Ameliorating the developmental neurotoxicity of chlorpyrifos: A mechanisms-based approach in PC12 cells

Environmental Health Perspectives

Volumn 115, Issue 9, 2007, Pages 1306-1313

  Slotkin, Theodore A ^a   MacKillop, Emiko A ^a   Ryde, Ian T ^a   Seidler, Frederic J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenylyl cyclase; Brain development; Chlorpyrifos; Cholinergic antagonists; Neurotoxicity; Nicotine; Organophosphate insecticides; Oxidative stress; Theophylline; Vitamin E

Indexed keywords

ADENYLATE CYCLASE; ALPHA TOCOPHEROL; ATROPINE; CHLORPYRIFOS; CHOLINERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP; MECAMYLAMINE; NICOTINE; NICOTINIC RECEPTOR; THEOPHYLLINE;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL LOSS; CELL SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; MAMMAL CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TOXICOKINETICS;

ADENYLATE CYCLASE; ANIMALS; ANTIDOTES; ANTIOXIDANTS; ATROPINE; BRAIN; CELL PROLIFERATION; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DNA; INSECTICIDES; MECAMYLAMINE; MUSCARINIC ANTAGONISTS; NEURONS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; NUCLEIC ACID SYNTHESIS INHIBITORS; OXIDATIVE STRESS; PC12 CELLS; RATS; THEOPHYLLINE; VITAMIN E;

MAMMALIA;

EID: 34748818046     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.10194     Document Type: Article

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