-
1
-
-
84857914247
-
Beta-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis
-
Tan J, Evin G. Beta-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis. J Neurochem. 2012;120(6):869-80.
-
(2012)
J Neurochem
, vol.120
, Issue.6
, pp. 869-880
-
-
Tan, J.1
Evin, G.2
-
2
-
-
80155123814
-
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation
-
Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation. Cell. 2011;147(3):615-28.
-
(2011)
Cell
, vol.147
, Issue.3
, pp. 615-628
-
-
Wu, J.1
Petralia, R.S.2
Kurushima, H.3
Patel, H.4
Jung, M.Y.5
Volk, L.6
Chowdhury, S.7
Shepherd, J.D.8
Dehoff, M.9
Li, Y.10
-
3
-
-
84893639063
-
Stuck in traffic: an emerging theme in diseases of the nervous system
-
Neefjes J, van der Kant R. Stuck in traffic: an emerging theme in diseases of the nervous system. Trends Neurosci. 2014;37(2):66-76.
-
(2014)
Trends Neurosci
, vol.37
, Issue.2
, pp. 66-76
-
-
Neefjes, J.1
Kant, R.2
-
5
-
-
84870984887
-
Endocytosis and autophagy: Shared machinery for degradation
-
Lamb CA, Dooley HC, Tooze SA. Endocytosis and autophagy: Shared machinery for degradation. Bioessays. 2013;35(1):34-45.
-
(2013)
Bioessays
, vol.35
, Issue.1
, pp. 34-45
-
-
Lamb, C.A.1
Dooley, H.C.2
Tooze, S.A.3
-
6
-
-
80052233389
-
Endosome maturation
-
Huotari J, Helenius A. Endosome maturation. EMBO J. 2011;30(17):3481-500.
-
(2011)
EMBO J
, vol.30
, Issue.17
, pp. 3481-3500
-
-
Huotari, J.1
Helenius, A.2
-
7
-
-
84893479572
-
Endosomal pH in neuronal signaling and synaptic transmission: role of Na+/H+ exchanger NHE5
-
Diering GH, Numata M. Endosomal pH in neuronal signaling and synaptic transmission: role of Na+/H+ exchanger NHE5. Frontiers in Physiology. 2014;4:412.
-
(2014)
Frontiers in Physiology
, vol.4
, pp. 412
-
-
Diering, G.H.1
Numata, M.2
-
8
-
-
84897981315
-
Rab-mediated trafficking role in neurite formation
-
Villarroel-Campos D, Gastaldi L, Conde C, Caceres A, Gonzalez-Billault C. Rab-mediated trafficking role in neurite formation. J Neurochem. 2014;129(2):240-8.
-
(2014)
J Neurochem
, vol.129
, Issue.2
, pp. 240-248
-
-
Villarroel-Campos, D.1
Gastaldi, L.2
Conde, C.3
Caceres, A.4
Gonzalez-Billault, C.5
-
9
-
-
34447123766
-
Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
-
Laifenfeld D, Patzek LJ, McPhie DL, Chen Y, Levites Y, Cataldo AM, et al. Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis. J Neurosci. 2007;27(27):7141-53.
-
(2007)
J Neurosci
, vol.27
, Issue.27
, pp. 7141-7153
-
-
Laifenfeld, D.1
Patzek, L.J.2
McPhie, D.L.3
Chen, Y.4
Levites, Y.5
Cataldo, A.M.6
Neve, R.L.7
-
10
-
-
84860677862
-
The recycling endosome and its role in neurological disorders
-
Li X, DiFiglia M. The recycling endosome and its role in neurological disorders. Prog Neurobiol. 2012;97(2):127-41.
-
(2012)
Prog Neurobiol
, vol.97
, Issue.2
, pp. 127-141
-
-
Li, X.1
DiFiglia, M.2
-
11
-
-
77955051719
-
Transport at the recycling endosome
-
Hsu VW, Prekeris R. Transport at the recycling endosome. Curr Opin Cell Biol. 2010;22(4):528-34.
-
(2010)
Curr Opin Cell Biol
, vol.22
, Issue.4
, pp. 528-534
-
-
Hsu, V.W.1
Prekeris, R.2
-
12
-
-
77951918362
-
Identification of the switch in early-to-late endosome transition
-
Poteryaev D, Datta S, Ackema K, Zerial M, Spang A. Identification of the switch in early-to-late endosome transition. Cell. 2010;141(3):497-508.
