Low fucose containing bacterial polysaccharide facilitate mitochondria-dependent ROS-induced apoptosis of human lung epithelial carcinoma via controlled regulation of MAPKs-mediated Nrf2/Keap1 homeostasis signaling

Molecular Carcinogenesis

Volumn 54, Issue 12, 2015, Pages 1636-1655

  Chowdhury, Sougata Roy ^a,b   Sengupta, Suman ^b   Biswas, Subir ^b   Sen, Ramkrishna ^a   Sinha, Tridib Kumar ^a   Basak, Ratan Kumar ^a   Adhikari, Basudam ^a   Bhattacharyya, Arindam ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

^b UNIVERSITY OF CALCUTTA   (India)

Author keywords

Apoptosis; Cell signaling; Fucose polysaccharide; Lung carcinoma; ROS

Indexed keywords

BACTERIAL POLYSACCHARIDE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; FUCOSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LOW FUCOSE CONTAINING BACTERIAL POLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; KEAP1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

A549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BACILLUS MEGATERIUM; BIOSYNTHESIS; CARBOHYDRATE METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; FEMALE; HELA CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMEOSTASIS; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOMA; MASS SPECTROMETRY; MEMBRANE PERMEABILITY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; CARCINOMA; DRUG EFFECTS; EPITHELIUM CELL; LUNG TUMOR; MCF 7 CELL LINE; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA; CELL LINE, TUMOR; EPITHELIAL CELLS; FUCOSE; HELA CELLS; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; MCF-7 CELLS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-E2-RELATED FACTOR 2; POLYSACCHARIDES, BACTERIAL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84944532386     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22236     Document Type: Article

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