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Volumn 16, Issue 6, 2013, Pages 625-631

Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management

Author keywords

brown adipose tissue; capsinoids; energy expenditure; food ingredients; obesity; transient receptor potential channels

Indexed keywords

CAPSAICIN; CAPSAICIN DERIVATIVE; CAPSINOID DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; UNCLASSIFIED DRUG;

EID: 84886404045     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3283653ee1     Document Type: Review
Times cited : (46)

References (48)
  • 1
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J, Bostrom P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012; 150:366-376.
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1    Bostrom, P.2    Sparks, L.M.3
  • 2
    • 83455198397 scopus 로고    scopus 로고
    • Recruited vs nonrecruited molecular signatures of brown, 'brite' and white adipose tissues
    • Walden TB, Hansen IR, Timmons JA, et al. Recruited vs. nonrecruited molecular signatures of brown, 'brite' and white adipose tissues. Am J Physiol Endocrinol Metab 2012; 302:E19-E31.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Walden, T.B.1    Hansen, I.R.2    Timmons, J.A.3
  • 3
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1 - A-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Boström P, Wu J, Jedrychowski MP, et al. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481:463-468.
    • (2012) Nature , vol.481 , pp. 463-468
    • Boström, P.1    Wu, J.2    Jedrychowski, M.P.3
  • 4
    • 84865747655 scopus 로고    scopus 로고
    • Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer
    • Nishio M, Yoneshiro T, Nakahara M, et al. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab 2012; 16:396-406.
    • (2012) Cell Metab , vol.16 , pp. 396-406
    • Nishio, M.1    Yoneshiro, T.2    Nakahara, M.3
  • 5
    • 84873854027 scopus 로고    scopus 로고
    • Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
    • Stanford KI, Middelbeek RJW, Townsend KL, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013; 123:215-223.
    • (2013) J Clin Invest , vol.123 , pp. 215-223
    • Stanford, K.I.1    Rjw, M.2    Townsend, K.L.3
  • 6
    • 84874953559 scopus 로고    scopus 로고
    • Brown adipose tissue as a regulator of energy expenditure and body fat in humans
    • Saito M. Brown adipose tissue as a regulator of energy expenditure and body fat in humans. Diabetes Metab J 2013; 37:22-29.
    • (2013) Diabetes Metab J , vol.37 , pp. 22-29
    • Saito, M.1
  • 7
    • 84878639728 scopus 로고    scopus 로고
    • Brown adipose tissue in adult humans: A metabolic renaissance
    • Lee P, Swarbrick MM, Ho KKY. Brown adipose tissue in adult humans: a metabolic renaissance. Endocr Rev 2013; 34:413-438.
    • (2013) Endocr Rev , vol.34 , pp. 413-438
    • Lee, P.1    Swarbrick, M.M.2    Ho, K.K.Y.3
  • 9
    • 84855904085 scopus 로고    scopus 로고
    • The effects of capsaicin and capsiate on energy balance: Critical review and meta-analyses of studies in humans
    • Ludy MJ, Moore GE, Mattes RD. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 2012; 37:103-121.
    • (2012) Chem Senses , vol.37 , pp. 103-121
    • Ludy, M.J.1    Moore, G.E.2    Mattes, R.D.3
  • 10
    • 84862283308 scopus 로고    scopus 로고
    • Capsaicinoids and capsinoids: A potential role for weight management? A systematic review of the evidence
    • Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids: a potential role for weight management? A systematic review of the evidence. Appetite 2012; 59:343-348.
    • (2012) Appetite , vol.59 , pp. 343-348
    • Whiting, S.1    Derbyshire, E.2    Tiwari, B.K.3
  • 11
    • 41949096621 scopus 로고    scopus 로고
    • Herbal compounds and toxins modulating TRP channels
    • Vriens J, Nilius B, Vennekens R. Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol 2008; 6:79-96.
    • (2008) Curr Neuropharmacol , vol.6 , pp. 79-96
    • Vriens, J.1    Nilius, B.2    Vennekens, R.3
  • 12
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: Is beige the new brown?
    • Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev 2013; 27:234-250.
    • (2013) Genes Dev , vol.27 , pp. 234-250