-
(2010)
Cell
, vol.141
, Issue.3
, pp. 497-508
-
-
Poteryaev, D.1
Datta, S.2
Ackema, K.3
Zerial, M.4
Spang, A.5
-
13
-
-
63649086486
-
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
-
Raiborg C, Stenmark H. The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature. 2009;458(7237):445-52.
-
(2009)
Nature
, vol.458
, Issue.7237
, pp. 445-452
-
-
Raiborg, C.1
Stenmark, H.2
-
14
-
-
0036566039
-
Endolysosomal proteolysis and its regulation
-
Pillay CS, Elliott E, Dennison C. Endolysosomal proteolysis and its regulation. Biochem J. 2002;363(Pt 3):417-29.
-
(2002)
Biochem J
, vol.363
, pp. 417-429
-
-
Pillay, C.S.1
Elliott, E.2
Dennison, C.3
-
15
-
-
0030463150
-
Isolation and characterization of early endosomes, late endosomes and terminal lysosomes: their role in protein degradation
-
Tjelle TE, Brech A, Juvet LK, Griffiths G, Berg T. Isolation and characterization of early endosomes, late endosomes and terminal lysosomes: their role in protein degradation. J Cell Sci. 1996;109(Pt 12):2905-14.
-
(1996)
J Cell Sci
, vol.109
, pp. 2905-2914
-
-
Tjelle, T.E.1
Brech, A.2
Juvet, L.K.3
Griffiths, G.4
Berg, T.5
-
16
-
-
84878563811
-
A model of lysosomal pH regulation
-
Ishida Y, Nayak S, Mindell JA, Grabe M. A model of lysosomal pH regulation. J Gen Physiol. 2013;141(6):705-20.
-
(2013)
J Gen Physiol
, vol.141
, Issue.6
, pp. 705-720
-
-
Ishida, Y.1
Nayak, S.2
Mindell, J.A.3
Grabe, M.4
-
18
-
-
84881137580
-
Membrane trafficking in neuronal maintenance and degeneration
-
Wang D, Chan CC, Cherry S, Hiesinger PR. Membrane trafficking in neuronal maintenance and degeneration. Cell Mol Life Sci. 2013;70(16):2919-34.
-
(2013)
Cell Mol Life Sci
, vol.70
, Issue.16
, pp. 2919-2934
-
-
Wang, D.1
Chan, C.C.2
Cherry, S.3
Hiesinger, P.R.4
-
19
-
-
84914145216
-
The vacuolar-type H(+)-ATPase at a glance - more than a proton pump
-
Maxson ME, Grinstein S. The vacuolar-type H(+)-ATPase at a glance - more than a proton pump. J Cell Sci. 2014;127(23):4987-93.
-
(2014)
J Cell Sci
, vol.127
, Issue.23
, pp. 4987-4993
-
-
Maxson, M.E.1
Grinstein, S.2
-
20
-
-
84883442790
-
Regulation of luminal acidification by the V-ATPase
-
Breton S, Brown D. Regulation of luminal acidification by the V-ATPase. Physiology (Bethesda). 2013;28(5):318-29.
-
(2013)
Physiology (Bethesda)
, vol.28
, Issue.5
, pp. 318-329
-
-
Breton, S.1
Brown, D.2
-
21
-
-
84930540208
-
The membrane domain of vacuolar H(+)ATPase: a crucial player in neurotransmitter exocytotic release
-
Morel N, Poea-Guyon S. The membrane domain of vacuolar H(+)ATPase: a crucial player in neurotransmitter exocytotic release. Cell Mol Life Sci. 2015;72(13):2561-73.
-
(2015)
Cell Mol Life Sci
, vol.72
, Issue.13
, pp. 2561-2573
-
-
Morel, N.1
Poea-Guyon, S.2
-
22
-
-
84924742620
-
Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia
-
Yuan N, Song L, Zhang S, Lin W, Cao Y, Xu F, et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015;100(3):345-56.
