Derivation of human biomonitoring guidance values for chlorpyrifos using a physiologically based pharmacokinetic and pharmacodynamic model of cholinesterase inhibition

Regulatory Toxicology and Pharmacology

Volumn 71, Issue 2, 2015, Pages 235-243

  Arnold, Scott M ^a   Morriss, Alistair ^b   Velovitch, Joseph ^c   Juberg, Daland ^c   Burns, Carol J ^a   Bartels, Michael ^a   Aggarwal, Manoj ^b   Poet, Torka ^d   Hays, Sean ^d   Price, Paul ^a  

^a DOW CHEMICAL COMPANY   (United States)

^b Dow AgroSciences Ltd   (United Kingdom)

^c DOW AGROSCIENCES LLC   (United States)

^d LLP   (United States)

Author keywords

Acetylcholinesterase inhibition; Biomonitoring; Biomonitoring guidance value; Chlorpyrifos; Physiologically based pharmacokinetic pharmacodynamic model; Risk assessment

Indexed keywords

BIOLOGICAL MARKER; CHLORPYRIFOS; CHOLINESTERASE; CHOLINESTERASE INHIBITOR;

ADULT; AGE; ARTICLE; BIOLOGICAL MODEL; BIOLOGICAL MONITORING; BIOMONITORING GUIDANCE VALUES; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; INFANT; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PHARMACODYNAMICS; PHARMACOKINETIC ASSAY; PRACTICE GUIDELINE; RAT; SENSITIVITY ANALYSIS; TOXICOKINETICS; ANIMAL; DOSE RESPONSE; ENVIRONMENTAL MONITORING; METABOLISM; PROCEDURES; STANDARDS;

ADULT; ANIMALS; BIOMARKERS; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL MONITORING; HUMANS; INFANT; MODELS, BIOLOGICAL; RATS;

EID: 84920984090     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2014.12.013     Document Type: Article

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