    • Wu, J.1    Cohen, P.2    Spiegelman, B.M.3
  • 13
    • 84871611304 scopus 로고    scopus 로고
    • Ephedrine activates brown adipose tissue in lean but not obese humans
    • Carey AL, Formosa MF, Van Every B, et al. Ephedrine activates brown adipose tissue in lean but not obese humans. Diabetologia 2013; 56:147-155.
    • (2013) Diabetologia , vol.56 , pp. 147-155
    • Carey, A.L.1    Formosa, M.F.2    Van Every, B.3
  • 14
    • 78650676545 scopus 로고    scopus 로고
    • Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men
    • Yoneshiro T, Aita S, Matsushita M, et al. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity 2011; 19:13-16.
    • (2011) Obesity , vol.19 , pp. 13-16
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3
  • 15
    • 79960945989 scopus 로고    scopus 로고
    • Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    • Orava J, Nuutila P, Lidell ME, et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 2011; 14:272-279.
    • (2011) Cell Metab , vol.14 , pp. 272-279
    • Orava, J.1    Nuutila, P.2    Lidell, M.E.3
  • 16
    • 80052139636 scopus 로고    scopus 로고
    • Age-related decrease in coldactivated brown adipose tissue and accumulation of body fat in healthy humans
    • Yoneshiro T, Aita S, Matsushita M, et al. Age-related decrease in coldactivated brown adipose tissue and accumulation of body fat in healthy humans. Obesity 2011; 19:1755-1760.
    • (2011) Obesity , vol.19 , pp. 1755-1760
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3
  • 17
    • 84881221754 scopus 로고    scopus 로고
    • Recruited brown adipose tissue as an antiobesity agent in humans
    • Yoneshiro T, Aita S, Matsushita M, et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 2013; 123:3404-3408.
    • (2013) J Clin Invest , vol.123 , pp. 3404-3408
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3
  • 19
    • 84869233588 scopus 로고    scopus 로고
    • Human BAT possesses molecular signatures that resemble beige/brite cells
    • Sharp LZ, Shinoda K, Onho H, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLos One 2012; 7:e49452.
    • (2012) PLos One , vol.7
    • Sharp, L.Z.1    Shinoda, K.2    Onho, H.3
  • 20
    • 84877263632 scopus 로고    scopus 로고
    • A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
    • Jespersen NZ, Larsen TJ, Peijs L, et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013; 17:798-805.
    • (2013) Cell Metab , vol.17 , pp. 798-805
    • Jespersen, N.Z.1    Larsen, T.J.2    Peijs, L.3
  • 21
    • 84896710569 scopus 로고    scopus 로고
    • Functional thermogenic beige adipogenesis is inducible in human neck fat
    • [Epub ahead of print]. doi:10.1038/ijo.2013.82
    • Lee P, Werner CD, Kebebew E, Celi FS. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes (Lond) 2013. [Epub ahead of print]. doi:10.1038/ijo.2013.82.
    • (2013) Int J Obes (Lond)
    • Lee, P.1    Werner, C.D.2    Kebebew, E.3    Celi, F.S.4
  • 22
    • 79954620647 scopus 로고    scopus 로고
    • Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses
    • Ono K, Tsukamoto-YasuiM, Hara-Kimura Y, et al. Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. J Appl Physiol 2011; 110:789-798.
    • (2011) J Appl Physiol , vol.110 , pp. 789-798
    • Ono, K.1    Tsukamoto-Yasui, M.2    Hara-Kimura, Y.3
  • 24
    • 33845889112 scopus 로고    scopus 로고
    • Effects of CH-19 Sweet, a nonpungent cultivar of red pepper, in decreasing the body weight and suppressing body fat accumulation by sympathetic nerve activation in humans
    • Kawabata F, Inoue N, Yazawa S, et al. Effects of CH-19 Sweet, a nonpungent cultivar of red pepper, in decreasing the body weight and suppressing body fat accumulation by sympathetic nerve activation in humans. Biosci Biotechnol Biochem 2006; 70:2824-2835.
    • (2006) Biosci Biotechnol Biochem , vol.70 , pp. 2824-2835
    • Kawabata, F.1    Inoue, N.2    Yazawa, S.3
  • 25
    • 33847189521 scopus 로고    scopus 로고
    • Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and nonpungent capsaicin analogues (capsinoids)
    • Inoue N, Matsunaga Y, Satoh H, Takahashi M. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and nonpungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem 2007; 71:380-389.