-
(2015)
Haematologica
, vol.100
, Issue.3
, pp. 345-356
-
-
Yuan, N.1
Song, L.2
Zhang, S.3
Lin, W.4
Cao, Y.5
Xu, F.6
Fang, Y.7
Wang, Z.8
Zhang, H.9
Li, X.10
-
23
-
-
63349098256
-
Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells
-
Wu YC, Wu WK, Li Y, Yu L, Li ZJ, Wong CC, et al. Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. Biochem Biophys Res Commun. 2009;382(2):451-6.
-
(2009)
Biochem Biophys Res Commun
, vol.382
, Issue.2
, pp. 451-456
-
-
Wu, Y.C.1
Wu, W.K.2
Li, Y.3
Yu, L.4
Li, Z.J.5
Wong, C.C.6
Li, H.T.7
Sung, J.J.8
Cho, C.H.9
-
24
-
-
78049403815
-
Sorting motifs of the endosomal/lysosomal CLC chloride transporters
-
Stauber T, Jentsch TJ. Sorting motifs of the endosomal/lysosomal CLC chloride transporters. J Biol Chem. 2010;285(45):34537-48.
-
(2010)
J Biol Chem
, vol.285
, Issue.45
, pp. 34537-34548
-
-
Stauber, T.1
Jentsch, T.J.2
-
25
-
-
22944479662
-
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins
-
Scheel O, Zdebik AA, Lourdel S, Jentsch TJ. Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature. 2005;436(7049):424-7.
-
(2005)
Nature
, vol.436
, Issue.7049
, pp. 424-427
-
-
Scheel, O.1
Zdebik, A.A.2
Lourdel, S.3
Jentsch, T.J.4
-
26
-
-
21844467751
-
The vacuolar H+ - ATPase mediates intracellular acidification required for neurodegeneration in C. elegans
-
Syntichaki P, Samara C, Tavernarakis N. The vacuolar H+ - ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol. 2005;15(13):1249-54.
-
(2005)
Curr Biol
, vol.15
, Issue.13
, pp. 1249-1254
-
-
Syntichaki, P.1
Samara, C.2
Tavernarakis, N.3
-
27
-
-
15544362767
-
Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models
-
Jentsch TJ, Poet M, Fuhrmann JC, Zdebik AA. Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models. Annu Rev Physiol. 2005;67:779-807.
-
(2005)
Annu Rev Physiol
, vol.67
, pp. 779-807
-
-
Jentsch, T.J.1
Poet, M.2
Fuhrmann, J.C.3
Zdebik, A.A.4
-
28
-
-
67349135343
-
ESCRT proteins in physiology and disease
-
Stuffers S, Brech A, Stenmark H. ESCRT proteins in physiology and disease. Exp Cell Res. 2009;315(9):1619-26.
-
(2009)
Exp Cell Res
, vol.315
, Issue.9
, pp. 1619-1626
-
-
Stuffers, S.1
Brech, A.2
Stenmark, H.3
-
29
-
-
39149132089
-
ESCRT complexes and the biogenesis of multivesicular bodies
-
Hurley JH. ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol. 2008;20(1):4-11.
-
(2008)
Curr Opin Cell Biol
, vol.20
, Issue.1
, pp. 4-11
-
-
Hurley, J.H.1
-
30
-
-
77649335931
-
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation
-
Teis D, Saksena S, Judson BL, Emr SD. ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. The EMBO Journal. 2010;29(5):871-83.
-
(2010)
The EMBO Journal
, vol.29
, Issue.5
, pp. 871-883
-
-
Teis, D.1
Saksena, S.2
Judson, B.L.3
Emr, S.D.4
-
31
-
-
84891658400
-
Retromer: a master conductor of endosome sorting
-
Burd C, Cullen PJ: Retromer: a master conductor of endosome sorting. Cold Spring Harb Perspect Biol 2014, 6(2). doi: 10.1101/cshperspect.a016774.
-
(2014)
Cold Spring Harb Perspect Biol
, vol.6
, Issue.2
-
-
Burd, C.1
Cullen, P.J.2
-
33
-
-
79960184162
-
Recent Advances in Retromer Biology
-
McGough IJ, Cullen PJ. Recent Advances in Retromer Biology. Traffic. 2011;12(8):963-71.
