94
-
-
67849087149
-
Central effects of thyronamines on glucose metabolism in rats
-
Klieverik L.P., et al. Central effects of thyronamines on glucose metabolism in rats. J. Endocrinol. 2009, 201:377-386.
-
(2009)
J. Endocrinol.
, vol.201
, pp. 377-386
-
-
Klieverik, L.P.1
-
95
-
-
59349103229
-
The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents
-
Dhillo W.S., et al. The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents. Diabetes Obes. Metab. 2009, 11:251-260.
-
(2009)
Diabetes Obes. Metab.
, vol.11
, pp. 251-260
-
-
Dhillo, W.S.1
|