p38 mitogen-activated protein kinase regulates bax translocation in cyanide-induced apoptosis

Toxicological Sciences

Volumn 75, Issue 1, 2003, Pages 99-107

  Shou, Y ^a   Li, L ^a   Prabhakaran, K ^a   Borowitz, J L ^a   Isom, Geisom ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Apoptosis; Bax; Cyanide; Cytochrome c; p38 MAP kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE; CYANIDE; CYTOCHROME C; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; SYNAPTOPHYSIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL FRACTIONATION; CELL LABELING; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; MITOCHONDRION; NONHUMAN; PROTEIN TRANSPORT; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; CYTOCHROMES C; CYTOPLASM; ENZYME INHIBITORS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POTASSIUM CYANIDE; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0041380813     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg157     Document Type: Article

References (39)

1. Antonsson, B., Contin, F., Ciavatta, A., Montessuit, S., Elwis, S., Martinoul, I., Bernascom, L., Bernard, A., Mermod, J. J., and Mazzei, G. (1997). Inhibition of Bax channel-forming activity by Bcl-2. Science 277, 370-372.
2. Chae, H. J., Kim, S. C., Han, K. S., Chae, S. W., An, N. H., Kim, H. M., Kim, H. H., Lee, Z. H., and Kim, H. R. (2001). Hypoxia induces apoptosis by caspase activation accompanying cytochrome c release from mitochondria in MC3T3E1 osteoblasts. p38 MAP kinase is related in hypoxia-induced apoptosis. Immunopharmacol. Immunotoxicol. 23, 133-152.
3. Desagher, S., Osen-Sand, A., Nichols, A., Eskes, R., Montessuit, S., Lauper, S., Maundrell, K., Antonsson, B., and Martinou, J. (1999). Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J. Cell Biol. 144, 891-901.
4. De Zutter, G. S., and Davis, R. J. (2001). Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Proc. Natl. Acad. Sci. U.S.A. 98, 6168-6173.
5. Eskes, R., Desagher, S., Antonsson, B., and Martinou, J. C. (2000). Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol. Cell Biol. 20, 929-935.
6. L. J. Biol. Chem. 274, 2225-2233.
7. Ghatan, S., Larner, S., Kinoshita, Y., Hetman, M., Patel, L., Xia, Z., Youle, R. J., and Morrison, R. S. (2000). p38 MAP kinase mediates Bax translocation in nitric oxide-induced apoptosis in neurons. J. Cell Biol. 150, 335-347.
8. Goping, I. S., Gross, A., Lavoie, J. N., Nguyen, M., Jemmerson, R., Roth, K., Korsmeyer, S. J., and Shore, G. C. (1998). Regulated targeting of Bax to mitochondria. J. Cell Biol. 143, 207-215.
9. Gross, A., McDonnell, J. M., and Korsmeyer, S. J. (1999). Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13, 1899-1911.
10. Jensen, M. S., Ahlemeyer, R. A., Thakur, P., Mennel, H-D., and Krieglstein, J. (2002). Preconditioning-induced protection against cyanide-induced neurotoxicity is mediated by preserving mitochondrial function. Neurochem. Int. 40, 285-293.
11. Jurgensmeier, J. M., Xie, Z., Deveraux, Q., Ellerby, L., Bredesen, D., and Reed, J. C. (1998). Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95, 4997-5002.
12. Kawasaki, H., Morooka, T., Shimohama, S., Kimura, J., Hirano, T., Gotoh, Y., and Nishida, E. (1997). Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem. 272, 18518-18521.
13. Khaled, A. R., Kim, K., Hofmeister, R., Muegge, K., and Durum, S. (1999). Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH. Proc. Natl. Acad. Sci. U.S.A. 96, 14476-14481.
14. Matzo, I., Brenner, C., Zamzami, N., Jurgensmeier, J. M., Susin, S. A., Vieira, H. L., Prevost, M. C., Xie, Z., Matsuyama, S., Reed, J. C., and Kroemer, G. (1998). Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281, 2027-2031.
15. Mills, E. M., Gunasekar, P. G., Borowitz, J. L., and Isom, G. E. (1999). Cyanide-induced neurodegeneration involves different susceptibility of brain areas and different modes of cell death. Toxicol. Appl. Pharmacol. 156, 6-16.
16. L, an inhibitor of programmed cell death. Nature 381, 335-341.
17. Murphy, K. M., Streips, U. N., and Lock, R. B. (1999). Bax membrane insertion during Fas (CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2. Oncogene 18, 5991-5999.