-
(2011)
Traffic
, vol.12
, Issue.8
, pp. 963-971
-
-
McGough, I.J.1
Cullen, P.J.2
-
34
-
-
0034629292
-
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease
-
Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, et al. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem. 2000;275(10):7410-5.
-
(2000)
J Biol Chem
, vol.275
, Issue.10
, pp. 7410-7415
-
-
Ulery, P.G.1
Beers, J.2
Mikhailenko, I.3
Tanzi, R.E.4
Rebeck, G.W.5
Hyman, B.T.6
Strickland, D.K.7
-
35
-
-
0033762062
-
Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway
-
Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, et al. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest. 2000;106(9):1159-66.
-
(2000)
J Clin Invest
, vol.106
, Issue.9
, pp. 1159-1166
-
-
Kang, D.E.1
Pietrzik, C.U.2
Baum, L.3
Chevallier, N.4
Merriam, D.E.5
Kounnas, M.Z.6
Wagner, S.L.7
Troncoso, J.C.8
Kawas, C.H.9
Katzman, R.10
-
36
-
-
42549148456
-
Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting
-
Rajendran L, Schneider A, Schlechtingen G, Weidlich S, Ries J, Braxmeier T, et al. Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting. Science. 2008;320(5875):520-3.
-
(2008)
Science
, vol.320
, Issue.5875
, pp. 520-523
-
-
Rajendran, L.1
Schneider, A.2
Schlechtingen, G.3
Weidlich, S.4
Ries, J.5
Braxmeier, T.6
Schwille, P.7
Schulz, J.B.8
Schroeder, C.9
Simons, M.10
-
37
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286(5440):735-41.
-
(1999)
Science
, vol.286
, Issue.5440
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
-
38
-
-
0033898887
-
Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
-
Kim HS, Park CH, Cha SH, Lee JH, Lee S, Kim Y, et al. Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. FASEB J. 2000;14(11):1508-17.
-
(2000)
FASEB J
, vol.14
, Issue.11
, pp. 1508-1517
-
-
Kim, H.S.1
Park, C.H.2
Cha, S.H.3
Lee, J.H.4
Lee, S.5
Kim, Y.6
Rah, J.C.7
Jeong, S.J.8
Suh, Y.H.9
-
39
-
-
4644319713
-
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
-
Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, et al. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging. 2004;25(10):1263-72.
-
(2004)
Neurobiol Aging
, vol.25
, Issue.10
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
Mercken, M.6
Mehta, P.D.7
Buxbaum, J.8
Haroutunian, V.9
Nixon, R.A.10
-
40
-
-
58449101589
-
Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
-
Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM. Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One. 2009;4(1):e4201.
-
(2009)
PLoS One
, vol.4
, Issue.1
, pp. e4201
-
-
Ling, D.1
Song, H.J.2
Garza, D.3
Neufeld, T.P.4
Salvaterra, P.M.5
-
41
-
-
11444267601
-
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
-
Nixon RA. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging. 2005;26(3):373-82.
-
(2005)
Neurobiol Aging
, vol.26
, Issue.3
, pp. 373-382
-
-
Nixon, R.A.1
-
42
-
-
0030836345
-
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis
-
Cataldo AM, Barnett JL, Pieroni C, Nixon RA. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. J Neurosci. 1997;17(16):6142-51.
-
(1997)
J Neurosci
, vol.17
, Issue.16
, pp. 6142-6151
-
-
Cataldo, A.M.1
Barnett, J.L.2
Pieroni, C.3
Nixon, R.A.4
-
43
-
-
78049427173
-
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression
-
Ginsberg SD, Alldred MJ, Counts SE, Cataldo AM, Neve RL, Jiang Y, et al. Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry. 2010;68(10):885-93.
-
(2010)
Biol Psychiatry
, vol.68
, Issue.10
, pp. 885-893
-
-
Ginsberg, S.D.1
Alldred, M.J.2
Counts, S.E.3
Cataldo, A.M.4
Neve, R.L.5
Jiang, Y.6
Wuu, J.7
Chao, M.V.8
Mufson, E.J.9
Nixon, R.A.10
-
44
-
-
0033869715
-
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
-
Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol. 2000;157(1):277-86.
