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Volumn 155, Issue 9, 2014, Pages 3448-3458

The PVH as a site of CB1-mediated stimulation of thermogenesis by MC4R agonism in male rats

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2 BROMOPALMITIC ACID; CANNABINOID 1 RECEPTOR; CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 1B; DRONABINOL; GLUCOSE; IODIDE PEROXIDASE; MELANOCORTIN 4 RECEPTOR; MELANOTAN II; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TYPE II IODOTHYRONINE DEIODINASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; ALPHA INTERMEDIN; CNR1 PROTEIN, RAT; CYCLOPEPTIDE; DRUG DERIVATIVE; MELANOTAN-II; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

EID: 84907043858     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-2092     Document Type: Article
Times cited : (21)

References (64)
  • 1
    • 84255199265 scopus 로고    scopus 로고
    • Central nervous control of energy and glucose balance: Focus on the central melanocortin system
    • Xu Y, Elmquist JK, Fukuda M. Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann NY Acad Sci. 2011;1243:1-14.
    • (2011) Ann NY Acad Sci. , vol.1243 , pp. 1-14
    • Xu, Y.1    Elmquist, J.K.2    Fukuda, M.3
  • 2
    • 79959560170 scopus 로고    scopus 로고
    • Distribution and function of melanocortin receptors within the brain
    • Mountjoy KG. Distribution and function of melanocortin receptors within the brain. Adv Exp Med Biol. 2010;681:29-48.
    • (2010) Adv Exp Med Biol. , vol.681 , pp. 29-48
    • Mountjoy, K.G.1
  • 3
    • 33845295812 scopus 로고    scopus 로고
    • The role of the central melanocortin system in the regulation of food intake and energy homeostasis: Lessons from mouse models
    • Ellacott KLJ, Cone RD. The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philos Trans R Soc Lond B Biol Sci. 2006;361: 1265-1274.
    • (2006) Philos Trans R Soc Lond B Biol Sci. , vol.361 , pp. 1265-1274
    • Ellacott, K.L.J.1    Cone, R.D.2
  • 4
    • 31544465224 scopus 로고    scopus 로고
    • The melanocortin system and energy balance
    • Butler AA. The melanocortin system and energy balance. Peptides. 2006;27:281-290.
    • (2006) Peptides. , vol.27 , pp. 281-290
    • Butler, A.A.1
  • 6
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L, Diehl N, Brennan MB, Hochgeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med. 1999;5:1066-1070.
    • (1999) Nat Med. , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 7
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19:155-157.
    • (1998) Nat Genet. , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Grüters, A.6
  • 8
    • 33845567553 scopus 로고    scopus 로고
    • Genetics of obesity in humans
    • Farooqi S, O'Rahilly S. Genetics of obesity in humans. Endocr Rev. 2006;27:710-718.
    • (2006) Endocr Rev. , vol.27 , pp. 710-718
    • Farooqi, S.1    O'Rahilly, S.2
  • 9
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997;88:131-141.
    • (1997) Cell. , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 11
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet. 1998;20:113-114.
    • (1998) Nat Genet. , vol.20 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3    Froguel, P.4
  • 12
    • 51149096739 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: Neuroanatomical and functional evidence
    • Song CK, Vaughan CH, Keen-Rhinehart E, Harris RBS, Richard D, Bartness TJ. Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence. Regul Integr Comp Physiol. 2008;295: R417-R428.
    • (2008) Regul Integr Comp Physiol. , vol.295 , pp. R417-R428
    • Song, C.K.1    Vaughan, C.H.2    Keen-Rhinehart, E.3    Harris, R.B.S.4    Richard, D.5    Bartness, T.J.6
  • 13
    • 35548962415 scopus 로고    scopus 로고
    • Differential activationofthe sympathetic innervationofadipose tissuesbymela-nocortin receptor stimulation
    • Brito MN, Brito NA, Baro DJ, Song CK, Bartness TJ. Differential activationofthe sympathetic innervationofadipose tissuesbymela-nocortin receptor stimulation. Endocrinology. 2007;148:5339-5347.
