Design of homo-organic acid producing strains using multi-objective optimization

Metabolic Engineering

Volumn 28, Issue , 2015, Pages 63-73

  Kim, Tae Yong ^b   Park, Jong Myoung ^a   Kim, Hyun Uk ^a,c   Cho, Kwang Myung ^b   Lee, Sang Yup ^a,c  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Samsung Advanced Institute of Technology (SAIT)   (South Korea)

^c Chalmers University of Technology   (Denmark)

Author keywords

Byproducts; Homo organic acid; Multi objective optimization; Systems metabolic engineering

Indexed keywords

BYPRODUCTS; COST ENGINEERING; ESCHERICHIA COLI; GENES; METABOLIC ENGINEERING; METABOLISM; ORGANIC ACIDS; STRAIN;

ACID PRODUCING; BIOPROCESS ENGINEERING; GENE KNOCKOUT TARGET; HIGH GROWTH RATE; OPERATION COST; SEPARATION PROCESS; SYSTEMS APPROACH; SYSTEMS METABOLIC ENGINEERINGS;

MULTIOBJECTIVE OPTIMIZATION;

ACETIC ACID; CARBOXYLIC ACID DERIVATIVE; DIHYDROXYACETONE; DIHYDROXYACETONE PHOSPHOTRANSFERASE; FORMIC ACID; FRUCTOSE 6 PHOSPHATE; FRUCTOSE 6 PHOSPHATE ALDOLASE; FUMARATE HYDRATASE; HOMO ORGANIC ACID; LACTIC ACID; LYASE; MULTIENZYME COMPLEX; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE; PYRUVATE FORMATE LYASE; PYRUVIC ACID; SUCCINIC ACID; UNCLASSIFIED DRUG; CARBOXYLIC ACID;

ANAEROBIC FERMENTATION; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BATCH FERMENTATION; CELL GROWTH; CITRIC ACID CYCLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENERGY YIELD; ESCHERICHIA COLI; GENE INACTIVATION; GLYCOLYSIS; METABOLIC CAPACITY; METABOLIC ENGINEERING; MULTI OBJECTIVE OPTIMIZATION; NONHUMAN; OXYGEN CONSUMPTION; PENTOSE PHOSPHATE CYCLE; PHENOTYPE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; WILD TYPE; GENE SILENCING; GENETICS; METABOLISM;

ESCHERICHIA COLI;

CARBOXYLIC ACIDS; ESCHERICHIA COLI; GENE KNOCKDOWN TECHNIQUES; METABOLIC ENGINEERING;

EID: 84920748206     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.11.012     Document Type: Article

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