MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells

Carcinogenesis

Volumn 27, Issue 4, 2006, Pages 874-881

  Moneypenny, Craig G ^a,c   Shao, Jing ^a   Song, Yanyu ^b   Gallagher, Evan P ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE;

ACUTE LEUKEMIA; ARTICLE; CANCER CHEMOTHERAPY; CELL CULTURE; CELL CYCLE ARREST; CELL DAMAGE; CELL POPULATION; CELL PROLIFERATION; CELL VIABILITY; CHROMOSOME 11Q; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DATA ANALYSIS; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG SENSITIVITY; ENZYME INHIBITION; FETUS CELL; FETUS DEVELOPMENT; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IN VITRO STUDY; LEUKEMOGENESIS; LIVER; LOW DRUG DOSE; LYMPHOID CELL; PRENATAL EXPOSURE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL SURVIVAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; FEMALE; FETUS; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA; MATERNAL-FETAL EXCHANGE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PREGNANCY;

EID: 33645319963     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi322     Document Type: Article

References (47)

1. Morrison,S.J., Uchida,N. and Weissman,I.L. (1995) The biology of hematopoietic stem cells. Annu. Rev. Cell Dev. Biol., 11, 35-71.
2. Hakkola,J., Pelkonen,O., Pasanen,M. and Raunio,H. (1998) Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: Role in intrauterine toxicity. Crit. Rev. Toxicol., 28, 35-72.
3. Sancewicz-Pach,K., Groszek,B., Pach,D. and Klys,M. (1997) Acute pesticides poisonings in pregnant women. Przegl Lek, 54, 741-744.
4. Moneypenny,C.G. and Gallagher,E.P. (2005) 4-Hydroxynonenal inhibits cell proliferation and alters differentiation pathways in human fetal liver hematopoietic stem cells. Biochem. Pharmacol., 69, 105-112.
5. Tavassoli,M. (1991) Embryonic and fetal hemopoiesis: An overview. Blood Cells, 17, 269-281, Discussion 282-286.
6. Infante-Rivard,C., Labuda,D., Krajinovic,M. and Sinnett,D. (1999) Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology, 10, 481-487.
7. Woodruff,T.J., Axelrad,D.A., Kyle,A.D., Nweke,O., Miller,G.G. and Hurley,B.J. (2004) Trends in environmentally related childhood illnesses. Pediatrics, 113, 1133-1140.
8. Alexander,F.E., Patheal,S.L., Biondi,A. et al. (2001) Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Cancer Res., 61, 2542-2546.
9. Zahm,S.H. (1999) Childhood leukemia and pesticides. Epidemiology, 10, 473-475.
10. Borkhardt,A., Wilda,M., Fuchs,U., Gortner,L. and Reiss,I. (2003) Congenital leukaemia after heavy abuse of permethrin during pregnancy. Arch. Dis. Child Fetal. Neonatal Ed., 88, F436-F437.
11. Ma,X., Buffler,P.A., Gunier,R.B., Dahl,G., Smith,M.T., Reinier,K. and Reynolds,P. (2002) Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ. Health Perspect., 110, 955-960.
12. Shu,X.O. (1997) Epidemiology of childhood leukemia. Curr. Opin. Hematol., 4, 227-232.
13. Thirman,M.J., Gill,H.J., Burnett,R.C. et al. (1993) Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N. Engl. J. Med., 329, 909-914.
14. Kaneko,Y., Shikano,T., Maseki,N., Sakurai,M., Takeda,T., Hiyoshi,Y., Mimaya,J. and Fujimoto,T. (1988) Clinical characteristics of infant acute leukemia with or without 11q23 translocations. Leukemia, 2, 672-676.
15. Yagi,T., Hibi,S., Tabata,Y. et al. (2000) Detection of clonotypic IGH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia. Blood, 96, 264-268.