    • (2007) Endocrinology. , vol.148 , pp. 5339-5347
    • Brito, M.N.1    Brito, N.A.2    Baro, D.J.3    Song, C.K.4    Bartness, T.J.5
  • 15
    • 33947387967 scopus 로고    scopus 로고
    • Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue
    • Voss-Andreae A, Murphy JG, Ellacott KLJ, et al. Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology. 2006;148:1550-1560.
    • (2006) Endocrinology. , vol.148 , pp. 1550-1560
    • Voss-Andreae, A.1    Murphy, J.G.2    Ellacott, K.L.J.3
  • 16
    • 0031264289 scopus 로고    scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Obes Res. 1997;5:650-656.
    • (1997) Obes Res. , vol.5 , pp. 650-656
    • Rothwell, N.J.1    Stock, M.J.2
  • 17
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84:277-359.
    • (2004) Physiol Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 19
    • 84856529575 scopus 로고    scopus 로고
    • Brown adipose tissue ox-idative metabolism contributes to energy expenditure during acute cold exposure in humans
    • Ouellet V, Labbé SM, Blondin DP, et al. Brown adipose tissue ox-idative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012;122:545-552.
    • (2012) J Clin Invest. , vol.122 , pp. 545-552
    • Ouellet, V.1    Labbé, S.M.2    Blondin, D.P.3
  • 20
    • 84877331455 scopus 로고    scopus 로고
    • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    • Cypess AM, White AP, Vernochet C, et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013;19:635-639.
    • (2013) Nat Med. , vol.19 , pp. 635-639
    • Cypess, A.M.1    White, A.P.2    Vernochet, C.3
  • 23
    • 3042640680 scopus 로고    scopus 로고
    • Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake
    • Verty ANA, McFarlane JR, McGregor IS, Mallet PE. Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake. Endocrinology. 2004;145: 3224-3231.
    • (2004) Endocrinology. , vol.145 , pp. 3224-3231
    • Verty, A.N.A.1    McFarlane, J.R.2    McGregor, I.S.3    Mallet, P.E.4
  • 25
    • 43049094858 scopus 로고    scopus 로고
    • Role of the endocannabinoid system in energy balance regulation and obesity
    • Cota D. Role of the endocannabinoid system in energy balance regulation and obesity. Obesity Metab (Basel: Karger Publishers). 2008;36:135-145.
    • (2008) Obesity Metab (Basel: Karger Publishers). , vol.36 , pp. 135-145
    • Cota, D.1
  • 26
    • 33846827125 scopus 로고    scopus 로고
    • The endocannabinoid system: Mechanisms behind metabolic homeostasis and imbalance
    • Woods SC. The endocannabinoid system: mechanisms behind metabolic homeostasis and imbalance. Am J Med. 2007;120:S9-S17.
    • (2007) Am J Med. , vol.120 , pp. S9-S17
    • Woods, S.C.1
  • 27
    • 33845673559 scopus 로고    scopus 로고
    • Endocannabinoids and the control of energy balance
    • Matias I, Di Marzo V. Endocannabinoids and the control of energy balance. Trends Endocrinol Metab. 2007;18:27-37.
    • (2007) Trends Endocrinol Metab. , vol.18 , pp. 27-37
    • Matias, I.1    Di Marzo, V.2
  • 29
    • 58849117501 scopus 로고    scopus 로고
    • The effects of rimonabant on brown adipose tissue in rat: Implications for energy expenditure
    • Verty ANA, Allen AM, Oldfield BJ. The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure. Obesity (Silver Spring). 2009;17:254-261.
    • (2009) Obesity (Silver Spring). , vol.17 , pp. 254-261
    • Verty, A.N.A.1    Allen, A.M.2    Oldfield, B.J.3
  • 30
    • 34447635408 scopus 로고    scopus 로고
    • Distributionoftype1cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus
    • Wittmann G, Deli L, Kalló I, et al. Distributionoftype1cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J Comp Neurol. 2007;503:270-279.
