Optimal cofactor swapping can increase the theoretical yield for chemical production in Escherichia coli and Saccharomyces cerevisiae

Metabolic Engineering

Volumn 24, Issue , 2014, Pages 117-128

  King, Zachary A ^a   Feist, Adam M ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Chalmers University of Technology   (Denmark)

Author keywords

Cofactor balancing; Constraint based modeling; Escherichia coli; Metabolic engineering; MILP; Saccharomyces cerevisiae; Theoretical yield

Indexed keywords

AMINO ACIDS; ENZYMES; ESCHERICHIA COLI; INTEGER PROGRAMMING; METABOLIC ENGINEERING; METABOLISM; STYRENE;

COFACTOR SPECIFICITY; COFACTORS; CONSTRAINT-BASED MODELING; GENOME-SCALE METABOLIC MODELS; HETEROLOGOUS PRODUCTION; MILP; OPTIMIZATION PROCEDURES; THEORETICAL YIELD;

YEAST;

1,3 PROPANEDIOL; 3 HYDROXYBUTYRIC ACID; 3 HYDROXYPROPANOATE; 3 HYDROXYVALERATE; ALCOHOL DEHYDROGENASE; ASPARTIC ACID; CARBON; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ISOLEUCINE; LYSINE; OXIDOREDUCTASE; PROLINE; PUTRESCINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE; STYRENE; UNCLASSIFIED DRUG; XYLOSE; 1,3-PROPANEDIOL; AMINO ACID; BETA-HYDROXYVALERIC ACID; ESCHERICHIA COLI PROTEIN; HYDRACRYLIC ACID; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROPANEDIOL DERIVATIVE; SACCHAROMYCES CEREVISIAE PROTEIN; VALERIC ACID DERIVATIVE;

ANAEROBIC GROWTH; ARTICLE; BIOMASS PRODUCTION; CHEMICAL ANALYSIS; CHEMICAL PARAMETERS; ENZYME MODIFICATION; ESCHERICHIA COLI; GENOME; GLUCOSE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; REACTION OPTIMIZATION; SACCHAROMYCES CEREVISIAE; SENSITIVITY ANALYSIS; YEAST; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; GENETICS; METABOLISM;

3-HYDROXYBUTYRIC ACID; AMINO ACIDS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; LACTIC ACID; NAD; NADP; OXIDOREDUCTASES; PENTANOIC ACIDS; PROPYLENE GLYCOLS; PUTRESCINE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STYRENE;

EID: 84901623994     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.05.009     Document Type: Article

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