Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis

Brain Research

Volumn 1411, Issue , 2011, Pages 17-27

  Vaughan, C H ^a   Shrestha, Y B ^a   Bartness, T J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Cyclo Ala His D Phe Arg Trp Glu NH2; HS024; Interscapular brown adipose tissue; Melanocortin 4 receptor; Melanotan II; Siberian hamster

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; ARGIPRESSIN; CYCLO BETA ALANYLHISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHANYLGLUTAMYLAMIDE; HORMONE RECEPTOR BLOCKING AGENT; HS 024; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; MELANOTAN II; MESSENGER RNA; OXYTOCIN; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; BROWN ADIPOSE TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE FIBER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THERMOGENESIS; ZONA INCERTA;

ADIPOSE TISSUE, BROWN; ANIMALS; ARGININE VASOPRESSIN; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOHISTOCHEMISTRY; MALE; MICROINJECTIONS; PHENOTYPE; PHODOPUS; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, MELANOCORTIN; STEREOTAXIC TECHNIQUES; SYMPATHETIC NERVOUS SYSTEM; TELEMETRY; THERMOGENESIS; VASOCONSTRICTOR AGENTS;

AGOUTI; CRICETINAE;

EID: 80052031271     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.07.003     Document Type: Article

References (58)

1. M. Bamshad, C.K. Song, and T.J. Bartness CNS origins of the sympathetic nervous system outflow to brown adipose tissue Am. J. Physiol. 276 1999 R1569 R1578 (Pubitemid 29323518)
2. K. Baran, E. Preston, D. Wilks, G.J. Cooney, E.W. Kraegen, and A. Sainsbury Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways Diabetes 51 2002 152 158 (Pubitemid 34517992)
3. T.J. Bartness, Y.B. Shrestha, C.H. Vaughan, G.J. Schwartz, and C.K. Song Sensory and sympathetic nervous system control of white adipose tissue lipolysis Mol. Cell. Endocrinol. 318 2010 34 43
4. T.J. Bartness, C.H. Vaughan, and C.K. Song Sympathetic and sensory innervation of brown adipose tissue Int. J. Obes. (Lond) 34 Suppl 1 2010 S36 S42
5. M.A. Bednarek, T. MacNeil, R.N. Kalyani, R. Tang, L.H. Van Der Ploeg, and D.H. Weinberg Analogs of lactam derivatives of alpha-melanotropin with basic and acidic residues Biochem. Biophys. Res. Commun. 272 2000 23 28 (Pubitemid 30444893)
6. M.A. Bednarek, T. MacNeil, R.N. Kalyani, R. Tang, L.H. Van Der Ploeg, and D.H. Weinberg Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro J. Med. Chem. 44 2001 3665 3672 (Pubitemid 33026674)
7. M.A. Bednarek, T. MacNeil, R. Tang, R.N. Kalyani, L.H. Van Der Ploeg, and D.H. Weinberg Potent and selective peptide agonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro Biochem. Biophys. Res. Commun. 286 2001 641 645 (Pubitemid 32912995)
8. A. Bjorklund, O. Lindvall, and A. Nobin Evidence of an incerto-hypothalamic dopamine neurone system in the rat Brain Res. 89 1975 29 42
9. R.R. Bowers, W.T.L. Festuccia, C.K. Song, H. Shi, R.H. Migliorini, and T.J. Bartness Sympathetic innervation of white adipose tissue and its regulation of fat cell number Am. J. Physiol. 286 2004 R1167 R1175 (Pubitemid 38661406)
10. M.N. Brito, N.A. Brito, D.J. Baro, C.K. Song, and T.J. Bartness Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation Endocrinology 148 2007 5339 53347
11. C. Broberger Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y Brain Res. 27 1999 101 113 (Pubitemid 30001659)
12. A.A. Butler, and R.D. Cone Knockout studies defining different roles for melanocortin receptors in energy homeostasis Ann. N. Y. Acad. Sci. 994 2003 240 245 (Pubitemid 36793873)
13. B. Cannon, and J. Nedergaard Brown adipose tissue: function and physiological significance Physiol. Rev. 84 2004 277 359 (Pubitemid 38054374)
14. V. Chan-Palay, L. Zaborszky, C. Kohler, M. Goldstein, and S.L. Palay Distribution of tyrosine-hydroxylase-immunoreactive neurons in the hypothalamus of rats J. Comp. Neurol. 227 1984 467 496 (Pubitemid 14059758)