-
(2000)
Am J Pathol
, vol.157
, Issue.1
, pp. 277-286
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Troncoso, J.C.3
Gomez-Isla, T.4
Hyman, B.T.5
Nixon, R.A.6
-
45
-
-
0026744303
-
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
-
Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, et al. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell. 1992;70(5):715-28.
-
(1992)
Cell
, vol.70
, Issue.5
, pp. 715-728
-
-
Bucci, C.1
Parton, R.G.2
Mather, I.H.3
Stunnenberg, H.4
Simons, K.5
Hoflack, B.6
Zerial, M.7
-
46
-
-
84890919877
-
A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production
-
Udayar V, Buggia-Prévot V, Guerreiro Rita L, Siegel G, Rambabu N, Soohoo Amanda L, et al. A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production. Cell Reports. 2013;5(6):1536-51.
-
(2013)
Cell Reports
, vol.5
, Issue.6
, pp. 1536-1551
-
-
Udayar, V.1
Buggia-Prévot, V.2
Guerreiro Rita, L.3
Siegel, G.4
Rambabu, N.5
Soohoo Amanda, L.6
Ponnusamy, M.7
Siegenthaler, B.8
Bali, J.9
Simons, M.10
-
47
-
-
84892377524
-
Trafficking regulation of proteins in Alzheimer's disease
-
Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW. Trafficking regulation of proteins in Alzheimer's disease. Mol Neurodegener. 2014;9:6.
-
(2014)
Mol Neurodegener
, vol.9
, pp. 6
-
-
Jiang, S.1
Li, Y.2
Zhang, X.3
Bu, G.4
Xu, H.5
Zhang, Y.W.6
-
48
-
-
38749117584
-
The endogenous alkaloid harmane: acidifying and activity-reducing effects on hippocampal neurons in vitro
-
Bonnet U, Scherbaum N, Wiemann M. The endogenous alkaloid harmane: acidifying and activity-reducing effects on hippocampal neurons in vitro. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(2):362-7.
-
(2008)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.32
, Issue.2
, pp. 362-367
-
-
Bonnet, U.1
Scherbaum, N.2
Wiemann, M.3
-
49
-
-
79955970157
-
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes
-
Majumdar A, Capetillo-Zarate E, Cruz D, Gouras GK, Maxfield FR. Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes. Mol Biol Cell. 2011;22(10):1664-76.
-
(2011)
Mol Biol Cell
, vol.22
, Issue.10
, pp. 1664-1676
-
-
Majumdar, A.1
Capetillo-Zarate, E.2
Cruz, D.3
Gouras, G.K.4
Maxfield, F.R.5
-
50
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, et al. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 2010;141(7):1146-58.
-
(2010)
Cell
, vol.141
, Issue.7
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
-
51
-
-
84897632293
-
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage
-
Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, et al. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014;24(3):344-58.
-
(2014)
Cell Res
, vol.24
, Issue.3
, pp. 344-358
-
-
Zhao, L.1
Hua, T.2
Crowley, C.3
Ru, H.4
Ni, X.5
Shaw, N.6
Jiao, L.7
Ding, W.8
Qu, L.9
Hung, L.-W.10
-
52
-
-
77949739596
-
Age-related changes in brain energetics and phospholipid metabolism
-
Forester BP, Berlow YA, Harper DG, Jensen JE, Lange N, Froimowitz MP, et al. Age-related changes in brain energetics and phospholipid metabolism. NMR in Biomedicine. 2010;23(3):242-50.
-
(2010)
NMR in Biomedicine
, vol.23
, Issue.3
, pp. 242-250
-
-
Forester, B.P.1
Berlow, Y.A.2
Harper, D.G.3
Jensen, J.E.4
Lange, N.5
Froimowitz, M.P.6
Ravichandran, C.7
Iosifescu, D.V.8
Lukas, S.E.9
Renshaw, P.F.10
-
53
-
-
0027332651
-
Brain aα-Ketoglutarate Dehydrotenase Complex Activity in Alzheimer's Disease
-
Mastrogiacomo F, Bergeron C, Kish SJ. Brain aα-Ketoglutarate Dehydrotenase Complex Activity in Alzheimer's Disease. J Neurochem. 1993;61(6):2007-14.
