메뉴 건너뛰기




Volumn 19, Issue , 2013, Pages 42-49

Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli

Author keywords

Antibiotic; E. coli; Erythromycin; Methylmalonyl CoA; Propionyl CoA; Substrate

Indexed keywords

E. COLI; ERYTHROMYCIN; ERYTHROMYCIN BIOSYNTHESIS; ERYTHROMYCIN PRODUCTION; HETEROLOGOUS PRODUCTION; METHYLMALONYL-COA; PATHWAY ENGINEERINGS; PROPIONYL-COA;

EID: 84879825498     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2013.05.005     Document Type: Article
Times cited : (27)

References (42)
  • 1
    • 0032532250 scopus 로고    scopus 로고
    • A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii-cloning, sequencing, and expression of the enzymes in Escherichia coli
    • An J.H., Kim Y.S. A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii-cloning, sequencing, and expression of the enzymes in Escherichia coli. Eur. J. Biochem. 1998, 257:395-402.
    • (1998) Eur. J. Biochem. , vol.257 , pp. 395-402
    • An, J.H.1    Kim, Y.S.2
  • 2
    • 0033571053 scopus 로고    scopus 로고
    • Identification of residues essential for a two-step reaction by malonyl-CoA synthetase from Rhizobium trifolii
    • An J.H., Lee G.Y., Jung J.W., Lee W., Kim Y.S. Identification of residues essential for a two-step reaction by malonyl-CoA synthetase from Rhizobium trifolii. Biochem. J. 1999, 344(Pt 1):159-166.
    • (1999) Biochem. J. , vol.344 , Issue.PART 1 , pp. 159-166
    • An, J.H.1    Lee, G.Y.2    Jung, J.W.3    Lee, W.4    Kim, Y.S.5
  • 3
    • 84855803016 scopus 로고    scopus 로고
    • LC-MS/MS quantification of short-chain acyl-CoA's in Escherichia coli demonstrates versatile propionyl-CoA synthetase substrate specificity
    • Armando J.W., Boghigian B.A., Pfeifer B.A. LC-MS/MS quantification of short-chain acyl-CoA's in Escherichia coli demonstrates versatile propionyl-CoA synthetase substrate specificity. Lett. Appl. Microbiol. 2012, 54:140-148.
    • (2012) Lett. Appl. Microbiol. , vol.54 , pp. 140-148
    • Armando, J.W.1    Boghigian, B.A.2    Pfeifer, B.A.3
  • 4
    • 57449098845 scopus 로고    scopus 로고
    • Directed evolution of Methanococcus jannaschii citramalate synthase for biosynthesis of 1-propanol and 1-butanol by Escherichia coli
    • Atsumi S., Liao J.C. Directed evolution of Methanococcus jannaschii citramalate synthase for biosynthesis of 1-propanol and 1-butanol by Escherichia coli. Appl. Environ. Microbiol. 2008, 74:7802-7808.
    • (2008) Appl. Environ. Microbiol. , vol.74 , pp. 7802-7808
    • Atsumi, S.1    Liao, J.C.2
  • 5
    • 45849114725 scopus 로고    scopus 로고
    • Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli
    • Boghigian B.A., Pfeifer B.A. Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli. Biotechnol. Lett. 2008, 30:1323-1330.
    • (2008) Biotechnol. Lett. , vol.30 , pp. 1323-1330
    • Boghigian, B.A.1    Pfeifer, B.A.2
  • 6
    • 76749097100 scopus 로고    scopus 로고
    • Metabolic flux analysis and pharmaceutical production
    • Boghigian B.A., Seth G., Kiss R., Pfeifer B.A. Metabolic flux analysis and pharmaceutical production. Metab. Eng. 2010, 12:81-95.
    • (2010) Metab. Eng. , vol.12 , pp. 81-95
    • Boghigian, B.A.1    Seth, G.2    Kiss, R.3    Pfeifer, B.A.4
  • 7
    • 79954618309 scopus 로고    scopus 로고
    • Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions
    • Boghigian B.A., Zhang H., Pfeifer B.A. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnol. Bioeng. 2011, 108:1360-1371.
    • (2011) Biotechnol. Bioeng. , vol.108 , pp. 1360-1371
    • Boghigian, B.A.1    Zhang, H.2    Pfeifer, B.A.3
  • 9
    • 84865590395 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of 1-propanol