15. R.D. Cone Anatomy and regulation of the central melanocortin system Nat. Neurosci. 8 2005 571 578 (Pubitemid 40594196)
16. A.M. Cypess, S. Lehman, G. Williams, I. Tal, D. Rodman, A.B. Goldfine, F.C. Kuo, E.L. Palmer, Y.H. Tseng, A. Doria, G.M. Kolodny, and C.R. Kahn Identification and importance of brown adipose tissue in adult humans N. Engl. J. Med. 360 2009 1509 1517
17. H.W. Dong, and L.W. Swanson Projections from the rhomboid nucleus of the bed nuclei of the stria terminalis: implications for cerebral hemisphere regulation of ingestive behaviors J. Comp. Neurol. 463 2003 434 472 (Pubitemid 36890526)
18. C.F. Elias, L.V. Sita, B.K. Zambon, E.R. Oliveira, L.A. Vasconcelos, and J.C. Bittencourt Melanin-concentrating hormone projections to areas involved in somatomotor responses J. Chem. Neuroanat. 35 2008 188 201
19. K.L. Ellacott, and R.D. Cone The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis, Recent Prog Horm. Res. 59 2004 395 408
20. H.J. Grill, A.B. Ginsberg, R.J. Seeley, and J.M. Kaplan Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight J. Neurosci. 18 1998 10128 10135 (Pubitemid 28543786)
21. G. Hollopeter, J.C. Erickson, R.J. Seeley, D.J. Marsh, and R.D. Palmiter Response of neuropeptide Y-deficient mice to feeding effectors Regul. Pept. 75-76 1998 383 389 (Pubitemid 28477551)
22. L. Jonsson, J.O. Skarphedinsson, G.V. Skuladottir, H. Watanobe, and H.B. Schioth Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats J. Endocrinol. 173 2002 517 523 (Pubitemid 34704723)
23. A. Kask, F. Mutulis, R. Muceniece, R. Pahkla, I. Mutule, J.E. Wikberg, L. Rago, and H.B. Schioth Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo Endocrinology 139 1998 5006 5014 (Pubitemid 28533449)
24. E. Kawana, and K. Watanabe A cytoarchitectonic study of zona incerta in the rat J. Hirnforsch. 22 1981 535 541 (Pubitemid 12128952)
25. U. Kim, E. Gregory, and W.C. Hall Pathway from the zona incerta to the superior colliculus in the rat J. Comp. Neurol. 321 1992 555 575
26. C. Kolmac, and J. Mitrofanis Distribution of various neurochemicals within the zona incerta: an immunocytochemical and histochemical study Anat. Embryol. (Berl) 199 1999 265 280 (Pubitemid 29132545)
27. C. Leitner, and T.J. Bartness Food deprivation-induced changes in body fat mobilization after neonatal monosodium glutamate treatment Am. J. Physiol. 294 2008 R775 R783 (Pubitemid 351346953)
28. C. Leitner, and T.J. Bartness Acute brown adipose tissue temperature response to cold in monosodium glutamate-treated Siberian hamsters Brain Res. 1292 2009 38 51
29. J. Mitrofanis Evidence for an auditory subsector within the zona incerta of rats Anat. Embryol. (Berl) 205 2002 453 462
30. J. Mitrofanis Some certainty for the "zone of uncertainty"? Exploring the function of the zona incerta Neuroscience 130 2005 1 15 (Pubitemid 39550410)
31. J. Mitrofanis, K. Ashkan, B.A. Wallace, and A.L. Benabid Chemoarchitectonic heterogeneities in the primate zona incerta: clinical and functional implications J. Neurocytol. 33 2004 429 440 (Pubitemid 39463165)
32. J. Nedergaard, T. Bengtsson, and B. Cannon Unexpected evidence for active brown adipose tissue in adult humans Am. J. Physiol. Endocrinol. Metab. 293 2007 E444 E452 (Pubitemid 47205086)
33. G. Paxinos, and K.B.J. Franklin The Mouse Brain in Stereotaxic Coordinates 2007 Academic Press New York
34. L.E. Pritchard, A.V. Turnbull, and A. White Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity J. Endocrinol. 172 2002 411 421 (Pubitemid 34232683)
35. P.D. Raposinho, R.B. White, and M.L. Aubert The melanocortin agonist melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat J. Neuroendocrinol. 15 2003 173 181 (Pubitemid 36193030)
36. D. Richard Energy expenditure: a critical determinant of energy balance with key hypothalamic controls Minerva Endocrinol. 32 2007 173 183
37. J. Rutanen, J. Pihlajamaki, P. Karhapaa, I. Vauhkonen, J. Kuusisto, M.L. Moilanen, and M. Laakso The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain Obes. Res. 12 2004 1060 1066 (Pubitemid 41132484)
