N-acetylcysteine prevents glucose/glucose oxidase-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells

Life Sciences

Volumn 84, Issue 11-12, 2009, Pages 328-336

  Kumar, Santosh ^a   Sitasawad, Sandhya L ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Apoptosis; Diabetes; Glucose oxidase; H9c2 cells; Mitochondrial damage; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; CYTOCHROME C; GLUCOSE; GLUCOSE OXIDASE; HYDROGEN PEROXIDE; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME RELEASE; HEART MUSCLE CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; GLUCOSE OXIDASE; HYPERGLYCEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PEROXYNITROUS ACID; REACTIVE OXYGEN SPECIES;

EID: 60349121674     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2008.12.016     Document Type: Article

References (41)

1. Allen D.A., Harwood S., Varagunam M., Raftery M.J., and Yaqoob M.M. High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB Journal 17 (2003) 908-910
2. Budihardjo I., Oliver H., Lutter M., Luo X., and Wang X. Biochemical pathways of caspase activation during apoptosis. Annual Review of Cell and Developmental Biology 15 (1999) 269-290
3. Cai L. Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy. Free Radical Biology and Medicine 41 (2006) 851-861
4. Cai L., and Kang Y.J. Oxidative stress and diabetic cardiomyopathy: a brief review. Cardiovascular Toxicology 1 (2001) 181-193
5. Cai L., Li W., Wang G., Guo L., Jiang Y., and Kang Y.J. Hyperglycemia induced apoptosis in mouse myocardium mitochondrial cytochrome c-mediated caspase-3 activation pathway. Diabetes 51 (2002) 1938-1948
6. Carmody R.J., and Cotter T.G. Signalling apoptosis: a radical approach. Redox Reports 6 (2001) 77-90
7. Chandra J., Samali A., and Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radical Biology and Medicine 29 (2000) 323-333
8. Chen Y., Saari J.T., and Kang Y.J. Weak antioxidant defenses make the heart a target for damage in copper-deficient rats. Free Radical Biology and Medicine 17 (1994) 529-536
9. Desagher S., and Martinou J.C. Mitochondria as the central control point of apoptosis. Trends in Cell Biology 10 (2000) 369-377
10. Eriksson U.J., and Borg L.A. Diabetes and embryonic malformations: role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos. Diabetes 42 (1993) 411-419
11. Fiordaliso F., Bianchi R., Staszewsky L., Cuccovillo I., Doni M., Laragione T., Salio M., Savino C., Melucci S., Santangelo F., Scanziani E., Masson S., Ghezzi P., and Latini R. Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. Journal of Molecular and Cellular Cardiology 37 (2004) 959-968
12. Gagnon C., Leblond F.A., and Filep J.G. Peroxynitrite production by human neutrophils, monocytes and lymphocytes challenged with lipopolysaccharide. FEBS Letters 431 (1998) 107-110
13. Galán A., García-Bermejo M.L., Troyano A., Vilaboa N.E., de Blas E., Kazanietz M.G., and Aller P. Stimulation of p38 mitogen activated protein kinase is an early regulatory event for the cadmium induced apoptosis in human promonocytic cells. Journal of Biological Chemistry 275 (2000) 11418-11424
14. Green D.R., and Read J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
15. Guo Z., Xia Z., Jiang J., and McNeill J.H. Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L cysteine. American J Physiol of Heart and Circulatory Physiology 292 (2007) 1728-1736
16. Jaffe A.S., Spadaro J.J., Schechtman K., Roberts R., Geltman E.M., and Sobel B.E. Increased congestive heart failure after myocardial infarction of modest extent in patients with diabetes mellitus. American Heart Journal 108 (1994) 31-37
17. Kaul N., Siveski-Iliskovic N., Hill M., Khaper N., Seneviratne C., and Singal P.K. Probucol treatment reverses antioxidant and functional deficit in diabetic cardiomyopathy. Molecular Cell Biochemistry 160-161 (1996) 283-288
18. Khan N., Afaq F., and Mukhtar H. Apoptosis by dietary factors: the suicide solution for delaying cancer growth. Carcinogenesis 28 (2007) 233-239
19. Krohn A.J., Wahlbrink T., and Prehn J.H. Mitochondrial depolarization is not required for neuronal apoptosis. Journal of Neuroscience 19 (1999) 7394-7404
20. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 47-489
21. Marchetti P., Castedo M., Susin S.A., Zamzami N., Hirsch T., Macho A., Haeffner A., Hirsch F., Geuskens M., and Kroemer G. Mitochondrial permeability transition is a central coordinating event of apoptosis. Journal of Experimental Medicine 184 (1996) 1155-1160
22. Maulik N., Sharma H.S., and Das D.K. Induction of the haem oxygenase gene expression during the reperfusion of ischemic rat myocardium. Journal of Molecular Cardiology 28 (1996) 1261-1270
23. Murugavel P., Pari L., Sitasawad S.L., Kumar S., and Kumar S. Cadmium induced mitochondrial injury and apoptosis in vero cells: protective effect of diallyl tetrasulfide from garlic. The International Journal of Biochemistry and Cell Biology 39 (2007) 161-170
24. Navarro-Antolín J., López-Muñoz M.J., Klatt P., Soria J., Michel T., and Lamas S. Formation of peroxynitrite in vascular endothelial cells exposed to cyclosporine A. FASEB Journal 15 (2001) 1291-1293
25. Nishikawa T., Edelstein D., Du X.L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M.A., Beebe D., Oates P.J., Hammes H.P., Giardino I., and Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404 (2000) 787-790
26. Nishio Y., Kashiwagi A., Taki H., Shinozaki K., Maeno Y., Kojima H., Maegawa H., Haneda M., Hidaka H., Yasuda H., Horiike K., and Kikkawa R. Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats. Diabetes 47 (1998) 1318-1325
27. Pocernich C.B., Cardin A.L., Racine C.L., Lauderback C.M., and Butterfield D.A. Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease. Neurochemistry International 39 (2001) 141-149
28. Rosen P., Ballhausen T., Bloch W., and Addicks K. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Diabetologia 38 (1995) 1157-1168
29. Scaduto Jr. R.C., and Grotyohann L.W. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophysical Journal 76 (1999) 469-477
30. Schlottmann K., and Schölmerich J. Bcl-2 family-members and mitochondria. In: Schunkert H., and Riegger G. (Eds). Apoptosis in Cardiac Biology (1999), Kluwer Academic Publishers, Boston 71-90 Dordrecht, London
31. Shih C.M., Ko W.C., Wu J.S., Wei Y.H., Wang L.F., Chang E.E., Lo T.Y., Cheng H.H., and Chen C.T. Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. Journal of Cellular Biochemistry 91 (2004) 384-397
32. i of cardiac myocytes. Kidney International 53 (1998) 1237-1243
33. Susin S.A., Zamzami N., Castedo M., Hirsch T., Marchetti P., Macho A., Daugas E., Geuskens M., and Kroemer G. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. Journal of Experimental Medicine 184 (1996) 1331-1341
34. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Brenner C., Larochette N., Prévost M.C., Alzari P.M., and Kroemer G. Mitochondrial release of caspase-2 and -9 during the apoptotic process. Journal of Experimental Medicine 189 (1999) 381-394
35. Verzola D., Bertolotto M.B., Villaggio B., Ottonello L., Dallegri F., Salvatore F., Berruti V., Gandolfo M.T., Garibotto G., and Deferrari G. Oxidative stress mediates apoptotic changes induced by hyperglycemia in human tubular kidney cells. Journal of American Society for Nephrology 15 (2004) S85-S87
36. Wang G.W., Klein J.B., and Kang Y.J. Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes. The Journal of Pharmacology and Experimental Therapeutics 298 (2001) 461-468
37. Wohaieb S.A., and Godin D.V. Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat: effects of insulin treatment. Diabetes 36 (1987) 1014-1018
38. Wolff S.P., Jiang Z.Y., and Hunt J.V. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radical Biology and Medicine 10 (1991) 339-352
39. Ye G., Metreveli N.S., Donthi R.V., Xia S., Xu M., Carlson E.C., and Epstein P.N. Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. Diabetes 53 (2004) 1336-1343
40. Zamzami N., Susin S.A., Marchetti P., Hirsch T., Gómez-Monterrey I., Castedo M., and Kroemer G. Mitochondrial control of nuclear apoptosis. Journal of Experimental Medicine 183 (1996) 1533-1544
41. Zou H., Li Y., Liu X., and Wang X. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. Journal of Biological Chemistry 274 (1999) 11549-11556