    • (2007) J Comp Neurol. , vol.503 , pp. 270-279
    • Wittmann, G.1    Deli, L.2    Kalló, I.3
  • 31
    • 0035499974 scopus 로고    scopus 로고
    • Modulation of transmitter release via presynaptic cannabinoid receptors
    • Schlicker E, Kathmann M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci. 2001; 22:565-572.
    • (2001) Trends Pharmacol Sci. , vol.22 , pp. 565-572
    • Schlicker, E.1    Kathmann, M.2
  • 32
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di Marzo V. Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov. 2008;7:438-455.
    • (2008) Nat Rev Drug Discov. , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 33
    • 0034721508 scopus 로고    scopus 로고
    • Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord
    • Pyner S, Coote JH. Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord. Neuroscience. 2000;100:549-556.
    • (2000) Neuroscience. , vol.100 , pp. 549-556
    • Pyner, S.1    Coote, J.H.2
  • 34
    • 84889659070 scopus 로고    scopus 로고
    • Glutamate mediates the function of melanocortin receptor 4 on sim1 neurons in body weight regulation
    • Xu Y, Wu Z, Sun H, et al. Glutamate mediates the function of melanocortin receptor 4 on sim1 neurons in body weight regulation. Cell Metab. 2013;18:860-870.
    • (2013) Cell Metab. , vol.18 , pp. 860-870
    • Xu, Y.1    Wu, Z.2    Sun, H.3
  • 35
    • 36048955043 scopus 로고    scopus 로고
    • The central melanocortin system directly controls peripheral lipid metabolism
    • Nogueiras R, Wiedmer P, Perez-Tilve D, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007;117:3475-3488.
    • (2007) J Clin Invest. , vol.117 , pp. 3475-3488
    • Nogueiras, R.1    Wiedmer, P.2    Perez-Tilve, D.3
  • 36
    • 0034881262 scopus 로고    scopus 로고
    • Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats
    • Hwa JJ, Ghibaudi L, Gao J, Parker EM. Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. Am J Physiol Regul Integr Comp Physiol. 2001;281: R444-R451.
    • (2001) Am J Physiol Regul Integr Comp Physiol. , vol.281 , pp. R444-R451
    • Hwa, J.J.1    Ghibaudi, L.2    Gao, J.3    Parker, E.M.4
  • 37
    • 0031786114 scopus 로고    scopus 로고
    • Discovery of a novel super-potent and selective melanocortin-4 receptor antagonist (HS024): Evaluation in vitro and in vivo
    • Kask A, Mutulis F, Muceniece R, et al. Discovery of a novel super-potent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139:5006-5014.
    • (1998) Endocrinology. , vol.139 , pp. 5006-5014
    • Kask, A.1    Mutulis, F.2    Muceniece, R.3
  • 38
    • 67649967402 scopus 로고    scopus 로고
    • The effects of intracerebroventric-ular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats
    • Kozan R, Ayyildiz M, Agar E. The effects of intracerebroventric-ular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats. Epilepsia. 2009;50:1760-1767.
    • (2009) Epilepsia. , vol.50 , pp. 1760-1767
    • Kozan, R.1    Ayyildiz, M.2    Agar, E.3
  • 40
    • 64149125631 scopus 로고    scopus 로고
    • Effects of intracere-broventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure
    • Guesdon B, Paradis E, Samson P, Richard D. Effects of intracere-broventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure. Am J Physiol Regul Integr Comp Physiol. 2009;296:R469-R475.
    • (2009) Am J Physiol Regul Integr Comp Physiol. , vol.296 , pp. R469-R475
    • Guesdon, B.1    Paradis, E.2    Samson, P.3    Richard, D.4
  • 41
    • 3843083938 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor y agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice
    • Sell H, Berger JP, Samson P, et al. Peroxisome proliferator-activated receptor y agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice. Endocrinology. 2004; 145:3925-3934.