16. Hjalgrim,L.L., Madsen,H.O., Melbye,M. et al. (2002) Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. Br. J. Cancer, 87, 994-999.
17. Armstrong,S.A., Golub,T.R. and Korsmeyer,S.J. (2003) MLL-rearranged leukemias: Insights from gene expression profiling. Semin. Hematol, 40, 268-273.
18. Gale,K.B., Ford,A.M., Repp,R., Borkhardt,A., Keller,C., Eden,O.B. and Greaves,M.F. (1997) Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots. Proc. Natl Acad. Sci. USA, 94, 13950-13954.
19. Blanco,J.G., Dervieux,T., Edick,M.J., Mehta,P.K., Rubnitz,J.E., Shurtleff,S., Raimondi,S.C., Behm,F.G., Pui,C.H. and Relling,M.V. (2001) Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia. Proc. Natl Acad. Sci. USA, 98, 10338-10343.
20. Zhang,Y., Poetsch,M., Weber-Matthiesen,K. et al. (1996) Secondary acute leukaemias with 11q23 rearrangement: Clinical, cytogenetic, FISH and FICTION studies. Br. J. Haematol., 92, 673-680.
21. Ahmed,S.A., Gogal,R.M.,Jr and Walsh,J.E. (1994) A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: An alternative to [3H]thymidine incorporation assay. J. Immunol. Meth., 170, 211-224.
22. Blood,A., Edwards,C.J., Ishii,H.H., Pat,B.K., Bryson,G., Sculley,T.B. and Gobe,G.C. (2004) Epstein-Barr virus-mediated protection against etoposide-induced apoptosis in BJA-B B cell lymphoma cells: Role of Bcl-2 and caspase proteins. Arch Virol., 149, 289-302.
23. Jackman,S.M., Grant,G.M., Kolanko,C.J., Stenger,D.A. and Nath,J. (2002) DNA damage assessment by comet assay of human lymphocytes exposed to jet propulsion fuels. Environ. Mol. Mutagen., 40, 18-23.
24. Behm,F.G., Smith,F.O., Raimondi,S.C., Pui,C.H. and Bernstein,I.D. (1996) Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements. Blood, 87, 1134-1139.
25. Smith,F.O., Rauch,C., Williams,D.E. et al. (1996) The human homologue of rat NG2, a chondroitin sulfate proteoglycan, is not expressed on the cell surface of normal hematopoietic cells but is expressed by acute myeloid leukemia blasts from poor-prognosis patients with abnormalities of chromosome band 11q23. Blood, 87, 1123-1133.
26. Hilden,J.M., Smith,F.O., Frestedt,J.L. et al. (1997) MLL gene rearrangement, cytogenetic 11q23 abnormalities, and expression of the NG2 molecule in infant acute myeloid leukemia. Blood, 89, 3801-3805.
27. Yamamoto,K., Hato,A., Minagawa,K., Yakushijin,K., Urahama,N., Gomyo,H., Sada,A., Okamura,A., Ito,M. and Matsui,T. (2004) Unbalanced translocation der(11)t(11;12)(q23;q13): A new recurrent cytogenetic aberration in myelodysplastic syndrome with a complex karyotype. Cancer Genet. Cytogenet., 155, 67-73.
28. Dube,S., Fetni,R., Hazourli,S., Champagne,M. and Lemieux,N. (2003) Rearrangement of the MLL gene and a region proximal to the RARalpha gene in a case of acute myelocytic leukemia M5 with a t(11;17)(q23;q21). Cancer Genet. Cytogenet., 145, 54-59.
29. Muench,M.O., Firpo,M.T. and Moore,M.A. (1993) Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential. Blood, 81, 3463-3473.
30. Martinez-Jaramillo,G., Flores-Guzman,P., Montesinos,J.J., Quintana,S., Bautista,J., Sanchez-Valle,E., de Jesus Nambo,M. and Mayani,H. (2004) In vitro proliferation and expansion of hematopoietic progenitors present in mobilized peripheral blood from normal subjects and cancer patients. Stem. Cells Dev., 13, 382-389.
