Chlorpyrifos induces MLL translocations through caspase 3-dependent genomic instability and topoisomerase II inhibition in human fetal liver hematopoietic stem cells

Toxicological Sciences

Volumn 147, Issue 2, 2015, Pages 588-606

  Lu, Chengquan ^a,c   Liu, Xiaohui ^a   Liu, Chang ^a   Wang, Jian ^a,c   Li, Chunna ^a   Liu, Qi ^a   Li, Yachen ^a   Li, Shuangyue ^a   Sun, Shu ^a,b   Yan, Jinsong ^a   Shao, Jing ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Maternal and Child Care Service Center of Dalian   (China)

^c Jinzhou City Center for Disease Control and Prevention   (China)

Author keywords

Apoptosis; Chlorpyrifos; DNA double strand break; Hematopoietic stem cells; MLL rearrangement; Topoisomerase II

Indexed keywords

CASPASE 3; CD34 ANTIGEN; CHLORPYRIFOS; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; MIXED LINEAGE LEUKEMIA PROTEIN; GYRASE INHIBITOR; LACTATE DEHYDROGENASE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; ENZYME INHIBITION; FETUS; FETUS LIVER; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE REARRANGEMENT; GENOMIC INSTABILITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEUKEMOGENESIS; LIVER CELL; ACUTE BIPHENOTYPIC LEUKEMIA; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; CHROMOSOMAL INSTABILITY; COMET ASSAY; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; GENE TRANSLOCATION; GENETICS; LIVER; METABOLISM; PHYSIOLOGY;

CASPASE 3; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHLORPYRIFOS; CHROMOSOMAL INSTABILITY; COMET ASSAY; DNA BREAKS, DOUBLE-STRANDED; DNA FRAGMENTATION; HEMATOPOIETIC STEM CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LEUKEMIA, BIPHENOTYPIC, ACUTE; LIVER; TOPOISOMERASE II INHIBITORS; TRANSLOCATION, GENETIC;

EID: 84943746380     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv153     Document Type: Article

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