    • Choi Y.J., Park J.H., Kim T.Y., Lee S.Y. Metabolic engineering of Escherichia coli for the production of 1-propanol. Metab. Eng. 2012, 14:477-486.
    • (2012) Metab. Eng. , vol.14 , pp. 477-486
    • Choi, Y.J.1    Park, J.H.2    Kim, T.Y.3    Lee, S.Y.4
  • 10
    • 0025081416 scopus 로고
    • An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
    • Cortes J., Haydock S.F., Roberts G.A., Bevitt D.J., Leadlay P.F. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature 1990, 348:176-178.
    • (1990) Nature , vol.348 , pp. 176-178
    • Cortes, J.1    Haydock, S.F.2    Roberts, G.A.3    Bevitt, D.J.4    Leadlay, P.F.5
  • 11
    • 0037161282 scopus 로고    scopus 로고
    • Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli
    • Dayem L.C., Carney J.R., Santi D.V., Pfeifer B.A., Khosla C., Kealey J.T. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry 2002, 41:5193-5201.
    • (2002) Biochemistry , vol.41 , pp. 5193-5201
    • Dayem, L.C.1    Carney, J.R.2    Santi, D.V.3    Pfeifer, B.A.4    Khosla, C.5    Kealey, J.T.6
  • 12
    • 0026415106 scopus 로고
    • Modular organization of genes required for complex polyketide biosynthesis
    • Donadio S., Staver M.J., McAlpine J.B., Swanson S.J., Katz L. Modular organization of genes required for complex polyketide biosynthesis. Science 1991, 252:675-679.
    • (1991) Science , vol.252 , pp. 675-679
    • Donadio, S.1    Staver, M.J.2    McAlpine, J.B.3    Swanson, S.J.4    Katz, L.5
  • 13
    • 78649323531 scopus 로고    scopus 로고
    • Engineered polyketide biosynthesis and biocatalysis in Escherichia coli
    • Gao X., Wang P., Tang Y. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl. Microbiol. Biotechnol. 2010, 88:1233-1242.
    • (2010) Appl. Microbiol. Biotechnol. , vol.88 , pp. 1233-1242
    • Gao, X.1    Wang, P.2    Tang, Y.3
  • 14
    • 84871840984 scopus 로고    scopus 로고
    • The structures of type I polyketide synthases
    • Keatinge-Clay A.T. The structures of type I polyketide synthases. Nat. Prod. Rep. 2012, 29:1050-1073.
    • (2012) Nat. Prod. Rep. , vol.29 , pp. 1050-1073
    • Keatinge-Clay, A.T.1
  • 15
    • 0345060483 scopus 로고    scopus 로고
    • 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering
    • Kennedy J., Murli S., Kealey J.T. 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. Biochemistry 2003, 42:14342-14348.
    • (2003) Biochemistry , vol.42 , pp. 14342-14348
    • Kennedy, J.1    Murli, S.2    Kealey, J.T.3
  • 16
    • 1942455740 scopus 로고    scopus 로고
    • Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli
    • Lau J., Tran C., Licari P., Galazzo J. Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. J. Biotechnol. 2004, 110:95-103.
    • (2004) J. Biotechnol. , vol.110 , pp. 95-103
    • Lau, J.1    Tran, C.2    Licari, P.3    Galazzo, J.4
  • 17
    • 42549160614 scopus 로고    scopus 로고
    • Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids
    • Leonard E., Yan Y., Fowler Z.L., Li Z., Lim C.G., Lim K.H., Koffas M.A. Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids. Mol. Pharm. 2008, 5:257-265.
    • (2008) Mol. Pharm. , vol.5 , pp. 257-265
    • Leonard, E.1    Yan, Y.2    Fowler, Z.L.3    Li, Z.4    Lim, C.G.5    Lim, K.H.6    Koffas, M.A.7
  • 20
    • 53149107492 scopus 로고    scopus 로고
    • Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
    • Ma J., Zhang P., Zhang Z., Zha M., Xu H., Zhao G., Ding J. Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans. Biochem. J. 2008, 415:45-56.
    • (2008) Biochem. J. , vol.415 , pp. 45-56
    • Ma, J.1    Zhang, P.2    Zhang, Z.3    Zha, M.4    Xu, H.5    Zhao, G.6    Ding, J.7
  • 22
    • 0033515090 scopus 로고    scopus 로고
    • Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    • McDaniel R., Thamchaipenet A., Gustafsson C., Fu H., Betlach M., Ashley G. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc. Nat. Acad. Sci. USA 1999, 96:1846-1851.
    • (1999) Proc. Nat. Acad. Sci. USA , vol.96 , pp. 1846-1851
    • McDaniel, R.1    Thamchaipenet, A.2    Gustafsson, C.3    Fu, H.4    Betlach, M.5    Ashley, G.6
  • 24
    • 23744444815 scopus 로고    scopus 로고
    • Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1
    • Murli S., MacMillan K.S., Hu Z., Ashley G.W., Dong S.D., Kealey J.T., Reeves C.D., Kennedy J. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. Appl. Environ. Microbiol. 2005, 71:4503-4509.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 4503-4509
    • Murli, S.1    MacMillan, K.S.2    Hu, Z.3    Ashley, G.W.4    Dong, S.D.5    Kealey, J.T.6    Reeves, C.D.7    Kennedy, J.8
  • 26
    • 0031888940 scopus 로고    scopus 로고
    • The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea
    • Pereda A., Summers R.G., Stassi D.L., Ruan X., Katz L. The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea. Microbiology 1998, 144(Pt 2):543-553.
    • (1998) Microbiology , vol.144 , Issue.PART 2 , pp. 543-553
    • Pereda, A.1    Summers, R.G.2    Stassi, D.L.3    Ruan, X.4    Katz, L.5
  • 27
    • 0035793858 scopus 로고    scopus 로고
    • Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
    • Pfeifer B.A., Admiraal S.J., Gramajo H., Cane D.E., Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 2001, 291:1790-1792.
    • (2001) Science , vol.291 , pp. 1790-1792
    • Pfeifer, B.A.1    Admiraal, S.J.2    Gramajo, H.3    Cane, D.E.4    Khosla, C.5
  • 28
    • 79959424209 scopus 로고    scopus 로고
    • Metabolic engineering for the production of natural products
    • Pickens L.B., Tang Y., Chooi Y. Metabolic engineering for the production of natural products. Ann. Rev. Chem. Biomol. Eng. 2011, 2:211-236.
    • (2011) Ann. Rev. Chem. Biomol. Eng. , vol.2 , pp. 211-236
    • Pickens, L.B.1    Tang, Y.2    Chooi, Y.3
  • 29
    • 0030049982 scopus 로고    scopus 로고
    • Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates
    • Pieper R., Ebert-Khosla S., Cane D., Khosla C. Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates. Biochemistry 1996, 35:2054-2060.
    • (1996) Biochemistry , vol.35 , pp. 2054-2060
    • Pieper, R.1    Ebert-Khosla, S.2    Cane, D.3    Khosla, C.4
  • 30
    • 0028784464 scopus 로고
    • Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
    • Pieper R., Luo G., Cane D.E., Khosla C. Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. Nature 1995, 378:263-266.
    • (1995) Nature , vol.378 , pp. 263-266
    • Pieper, R.1    Luo, G.2    Cane, D.E.3    Khosla, C.4
  • 31
    • 0032746921 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)
    • Rodriguez E., Gramajo H. Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). Microbiology 1999, 145(Pt 11):3109-3119.
    • (1999) Microbiology , vol.145 , Issue.PART 11 , pp. 3109-3119
    • Rodriguez, E.1    Gramajo, H.2
  • 32
    • 0030831132 scopus 로고    scopus 로고
    • Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in l-mycarose and d-desosamine production
    • Summers R.G., Donadio S., Staver M.J., Wendt-Pienkowski E., Hutchinson C.R., Katz L. Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in l-mycarose and d-desosamine production. Microbiology 1997, 143(Pt 10):3251-3262.
    • (1997) Microbiology , vol.143 , Issue.PART 10 , pp. 3251-3262
    • Summers, R.G.1    Donadio, S.2    Staver, M.J.3    Wendt-Pienkowski, E.4    Hutchinson, C.R.5    Katz, L.6
  • 33
    • 78649326953 scopus 로고    scopus 로고
