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Volumn 215, Issue 1, 2012, Pages 42-48

The contribution of human small intestine to chlorpyrifos biotransformation

Author keywords

Chlorpyrifos; CYP3A4; Human small intestine metabolism; Organophosphorothionate pesticide

Indexed keywords

3,5,6 TRICHLOROPYRIN 2 OL; CHLORPYRIFOS; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 84867604028     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.09.016     Document Type: Article
Times cited : (14)

References (48)
  • 2
    • 0037406440 scopus 로고    scopus 로고
    • Poor correlation between intestinal and hepatic metabolic rates of CYP3A4 substrates in rats
    • Aiba T., Takehara Y., Okuno M., Hashimoto Y. Poor correlation between intestinal and hepatic metabolic rates of CYP3A4 substrates in rats. Pharmaceutical Research 2003, 20:745-748.
    • (2003) Pharmaceutical Research , vol.20 , pp. 745-748
    • Aiba, T.1    Takehara, Y.2    Okuno, M.3    Hashimoto, Y.4
  • 3
    • 33751184937 scopus 로고    scopus 로고
    • Foetal and adult human CYP3A isoform in the bioactivation of organophosphorothionate insecticides
    • Buratti F.M., Leoni C., Testai E. Foetal and adult human CYP3A isoform in the bioactivation of organophosphorothionate insecticides. Toxicology Letters 2006, 167:245-255.
    • (2006) Toxicology Letters , vol.167 , pp. 245-255
    • Buratti, F.M.1    Leoni, C.2    Testai, E.3
  • 4
    • 31344438066 scopus 로고    scopus 로고
    • Malathion detoxification by human hepatic carboxylesterases and its inhibition by isomalathion and other pesticides
    • Buratti F.M., Testai E. Malathion detoxification by human hepatic carboxylesterases and its inhibition by isomalathion and other pesticides. Journal of Biochemical and Molecular Toxicology 2005, 19:406-414.
    • (2005) Journal of Biochemical and Molecular Toxicology , vol.19 , pp. 406-414
    • Buratti, F.M.1    Testai, E.2
  • 6
    • 34047110668 scopus 로고    scopus 로고
    • Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice
    • Cometa M.F., Buratti F.M., Fortuna S., Lorenzini P., Volpe M.T., Parisi L., Testai E., Meneguz A. Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice. Toxicology 2007, 234:90-102.
    • (2007) Toxicology , vol.234 , pp. 90-102
    • Cometa, M.F.1    Buratti, F.M.2    Fortuna, S.3    Lorenzini, P.4    Volpe, M.T.5    Parisi, L.6    Testai, E.7    Meneguz, A.8
  • 7
    • 0036177206 scopus 로고    scopus 로고
    • Appraisal of risks from nonoccupational exposure to chlorpyrifos
    • Cochran R.C. Appraisal of risks from nonoccupational exposure to chlorpyrifos. Regulatory Toxicology and Pharmacology 2002, 35(1):105-121.
    • (2002) Regulatory Toxicology and Pharmacology , vol.35 , Issue.1 , pp. 105-121
    • Cochran, R.C.1
  • 8
    • 0037416093 scopus 로고    scopus 로고
    • Intestinal permeability of chlorpyrifos using the single-pass intestinal perfusion method in the rat
    • Cook T.J., Shenoy S.S. Intestinal permeability of chlorpyrifos using the single-pass intestinal perfusion method in the rat. Toxicology 2003, 184:125-133.
    • (2003) Toxicology , vol.184 , pp. 125-133
    • Cook, T.J.1    Shenoy, S.S.2
  • 10
    • 77957287125 scopus 로고    scopus 로고
    • Human variation in CYP-specific chlorpyrifos metabolism
    • Croom E.L., Wallace A.D., Hogdson E. Human variation in CYP-specific chlorpyrifos metabolism. Toxicology 2010, 276:184-191.
    • (2010) Toxicology , vol.276 , pp. 184-191
    • Croom, E.L.1    Wallace, A.D.2    Hogdson, E.3
  • 11
    • 84855429902 scopus 로고    scopus 로고
    • Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon
    • Crow J.A., Bittles V., Herring K.L., Borazjani A., Potter P.M., Ross M.K. Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon. Toxicology and Applied Pharmacology 2012, 258:145-150.