31. Gardner,J.L., Doi,A.M., Pham,R.T., Huisden,C.M. and Gallagher,E.P. (2003) Ontogenic differences in human liver 4-hydroxynonenal detoxification are associated with in vitro injury to fetal hematopoietic stem cells. Toxicol. Appl. Pharmacol., 191, 95-106.
32. - hematopoietic precursors derived from human embryonic stem cells exhibit an embryonic gene expression pattern. Blood, 103, 4134-4141.
33. Ng,Y.Y., van Kessel,B., Lokhorst,H.M., Baert,M.R., van den Burg,C.M., Bloem,A.C. and Staal,F.J. (2004) Gene-expression profiling of CD34+ cells from various hematopoiesic stem-cell sources reveals functional differences in stem-cell activity. J. Leukoc. Biol., 75, 314-323.
34. Shojaei,F., Gallacher,L. and Bhatia,M. (2004) Differential gene expression of human stem progenitor cells derived from early stages of in utero human hematopoiesis. Blood, 103, 2530-2540.
35. Edick,M.J., Gajjar,A., Mahmoud,H.H. et al. (2003) Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia. J. Clin. Oncol., 21, 1340-1346.
36. Godard,T., Deslandes,E., Sichel,F., Poul,J.M. and Gauduchon,P. (2002) Detection of topoisomerase inhibitor-induced DNA strand breaks and apoptosis by the alkaline comet assay. Mutat Res., 520, 47-56.
37. Chandna,S. (2004) Single-cell gel electrophoresis assay monitors precise kinetics of DNA fragmentation induced during programmed cell death. Cytometry A, 61, 127-133.
38. Davies,J.H., Evans,B.A., Jenney,M.E. and Gregory,J.W. (2002) In vitro effects of chemotherapeutic agents on human osteoblast-like cells. Calcif. Tissue Int., 70, 408-415.
39. Li,J., Law,H.K., Lau,Y.L. and Chan,G.C. (2004) Differential damage and recovery of human mesenchymal stem cells after exposure to chemotherapeutic agents. Br. J. Haematol., 127, 326-334.
40. Meyer,C., Schneider,B., Reichel,M. et al. (2005) Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc. Natl Acad. Sci. USA, 102, 449-454.
41. Cuthbert,G., Thompson,K., Breese,G., McCullough,S. and Bown,N. (2000) Sensitivity of FISH in detection of MLL translocations. Genes Chromosomes Cancer, 29, 180-185.
42. Metzler,M., Strissel,P.L., Strick,R. et al. (2004) Emergence of translocation t(9;11)-positive leukemia during treatment of childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer, 41, 291-296.
43. Libura,J., Slater,D.J., Felix,C.A. and Richardson,C. (2005) Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Blood, 105, 2124-2131.
44. Aplan,P.D., Chervinsky,D.S., Stanulla,M. and Burhans,W.C. (1996) Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood, 87, 2649-2658.
45. Ishii,E., Eguchi,M., Eguchi-Ishimae,M., Yoshida,N., Oda,M., Zaitsu,M., Fujita,I., Miyazaki,S., Hamasaki,Y. and Mizutani,S. (2002) In vitro cleavage of the MLL gene by topoisomerase II inhibitor (etoposide) in normal cord and peripheral blood mononuclear cells. Int. J. Hematol., 76, 74-79.
46. Park,J., Ahn,Y.C., Kim,H. et al. (2003) A phase II trial of concurrent chemoradiation therapy followed by consolidation chemotherapy with oral etoposide and cisplatin for locally advanced inoperable non-small cell lung cancers. Lung Cancer, 42, 227-235.
47. Bocskay,K.A., Tang,D., Orjuela,M.A., Liu,X., Warburton,D.P. and Perera,F.P. (2005) Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons. Cancer Epidemiol. Biomarkers Prev., 14, 506-511.