    • (2004) Endocrinology. , vol.145 , pp. 3925-3934
    • Sell, H.1    Berger, J.P.2    Samson, P.3
  • 42
    • 0025333695 scopus 로고
    • Thermal biology of the laboratory rat
    • Gordon CJ. Thermal biology of the laboratory rat. Physiol Behav. 1990;47:963-991.
    • (1990) Physiol Behav. , vol.47 , pp. 963-991
    • Gordon, C.J.1
  • 43
    • 59449089317 scopus 로고    scopus 로고
    • Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in rats
    • Ménard SL, Ci X, Frisch F, et al. Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in rats. Mol Imaging Biol. 2008;11:6-14.
    • (2008) Mol Imaging Biol. , vol.11 , pp. 6-14
    • Ménard, S.L.1    Ci, X.2    Frisch, F.3
  • 44
    • 77950798252 scopus 로고    scopus 로고
    • Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats
    • Menard SL, Croteau E, Sarrhini O, et al. Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats. Am J Physiol Endocrinol Metab. 2010;298: E1049-E1057.
    • (2010) Am J Physiol Endocrinol Metab. , vol.298 , pp. E1049-E1057
    • Menard, S.L.1    Croteau, E.2    Sarrhini, O.3
  • 45
    • 33646430823 scopus 로고    scopus 로고
    • Cardiac metabolism in mice: Tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes
    • Oakes ND, Thalén P, Aasum E, et al. Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes. Am J Physiol Endocrinol Metab. 2006;290:E870-E881.
    • (2006) Am J Physiol Endocrinol Metab. , vol.290 , pp. E870-E881
    • Oakes, N.D.1    Thalén, P.2    Aasum, E.3
  • 46
    • 33746863327 scopus 로고    scopus 로고
    • The effect of insulin on the intracellular distribution of 14(R S)-[18F]Fluoro-6-thia-heptadecanoic acid in rats
    • Ci X, Frisch F, Lavoie F, et al. The effect of insulin on the intracellular distribution of 14(R, S)-[18F]Fluoro-6-thia-heptadecanoic acid in rats. Mol Imaging Biol. 2006;8:237-244.
    • (2006) Mol Imaging Biol. , vol.8 , pp. 237-244
    • Ci, X.1    Frisch, F.2    Lavoie, F.3
  • 47
    • 0021839186 scopus 로고
    • A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat
    • Ferré P, Leturque A, Burnol AF, Pénicaud L, Girard J. A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem J. 1985;228:103-110.
    • (1985) Biochem J. , vol.228 , pp. 103-110
    • Ferré, P.1    Leturque, A.2    Burnol, A.F.3    Pénicaud, L.4    Girard, J.5
  • 48
    • 84883287842 scopus 로고    scopus 로고
    • Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease
    • Chechi K, Blanchard P-G, Mathieu P, Deshaies Y, Richard D. Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease. Int J Cardiol. 2013;167:2264-2270.
    • (2013) Int J Cardiol. , vol.167 , pp. 2264-2270
    • Chechi, K.1    Blanchard, P.-G.2    Mathieu, P.3    Deshaies, Y.4    Richard, D.5
  • 49
    • 80052031271 scopus 로고    scopus 로고
    • Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis
    • Vaughan CH, Shrestha YB, Bartness TJ. Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis. Brain Res. 2011; 1411:17-27.
    • (2011) Brain Res. , vol.1411 , pp. 17-27
    • Vaughan, C.H.1    Shrestha, Y.B.2    Bartness, T.J.3
  • 50
    • 0034981271 scopus 로고    scopus 로고
    • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
    • Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci. 2001;4:605-611.
    • (2001) Nat Neurosci. , vol.4 , pp. 605-611
    • Butler, A.A.1    Marks, D.L.2    Fan, W.3    Kuhn, C.M.4    Bartolome, M.5    Cone, R.D.6
  • 51
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPAR7
    • Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPAR7. Annu Rev Biochem. 2008;77:289-312.