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 380-389
    • Inoue, N.1    Matsunaga, Y.2    Satoh, H.3    Takahashi, M.4
  • 26
    • 58149394253 scopus 로고    scopus 로고
    • Effects of novel capsinoid treatment on fatness and energy metabolism in humans: Possible pharmacogenetic implications
    • Snitker S, Fujishima Y, Shen H, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009; 89:45-50.
    • (2009) Am J Clin Nutr , vol.89 , pp. 45-50
    • Snitker, S.1    Fujishima, Y.2    Shen, H.3
  • 27
    • 84859046511 scopus 로고    scopus 로고
    • Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans
    • Yoneshiro T, Aita S, Kawai Y, et al. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012; 95:845-850.
    • (2012) Am J Clin Nutr , vol.95 , pp. 845-850
    • Yoneshiro, T.1    Aita, S.2    Kawai, Y.3
  • 28
    • 57049155037 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids: X Safety assessment and pharmacokinetics of capsinoids in healthymale volunteers after a single oral ingestion of CH-19Sweet extract
    • Bernard BK, Tsubuku S, Kayahara T, et al. Studies of the toxicological potential of capsinoids: X Safety assessment and pharmacokinetics of capsinoids in healthymale volunteers after a single oral ingestion of CH-19Sweet extract. Int J Toxicol 2008; 27 (Suppl 3):137-147.
    • (2008) Int J Toxicol , vol.27 , Issue.SUPPL. 3 , pp. 137-147
    • Bernard, B.K.1    Tsubuku, S.2    Kayahara, T.3
  • 29
    • 74349091894 scopus 로고    scopus 로고
    • Nonpungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice
    • Kawabata F, Inoue N, Masamoto Y, et al. Nonpungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. Biosci Biotechnol Biochem 2009; 73:2690-2697.
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 2690-2697
    • Kawabata, F.1    Inoue, N.2    Masamoto, Y.3
  • 30
    • 84876788350 scopus 로고    scopus 로고
    • Grains of paradise (Aframomum Melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men
    • Sugita J, Yoneshiro T, Hatano T, et al. Grains of paradise (Aframomum Melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr 2013; 110:733-738.
    • (2013) Br J Nutr , vol.110 , pp. 733-738
    • Sugita, J.1    Yoneshiro, T.2    Hatano, T.3
  • 31
    • 70350338210 scopus 로고    scopus 로고
    • Compounds from Sichuan and Melegueta peppers activate, covalently and noncovalently, TRPA1 and TRPV1 channels
    • Riera CE, Menozzi-Smarrito C, Affolter M, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and noncovalently, TRPA1 and TRPV1 channels. Br J Pharmacol 2009; 157:1398-1409.
    • (2009) Br J Pharmacol , vol.157 , pp. 1398-1409
    • Riera, C.E.1    Menozzi-Smarrito, C.2    Affolter, M.3
  • 32
    • 84856677167 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of [6] -gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators
    • Morera E, Petrocellis De L, Morera L, et al. Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorg Med Chem Lett 2012; 22:1674-1677.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 1674-1677
    • Morera, E.1    De L, P.2    Morera, L.3
  • 33
    • 36048982077 scopus 로고    scopus 로고
    • Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses
    • Tajino K, Matsumura K, Kosada K, et al. Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses. Am J Physiol Regul Integr Comp Physiol 2007; 293:R2128-R2135.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293
    • Tajino, K.1    Matsumura, K.2    Kosada, K.3
  • 34
    • 67049154139 scopus 로고    scopus 로고
    • Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice
    • Masamoto Y, Kawabata F, Fushiki T. Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci Biotechnol Biochem 2009; 73:1021-1027.
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 1021-1027
    • Masamoto, Y.1    Kawabata, F.2    Fushiki, T.3
  • 35
    • 84860176201 scopus 로고    scopus 로고
    • Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity
    • Ma S, Yu H, Zhao Z, et al. Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. J Mol Cell Biol 2012; 4:88-96.
    • (2012) J Mol Cell Biol , vol.4 , pp. 88-96
    • Ma, S.1    Yu, H.2    Zhao, Z.3
  • 36
    • 84862150176 scopus 로고    scopus 로고
    • Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet
    • Tamura Y, Iwasaki Y, Narukawa M, Watanabe T. Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet. J Nutr Sci Vitaminol 2012; 58:9-13.
    • (2012) J Nutr Sci Vitaminol , vol.58 , pp. 9-13
    • Tamura, Y.1    Iwasaki, Y.2    Narukawa, M.3    Watanabe, T.4
  • 37
    • 84876698097 scopus 로고    scopus 로고
    • TRP channels as targets for therapeutic intervention in obesity: Focus on TRPV1 and TRPM5
    • Palmer RK, Lunn CA. TRP channels as targets for therapeutic intervention in obesity: focus on TRPV1 and TRPM5. Curr Top Med Chem 2013; 13:247-257.
    • (2013) Curr Top Med Chem , vol.13 , pp. 247-257
    • Palmer, R.K.1    Lunn, C.A.2
  • 38
    • 84862610589 scopus 로고    scopus 로고
    • The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice
    • Glendinning JI, Gillman J, Zamer H, et al. The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice. Physiol Behav 2012; 107:50-57.
    • (2012) Physiol Behav , vol.107 , pp. 50-57
    • Glendinning, J.I.1    Gillman, J.2    Zamer, H.3
  • 39
    • 0030808856 scopus 로고    scopus 로고
    • A possible role for palatability of the food in diet-induced thermogenesis
    • LeBlanc J, Labrie A. A possible role for palatability of the food in diet-induced thermogenesis. Int J Obes Relat Metab Disord 1997; 21:1100-1103.
    • (1997) Int J Obes Relat Metab Disord , vol.21 , pp. 1100-1103
    • Leblanc, J.1    Labrie, A.2
  • 40
    • 0024465423 scopus 로고
    • Metabolic and sympathetic nerve activities of brown adipose tissue in tube-fed rat
    • Saito M, Minokoshi Y, Shimazu T. Metabolic and sympathetic nerve activities of brown adipose tissue in tube-fed rat. Am J Physiol 1989; 257:E374-E378.
    • (1989) Am J Physiol , vol.257
    • Saito, M.1    Minokoshi, Y.2    Shimazu, T.3
  • 41
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Nature 1979; 281:31-35.
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 42
    • 84859613211 scopus 로고    scopus 로고
    • TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity
    • Kusudo T, Wang Z, Mizuno A, et al. TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity. J Appl Physiol 2012; 112:1223-1232.
    • (2012) J Appl Physiol , vol.112 , pp. 1223-1232
    • Kusudo, T.1    Wang, Z.2    Mizuno, A.3
  • 43
    • 84869101137 scopus 로고    scopus 로고
    • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
    • Ye L, Kleiner S, Wu J, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 2012; 151:96-110.
    • (2012) Cell , vol.151 , pp. 96-110
    • Ye, L.1    Kleiner, S.2    Wu, J.3
  • 44
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011; 17:200-205.
    • (2011) Nat Med , vol.17 , pp. 200-205
    • Bartelt, A.1    Bruns, O.T.2    Reimer, R.3
  • 45
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • Ouellet V, Routhier-Labadie A, Bellemare W, et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 2011; 96:192-199.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 192-199
    • Ouellet, V.1    Routhier-Labadie, A.2    Bellemare, W.3
  • 46
    • 0025081075 scopus 로고
    • Stimulatory effects of cold exposure and cold acclimation on glucose uptake in rat peripheral tissues
    • Vallerand AL, Pesusse F, Bukowiecki LJ. Stimulatory effects of cold exposure and cold acclimation on glucose uptake in rat peripheral tissues. Am J Physiol 1990; 259:R1043-R1049.
    • (1990) Am J Physiol , vol.259
    • Vallerand, A.L.1    Pesusse, F.2    Bukowiecki, L.J.3
  • 47
    • 0142125315 scopus 로고    scopus 로고
    • Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus
    • Gasparetti AL, de Souza CT, Pereira-da-Silva M, et al. Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus. J Physiol 2003; 552:149-162.
    • (2003) J Physiol , vol.552 , pp. 149-162
    • Gasparetti, A.L.1    De Souza, C.T.2    Pereira-Da-Silva, M.3
  • 48
    • 84878014185 scopus 로고    scopus 로고
    • Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats
    • Kwon DY, Kim YS, Ryu SY, et al. Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats. J Nutr Biochem 2012; 24:1078-1085.
    • (2012) J Nutr Biochem , vol.24 , pp. 1078-1085
    • Kwon, D.Y.1    Kim, Y.S.2    Ryu, S.Y.3


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