Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing basfia succiniciproducens

Biotechnology and Bioengineering

Volumn 110, Issue 11, 2013, Pages 3013-3023

  Becker, Judith ^a   Reinefeld, Jasper ^a   Stellmacher, René ^a   Schäfer, Rudolf ^a   Lange, Anna ^a   Meyer, Hanna ^b   Lalk, Michael ^b   Zelder, Oskar ^c   von Abendroth, Gregory ^c   Schröder, Hartwig ^c   Haefner, Stefan ^c   Wittmann, Christoph ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c BASF SE   (Germany)

Author keywords

13C metabolic flux analysis; Central carbon pathways; Lactate dehydrogenase; OpenFlux; Pyruvate formate lyase; Redox metabolism; Succinic acid

Indexed keywords

CENTRAL CARBON PATHWAYS; LACTATE DEHYDROGENASE; METABOLIC FLUX ANALYSIS; OPENFLUX; PYRUVATE-FORMATE LYASE; REDOX METABOLISM; SUCCINIC ACIDS;

BATCH CELL CULTURE;

METABOLISM;

BIOSUCCINATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BACTERIAL GENE; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIUM CULTURE; BASFIA SUCCINICIPRODUCENS; BIOSYNTHESIS; CITRIC ACID CYCLE; DELETION MUTANT; GENETIC ENGINEERING; GRAM NEGATIVE BACTERIUM; METABOLIC ENGINEERING; NONHUMAN; STRUCTURAL GENE;

13C METABOLIC FLUX ANALYSIS; CENTRAL CARBON PATHWAYS; LACTATE DEHYDROGENASE; OPENFLUX; PYRUVATE-FORMATE LYASE; REDOX METABOLISM; SUCCINIC ACID;

GENE DELETION; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; PASTEURELLACEAE; SUCCINATES; SYSTEMS BIOLOGY;

EID: 84884531356     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24963     Document Type: Article

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