Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

EMBO Journal

Volumn 31, Issue 1, 2012, Pages 187-200

  Schmidt, Vanessa ^a   Baum, Katharina ^a   Lao, Angelyn ^b   Rateitschak, Katja ^b   Schmitz, Yvonne ^b   Teichmann, Anke ^c   Wiesner, Burkhard ^c   Munck, Claus ^f   Petersen, Claus Munck ^d   Nykjaer, Anders ^d   Wolf, Jana ^a   Wolkenhauer, Olaf ^b,e   Willnow, Thomas E ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^d AARHUS UNIVERSITY   (Denmark)

^e STELLENBOSCH INSTITUTE FOR ADVANCED STUDY   (South Africa)

^f NONE

Author keywords

amyloidogenic processing; LR11; secretases; SORL1; VPS10P domain receptors

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; RECEPTOR; SORTING PROTEIN RELATED RECEPTOR WITH A TYPE REPEAT; UNCLASSIFIED DRUG;

ALLOSTERISM; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELLULAR DISTRIBUTION; CHO CELL; ENZYME ACTIVITY; FEMALE; GENETIC RISK; IN VIVO STUDY; MATHEMATICAL MODEL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; QUANTITATIVE STUDY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL;

EID: 84855356440     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.352     Document Type: Article

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