    • Biosynthesis of chiral 3-hydroxyvalerate from single propionate-unrelated carbon sources in metabolically engineered E. coli
    • Tseng H.C., Harwell C.L., Martin C.H., Prather K.L. Biosynthesis of chiral 3-hydroxyvalerate from single propionate-unrelated carbon sources in metabolically engineered E. coli. Microb. Cell Factories 2010, 9:96-104.
    • (2010) Microb. Cell Factories , vol.9 , pp. 96-104
    • Tseng, H.C.1    Harwell, C.L.2    Martin, C.H.3    Prather, K.L.4
  • 34
    • 84865783440 scopus 로고    scopus 로고
    • Biosynthetic pathway for poly(3-hydroxypropionate) in recombinant Escherichia coli
    • Wang Q., Liu C., Xian M., Zhang Y., Zhao G. Biosynthetic pathway for poly(3-hydroxypropionate) in recombinant Escherichia coli. J. Microbiol. 2012, 50:693-697.
    • (2012) J. Microbiol. , vol.50 , pp. 693-697
    • Wang, Q.1    Liu, C.2    Xian, M.3    Zhang, Y.4    Zhao, G.5
  • 36
    • 27844461167 scopus 로고    scopus 로고
    • Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways
    • Wenzel S.C., Muller R. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr. Opin. Biotechnol. 2005, 16:594-606.
    • (2005) Curr. Opin. Biotechnol. , vol.16 , pp. 594-606
    • Wenzel, S.C.1    Muller, R.2
  • 37
    • 34250701119 scopus 로고    scopus 로고
    • Mining and engineering natural-product biosynthetic pathways
    • Wilkinson B., Micklefield J. Mining and engineering natural-product biosynthetic pathways. Nat. Chem. Biol. 2007, 3:379-386.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 379-386
    • Wilkinson, B.1    Micklefield, J.2
  • 38
    • 39549101609 scopus 로고    scopus 로고
    • Engineering poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer composition in E. coli
    • Wong M.S., Causey T.B., Mantzaris N., Bennett G.N., San K.Y. Engineering poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer composition in E. coli. Biotechnol. Bioeng. 2008, 99:919-928.
    • (2008) Biotechnol. Bioeng. , vol.99 , pp. 919-928
    • Wong, M.S.1    Causey, T.B.2    Mantzaris, N.3    Bennett, G.N.4    San, K.Y.5
  • 39
    • 84865144344 scopus 로고    scopus 로고
    • Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli
    • Yuzawa S., Kim W., Katz L., Keasling J.D. Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli. Curr. Opin. Biotechnol. 2012, 23:727-735.
    • (2012) Curr. Opin. Biotechnol. , vol.23 , pp. 727-735
    • Yuzawa, S.1    Kim, W.2    Katz, L.3    Keasling, J.D.4
  • 40
    • 78649391538 scopus 로고    scopus 로고
    • Methods and options for the heterologous production of complex natural products
    • Zhang H., Boghigian B.A., Armando J., Pfeifer B.A. Methods and options for the heterologous production of complex natural products. Nat. Prod. Rep. 2011, 28:125-151.
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 125-151
    • Zhang, H.1    Boghigian, B.A.2    Armando, J.3    Pfeifer, B.A.4
  • 41
    • 74849084621 scopus 로고    scopus 로고
    • Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli
    • Zhang H., Boghigian B.A., Pfeifer B.A. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnol. Bioeng. 2010, 105:567-573.
    • (2010) Biotechnol. Bioeng. , vol.105 , pp. 567-573
    • Zhang, H.1    Boghigian, B.A.2    Pfeifer, B.A.3
  • 42
    • 78649386219 scopus 로고    scopus 로고
    • Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host
    • Zhang H., Wang Y., Wu J., Skalina K., Pfeifer B.A. Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chem. Biol. 2010, 17:1232-1240.
    • (2010) Chem. Biol. , vol.17 , pp. 1232-1240
    • Zhang, H.1    Wang, Y.2    Wu, J.3    Skalina, K.4    Pfeifer, B.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.