18. Myers, K. M., Fiskum, G., Liu, Y., Simmens, S. J., Bresdesen, D. E., and Murphy, A. N. (1995). Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J. Neurochem. 65, 2432-2440.
19. Narita, M., Shinizu, S., Ito, T., Chittenden, T., Lutz, R. J., Matsuda, H., and Tsujimoto, Y. (1998). Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95, 14681-14686.
20. Nechushtan, A., Smith, C. L., Hsu, Y., and Youle, R. J. (1999). Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J. 18, 2330-2341.
21. Noh, J. S., Kang, H. J., Kim, E. Y., Sohn, S., Chung, Y. K., Kim, S. U., and Gwag, B. J. (2000). Haloperidol-induced neuronal apoptosis: Role of p38 and c-Jun-NH(2)-terminal protein kinase. J. Neurochem. 75, 2327-2334.
22. Patel, M. N., Yim, G. K. W., and Isom, G. E. (1992). Blockade of N-methyl-D-aspartate receptors prevent cyanide-induced neuronal injury in primary hippocampal cultures. Toxicol. Appl. Pharmacol. 115, 124-129.
23. Prabhakaran, K., Li, L., Borowitz, J. L., and Isom, G. E. (2002). Cyanide induces different modes of death in cortical and mesencephalon cells. J. Pharmacol. Exp. Ther. 303, 510-519.
24. Putcha, G. V., Deshmukl, M., and Johnson, E. M. (1999). Bax translocation 'is a critical event in neuronal apoptosis: Regulation by neuroprotectants Bcl-2 and caspases. J. Neurosci. 19, 7476-7485.
25. Rosse, T., Olivier, R., Monney, L., Rager, M., Conus, S., Fellay, L., Jansen, B., and Borner, C. (1998). Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 391, 496-499.
26. Shimizu, S., Eguchi, Y., Kamuke, W., Waguri, S., Zuchiyama, Y., Matsuda, H., and Tsujimoto, Y. (1996). Bcl-2 block loss of mitochondrial membrane potential while ICE inhibitors act as a different step during inhibition of death induced respiratory chain inhibitors. Oncogene 13, 21-29.
27. Shimizu, S., Narita, M., and Tsujimoto, Y. (1999). Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399, 483-487.
28. L determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax. Oncogene 18, 5703-5713.
29. Shou, Y., Gunasekar, P. G., Borowitz, J. L., and Isom, G. E. (2000). Cyanide-induced apoptosis involves oxidative-stress-activated NF-κB in cortical neurons. Toxicol. Appl. Pharmacol. 164, 196-205.
30. S and Bax contributes to cyotchrome c release in cyanide-induced apoptosis. J. Neurochem. 81, 842-852.
31. Sun, P., Rane, S. G., Gunasekar, P. G., Borowitz, J. L., and Isom, G. E. (1997). Modulation of the NMDA receptor by cyanide: Enhancement of receptor-mediated responses. J. Pharmacol. Exp. Ther. 280, 1341-1348.
32. Takagi, Y., Nozaki, K., Sugino, T., Hattori, I., and Hashimoto, N. (2000). Phosphorylation of c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase after transient forebrain ischemia in mice. Neurosci. Lett. 294, 117-120.
33. Wiu, J., Grate, M. R., Schmura, S. M., Glasgow, J. N., Kent, T. A., Rassin, D. K., and Perez-Polo, J. R. (2001). Differential NF-κB regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia. J. Neurosci. Res. 64, 223-234.
34. Wolter, K. G., Hsu, Y., Smith, C. L., Nechushtan, A., Xi, X., and Youle, R. J. (1997). Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 139, 1281-1292.
35. Yamagishi, S., Yamada, M., Ishikawa, Y., Matsumoto, T., Ikeuchi, T., and Hatanaka, H. (2001). p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons. J. Biol. Chem. 276, 5129-5133.
36. Yang, C. W., Borowitz, J. L., Gunasekar, P. G. and Isom, G. E. (1997). Cyanide stimulated inositol 1,4,5-triphosphate formation: An intracellular neurotoxic signaling cascade. J. Biochem. Toxicol. 11, 251-256.
37. Yin, X. M., Lao, Y., Cao, G., Bai, L., Pei, W., Kuharsky, D. K., and Chen, J. (2002). Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia. J. Biol. Chem. 277, 42074-42081.
38. Yoshino, T., Kishi, H., Nagata, T., Tsukada, K., Saito, S., and Muraguchi, A. (2001). Differential involvement of p38 MAP kinase pathway and Bax translocation in the mitochondrial-mediated cell death in TCR- and dexamethasone-stimulated thymocytes. Eur. J. Immunol. 31, 2702-2708.
39. Zhu, X., Rottkamp, C. A., Boux, H., Takeda, A., Perry, G., and Smith, M. A. (2000). Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J. Neuropathol. Exp. Neurol. 59, 880-888.