Baicalein protects Human melanocytes from H2O 2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway

Free Radical Biology and Medicine

Volumn 53, Issue 2, 2012, Pages 183-193

  Liu, Bangmin ^a   Jian, Zhe ^a   Li, Qiang ^a   Li, Kai ^a   Wang, Zhiyong ^a   Liu, Ling ^a   Tang, Lingzhen ^a   Yi, Xiuli ^a   Wang, Hua ^a   Li, Chunying ^a   Gao, Tianwen ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Baicalein; Hydrogen peroxide; Melanocyte; Mitochondrion; Oxidative stress; Vitiligo

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIOXIDANT; BAICALEIN; CASPASE 3; CYTOCHROME C; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MELANOCYTE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; TREATMENT OUTCOME; WESTERN BLOTTING;

ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASE INHIBITORS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAVANONES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; MELANOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES;

EID: 84861976686     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.04.015     Document Type: Article

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