-
(1993)
J Neurochem
, vol.61
, Issue.6
, pp. 2007-2014
-
-
Mastrogiacomo, F.1
Bergeron, C.2
Kish, S.J.3
-
54
-
-
84910669129
-
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
-
Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, et al. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nat Med. 2014;20(11):1254-62.
-
(2014)
Nat Med
, vol.20
, Issue.11
, pp. 1254-1262
-
-
Zhang, Z.1
Song, M.2
Liu, X.3
Kang, S.S.4
Kwon, I.S.5
Duong, D.M.6
Seyfried, N.T.7
Hu, W.T.8
Liu, Z.9
Wang, J.Z.10
-
55
-
-
84879232282
-
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
-
Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci. 2013;37(12):1949-61.
-
(2013)
Eur J Neurosci
, vol.37
, Issue.12
, pp. 1949-1961
-
-
Wolfe, D.M.1
Lee, J.H.2
Kumar, A.3
Lee, S.4
Orenstein, S.J.5
Nixon, R.A.6
-
56
-
-
34247264399
-
Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils
-
Majumdar A, Cruz D, Asamoah N, Buxbaum A, Sohar I, Lobel P, et al. Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils. Mol Biol Cell. 2007;18(4):1490-6.
-
(2007)
Mol Biol Cell
, vol.18
, Issue.4
, pp. 1490-1496
-
-
Majumdar, A.1
Cruz, D.2
Asamoah, N.3
Buxbaum, A.4
Sohar, I.5
Lobel, P.6
Maxfield, F.R.7
-
57
-
-
84879607073
-
Lysosomal impairment in Parkinson's disease
-
Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, et al. Lysosomal impairment in Parkinson's disease. Mov Disord. 2013;28(6):725-32.
-
(2013)
Mov Disord
, vol.28
, Issue.6
, pp. 725-732
-
-
Dehay, B.1
Martinez-Vicente, M.2
Caldwell, G.A.3
Caldwell, K.A.4
Yue, Z.5
Cookson, M.R.6
Klein, C.7
Vila, M.8
Bezard, E.9
-
58
-
-
84881565288
-
The lysosome: from waste bag to potential therapeutic target
-
Appelqvist H, Waster P, Kagedal K, Ollinger K. The lysosome: from waste bag to potential therapeutic target. J Mol Cell Biol. 2013;5(4):214-26.
-
(2013)
J Mol Cell Biol
, vol.5
, Issue.4
, pp. 214-226
-
-
Appelqvist, H.1
Waster, P.2
Kagedal, K.3
Ollinger, K.4
-
59
-
-
79953197650
-
Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease
-
Dammer EB, Na CH, Xu P, Seyfried NT, Duong DM, Cheng D, et al. Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease. J Biol Chem. 2011;286(12):10457-65.
-
(2011)
J Biol Chem
, vol.286
, Issue.12
, pp. 10457-10465
-
-
Dammer, E.B.1
Na, C.H.2
Xu, P.3
Seyfried, N.T.4
Duong, D.M.5
Cheng, D.6
Gearing, M.7
Rees, H.8
Lah, J.J.9
Levey, A.I.10
-
60
-
-
70349649217
-
Autophagy defects contribute to neurodegeneration induced by dysfunctional ESCRT-III
-
Lee JA, Liu L, Gao FB. Autophagy defects contribute to neurodegeneration induced by dysfunctional ESCRT-III. Autophagy. 2009;5(7):1070-2.
-
(2009)
Autophagy
, vol.5
, Issue.7
, pp. 1070-1072
-
-
Lee, J.A.1
Liu, L.2
Gao, F.B.3
-
61
-
-
84907245350
-
Chaperone-mediated autophagy: roles in neurodegeneration
-
Wang G, Mao Z. Chaperone-mediated autophagy: roles in neurodegeneration. Transl Neurodegener. 2014;3:20.
-
(2014)
Transl Neurodegener
, vol.3
, pp. 20
-
-
Wang, G.1
Mao, Z.2
-
62
-
-
79960743373
-
MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between
-
Babst M. MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between. Curr Opin Cell Biol. 2011;23(4):452-7.
-
(2011)
Curr Opin Cell Biol
, vol.23
, Issue.4
, pp. 452-457
-
-
Babst, M.1
-
63
-
-
34548492271
-
ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
-
Lee JA, Beigneux A, Ahmad ST, Young SG, Gao FB. ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol. 2007;17(18):1561-7.