38. P.E. Sawchenko, and L.W. Swanson Central noradrenergic pathways for the integration of hypothalamic neuroendocrine and autonomic responses Science 214 1981 685 687 (Pubitemid 12208596)
39. P.E. Sawchenko, and L.W. Swanson Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat J. Comp. Neurol. 205 1982 260 272 (Pubitemid 12135370)
40. H.B. Schioth, A.A. Bouifrouri, R. Rudzish, R. Muceniece, H. Watanobe, J.E. Wikberg, and D. Larhammar Pharmacological comparison of rat and human melanocortin 3 and 4 receptors in vitro Regul. Pept. 106 2002 7 12 (Pubitemid 34607331)
41. H. Shi, and T.J. Bartness Catecholaminergic enzyme, vasopressin and oxytocin distribution in Siberian hamster brain Brain Res. Bull. 53 2000 833 843 (Pubitemid 32120291)
42. H. Shi, and T.J. Bartness Neurochemical phenotype of sympathetic nervous system outflow from brain to white fat Brain Res. Bull. 54 2001 375 385 (Pubitemid 32288718)
43. D.M. Simmons, and L.W. Swanson Comparison of the spatial distribution of seven types of neuroendocrine neurons in the rat paraventricular nucleus: toward a global 3D model J. Comp. Neurol. 516 2009 423 441
44. P.S. Sinha, H.B. Schioth, and J.B. Tatro Activation of central melanocortin-4 receptor suppresses lipopolysaccharide-induced fever in rats Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 2003 R1595 R1603 (Pubitemid 36617501)
45. L.V. Sita, C.F. Elias, and J.C. Bittencourt Dopamine and melanin-concentrating hormone neurons are distinct populations in the rat rostromedial zona incerta Brain Res. 970 2003 232 237 (Pubitemid 36423200)
46. L.V. Sita, C.F. Elias, and J.C. Bittencourt Connectivity pattern suggests that incerto-hypothalamic area belongs to the medial hypothalamic system Neuroscience 148 2007 949 969 (Pubitemid 47422391)
47. K.P. Skibicka, and H.J. Grill Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits Endocrinology 7 2008 3605 3616 (Pubitemid 351919582)
48. K.P. Skibicka, and H.J. Grill Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins Endocrinology 150 2009 5351 5361
49. C.J. Small, M.S. Kim, S.A. Stanley, J.R. Mitchell, K. Murphy, D.G. Morgan, M.A. Ghatei, and S.R. Bloom Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals Diabetes 50 2001 248 254 (Pubitemid 32127279)
50. C.K. Song, R.M. Jackson, R.B. Harris, D. Richard, and T.J. Bartness Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 2005 R1467 R1476 (Pubitemid 41507413)
51. C.K. Song, C.H. Vaughan, E. Keen-Rhinehart, R.B. Harris, D. Richard, and T.J. Bartness Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence Am. J. Physiol. 295 2008 R417 R428
52. L.W. Swanson, and P.E. Sawchenko Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms Neuroendocrinology 31 1980 410 417 (Pubitemid 11250989)
53. W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M. Drossaerts, G.J. Kemerink, N.D. Bouvy, P. Schrauwen, and G.J. Teule Cold-activated brown adipose tissue in healthy men N. Engl. J. Med. 360 2009 1500 1508
54. C.H. Vaughan, C.K. Song, E. Keen-Rhinehart, and T.J. Bartness Effects of central melanocortin administration on brown adipose tissue (BAT) thermogenesis Appetite 49 1 2007 336
55. A.N. Verty, A.M. Allen, and B.J. Oldfield The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure Obesity (Silver Spring) 17 2009 254 261
56. K. Watanabe, and E. Kawana The cells of origin of the incertofugal projections to the tectum, thalamus, tegmentum and spinal cord in the rat: a study using the autoradiographic and horseradish peroxidase methods Neuroscience 7 1982 2389 2406 (Pubitemid 12004424)
57. D.L. Williams, R.R. Bowers, T.J. Bartness, J.M. Kaplan, and H.J. Grill Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat Endocrinology 144 2003 4692 4697 (Pubitemid 37378377)
58. T. Yoshida, J.W. Kemnitz, and G.A. Bray Lateral hypothalamic lesions and norepinephrine turnover in rats J. Clin. Invest. 72 1983 919 927 (Pubitemid 14211402)