    • (2008) Annu Rev Biochem. , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 52
    • 10744221610 scopus 로고    scopus 로고
    • Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
    • Christoffolete MA, Linardi CCG, de Jesus L, et al. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes. 2004;53: 577-584.
    • (2004) Diabetes. , vol.53 , pp. 577-584
    • Christoffolete, M.A.1    Linardi, C.C.G.2    De Jesus, L.3
  • 53
    • 79955032433 scopus 로고    scopus 로고
    • Brown fat biology and thermogenesis
    • Richard D, Picard F. Brown fat biology and thermogenesis. Front Biosci. 2011;16:1233-1260.
    • (2011) Front Biosci. , vol.16 , pp. 1233-1260
    • Richard, D.1    Picard, F.2
  • 54
    • 0242713017 scopus 로고    scopus 로고
    • Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat
    • Williams DL, Bowers RR, Bartness TJ, Kaplan JM, Grill HJ. Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Endocrinology. 2003;144: 4692-4697.
    • (2003) Endocrinology. , vol.144 , pp. 4692-4697
    • Williams, D.L.1    Bowers, R.R.2    Bartness, T.J.3    Kaplan, J.M.4    Grill, H.J.5
  • 55
    • 2642576000 scopus 로고    scopus 로고
    • Melanocortin 4 receptor-mediated hyperphagia and activation of neuropeptide y expression in the dorsomedial hypothalamus during lactation
    • Chen P. Melanocortin 4 receptor-mediated hyperphagia and activation of neuropeptide Y expression in the dorsomedial hypothalamus during lactation. J Neurosci. 2004;24:5091-5100.
    • (2004) J Neurosci. , vol.24 , pp. 5091-5100
    • Chen, P.1
  • 56
    • 1442324342 scopus 로고    scopus 로고
    • Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue
    • Yasuda T, Masaki T, Kakuma T, Yoshimatsu H. Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue. Exp Biol Med (Maywood). 2004;229:235-239.
    • (2004) Exp Biol Med (Maywood). , vol.229 , pp. 235-239
    • Yasuda, T.1    Masaki, T.2    Kakuma, T.3    Yoshimatsu, H.4
  • 59
    • 77950199353 scopus 로고    scopus 로고
    • CB1 signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance
    • Quarta C, Bellocchio L, Mancini G, et al. CB1 signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metab. 2010;11:273-285.
    • (2010) Cell Metab. , vol.11 , pp. 273-285
    • Quarta, C.1    Bellocchio, L.2    Mancini, G.3
  • 60
    • 82455168018 scopus 로고    scopus 로고
    • Cannabinoidreceptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice
    • Bajzer M, Olivieri M, Haas MK, et al. Cannabinoidreceptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice. Diabetologia. 2011;54: 3121-3131.
    • (2011) Diabetologia. , vol.54 , pp. 3121-3131
    • Bajzer, M.1    Olivieri, M.2    Haas, M.K.3
  • 61
    • 73249136773 scopus 로고    scopus 로고
    • Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues
    • Toda C, Shiuchi T, Lee S, et al. Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes. 2009;58: 2757-2765.
    • (2009) Diabetes. , vol.58 , pp. 2757-2765
    • Toda, C.1    Shiuchi, T.2    Lee, S.3
  • 62
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY AGRP and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron. 1999;24:155-163.
    • (1999) Neuron. , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 63
    • 17844388556 scopus 로고    scopus 로고
    • Endocannabinoid control of food intake and energy balance
    • Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci. 2005;8:585-589.
    • (2005) Nat Neurosci. , vol.8 , pp. 585-589
    • Di Marzo, V.1    Matias, I.2
  • 64
    • 48249095521 scopus 로고    scopus 로고
    • Feeding induced by canna-binoids is mediated independently of the melanocortin system
    • Sinnayah P, Jobst EE, Rathner JA, et al. Feeding induced by canna-binoids is mediated independently of the melanocortin system. PLoS One. 2008;3:e2202.
    • (2008) PLoS One. , vol.3 , pp. e2202
    • Sinnayah, P.1    Jobst, E.E.2    Rathner, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.