-
(2007)
Curr Biol
, vol.17
, Issue.18
, pp. 1561-1567
-
-
Lee, J.A.1
Beigneux, A.2
Ahmad, S.T.3
Young, S.G.4
Gao, F.B.5
-
64
-
-
84902242103
-
Autophagy dysfunction and its link to Alzheimer's disease and type II diabetes mellitus
-
Wilson CM, Magnaudeix A, Yardin C, Terro F. Autophagy dysfunction and its link to Alzheimer's disease and type II diabetes mellitus. CNS Neurol Disord Drug Targets. 2014;13(2):226-46.
-
(2014)
CNS Neurol Disord Drug Targets
, vol.13
, Issue.2
, pp. 226-246
-
-
Wilson, C.M.1
Magnaudeix, A.2
Yardin, C.3
Terro, F.4
-
65
-
-
84859743802
-
Autophagy: a double-edged sword in Alzheimer's disease
-
Tung YT, Wang BJ, Hu MK, Hsu WM, Lee H, Huang WP, et al. Autophagy: a double-edged sword in Alzheimer's disease. J Biosci. 2012;37(1):157-65.
-
(2012)
J Biosci
, vol.37
, Issue.1
, pp. 157-165
-
-
Tung, Y.T.1
Wang, B.J.2
Hu, M.K.3
Hsu, W.M.4
Lee, H.5
Huang, W.P.6
Liao, Y.F.7
-
66
-
-
44449165118
-
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
-
Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, et al. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A. 2008;105(20):7327-32.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.20
, pp. 7327-7332
-
-
Muhammad, A.1
Flores, I.2
Zhang, H.3
Yu, R.4
Staniszewski, A.5
Planel, E.6
Herman, M.7
Ho, L.8
Kreber, R.9
Honig, L.S.10
-
67
-
-
84905646690
-
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
-
Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin UM, et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet. 2014;23(17):4621-38.
-
(2014)
Hum Mol Genet
, vol.23
, Issue.17
, pp. 4621-4638
-
-
Tsika, E.1
Glauser, L.2
Moser, R.3
Fiser, A.4
Daniel, G.5
Sheerin, U.M.6
Lees, A.7
Troncoso, J.C.8
Lewis, P.A.9
Bandopadhyay, R.10
-
68
-
-
84931575624
-
A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration
-
Damseh N, Danson CM, Al-Ashhab M, Abu-Libdeh B, Gallon M, Sharma K, et al. A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration. Neurogenetics. 2015;16(3):215-21.
-
(2015)
Neurogenetics
, vol.16
, Issue.3
, pp. 215-221
-
-
Damseh, N.1
Danson, C.M.2
Al-Ashhab, M.3
Abu-Libdeh, B.4
Gallon, M.5
Sharma, K.6
Yaacov, B.7
Coulthard, E.8
Caldwell, M.A.9
Edvardson, S.10
-
69
-
-
84925489584
-
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review
-
Epub 2014 Oct 21. Review.
-
Reitz C. The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review. Mol Genet Genomics. 2014;290(2):413-27.doi: 10.1007/s00438-014-0939-9. Epub 2014 Oct 21. Review.
-
(2014)
Mol Genet Genomics
, vol.290
, Issue.2
, pp. 413-427
-
-
Reitz, C.1
-
70
-
-
76549096350
-
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
-
Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A. 2010;107(4):1630-5.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.4
, pp. 1630-1635
-
-
Jiang, Y.1
Mullaney, K.A.2
Peterhoff, C.M.3
Che, S.4
Schmidt, S.D.5
Boyer-Boiteau, A.6
Ginsberg, S.D.7
Cataldo, A.M.8
Mathews, P.M.9
Nixon, R.A.10
-
71
-
-
79958188530
-
Retromer disruption promotes amyloidogenic APP processing
-
Sullivan CP, Jay AG, Stack EC, Pakaluk M, Wadlinger E, Fine RE, et al. Retromer disruption promotes amyloidogenic APP processing. Neurobiol Dis. 2011;43(2):338-45.