    • (2012) Toxicology and Applied Pharmacology , vol.258 , pp. 145-150
    • Crow, J.A.1    Bittles, V.2    Herring, K.L.3    Borazjani, A.4    Potter, P.M.5    Ross, M.K.6
  • 13
    • 0029855969 scopus 로고    scopus 로고
    • Comparison between permeability coefficients in rat and human jejunum
    • Fagerholm U., Johansson M., Lennemas H. Comparison between permeability coefficients in rat and human jejunum. Pharmaceutical Research 1996, 13:1336-1342.
    • (1996) Pharmaceutical Research , vol.13 , pp. 1336-1342
    • Fagerholm, U.1    Johansson, M.2    Lennemas, H.3
  • 15
    • 33747599176 scopus 로고    scopus 로고
    • Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism
    • Galetin A., Houston J.B. Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism. Journal of Pharmacology and Experimental Therapeutics 2006, 318:1220-1229.
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.318 , pp. 1220-1229
    • Galetin, A.1    Houston, J.B.2
  • 17
    • 77950953973 scopus 로고    scopus 로고
    • Sex-dependent differences in cytochrome P450 3A activity as assessed by midazolam disposition in humans: a meta-analysis
    • Hu Z.Y., Zhao Y.S. Sex-dependent differences in cytochrome P450 3A activity as assessed by midazolam disposition in humans: a meta-analysis. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2010, 38(5):817-823.
    • (2010) Drug Metabolism and Disposition: The Biological Fate of Chemicals , vol.38 , Issue.5 , pp. 817-823
    • Hu, Z.Y.1    Zhao, Y.S.2
  • 19
    • 48549096838 scopus 로고    scopus 로고
    • Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates
    • Komura H., Iwaki M. Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates. Journal of Pharmaceutical Sciences 2007, 97:1775-1800.
    • (2007) Journal of Pharmaceutical Sciences , vol.97 , pp. 1775-1800
    • Komura, H.1    Iwaki, M.2
  • 22
    • 56049096438 scopus 로고    scopus 로고
    • The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion
    • Leoni C., Buratti F.M., Testai E. The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicology and Applied Pharmacology 2008, 233(2):343-352.
    • (2008) Toxicology and Applied Pharmacology , vol.233 , Issue.2 , pp. 343-352
    • Leoni, C.1    Buratti, F.M.2    Testai, E.3
  • 30
    • 0037387854 scopus 로고    scopus 로고
    • In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon
    • Poet T.S., Wu K., Kousba A.A., Timchalk C. In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon. Toxicological Sciences 2003, 72:193-200.
    • (2003) Toxicological Sciences , vol.72 , pp. 193-200
    • Poet, T.S.1    Wu, K.2    Kousba, A.A.3    Timchalk, C.4
  • 31
    • 0018886929 scopus 로고
    • Biotransformation of xenobiotics in the fetus
    • Pelkonen O. Biotransformation of xenobiotics in the fetus. Pharmacology & Therapeutics 1980, 10:261-281.
    • (1980) Pharmacology & Therapeutics , vol.10 , pp. 261-281
    • Pelkonen, O.1
  • 33
    • 0034990759 scopus 로고    scopus 로고
    • Use of pharmacokinetic model to assess chlorpyrifos exposure and dose in children, based on urinary biomarker measurement
    • Rigas M.L., Okino M.S., Quackenboss J.J. Use of pharmacokinetic model to assess chlorpyrifos exposure and dose in children, based on urinary biomarker measurement. Toxicological Sciences 2001, 61:374-381.
    • (2001) Toxicological Sciences , vol.61 , pp. 374-381
    • Rigas, M.L.1    Okino, M.S.2    Quackenboss, J.J.3
  • 36
    • 0032451517 scopus 로고    scopus 로고
    • Aggregate exposures under the food quality protection act: an approach using chlorpyrifos
    • Schurdut B.A., Barraj L., Francis M. Aggregate exposures under the food quality protection act: an approach using chlorpyrifos. Regulatory Toxicology and Pharmacology 1998, 28:165-177.
    • (1998) Regulatory Toxicology and Pharmacology , vol.28 , pp. 165-177
    • Schurdut, B.A.1    Barraj, L.2    Francis, M.3
  • 37
    • 21344447719 scopus 로고    scopus 로고
    • Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line:molective secretion of PON1 and PON2
    • Shamir R., Hartman C., Karry R., Pavlotzky E., Eliakim R., Lachter J., Suissa A., Aviram M. Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line:molective secretion of PON1 and PON2. Free Radical Biology and Medicine 2005, 39:336-344.
    • (2005) Free Radical Biology and Medicine , vol.39 , pp. 336-344
    • Shamir, R.1    Hartman, C.2    Karry, R.3    Pavlotzky, E.4    Eliakim, R.5    Lachter, J.6    Suissa, A.7    Aviram, M.8
  • 38
    • 0141569628 scopus 로고    scopus 로고
    • Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug ensistance 1 subfamily mRNAs in rat small intestine
    • Takara K., Ohnishi N., Horibe S., Yokoyama T. Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug ensistance 1 subfamily mRNAs in rat small intestine. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2003, 31:1235-1239.
    • (2003) Drug Metabolism and Disposition: The Biological Fate of Chemicals , vol.31 , pp. 1235-1239
    • Takara, K.1    Ohnishi, N.2    Horibe, S.3    Yokoyama, T.4
  • 39
    • 34548498086 scopus 로고    scopus 로고
    • Carboxylesterase in the liver and small intestine of experimental animals and human
    • Taketani M., Shii M., Ohura K., Ninomiya S., Imai T. Carboxylesterase in the liver and small intestine of experimental animals and human. Life Sciences 2007, 81:924-932.
    • (2007) Life Sciences , vol.81 , pp. 924-932
    • Taketani, M.1    Shii, M.2    Ohura, K.3    Ninomiya, S.4    Imai, T.5
  • 42
    • 0036191658 scopus 로고    scopus 로고
    • A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans
    • Timchalk C., Nolan R.J., Mendrala A.L., Dittenber D.A., Brzak K.A., Mattsson J.L. A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicological Sciences 2002, 66:34-53.
    • (2002) Toxicological Sciences , vol.66 , pp. 34-53
    • Timchalk, C.1    Nolan, R.J.2    Mendrala, A.L.3    Dittenber, D.A.4    Brzak, K.A.5    Mattsson, J.L.6
  • 44
    • 78650517988 scopus 로고    scopus 로고
    • Caco-2/TC7 cell line characterization for intestinal absorption: how reliable is this in vitro model for the prediction of the oral dose fraction absorbed in human?
    • Turco L., Catone T., Caloni F., Di Consiglio E., Testai E., Stammati A. Caco-2/TC7 cell line characterization for intestinal absorption: how reliable is this in vitro model for the prediction of the oral dose fraction absorbed in human?. Toxicology in Vitro 2011, 25:13-20.
    • (2011) Toxicology in Vitro , vol.25 , pp. 13-20
    • Turco, L.1    Catone, T.2    Caloni, F.3    Di Consiglio, E.4    Testai, E.5    Stammati, A.6
  • 45
    • 1542376174 scopus 로고    scopus 로고
    • Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: a comparative analysis in paired tissue specimens
    • von Richter O., Burk O., Fromm M.F., Thon K.P., Eichelbaum M., Kivistö K.T. Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: a comparative analysis in paired tissue specimens. Clinical Pharmacology and Therapeutics 2004, 75:172-183.
    • (2004) Clinical Pharmacology and Therapeutics , vol.75 , pp. 172-183
    • von Richter, O.1    Burk, O.2    Fromm, M.F.3    Thon, K.P.4    Eichelbaum, M.5    Kivistö, K.T.6
  • 48
    • 0035054725 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption combined role of cytochrome P450 3A and P-glycoprotein
    • Zhang Y., Benet L.Z. The gut as a barrier to drug absorption combined role of cytochrome P450 3A and P-glycoprotein. Clinical Pharmacokinetics 2001, 40:159-168.
    • (2001) Clinical Pharmacokinetics , vol.40 , pp. 159-168
    • Zhang, Y.1    Benet, L.Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.