-
(2011)
Neurobiol Dis
, vol.43
, Issue.2
, pp. 338-345
-
-
Sullivan, C.P.1
Jay, A.G.2
Stack, E.C.3
Pakaluk, M.4
Wadlinger, E.5
Fine, R.E.6
Wells, J.M.7
Morin, P.J.8
-
72
-
-
84862907635
-
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology
-
Wen L, Tang FL, Hong Y, Luo SW, Wang CL, He W, et al. VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol. 2011;195(5):765-79.
-
(2011)
J Cell Biol
, vol.195
, Issue.5
, pp. 765-779
-
-
Wen, L.1
Tang, F.L.2
Hong, Y.3
Luo, S.W.4
Wang, C.L.5
He, W.6
Shen, C.7
Jung, J.U.8
Xiong, F.9
Lee, D.H.10
-
73
-
-
84901190201
-
Pharmacological chaperones stabilize retromer to limit APP processing
-
Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014;10(6):443-9.
-
(2014)
Nat Chem Biol
, vol.10
, Issue.6
, pp. 443-449
-
-
Mecozzi, V.J.1
Berman, D.E.2
Simoes, S.3
Vetanovetz, C.4
Awal, M.R.5
Patel, V.M.6
Schneider, R.T.7
Petsko, G.A.8
Ringe, D.9
Small, S.A.10
-
74
-
-
84863011338
-
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing
-
Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, et al. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci. 2012;32(4):1467-80.
-
(2012)
J Neurosci
, vol.32
, Issue.4
, pp. 1467-1480
-
-
Fjorback, A.W.1
Seaman, M.2
Gustafsen, C.3
Mehmedbasic, A.4
Gokool, S.5
Wu, C.6
Militz, D.7
Schmidt, V.8
Madsen, P.9
Nyengaard, J.R.10
-
75
-
-
84896332732
-
Sorting the role of SORLA in Alzheimer's disease
-
Buggia-Prevot V, Thinakaran G. Sorting the role of SORLA in Alzheimer's disease. Sci Transl Med. 2014;6(223):223fs228.
-
(2014)
Sci Transl Med
, vol.6
, Issue.223
, pp. 223fs228
-
-
Buggia-Prevot, V.1
Thinakaran, G.2
-
76
-
-
78349284756
-
SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease
-
Willnow TE, Carlo AS, Rohe M, Schmidt V. SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease. Rev Neurosci. 2010;21(4):315-29.
-
(2010)
Rev Neurosci
, vol.21
, Issue.4
, pp. 315-329
-
-
Willnow, T.E.1
Carlo, A.S.2
Rohe, M.3
Schmidt, V.4
-
77
-
-
84861230374
-
The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport
-
Bhalla A, Vetanovetz CP, Morel E, Chamoun Z, Di Paolo G, Small SA. The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis. 2012;47(1):126-34.
-
(2012)
Neurobiol Dis
, vol.47
, Issue.1
, pp. 126-134
-
-
Bhalla, A.1
Vetanovetz, C.P.2
Morel, E.3
Chamoun, Z.4
Paolo, G.5
Small, S.A.6
-
78
-
-
84855356440
-
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease
-
Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, et al. Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J. 2012;31(1):187-200.
-
(2012)
EMBO J
, vol.31
, Issue.1
, pp. 187-200
-
-
Schmidt, V.1
Baum, K.2
Lao, A.3
Rateitschak, K.4
Schmitz, Y.5
Teichmann, A.6
Wiesner, B.7
Petersen, C.M.8
Nykjaer, A.9
Wolf, J.10
-
79
-
-
84902975099
-
Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions
-
Arrese EL, Saudale FZ, Soulages JL. Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions. Lipid Insights. 2014;7:7-16.
-
(2014)
Lipid Insights
, vol.7
, pp. 7-16
-
-
Arrese, E.L.1
Saudale, F.Z.2
Soulages, J.L.3
-
80
-
-
84920995154
-
Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration
-
Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, et al. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell. 2015;160(1-2):177-90.
-
(2015)
Cell
, vol.160
, Issue.1-2
, pp. 177-190
-
-
Liu, L.1
Zhang, K.2
Sandoval, H.3
Yamamoto, S.4
Jaiswal, M.5
Sanz, E.6
Li, Z.7
Hui, J.8
Graham, B.H.9
Quintana, A.10
|